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I3L9Z6_PIG | Uncharacterized protein. (335 aa) | ||||
IL17A | Interleukin-17A; Ligand for IL17RA and IL17RC. The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC. Involved in inducing stromal cells to produce proinflammatory and hematopoietic cytokines. Belongs to the IL-17 family. (153 aa) | ||||
ADAMTS7 | ADAM metallopeptidase with thrombospondin type 1 motif 7. (1660 aa) | ||||
USP10 | Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (805 aa) | ||||
CCL22 | C-C motif chemokine. (93 aa) | ||||
RORA | RAR related orphan receptor A. (530 aa) | ||||
ANXA1 | Annexin A1; Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity. Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response. Promotes resolution of inflammation and wound healing (By similarity). Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (By similarity). Contribut [...] (346 aa) | ||||
DAB2IP | DAB2 interacting protein. (1196 aa) | ||||
PTGES | Microsomal prostaglandin E synthase-1. (153 aa) | ||||
XCL1 | Lymphotactin isoform X1. (110 aa) | ||||
IKBKB | Inhibitor of kappa light chain gene enhancer in B cells, kinase beta. (755 aa) | ||||
PTGIS | Prostacyclin synthase; Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2); Belongs to the cytochrome P450 family. (503 aa) | ||||
IL1B2 | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (267 aa) | ||||
LOC110258578 | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (267 aa) | ||||
CXCL8 | Interleukin-8; IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus; Belongs to the intercrine alpha (chemokine CxC) family. (103 aa) | ||||
CCL19 | C-C motif chemokine. (100 aa) | ||||
MYD88 | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] (323 aa) | ||||
HYAL2 | Hyaluronidase. (476 aa) | ||||
IRAK1 | Interleukin 1 receptor associated kinase 1. (691 aa) | ||||
RELA | Transcription factor p65 isoform 1. (573 aa) | ||||
EGR1 | Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (542 aa) | ||||
SMPD1 | Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. (640 aa) | ||||
SOX9 | Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (511 aa) | ||||
PRKCA | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (669 aa) | ||||
CCL1 | C-C motif chemokine. (94 aa) | ||||
CCL11 | C-C motif chemokine. (97 aa) | ||||
CCL2 | C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...] (99 aa) | ||||
CCL17 | C-C motif chemokine. (102 aa) | ||||
IL1RL2 | Interleukin 1 receptor like 2. (644 aa) | ||||
RPS6KA5 | Non-specific serine/threonine protein kinase. (957 aa) | ||||
ADAMTS12 | ADAM metallopeptidase with thrombospondin type 1 motif 12. (1598 aa) | ||||
RPS6KA4 | Ribosomal protein S6 kinase. (806 aa) | ||||
CCL5 | C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Belongs to the intercrine beta (chemokine CC) family. (91 aa) | ||||
RIPK2 | Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (533 aa) | ||||
TNFRSF11A | TNF receptor superfamily member 11a. (629 aa) | ||||
SFRP1 | Secreted frizzled-related protein 1. (308 aa) | ||||
RBMX | RNA binding motif protein X-linked. (408 aa) | ||||
SRC | Tyrosine-protein kinase. (559 aa) | ||||
CCL20 | C-C motif chemokine. (153 aa) | ||||
MAPK11 | Mitogen-activated protein kinase. (364 aa) | ||||
CCL24 | SCY domain-containing protein. (183 aa) | ||||
CCL8 | C-C motif chemokine 8; Chemotactic factor that attracts monocytes. This protein can bind heparin. (99 aa) | ||||
LOC110258125 | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (268 aa) | ||||
LOC100515857 | C-C motif chemokine. (132 aa) | ||||
TRAF6 | TNF receptor-associated factor 6; E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Mediates activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to [...] (541 aa) | ||||
NR1D1 | Nuclear receptor subfamily 1 group D member 1 isoform X2. (616 aa) | ||||
LOC100516039 | C-C motif chemokine. (243 aa) | ||||
CCL21 | Putative CCL21 chemokine. (134 aa) | ||||
UPF1 | UPF1 RNA helicase and ATPase. (1127 aa) | ||||
TOLLIP | CUE domain-containing protein. (272 aa) | ||||
LOC110258582 | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (245 aa) | ||||
RC3H1 | Ring finger and CCCH-type domains 1. (1132 aa) | ||||
IRAK2 | Interleukin-1 receptor-associated kinase-like 2. (621 aa) | ||||
IL1B-2 | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (244 aa) | ||||
LOC110258579 | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (272 aa) | ||||
ANKRD1 | Ankyrin repeat domain-containing protein 1; May play an important role in endothelial cell activation. May act as a nuclear transcription factor that negatively regulates the expression of cardiac genes (By similarity). (339 aa) | ||||
NFKB1 | Uncharacterized protein. (898 aa) | ||||
PYCARD | Apoptosis-associated speck-like protein containing a CARD isoform a. (196 aa) | ||||
YTHDC2 | YTH domain containing 2. (1430 aa) | ||||
HIF1A | Hypoxia-inducible factor 1-alpha isoform 1. (824 aa) | ||||
LOC110255300 | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (267 aa) | ||||
HYAL3 | Hyaluronidase-3; Facilitates sperm penetration into the layer of cumulus cells surrounding the egg by digesting hyaluronic acid. Involved in induction of the acrosome reaction in the sperm. Involved in follicular atresia, the breakdown of immature ovarian follicles that are not selected to ovulate. Induces ovarian granulosa cell apoptosis, possibly via apoptotic signaling pathway involving CASP8 and CASP3 activation, and poly(ADP-ribose) polymerase (PARP) cleavage. Has no hyaluronidase activity in embryonic fibroblasts in vitro. Has no hyaluronidase activity in granulosa cells in vitro. (490 aa) | ||||
CD40 | Tumor necrosis factor receptor superfamily member 5; Receptor for TNFSF5/CD40LG (By similarity). Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion (By similarity). (278 aa) | ||||
MYLK3 | Myosin light chain kinase 3. (797 aa) | ||||
SHAS2 | Uncharacterized protein. (553 aa) | ||||
CCL14 | C-C motif chemokine. (99 aa) | ||||
ZC3H12A | Zinc finger CCCH-type containing 12A. (582 aa) | ||||
HYAL1 | Hyaluronidase-1; May have a role in promoting tumor progression. May block the TGFB1-enhanced cell growth (By similarity); Belongs to the glycosyl hydrolase 56 family. (650 aa) | ||||
CACTIN | Cactin, spliceosome C complex subunit. (755 aa) | ||||
CHI3L1 | Chitinase-3-like protein 1; Carbohydrate-binding lectin with a preference for chitin. Has no chitinase activity. May play a role in tissue remodeling and in the capacity of cells to respond to and cope with changes in their environment. Plays a role in T-helper cell type 2 (Th2) inflammatory response and IL-13-induced inflammation, regulating allergen sensitization, inflammatory cell apoptosis, dendritic cell accumulation and M2 macrophage differentiation. Facilitates invasion of pathogenic enteric bacteria into colonic mucosa and lymphoid organs. Mediates activation of AKT1 signaling [...] (427 aa) | ||||
NKX3-1 | Homeobox protein Nkx-3.1 isoform 1. (247 aa) | ||||
CCL26 | C-C motif chemokine. (94 aa) | ||||
MAPK3 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (361 aa) | ||||
LOC110259156 | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (267 aa) | ||||
CCL16 | C-C motif chemokine. (120 aa) | ||||
IRAK3 | Interleukin 1 receptor associated kinase 3. (752 aa) | ||||
TAF9 | Transcription initiation factor TFIID subunit 9. (265 aa) | ||||
PLCB1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1173 aa) | ||||
CCL4 | C-C motif chemokine 4; Monokine with inflammatory and chemokinetic properties. (96 aa) | ||||
IL1R1 | Interleukin-1 receptor type 1 isoform 1. (572 aa) | ||||
CCL25 | C-C motif chemokine 25; Potentially involved in T-cell development. Recombinant protein shows chemotactic activity on thymocytes, macrophages, THP-1 cells, and dendritics cells but is inactive on peripheral blood lymphocytes and neutrophils. Binds to CCR9. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4 (By similarity); Belongs to the intercrine beta (chemokine CC) family. (220 aa) | ||||
MAPK13 | Mitogen-activated protein kinase. (435 aa) |