(17 nodes) tRNA threonylcarbamoyladenosine metabolic process network (Sus scrofa)

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Your Input:
	YRDC	YrdC N6-threonylcarbamoyltransferase domain containing. (319 aa)
	TPRKB	TP53RK binding protein; Belongs to the CGI121/TPRKB family. (199 aa)
	TRMT10C	tRNA methyltransferase 10C, mitochondrial RNase P subunit. (415 aa)
	LOC102166335	Uncharacterized protein. (187 aa)
	GON7	EKC/KEOPS complex subunit GON7; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. GON7 likely plays a supporting role to the catalytic subunit OSGEP in the complex. (206 aa)
	TRMT5	tRNA (guanine(37)-N1)-methyltransferase; Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding; Belongs to the TRM5 / TYW2 family. (504 aa)
	OSGEPL1	Probable tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance. (414 aa)
	SNTA1	Uncharacterized protein. (1071 aa)
	LAGE3	Uncharacterized protein. (155 aa)
	HSD17B10	Hydroxysteroid 17-beta dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (293 aa)
	TRMT61B	tRNA methyltransferase 61B. (492 aa)
	F1S0K0_PIG	EKC/KEOPS complex subunit LAGE3. (198 aa)
	RPUSD4	RNA pseudouridylate synthase domain-containing protein 4. (376 aa)
	TP53RK	TP53 regulating kinase. (255 aa)
	MTO1	Mitochondrial tRNA translation optimization 1. (691 aa)
	TRIT1	tRNA dimethylallyltransferase; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37; Belongs to the IPP transferase family. (470 aa)
	OSGEP	Probable tRNA N6-adenosine threonylcarbamoyltransferase; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. OSGEP likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity. (335 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
F1S0K0_PIG	GON7	ENSSSCP00000018487	ENSSSCP00000074435	EKC/KEOPS complex subunit LAGE3.	EKC/KEOPS complex subunit GON7; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. GON7 likely plays a supporting role to the catalytic subunit OSGEP in the complex.	0.960
F1S0K0_PIG	LAGE3	ENSSSCP00000018487	ENSSSCP00000044492	EKC/KEOPS complex subunit LAGE3.	Uncharacterized protein.	0.570
F1S0K0_PIG	OSGEP	ENSSSCP00000018487	ENSSSCP00000002337	EKC/KEOPS complex subunit LAGE3.	Probable tRNA N6-adenosine threonylcarbamoyltransferase; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. OSGEP likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity.	0.991
F1S0K0_PIG	OSGEPL1	ENSSSCP00000018487	ENSSSCP00000050728	EKC/KEOPS complex subunit LAGE3.	Probable tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance.	0.853
F1S0K0_PIG	TP53RK	ENSSSCP00000018487	ENSSSCP00000007940	EKC/KEOPS complex subunit LAGE3.	TP53 regulating kinase.	0.884
F1S0K0_PIG	TPRKB	ENSSSCP00000018487	ENSSSCP00000061946	EKC/KEOPS complex subunit LAGE3.	TP53RK binding protein; Belongs to the CGI121/TPRKB family.	0.890
F1S0K0_PIG	YRDC	ENSSSCP00000018487	ENSSSCP00000064051	EKC/KEOPS complex subunit LAGE3.	YrdC N6-threonylcarbamoyltransferase domain containing.	0.471
GON7	F1S0K0_PIG	ENSSSCP00000074435	ENSSSCP00000018487	EKC/KEOPS complex subunit GON7; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. GON7 likely plays a supporting role to the catalytic subunit OSGEP in the complex.	EKC/KEOPS complex subunit LAGE3.	0.960
GON7	LAGE3	ENSSSCP00000074435	ENSSSCP00000044492	EKC/KEOPS complex subunit GON7; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. GON7 likely plays a supporting role to the catalytic subunit OSGEP in the complex.	Uncharacterized protein.	0.540
GON7	OSGEP	ENSSSCP00000074435	ENSSSCP00000002337	EKC/KEOPS complex subunit GON7; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. GON7 likely plays a supporting role to the catalytic subunit OSGEP in the complex.	Probable tRNA N6-adenosine threonylcarbamoyltransferase; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. OSGEP likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity.	0.953
GON7	OSGEPL1	ENSSSCP00000074435	ENSSSCP00000050728	EKC/KEOPS complex subunit GON7; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. GON7 likely plays a supporting role to the catalytic subunit OSGEP in the complex.	Probable tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance.	0.742
GON7	TP53RK	ENSSSCP00000074435	ENSSSCP00000007940	EKC/KEOPS complex subunit GON7; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. GON7 likely plays a supporting role to the catalytic subunit OSGEP in the complex.	TP53 regulating kinase.	0.908
GON7	TPRKB	ENSSSCP00000074435	ENSSSCP00000061946	EKC/KEOPS complex subunit GON7; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. GON7 likely plays a supporting role to the catalytic subunit OSGEP in the complex.	TP53RK binding protein; Belongs to the CGI121/TPRKB family.	0.778
GON7	YRDC	ENSSSCP00000074435	ENSSSCP00000064051	EKC/KEOPS complex subunit GON7; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. GON7 likely plays a supporting role to the catalytic subunit OSGEP in the complex.	YrdC N6-threonylcarbamoyltransferase domain containing.	0.539
HSD17B10	TRMT10C	ENSSSCP00000029637	ENSSSCP00000055430	Hydroxysteroid 17-beta dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	tRNA methyltransferase 10C, mitochondrial RNase P subunit.	0.946
HSD17B10	TRMT61B	ENSSSCP00000029637	ENSSSCP00000022671	Hydroxysteroid 17-beta dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	tRNA methyltransferase 61B.	0.428
HSD17B10	YRDC	ENSSSCP00000029637	ENSSSCP00000064051	Hydroxysteroid 17-beta dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	YrdC N6-threonylcarbamoyltransferase domain containing.	0.466
LAGE3	F1S0K0_PIG	ENSSSCP00000044492	ENSSSCP00000018487	Uncharacterized protein.	EKC/KEOPS complex subunit LAGE3.	0.570
LAGE3	GON7	ENSSSCP00000044492	ENSSSCP00000074435	Uncharacterized protein.	EKC/KEOPS complex subunit GON7; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. GON7 likely plays a supporting role to the catalytic subunit OSGEP in the complex.	0.540
LAGE3	OSGEP	ENSSSCP00000044492	ENSSSCP00000002337	Uncharacterized protein.	Probable tRNA N6-adenosine threonylcarbamoyltransferase; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. OSGEP likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity.	0.561