56 items (Sus scrofa) - STRING interaction network

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second shell of interactors

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proteins of unknown 3D structure

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Your Input:
	DCPS	m7GpppX diphosphatase; Decapping scavenger enzyme that catalyzes the cleavage of a residual cap structure following the degradation of mRNAs by the 3'->5' exosome-mediated mRNA decay pathway. Hydrolyzes cap analog structures like 7-methylguanosine nucleoside triphosphate (m7GpppG) with up to 10 nucleotide substrates (small capped oligoribonucleotides) and specifically releases 5'-phosphorylated RNA fragments and 7- methylguanosine monophosphate (m7GMP). Cleaves cap analog structures like tri-methyl guanosine nucleoside triphosphate (m3(2,2,7)GpppG) with very poor efficiency. Does not h [...] (337 aa)
	DND1	DND microRNA-mediated repression inhibitor 1. (353 aa)
	DCP2	Decapping mRNA 2. (478 aa)
	PDE12	2',5'-phosphodiesterase 12 isoform 1. (609 aa)
	EXOSC7	Uncharacterized protein. (349 aa)
	PARN	Poly(A)-specific ribonuclease. (715 aa)
	EXOSC2	Exosome component 2. (271 aa)
	SAMD4A	Sterile alpha motif domain containing 4A. (718 aa)
	ZFP36L2	ZFP36 ring finger protein like 2. (564 aa)
	YTHDF2	YTH N6-methyladenosine RNA binding protein 2. (600 aa)
	CNOT8	CCR4-NOT transcription complex subunit 8. (312 aa)
	ROCK1	Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa)
	CNOT6	CCR4-NOT transcription complex subunit 6. (590 aa)
	LRRC27	Leucine rich repeat containing 27. (557 aa)
	EXOSC5	Exosome component 5. (299 aa)
	EXOSC3	Exosome complex component RRP40 isoform 1. (275 aa)
	CNOT6L	CCR4-NOT transcription complex subunit 6 like. (651 aa)
	PAN3	PAN2-PAN3 deadenylation complex subunit PAN3; Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA deca [...] (906 aa)
	DIS3L2	DIS3-like exonuclease 2; 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mi [...] (914 aa)
	ZC3H12A	Zinc finger CCCH-type containing 12A. (582 aa)
	CPEB3	Cytoplasmic polyadenylation element binding protein 3. (758 aa)
	MOV10	Mov10 RISC complex RNA helicase. (1093 aa)
	TRIM71	E3 ubiquitin-protein ligase TRIM71. (869 aa)
	CNOT2	NOT2_3_5 domain-containing protein. (578 aa)
	LSM1	Steroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone (By similarity). (302 aa)
	YTHDF3	YTH domain-containing family protein 3 isoform b. (588 aa)
	PATL1	PAT1 homolog 1, processing body mRNA decay factor. (786 aa)
	FTO	FTO_NTD domain-containing protein. (509 aa)
	METTL14	N6-adenosine-methyltransferase non-catalytic subunit; Belongs to the MT-A70-like family. (456 aa)
	PNPT1	Polyribonucleotide nucleotidyltransferase 1, mitochondrial. (784 aa)
	CNOT3	CCR4-NOT transcription complex subunit 3. (774 aa)
	RC3H1	Ring finger and CCCH-type domains 1. (1132 aa)
	PUM1	Pumilio RNA binding family member 1. (1189 aa)
	PAN2	PAN2-PAN3 deadenylation complex catalytic subunit PAN2; Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent [...] (1198 aa)
	TARDBP	TAR DNA binding protein. (414 aa)
	CNOT7	CCR4-NOT transcription complex subunit 7 isoform 1. (285 aa)
	UPF1	UPF1 RNA helicase and ATPase. (1127 aa)
	RBM24	RRM domain-containing protein. (528 aa)
	EXOSC9	Exosome component 9. (455 aa)
	GIGYF2	GRB10 interacting GYF protein 2. (1310 aa)
	RIDA	Reactive intermediate imine deaminase A homolog. (137 aa)
	YTHDF1	YTH N6-methyladenosine RNA binding protein 1. (652 aa)
	SAMD4B	Sterile alpha motif domain containing 4B. (827 aa)
	DHX36	DEAH (Asp-Glu-Ala-His) box polypeptide 36 tv1. (1012 aa)
	NOCT	Nocturnin. (427 aa)
	MEX3D	RNA-binding protein MEX3D isoform 1. (649 aa)
	PLEKHN1	Pleckstrin homology domain containing N1. (564 aa)
	CNOT1	CCR4-NOT transcription complex subunit 1. (2343 aa)
	EXOSC8	Exosome component 8. (281 aa)
	ZFP36L1	ZFP36 ring finger protein like 1. (348 aa)
	AGO2	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] (874 aa)
	RC3H2	Ring finger and CCCH-type domains 2. (1192 aa)
	DCP1A	mRNA-decapping enzyme 1A; Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Contributes to the transactivation of target genes after stimulation by TGFB1; Belongs to the DCP1 family. (580 aa)
	DCP1B	Decapping mRNA 1B. (559 aa)
	ZFP36	Uncharacterized protein. (372 aa)
	PABPN1L	Poly(A) binding protein nuclear 1 like, cytoplasmic. (282 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGO2	CNOT1	ENSSSCP00000059624	ENSSSCP00000023830	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	CCR4-NOT transcription complex subunit 1.	0.594
AGO2	CNOT2	ENSSSCP00000059624	ENSSSCP00000048840	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	NOT2_3_5 domain-containing protein.	0.515
AGO2	CNOT7	ENSSSCP00000059624	ENSSSCP00000039703	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	CCR4-NOT transcription complex subunit 7 isoform 1.	0.480
AGO2	DCP1A	ENSSSCP00000059624	ENSSSCP00000023625	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	mRNA-decapping enzyme 1A; Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Contributes to the transactivation of target genes after stimulation by TGFB1; Belongs to the DCP1 family.	0.596
AGO2	DCP2	ENSSSCP00000059624	ENSSSCP00000015112	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Decapping mRNA 2.	0.710
AGO2	MOV10	ENSSSCP00000059624	ENSSSCP00000051048	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Mov10 RISC complex RNA helicase.	0.796
AGO2	PATL1	ENSSSCP00000059624	ENSSSCP00000047869	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	PAT1 homolog 1, processing body mRNA decay factor.	0.545
AGO2	PUM1	ENSSSCP00000059624	ENSSSCP00000041520	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Pumilio RNA binding family member 1.	0.486
AGO2	RC3H2	ENSSSCP00000059624	ENSSSCP00000057225	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Ring finger and CCCH-type domains 2.	0.611
AGO2	TRIM71	ENSSSCP00000059624	ENSSSCP00000050490	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	E3 ubiquitin-protein ligase TRIM71.	0.485
AGO2	UPF1	ENSSSCP00000059624	ENSSSCP00000036535	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	UPF1 RNA helicase and ATPase.	0.640
AGO2	ZFP36	ENSSSCP00000059624	ENSSSCP00000022373	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Uncharacterized protein.	0.490
AGO2	ZFP36L2	ENSSSCP00000059624	ENSSSCP00000068997	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	ZFP36 ring finger protein like 2.	0.440
CNOT1	AGO2	ENSSSCP00000023830	ENSSSCP00000059624	CCR4-NOT transcription complex subunit 1.	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	0.594
CNOT1	CNOT2	ENSSSCP00000023830	ENSSSCP00000048840	CCR4-NOT transcription complex subunit 1.	NOT2_3_5 domain-containing protein.	0.998
CNOT1	CNOT3	ENSSSCP00000023830	ENSSSCP00000042067	CCR4-NOT transcription complex subunit 1.	CCR4-NOT transcription complex subunit 3.	0.998
CNOT1	CNOT6	ENSSSCP00000023830	ENSSSCP00000063043	CCR4-NOT transcription complex subunit 1.	CCR4-NOT transcription complex subunit 6.	0.962
CNOT1	CNOT6L	ENSSSCP00000023830	ENSSSCP00000009593	CCR4-NOT transcription complex subunit 1.	CCR4-NOT transcription complex subunit 6 like.	0.985
CNOT1	CNOT7	ENSSSCP00000023830	ENSSSCP00000039703	CCR4-NOT transcription complex subunit 1.	CCR4-NOT transcription complex subunit 7 isoform 1.	0.996
CNOT1	CNOT8	ENSSSCP00000023830	ENSSSCP00000064843	CCR4-NOT transcription complex subunit 1.	CCR4-NOT transcription complex subunit 8.	0.974