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| | ARNT | Aryl hydrocarbon receptor nuclear translocator isoform X3. (790 aa) |
| | PPARA | Uncharacterized protein. (469 aa) |
| | BBS10 | Bardet-Biedl syndrome 10. (721 aa) |
| | POU5F1 | POU domain, class 5, transcription factor 1; Transcription factor that binds to the octamer motif (5'- ATTTGCAT-3'). Forms a trimeric complex with SOX2 or SOX15 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency. Belongs to the POU transcription factor family. Class-5 subfamily. (361 aa) |
| | DAXX | Death domain associated protein. (751 aa) |
| | SRF | Serum response factor. (512 aa) |
| | NFKBIA | NF-kappa-B inhibitor alpha; Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription. (314 aa) |
| | GTF2A1 | General transcription factor IIA subunit 1. (376 aa) |
| | GSC | Goosecoid homeobox. (256 aa) |
| | MED25 | Mediator complex subunit 25. (794 aa) |
| | NR1H2 | Nuclear receptor subfamily 1 group H member 2. (458 aa) |
| | PARK7 | DJ-1 protein. (189 aa) |
| | KDM1A | Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (875 aa) |
| | GATA6 | Transcription factor GATA-6; Transcriptional activator that regulates SEMA3C and PLXNA2. May regulate genes that protect epithelial cells from bacterial infection. Involved in gene regulation specifically in the gastric epithelium. Involved in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression. Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions. (592 aa) |
| | TAF4B | TATA-box binding protein associated factor 4b. (869 aa) |
| | CITED2 | Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (278 aa) |
| | NCOA7 | Nuclear receptor coactivator 7. (968 aa) |
| | HEY2 | Hes related family bHLH transcription factor with YRPW motif 2. (337 aa) |
| | HDAC2 | Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa) |
| | SMAD4 | Mothers against decapentaplegic homolog 4; Common SMAD (co-SMAD) is the coactivator and mediator of signal transduction by TGF-beta (transforming growth factor). Component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling. Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. Component of the multimeric SMAD3/SMAD4/JUN/FOS complex which forms at the AP1 promoter site; required for synergistic transcriptional activity in r [...] (552 aa) |
| | LOC100359361 | Uncharacterized protein. (108 aa) |
| | GFI1B | Growth factor independent 1B transcriptional repressor. (436 aa) |
| | CTDP1 | RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II. (929 aa) |
| | FOXH1 | Forkhead box H1. (354 aa) |
| | ZFPM2 | Uncharacterized protein. (1153 aa) |
| | DCAF13 | DDB1 and CUL4 associated factor 13. (444 aa) |
| | HEY1 | Hes related family bHLH transcription factor with YRPW motif 1. (304 aa) |
| | SOX17 | SRY-box transcription factor 17. (407 aa) |
| | PRKDC | Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4136 aa) |
| | NHLH1 | Nescient helix-loop-helix 1. (133 aa) |
| | NOTCH2 | Neurogenic locus notch homolog protein 2 isoform 1 preproprotein. (2471 aa) |
| | NHLH2 | Nescient helix-loop-helix 2. (135 aa) |
| | LRIF1 | Ligand-dependent nuclear receptor-interacting factor 1 isoform X1. (762 aa) |
| | GTF2B | General transcription factor IIB. (337 aa) |
| | BCL10 | B-cell lymphoma/leukemia 10 isoform 1. (233 aa) |
| | MKKS | McKusick-Kaufman syndrome. (570 aa) |
| | ASXL1 | ASXL transcriptional regulator 1. (1542 aa) |
| | NCOA6 | Nuclear receptor coactivator 6. (2061 aa) |
| | NCOA3 | Uncharacterized protein. (1296 aa) |
| | BUD31 | Protein BUD31 homolog isoform X2. (144 aa) |
| | HSPB1 | Heat shock protein beta-1; Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding- competent state. Plays a role in stress resistance and actin organization. Through its molecular chaperone activity may regulate numerous biological processes including the phosphorylation and the axonal transport of neurofilament proteins. (365 aa) |
| | GTF2I | General transcription factor II-I isoform 1. (999 aa) |
| | SETD1A | SET domain containing 1A, histone lysine methyltransferase. (1703 aa) |
| | CREBBP | CREB-binding protein isoform a. (2440 aa) |
| | ANXA4 | Annexin A4; Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis; Belongs to the annexin family. (337 aa) |
| | EPAS1 | Uncharacterized protein. (870 aa) |
| | STRN | Striatin isoform X1. (809 aa) |
| | SLC30A9 | Uncharacterized protein. (541 aa) |
| | PPID | Peptidylprolyl isomerase D. (370 aa) |
| | BBS7 | Bardet-Biedl syndrome 7. (871 aa) |
| | RB1 | RB transcriptional corepressor 1. (938 aa) |
| | CCDC62 | Coiled-coil domain containing 62. (692 aa) |
| | TBX3 | T-box transcription factor TBX3 isoform 2. (745 aa) |
| | TBX5 | T-box transcription factor 5. (535 aa) |
| | YWHAH | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta; Belongs to the 14-3-3 family. (246 aa) |
| | SMARCB1 | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1; Belongs to the SNF5 family. (385 aa) |
| | CRKL | CRK like proto-oncogene, adaptor protein. (303 aa) |
| | EGR2 | E3 SUMO-protein ligase EGR2; Sequence-specific DNA-binding transcription factor. Binds to two specific DNA sites located in the promoter region of HOXA4. Binds to the promoter region of ERBB2 (By similarity); Belongs to the EGR C2H2-type zinc-finger protein family. (471 aa) |
| | SIRT1 | NAD-dependent protein deacetylase sirtuin-1 isoform a. (742 aa) |
| | KAT6B | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (2065 aa) |
| | MMS19 | MMS19 homolog, cytosolic iron-sulfur assembly component. (1039 aa) |
| | LDB1 | LID domain-containing protein. (411 aa) |
| | PDCD11 | Programmed cell death 11. (1875 aa) |
| | TCF7L2 | Transcription factor 7 like 2. (669 aa) |
| | CTBP2 | C-terminal binding protein 2. (982 aa) |
| | KLHL40 | Kelch like family member 40. (623 aa) |
| | IFRD2 | Interferon-related developmental regulator 2. (441 aa) |
| | TMF1 | TATA element modulatory factor 1. (1096 aa) |
| | TADA3 | Transcriptional adapter 3 isoform a. (432 aa) |
| | NR1I2 | Nuclear receptor subfamily 1 group I member 2. (437 aa) |
| | POU1F1 | Pituitary-specific positive transcription factor 1; Transcription factor involved in the specification of the lactotrope, somatotrope, and thyrotrope phenotypes in the developing anterior pituitary. Activates growth hormone and prolactin genes. Specifically binds to the consensus sequence 5'-TAAAT-3'. (317 aa) |
| | NR0B1 | Nuclear receptor subfamily 0 group B member 1; Orphan nuclear receptor. Component of a cascade required for the development of the hypothalamic-pituitary-adrenal-gonadal axis. Acts as a coregulatory protein that inhibits the transcriptional activity of other nuclear receptors through heterodimeric interactions. May also have a role in the development of the embryo and in the maintenance of embryonic stem cell pluripotency (By similarity). Belongs to the nuclear hormone receptor family. NR0 subfamily. (490 aa) |
| | AR | Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. (896 aa) |
| | AIP | Aryl hydrocarbon receptor interacting protein. (330 aa) |
| | RELA | Transcription factor p65 isoform 1. (573 aa) |
| | MTA2 | Metastasis associated 1 family member 2. (628 aa) |
| | NR1H3 | Nuclear receptor subfamily 1 group H member 3. (470 aa) |
| | CRY2 | Cryptochrome circadian regulator 2. (615 aa) |
| | GTF2H1 | General transcription factor IIH subunit 1. (674 aa) |
| | MYOD1 | Myoblast determination protein 1; Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Together with MYF5 and MYOG, co-occupies muscle-specific gene promoter core region during myogenesis. Induces fibroblasts to differentiate into myoblasts. Interacts with and is inhibited by the twist protein. This interaction probably involves the basic domains of both proteins (By similarity). (319 aa) |
| | MED16 | Mediator of RNA polymerase II transcription subunit 16; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (837 aa) |
| | CALR | Calreticulin; Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export (By similarity). Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis; Belongs to the calreticulin family. (417 aa) |
| | MEF2C | Myocyte-specific enhancer factor 2C; Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Enhances transcriptional activation mediated by SOX18. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex [...] (483 aa) |
| | STING1 | Stimulator of interferon genes protein; Facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double-stranded DNA from viruses and bacteria delivered to the cytoplasm. Acts by binding cyclic dinucleotides: recognizes and binds cyclic di-GMP (c-di-GMP), a second messenger produced by bacteria, and cyclic GMP-AMP (cGAMP), a messenger produced by CGAS in response to DNA virus in the cytosol. Upon binding of [...] (440 aa) |
| | RNF14 | RBR-type E3 ubiquitin transferase. (474 aa) |
| | PPARGC1B | Peroxisome proliferator-activated receptor gamma coactivator 1-beta isoform 1. (1028 aa) |
| | TRIM68 | Tripartite motif containing 68. (484 aa) |
| | DUSP26 | Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (211 aa) |
| | SP3 | Sp3 transcription factor. (789 aa) |
| | NEUROD1 | Neurogenic differentiation factor. (356 aa) |
| | GBX2 | Gastrulation brain homeobox 2. (348 aa) |
| | TRIM24 | Transcription intermediary factor 1-alpha isoform X1. (1050 aa) |
| | MDFIC | MyoD family inhibitor domain containing. (242 aa) |
| | IFRD1 | Interferon-related developmental regulator 1; Could play a role in regulating gene activity in the proliferative and/or differentiative pathways induced by NGF. May be an autocrine factor that attenuates or amplifies the initial ligand- induced signal (By similarity); Belongs to the IFRD family. (437 aa) |
| | TBX20 | T-box transcription factor TBX20 isoform 1. (449 aa) |
| | ISL1 | Insulin gene enhancer protein ISL-1. (349 aa) |
| | HDAC5 | Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1131 aa) |
| | STAT3 | Signal transducer and activator of transcription 3; Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors. Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA (By similarity). Acts as a regulator of inflammatory response by regul [...] (772 aa) |
| | STAT5B | Signal transducer and activator of transcription 5B; Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Binds to the GAS element and activates PRL-induced transcription. Positively regulates hematopoietic/erythroid differentiation. (787 aa) |
| | SMARCE1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1. (411 aa) |
| | MED24 | Mediator complex subunit 24. (1007 aa) |
| | MED1 | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1517 aa) |
| | MED13 | Mediator of RNA polymerase II transcription subunit 13; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (2173 aa) |
| | F1SDC8_PIG | Uncharacterized protein. (1369 aa) |
| | SNW1 | SNW domain-containing protein 1 isoform 2. (536 aa) |
| | EP300 | E1A binding protein p300. (2420 aa) |
| | HDAC1 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (491 aa) |
| | RNF25 | Ring finger protein 25. (459 aa) |
| | BRD8 | Bromodomain containing 8. (1236 aa) |
| | PARP1 | Poly [ADP-ribose] polymerase. (1017 aa) |
| | TAF10 | Transcription initiation factor TFIID subunit 10; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors; Belongs to the TAF10 family. (217 aa) |
| | GATA1 | Erythroid transcription factor. (412 aa) |
| | AHR | Aryl hydrocarbon receptor. (849 aa) |
| | WWP2 | E3 ubiquitin-protein ligase. (895 aa) |
| | RNF6 | Ring finger protein 6. (663 aa) |
| | HIPK2 | Homeodomain interacting protein kinase 2. (1208 aa) |
| | THRAP3 | Thyroid hormone receptor-associated protein 3 isoform 1. (958 aa) |
| | CNOT1 | CCR4-NOT transcription complex subunit 1. (2343 aa) |
| | FAM162A | Family with sequence similarity 162 member A. (155 aa) |
| | MAD2L2 | Mitotic spindle assembly checkpoint protein MAD2B. (211 aa) |
| | PADI2 | Peptidyl arginine deiminase 2. (689 aa) |
| | DLL1 | Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (729 aa) |
| | TP73 | Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (640 aa) |
| | TAF7 | Transcription initiation factor TFIID subunit 7. (349 aa) |
| | MEF2A | Myocyte-specific enhancer factor 2A; Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific genes. Also involved in the activation of numerous growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. In cerebellar granule neurons, phosphorylate [...] (505 aa) |
| | UBXN7 | UBX domain-containing protein. (519 aa) |
| | MIXL1 | Mix paired-like homeobox. (237 aa) |
| | DTX3L | Deltex E3 ubiquitin ligase 3L. (737 aa) |
| | TAF4 | TATA-box binding protein associated factor 4. (1031 aa) |
| | BBS2 | Bardet-Biedl syndrome 2 protein homolog. (727 aa) |
| | GATA4 | Transcription factor GATA-4 isoform 2. (442 aa) |
| | CSNK2B | Casein kinase II subunit beta; Participates in Wnt signaling. Plays a complex role in regulating the basal catalytic activity of the alpha subunit (By similarity). (298 aa) |
| | DHX9 | ATP-dependent RNA helicase A. (1384 aa) |
| | ESR1 | Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] (595 aa) |
| | SMARCA4 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4. (1647 aa) |
| | TCF3 | Transcription factor E2-alpha isoform X12. (642 aa) |
| | SPEN | Spen family transcriptional repressor. (2726 aa) |
| | CTNNB1 | Catenin beta 1. (808 aa) |
| | RBBP8 | RB binding protein 8, endonuclease. (897 aa) |
| | PPARGC1A | Peroxisome proliferator-activated receptor gamma coactivator 1-alpha; Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. Induces the expression of PERM1 in [...] (796 aa) |
| | ARNT2 | Aryl hydrocarbon receptor nuclear translocator 2. (892 aa) |
| | RARG | Retinoic acid receptor gamma. (554 aa) |
| | CRY1 | Cryptochrome circadian regulator 1. (588 aa) |
| | BCAS3 | BCAS3 microtubule associated cell migration factor. (950 aa) |
| | LEF1 | Lymphoid enhancer binding factor 1. (429 aa) |
| | HIRA | Protein HIRA; Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle; Belongs to the WD repeat HIR1 family. (1009 aa) |
| | TP53BP2 | Apoptosis-stimulating of p53 protein 2 isoform 1. (1157 aa) |
| | PRMT2 | Protein arginine methyltransferase 2; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (435 aa) |
| | SMARCD3 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3. (548 aa) |
| | PITX1 | Homeobox protein. (314 aa) |
| | LHX3 | LIM/homeobox protein Lhx3; Required for the establishment of the specialized cells of the pituitary gland and the nervous system. Involved in the development of interneurons and motor neurons in cooperation with LDB1 and ISL1. Acts as a transcriptional activator. Binds to and activates the promoter of the alpha-glycoprotein gene, and synergistically enhances transcription from the prolactin promoter in cooperation with POU1F1/Pit-1 (By similarity). (538 aa) |
| | ACTB | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (375 aa) |
| | BBS1 | Bardet-Biedl syndrome 1 protein. (593 aa) |
| | CREB1 | Cyclic AMP-responsive element-binding protein 1 isoform B. (341 aa) |
| | ISG12(A) | Uncharacterized protein. (217 aa) |
| | TACC1 | TACC_C domain-containing protein. (801 aa) |
| | MED30 | Mediator of RNA polymerase II transcription subunit 30 isoform 1. (185 aa) |
| | LCOR | Ligand dependent nuclear receptor corepressor. (1695 aa) |
| | KDM3A | Lysine demethylase 3A. (1323 aa) |
| | PRKCB | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa) |
| | MED4 | Mediator of RNA polymerase II transcription subunit 4; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (271 aa) |
| | SP1 | Transcription factor Sp1 isoform a. (786 aa) |
| | TP53BP1 | Tumor protein p53 binding protein 1. (1931 aa) |
| | ANKRD42 | Ankyrin repeat domain 42. (545 aa) |
| | PRRX1 | Paired mesoderm homeobox protein 1 isoform pmx-1b. (245 aa) |
| | NR4A2 | Nuclear receptor subfamily 4 group A member 2 isoform X1. (609 aa) |
| | ETS2 | Protein C-ets-2; Transcription factor; Belongs to the ETS family. (470 aa) |
| | TRIP4 | Thyroid hormone receptor interactor 4. (649 aa) |
| | CTBP1 | C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (428 aa) |
| | ACTN4 | Actinin alpha 4. (1160 aa) |
| | ZBTB7A | Zinc finger and BTB domain containing 7A. (596 aa) |
| | SIN3A | SIN3 transcription regulator family member A. (1274 aa) |
| | CHD4 | Uncharacterized protein. (1863 aa) |
| | GATA3 | Trans-acting T-cell-specific transcription factor GATA-3. (444 aa) |
| | HAND1 | Heart and neural crest derivatives expressed 1. (218 aa) |
| | NKX2-5 | NK2 homeobox 5. (323 aa) |
| | NCOA2 | Nuclear receptor coactivator. (1463 aa) |
| | MEF2D | Myocyte enhancer factor 2D. (531 aa) |
| | LOC100622504 | Uncharacterized protein. (469 aa) |
| | KLHL41 | Kelch like family member 41. (601 aa) |
| | MED12 | Mediator complex subunit 12. (2187 aa) |
| | DDIT3 | DNA-damage-inducible transcript 3. (167 aa) |
| | LATS1 | Large tumor suppressor kinase 1. (1146 aa) |
| | FOXP1 | Forkhead box P1. (692 aa) |
| | NR4A1 | Nuclear receptor subfamily 4 group A member 1 isoform 2. (598 aa) |
| | ANKRD1 | Ankyrin repeat domain-containing protein 1; May play an important role in endothelial cell activation. May act as a nuclear transcription factor that negatively regulates the expression of cardiac genes (By similarity). (339 aa) |
| | GSK3B | Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (414 aa) |
| | NSD1 | Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific isoform X1. (2701 aa) |
| | PTPRT | Protein tyrosine phosphatase receptor type T. (1460 aa) |
| | ARID5A | AT-rich interaction domain 5A. (846 aa) |
| | NIF3L1 | NGG1 interacting factor 3 like 1. (442 aa) |
| | PRPF6 | Pre-mRNA processing factor 6. (1150 aa) |
| | HES1 | Uncharacterized protein. (280 aa) |
| | MLXIPL | MLX interacting protein like. (970 aa) |
| | NCOA1 | Nuclear receptor coactivator 1; Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone- dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase activity toward H3 and H4; the relevance of such activity remains however unclear. Plays a central role in creating m [...] (1441 aa) |
| | DCAF1 | DDB1 and CUL4 associated factor 1. (1511 aa) |
| | ZBTB8A | Zinc finger and BTB domain containing 8A. (441 aa) |
| | TBXT | T-box transcription factor T. (435 aa) |
| | BHLHE41 | Class E basic helix-loop-helix protein 41. (482 aa) |
| | PKN1 | Protein kinase N1. (956 aa) |
| | ZFPM1 | Zinc finger protein, FOG family member 1. (965 aa) |
| | DMAP1 | DNA methyltransferase 1-associated protein 1 isoform X1. (468 aa) |
| | FBP1 | Fructose-1,6-bisphosphatase 1; Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. Appears to modulate glycerol gluconeogenesis in liver. Important regulator of appetite and adiposity; increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism [...] (338 aa) |
| | FOXP3 | Forkhead box protein P3 isoform a. (475 aa) |
| | A0A287B1R4_PIG | Uncharacterized protein. (34 aa) |
| | PITX2 | Homeobox protein. (326 aa) |
| | NRBF2 | Nuclear receptor binding factor 2. (288 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (442 aa) |
| | HIF1A | Hypoxia-inducible factor 1-alpha isoform 1. (824 aa) |
| | HIF1AN | Hypoxia inducible factor 1 subunit alpha inhibitor. (361 aa) |
| | PARP9 | Poly(ADP-ribose) polymerase family member 9. (847 aa) |
| | TBX6 | T-box transcription factor TBX6 isoform X1. (436 aa) |
| | ARNTL | Aryl hydrocarbon receptor nuclear translocator like. (633 aa) |
| | HDAC3 | Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (520 aa) |
| | SRARP | Steroid receptor associated and regulated protein. (170 aa) |
| | TGFB1I1 | Transforming growth factor beta-1-induced transcript 1 protein; Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. (519 aa) |
| | A0A287B5X5_PIG | FAM220 domain-containing protein. (228 aa) |
| | PROX1 | Prospero homeobox 1. (737 aa) |
| | TAF6 | TATA-box binding protein associated factor 6. (705 aa) |
| | ATF2 | Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa) |
| | TCF21 | Transcription factor 21. (179 aa) |
| | POU4F1 | POU domain protein. (421 aa) |
| | TRIB2 | Tribbles pseudokinase 2. (343 aa) |
| | LOC106506226 | TACC_C domain-containing protein. (378 aa) |
| | NKX2-1 | NK2 homeobox 1. (399 aa) |
| | SETD3 | Protein-histidine N-methyltransferase. (595 aa) |
| | TTC8 | Tetratricopeptide repeat domain 8. (587 aa) |
| | VDR | Vitamin D3 receptor; Nuclear receptor for calcitriol, the active form of vitamin D3 which mediates the action of this vitamin on cells (By similarity). Enters the nucleus upon vitamin D3 binding where it forms heterodimers with the retinoid X receptor/RXR (By similarity). The VDR-RXR heterodimers bind to specific response elements on DNA and activate the transcription of vitamin D3-responsive target genes (By similarity). Plays a central role in calcium homeostasis (By similarity). (520 aa) |
| | TOB2 | Protein Tob2 isoform X1. (353 aa) |
| | DDX54 | ATP-dependent RNA helicase DDX54; Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily. (879 aa) |
| | DACT1 | Dishevelled binding antagonist of beta catenin 1. (807 aa) |
| | A0A287BJ29_PIG | Uncharacterized protein. (118 aa) |
| | KEAP1 | Kelch-like ECH-associated protein 1; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that regulates the response to oxidative stress by targeting NFE2L2/NRF2 for ubiquitination. KEAP1 acts as a key sensor of oxidative and electrophilic stress: in normal conditions, the BCR(KEAP1) complex mediates ubiquitination and degradation of NFE2L2/NRF2, a transcription factor regulating expression of many cytoprotective genes. In response to oxidative stress, different electrophile metabolites trigger non-enzymatic covalent modifications of highly reactive cysteine [...] (624 aa) |
| | BRMS1 | BRMS1 transcriptional repressor and anoikis regulator. (268 aa) |
| | KAT6A | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (829 aa) |
| | HAND2 | Heart-and neural crest derivatives-expressed protein 2. (217 aa) |
| | DDX5 | DEAD-box helicase 5; Belongs to the DEAD box helicase family. (617 aa) |
| | ARID1A | AT-rich interaction domain 1A. (2289 aa) |
| | C1D | Uncharacterized protein. (141 aa) |
| | NKX3-1 | Homeobox protein Nkx-3.1 isoform 1. (247 aa) |
| | ATF4 | Activating transcription factor 4. (329 aa) |
| | ZNF366 | Zinc finger protein 366. (740 aa) |
| | NR4A3 | Nuclear receptor subfamily 4 group A member 3 isoform b. (643 aa) |
| | DDRGK1 | DDRGK domain-containing protein 1. (312 aa) |
| | TACC2 | Uncharacterized protein. (2041 aa) |
| | PTPN2 | Tyrosine-protein phosphatase non-receptor type. (447 aa) |
| | BHLHE40 | Basic helix-loop-helix family member e40. (415 aa) |
| | TEAD3 | YBD domain-containing protein. (395 aa) |
| | MLX | MAX dimerization protein MLX. (304 aa) |
| | KAT8 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (461 aa) |
| | FIZ1 | FLT3 interacting zinc finger 1. (500 aa) |
| | NRIP1 | Nuclear receptor-interacting protein 1 isoform X1. (1156 aa) |
| | MED17 | Mediator of RNA polymerase II transcription subunit 17; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (677 aa) |
| | HMGA2 | Uncharacterized protein. (143 aa) |
| | ETS1 | ETS proto-oncogene 1, transcription factor. (621 aa) |
| | SDR16C5 | Short chain dehydrogenase/reductase family 16C, member 5; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (309 aa) |
| | GRIP1 | Glutamate receptor interacting protein 1. (1210 aa) |
| | TAF7L | TATA-box binding protein associated factor 7 like. (468 aa) |
| | NR1H4 | Nuclear receptor subfamily 1 group H member 4. (509 aa) |
| | MTDH | Metadherin. (613 aa) |
| | NFE2L2 | Nuclear factor, erythroid 2 like 2. (656 aa) |
| | E4F1 | E4F transcription factor 1. (787 aa) |
| | HES6 | Hes family bHLH transcription factor 6. (251 aa) |
| | ANKRD2 | Ankyrin repeat domain 2. (334 aa) |
| | BBS4 | Uncharacterized protein. (826 aa) |
| | HNF4A | Hepatocyte nuclear factor 4 alpha. (505 aa) |
| | A0A5G2RAG6_PIG | Uncharacterized protein. (876 aa) |
| | MYOCD | Myocardin; Smooth muscle cells (SM) and cardiac muscle cells-specific transcriptional factor which uses the canonical single or multiple CArG boxes DNA sequence. Acts as a cofactor of serum response factor (SRF) with the potential to modulate SRF-target genes. Plays a crucial role in cardiogenesis and differentiation of the smooth muscle cell lineage (myogenesis) (By similarity). (993 aa) |
| | WIPI1 | Uncharacterized protein. (477 aa) |
| | TRIB1 | Tribbles pseudokinase 1. (372 aa) |
| | PIAS2 | Protein inhibitor of activated STAT 2. (612 aa) |
| | RXRA | Retinoid X receptor alpha. (701 aa) |
| | DNAAF4 | Dynein axonemal assembly factor 4. (531 aa) |
| | HCLS1 | Hematopoietic cell-specific Lyn substrate 1. (525 aa) |
| | FAF1 | Fas associated factor 1. (657 aa) |
| | IWS1 | Interacts with SUPT6H, CTD assembly factor 1. (847 aa) |
| | STK4 | Serine/threonine kinase 4. (502 aa) |
| | NFKBID | NFKB inhibitor delta. (489 aa) |
| | KDM5D | Lysine demethylase 5D. (1506 aa) |
| | REST | RE1 silencing transcription factor. (1108 aa) |
| | CDK5RAP3 | CDK5 regulatory subunit associated protein 3. (513 aa) |
| | SMAD3 | Mothers against decapentaplegic homolog. (434 aa) |
| | CRX | Cone-rod homeobox. (345 aa) |
