STRINGSTRING
NTN1 NTN1 VWF VWF NTN4 NTN4 LUM LUM LOXL1 LOXL1 FBLN5 FBLN5 NTN5 NTN5 VWA1 VWA1 LAMA3 LAMA3 ANGPTL3 ANGPTL3 SMOC2 SMOC2 LOC100520342 LOC100520342 LAMA4 LAMA4 COL10A1 COL10A1 FBN1 FBN1 THBS1 THBS1 COL15A1 COL15A1 MEGF9 MEGF9 ANGPTL2 ANGPTL2 HMCN2 HMCN2 FIBCD1 FIBCD1 LAMC3 LAMC3 COL5A1 COL5A1 PCSK6 PCSK6 BCAN BCAN ANGPT4 ANGPT4 GPC2 GPC2 ZP3 ZP3 ZP2 ZP2 NTN3 NTN3 OMD OMD MATN3 MATN3 IGFBP7 IGFBP7 AMTN AMTN MMRN1 MMRN1 SPARCL1 SPARCL1 POSTN POSTN FREM2 FREM2 COL4A2 COL4A2 ZP4 ZP4 NID1 NID1 RBP3 RBP3 LOXL4 LOXL4 VWA2 VWA2 ATRNL1 ATRNL1 FBLN2 FBLN2 P3H2 P3H2 ADAMTS5 ADAMTS5 EGFL6 EGFL6 TIMP1 TIMP1 COL4A6 COL4A6 GPC4 GPC4 F2 F2 NAV2 NAV2 ANGPTL4 ANGPTL4 ANGPTL6 ANGPTL6 COL5A3 COL5A3 PODNL1 PODNL1 COMP COMP VCAN VCAN LOX LOX RELL2 RELL2 ANGPTL5 ANGPTL5 ADAMTS15 ADAMTS15 FMOD FMOD COL1A2 COL1A2 FGL2 FGL2 LAMB1 LAMB1 LAMC2 LAMC2 LAMB3 LAMB3 COL4A3 COL4A3 SNORC SNORC FGF10 FGF10 MATN1 MATN1 FCN2 FCN2 PRG4 PRG4 THBS4 THBS4 VTN VTN ADAMTS2 ADAMTS2 ECM1 ECM1 LRRC15 LRRC15 COCH COCH PXDN PXDN TINAG TINAG FBN3 FBN3 VIT VIT FGG FGG COL6A2 COL6A2 SERPINE1 SERPINE1 ECM2 ECM2 SOD3 SOD3 COL17A1 COL17A1 COL6A3 COL6A3 ATRN ATRN SFRP1 SFRP1 GPC3 GPC3 FGFR2 FGFR2 TNXB TNXB TGFB3 TGFB3 DLG1 DLG1 ANGPTL1 ANGPTL1 ANXA2 ANXA2 IMPG2 IMPG2 COL25A1 COL25A1 COL3A1 COL3A1 COL16A1 COL16A1 AGRN AGRN EFNA5 EFNA5 PTPRZ1 PTPRZ1 TGFB2 TGFB2 COL2A1 COL2A1 LTBP1 LTBP1 FGL1 FGL1 TIMP3 TIMP3 LAMA2 LAMA2 LAMC1 LAMC1 LAMA2-2 LAMA2-2 CCDC80 CCDC80 KAZALD1 KAZALD1 MYOC MYOC NTNG2 NTNG2 COL9A3 COL9A3 ENTPD2 ENTPD2 HSPG2 HSPG2 COL20A1 COL20A1 GPC5 GPC5 GPC6 GPC6 THBS3 THBS3 NID2 NID2 FBLN1 FBLN1 ANGPTL7 ANGPTL7 LOXL2 LOXL2 EFEMP1 EFEMP1 LOC110259263 LOC110259263 GPC1 GPC1 COL4A5 COL4A5 TNC TNC LAMB2 LAMB2 ADAMTSL4 ADAMTSL4 ELN ELN MATN2 MATN2 SERPINE2 SERPINE2 COL4A4 COL4A4 MFAP4 MFAP4 LOC100625180 LOC100625180 PRELP PRELP LAMB4 LAMB4 WNT2 WNT2 USH2A USH2A RARRES2 RARRES2 ACAN ACAN CHADL CHADL ADAMTS8 ADAMTS8 MMRN2 MMRN2 SSC5D SSC5D DAG1 DAG1 COL5A2 COL5A2 TNN TNN COL28A1 COL28A1 FREM1 FREM1 COL6A5 COL6A5 LTBP3 LTBP3 NTNG1 NTNG1 VWC2 VWC2 LOC100517188 LOC100517188 CILP CILP COL11A2 COL11A2 TNR TNR SMOC1 SMOC1 THBS2 THBS2 EMILIN1 EMILIN1 LAD1 LAD1 TECTA TECTA A0A5G2QUL4_PIG A0A5G2QUL4_PIG AMELX AMELX COL9A1 COL9A1 DEF8 DEF8 ABI3BP ABI3BP COL4A1 COL4A1 PLOD3 PLOD3 MGP MGP HTRA1 HTRA1 ANGPT1 ANGPT1 COL14A1 COL14A1 FBN2 FBN2 ACHE ACHE COL9A2 COL9A2 COL6A1 COL6A1 COL1A1 COL1A1 LOXL3 LOXL3 FRAS1 FRAS1 ANGPT2 ANGPT2 FCN1 FCN1 ANG ANG IMPG1 IMPG1 ITGB4 ITGB4 A0A5G2QWB6_PIG A0A5G2QWB6_PIG LTBP4 LTBP4 ADAMTS1 ADAMTS1 TGFBR3 TGFBR3 COL6A6 COL6A6 CASK CASK MATN4 MATN4 A0A5G2RI39_PIG A0A5G2RI39_PIG LGALSL LGALSL AMELY AMELY COL11A1 COL11A1 COL21A1 COL21A1 SPARC SPARC
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NTN1Netrin-1; Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. Binding to UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion (By similarity). Involved in dorsal root ganglion axon projection towards the spinal cord (By similarity). It also serves as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involve [...] (651 aa)
VWFVon Willebrand factor; Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet- surface receptor complex, glycoprotein Ibalpha/IX/V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma (By similarity). (2940 aa)
NTN4Netrin 4. (628 aa)
LUMLumican. (341 aa)
LOXL1Lysyl oxidase like 1. (591 aa)
FBLN5Fibulin-5 isoform X2. (461 aa)
NTN5Netrin-5. (499 aa)
VWA1Von Willebrand factor A domain containing 1. (480 aa)
LAMA3Laminin subunit alpha 3. (3345 aa)
ANGPTL3Fibrinogen C-terminal domain-containing protein. (461 aa)
SMOC2SPARC related modular calcium binding 2. (613 aa)
LOC100520342Nephrocan-like. (512 aa)
LAMA4Laminin subunit alpha 4. (1815 aa)
COL10A1Type X collagen. (675 aa)
FBN1Fibrillin-1; [Fibrillin-1]: Structural component of the 10-12 nm diameter microfibrils of the extracellular matrix, which conveys both structural and regulatory properties to load-bearing connective tissues. Fibrillin-1-containing microfibrils provide long-term force bearing structural support. In tissues such as the lung, blood vessels and skin, microfibrils form the periphery of the elastic fiber, acting as a scaffold for the deposition of elastin. In addition, microfibrils can occur as elastin-independent networks in tissues such as the ciliary zonule, tendon, cornea and glomerulus [...] (2871 aa)
THBS1Uncharacterized protein. (1170 aa)
COL15A1Collagen type XV alpha 1 chain. (1359 aa)
MEGF9Multiple EGF like domains 9. (599 aa)
ANGPTL2Angiopoietin-related protein 2. (493 aa)
HMCN2Hemicentin 2. (5047 aa)
FIBCD1Fibrinogen C domain containing 1. (461 aa)
LAMC3Laminin subunit gamma 3. (1575 aa)
COL5A1Fibrillar collagen NC1 domain-containing protein. (1918 aa)
PCSK6Proprotein convertase subtilisin/kexin type 6 isoform PACE4-AI preproprotein; Belongs to the peptidase S8 family. (965 aa)
BCANBrevican core protein isoform X1. (906 aa)
ANGPT4Angiopoietin 4. (503 aa)
GPC2Glypican 2; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (577 aa)
ZP3Processed zona pellucida sperm-binding protein 3; Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for zona matrix formation. May not have a sperm- binding activity by itself but may increase sperm-binding activity of ZPB. (421 aa)
ZP2Processed zona pellucida sperm-binding protein 2; Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP2 may act as a secondary sperm receptor. Belongs to the ZP domain family. ZPA subfamily. (716 aa)
NTN3Netrin 3. (579 aa)
OMDOsteomodulin. (422 aa)
MATN3Matrilin 3. (487 aa)
IGFBP7Uncharacterized protein. (278 aa)
AMTNAmelotin. (209 aa)
MMRN1Multimerin 1. (1220 aa)
SPARCL1SPARC like 1. (675 aa)
POSTNPeriostin. (836 aa)
FREM2FRAS1 related extracellular matrix 2. (3174 aa)
COL4A2Collagen type IV alpha 2 chain. (1712 aa)
ZP4Processed zona pellucida sperm-binding protein 4; Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP4 may act as a sperm receptor. (536 aa)
NID1Nidogen 1. (1309 aa)
RBP3Retinol-binding protein 3; IRBP shuttles 11-cis and all trans retinoids between the retinol isomerase in the pigment epithelium and the visual pigments in the photoreceptor cells of the retina. (1284 aa)
LOXL4Lysyl oxidase like 4. (757 aa)
VWA2Von Willebrand factor A domain containing 2. (735 aa)
ATRNL1Attractin like 1. (1382 aa)
FBLN2Fibulin-2 isoform a. (1221 aa)
P3H2Prolyl 3-hydroxylase 2 isoform a. (706 aa)
ADAMTS5ADAM metallopeptidase with thrombospondin type 1 motif 5. (929 aa)
EGFL6EGF like domain multiple 6. (536 aa)
TIMP1Metalloproteinase inhibitor 1; Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling (By similarity). (207 aa)
COL4A6Collagen type IV alpha 6 chain. (1547 aa)
GPC4Glypican 4; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (556 aa)
F2Activation peptide fragment 1; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity). (623 aa)
NAV2Neuron navigator 2. (2407 aa)
ANGPTL4Angiopoietin-related protein 4; Mediates inactivation of the lipoprotein lipase LPL, and thereby plays a role in the regulation of triglyceride clearance from the blood serum and in lipid metabolism. May also play a role in regulating glucose homeostasis and insulin sensitivity. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage (By similarity). Upon heterologous expression, inhibits the adhesion of endothelial cell to the extracellular matrix (ECM), and inhibits the reorganization of the actin cytoskeleton, formation of actin stre [...] (412 aa)
ANGPTL6Angiopoietin like 6. (463 aa)
COL5A3Collagen type V alpha 3 chain. (1747 aa)
PODNL1Podocan like 1. (576 aa)
COMPCartilage oligomeric matrix protein. (756 aa)
VCANVersican. (3456 aa)
LOXProtein-lysine 6-oxidase, short form; Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Regulator of Ras expression. May play a role in tumor suppression. Plays a role in the aortic wall architecture (By similarity); Belongs to the lysyl oxidase family. (419 aa)
RELL2RELT like 2. (305 aa)
ANGPTL5Angiopoietin-related protein 5. (388 aa)
ADAMTS15A disintegrin and metalloproteinase with thrombospondin motifs 15 preproprotein. (950 aa)
FMODFibromodulin; Affects the rate of fibrils formation. May have a primary role in collagen fibrillogenesis (By similarity). (376 aa)
COL1A2Fibrillar collagen NC1 domain-containing protein. (1135 aa)
FGL2Fibroleukin. (495 aa)
LAMB1Laminin subunit beta 1. (1785 aa)
LAMC2Laminin subunit gamma-2 isoform a. (1191 aa)
LAMB3Laminin subunit beta 3. (1172 aa)
COL4A3Collagen type IV alpha 3 chain. (1669 aa)
SNORCUncharacterized protein. (121 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
MATN1Matrilin 1. (496 aa)
FCN2Ficolin-2. (429 aa)
PRG4Uncharacterized protein. (370 aa)
THBS4Thrombospondin 4. (976 aa)
VTNVitronectin; Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway (By similarity). (523 aa)
ADAMTS2ADAM metallopeptidase with thrombospondin type 1 motif 2. (1204 aa)
ECM1Extracellular matrix protein 1. (559 aa)
LRRC15Leucine rich repeat containing 15. (581 aa)
COCHCochlin isoform X2. (551 aa)
PXDNPeroxidasin. (1529 aa)
TINAGTubulointerstitial nephritis antigen; Belongs to the peptidase C1 family. (476 aa)
FBN3Fibrillin 3. (2858 aa)
VITVitrin. (656 aa)
FGGFibrinogen gamma chain. (454 aa)
COL6A2Collagen type VI alpha 2 chain. (943 aa)
SERPINE1Plasminogen activator inhibitor 1; Serine protease inhibitor. Inhibits TMPRSS7. Is a primary inhibitor of tissue-type plasminogen activator (PLAT) and urokinase- type plasminogen activator (PLAU). As PLAT inhibitor, it is required for fibrinolysis down-regulation and is responsible for the controlled degradation of blood clots. As PLAU inhibitor, it is involved in the regulation of cell adhesion and spreading. Acts as a regulator of cell migration, independently of its role as protease inhibitor. It is required for stimulation of keratinocyte migration during cutaneous injury repair. I [...] (401 aa)
ECM2Extracellular matrix protein 2. (696 aa)
SOD3Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family. (303 aa)
COL17A1Collagen type XVII alpha 1 chain. (1506 aa)
COL6A3Collagen type VI alpha 3 chain. (2911 aa)
ATRNAttractin. (1416 aa)
SFRP1Secreted frizzled-related protein 1. (308 aa)
GPC3Glypican-3 isoform 2; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (579 aa)
FGFR2Fibroblast growth factor receptor. (820 aa)
TNXBUncharacterized protein. (4137 aa)
TGFB3Transforming growth factor beta-3 proprotein; Transforming growth factor beta-3 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-3 (TGF-beta-3) chains, which constitute the regulatory and active subunit of TGF-beta-3, respectively. Transforming growth factor beta-3: Multifunctional protein that regulates embryogenesis and cell differentiation and is required in various processes such as secondary palate development (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi appa [...] (456 aa)
DLG1Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (939 aa)
ANGPTL1Angiopoietin-related protein 1 isoform X1. (502 aa)
ANXA2Annexin A2; Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9. (414 aa)
IMPG2Interphotoreceptor matrix proteoglycan 2. (1244 aa)
COL25A1Collagen type XXV alpha 1 chain. (695 aa)
COL3A1Collagen alpha-1(III) chain preproprotein. (1471 aa)
COL16A1Collagen alpha-1(XVI) chain isoform X2. (1624 aa)
AGRNAgrin. (2108 aa)
EFNA5Ephrin A5; Belongs to the ephrin family. (228 aa)
PTPRZ1Protein tyrosine phosphatase receptor type Z1. (2323 aa)
TGFB2Transforming growth factor beta-2 proprotein; Transforming growth factor beta-2 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively. Transforming growth factor beta-2: Multifunctional protein that regulates various processes such as angiogenesis and heart development (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transfor [...] (443 aa)
COL2A1Collagen type II alpha 1 chain. (1486 aa)
LTBP1Latent transforming growth factor beta binding protein 1. (1708 aa)
FGL1Fibrinogen like 1. (315 aa)
TIMP3TIMP metallopeptidase inhibitor 3. (211 aa)
LAMA2Uncharacterized protein. (2070 aa)
LAMC1Uncharacterized protein. (1607 aa)
LAMA2-2Uncharacterized protein. (921 aa)
CCDC80Coiled-coil domain containing 80. (1016 aa)
KAZALD1Kazal-type serine protease inhibitor domain-containing protein 1 isoform X1. (315 aa)
MYOCMyocilin. (489 aa)
NTNG2Netrin G2. (529 aa)
COL9A3Collagen type IX alpha 3 chain. (684 aa)
ENTPD2Ectonucleoside triphosphate diphosphohydrolase 2 isoform 1; Belongs to the GDA1/CD39 NTPase family. (495 aa)
HSPG2Heparan sulfate proteoglycan 2. (4346 aa)
COL20A1Uncharacterized protein. (1338 aa)
GPC5Glypican 5; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (571 aa)
GPC6Glypican-6 isoform X1; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (555 aa)
THBS3Thrombospondin-3 isoform 1. (973 aa)
NID2Nidogen 2. (1348 aa)
FBLN1Fibulin-1; Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes. (819 aa)
ANGPTL7Angiopoietin-related protein 7. (344 aa)
LOXL2Lysyl oxidase like 2. (758 aa)
EFEMP1EGF containing fibulin extracellular matrix protein 1. (512 aa)
LOC110259263C-type lectin domain-containing protein. (172 aa)
GPC1Glypican 1; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (559 aa)
COL4A5Collagen type IV alpha 5 chain. (1689 aa)
TNCTenascin; Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha- V/beta-6. In tumors, stimulates angiogenesis by elongation, migration and sprouting of endothelial cells (By similarity). Belongs to the tenascin family. (2420 aa)
LAMB2Laminin subunit beta-2. (1881 aa)
ADAMTSL4ADAMTS like 4. (1079 aa)
ELNElastin. (674 aa)
MATN2Matrilin 2. (956 aa)
SERPINE2SERPIN domain-containing protein; Belongs to the serpin family. (378 aa)
COL4A4Collagen type IV alpha 4 chain. (1691 aa)
MFAP4Microfibril associated protein 4. (304 aa)
LOC100625180C-type lectin domain-containing protein. (252 aa)
PRELPProline and arginine rich end leucine rich repeat protein. (381 aa)
LAMB4Uncharacterized protein. (719 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
USH2AUncharacterized protein. (1544 aa)
RARRES2Retinoic acid receptor responder 2. (177 aa)
ACANAggrecan core protein 2; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. (2434 aa)
CHADLChondroadherin like. (760 aa)
ADAMTS8ADAM metallopeptidase with thrombospondin type 1 motif 8. (1019 aa)
MMRN2Multimerin 2. (931 aa)
SSC5DScavenger receptor cysteine rich family member with 5 domains. (1634 aa)
DAG1Alpha-dystroglycan; The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sacrolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization. Beta-dystroglycan is a transmembrane protein that plays important roles in connecting the extracellular matrix to the cytoskeleton. Acts as a cell adhesion receptor in both muscle and non- muscle tissues. Receptor for both DMD and UTRN and, through these interactions, scaffolds axin to the cytoskeleton. Also functions in cell ad [...] (912 aa)
COL5A2Collagen alpha-2(V) chain preproprotein. (1499 aa)
TNNTenascin N. (1472 aa)
COL28A1Collagen type XXVIII alpha 1 chain. (1236 aa)
FREM1FRAS1 related extracellular matrix 1. (2182 aa)
COL6A5Collagen type VI alpha 5 chain. (2337 aa)
LTBP3Latent transforming growth factor beta binding protein 3. (1332 aa)
NTNG1Netrin G1. (588 aa)
VWC2Von Willebrand factor C domain containing 2. (325 aa)
LOC100517188Uncharacterized protein. (1592 aa)
CILPCartilage intermediate layer protein 1 C2; Probably plays a role in cartilage scaffolding. May act by antagonizing TGF-beta1 (TGFB1) and IGF1 functions. Has the ability to suppress IGF1-induced proliferation and sulfated proteoglycan synthesis, and inhibits ligand-induced IGF1R autophosphorylation. May inhibit TGFB1-mediated induction of cartilage matrix genes via its interaction with TGFB1. Overexpression may lead to impair chondrocyte growth and matrix repair and indirectly promote inorganic pyrophosphate (PPi) supersaturation in aging and osteoarthritis cartilage (By similarity). (1193 aa)
COL11A2Collagen type XI alpha 2 chain. (1796 aa)
TNRTenascin R. (1270 aa)
SMOC1SPARC related modular calcium binding 1. (469 aa)
THBS2Thrombospondin 2. (1223 aa)
EMILIN1Elastin microfibril interfacer 1. (1292 aa)
LAD1Uncharacterized protein. (582 aa)
TECTATectorin alpha. (2469 aa)
A0A5G2QUL4_PIGUncharacterized protein. (536 aa)
AMELXUncharacterized protein. (203 aa)
COL9A1Collagen type IX alpha 1 chain. (922 aa)
DEF8Differentially expressed in FDCP 8 homolog. (522 aa)
ABI3BPABI family member 3 binding protein. (1668 aa)
COL4A1Collagen IV NC1 domain-containing protein. (461 aa)
PLOD3Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3. (744 aa)
MGPMatrix Gla protein; Associates with the organic matrix of bone and cartilage. Thought to act as an inhibitor of bone formation. (127 aa)
HTRA1HtrA serine peptidase 1. (479 aa)
ANGPT1Angiopoietin-1; Binds and activates TIE2 receptor by inducing its tyrosine phosphorylation. Implicated in endothelial developmental processes later and distinct from that of VEGF. Appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme. Mediates blood vessel maturation/stability. It may play an important role in the heart early development (By similarity). (510 aa)
COL14A1Collagen alpha-1(XIV) chain isoform X1. (1796 aa)
FBN2Fibrillin 2. (2910 aa)
ACHEAcetylcholinesterase (Cartwright blood group); Belongs to the type-B carboxylesterase/lipase family. (765 aa)
COL9A2Uncharacterized protein. (709 aa)
COL6A1Collagen type VI alpha 1 chain. (1028 aa)
COL1A1Collagen type I alpha 1 chain. (1477 aa)
LOXL3Lysyl oxidase like 3. (814 aa)
FRAS1Fraser extracellular matrix complex subunit 1. (4013 aa)
ANGPT2Angiopoietin-2; Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating angiogenic signals mediated by ANGPT1. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell- matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal (By similarity). (495 aa)
FCN1Ficolin-1; Extracellular lectin functioning as a pattern-recognition receptor in innate immunity. Binds the sugar moieties of pathogen- associated molecular patterns (PAMPs) displayed on microbes and activates the lectin pathway of the complement system. May also activate monocytes through a G protein-coupled receptor, FFAR2, inducing the secretion of interleukin-8/IL-8. Binds preferentially to 9-O-acetylated 2-6-linked sialic acid derivatives and to various glycans containing sialic acid engaged in a 2-3 linkage (By similarity). (405 aa)
ANGRibonuclease 4; This RNase has marked specificity towards the 3' side of uridine nucleotides; Belongs to the pancreatic ribonuclease family. (177 aa)
IMPG1Interphotoreceptor matrix proteoglycan 1. (787 aa)
ITGB4Integrin beta. (1814 aa)
A0A5G2QWB6_PIGUncharacterized protein. (979 aa)
LTBP4Latent transforming growth factor beta binding protein 4. (1622 aa)
ADAMTS1Peptidase M12B domain-containing protein. (963 aa)
TGFBR3Transforming growth factor beta receptor type 3; Binds to TGF-beta. Could be involved in capturing and retaining TGF-beta for presentation to the signaling receptors. (952 aa)
COL6A6Collagen type VI alpha 6 chain. (2266 aa)
CASKCalcium/calmodulin dependent serine protein kinase; Belongs to the MAGUK family. (925 aa)
MATN4Matrilin 4. (774 aa)
A0A5G2RI39_PIGC-type lectin domain-containing protein. (217 aa)
LGALSLGalectin. (183 aa)
AMELYAmelogenin; Plays a role in the biomineralization of teeth. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel; Belongs to the amelogenin family. (189 aa)
COL11A1Collagen type XI alpha 1 chain. (1816 aa)
COL21A1Collagen type XXI alpha 1 chain. (957 aa)
SPARCSPARC; Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity (By similarity); Belongs to the SPARC family. (331 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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