STRINGSTRING
I3L9Z6_PIG I3L9Z6_PIG IL17A IL17A ADAMTS7 ADAMTS7 USP10 USP10 CCL22 CCL22 RORA RORA ANXA1 ANXA1 DAB2IP DAB2IP PTGES PTGES XCL1 XCL1 IKBKB IKBKB PTGIS PTGIS IL1B2 IL1B2 LOC110258578 LOC110258578 CXCL8 CXCL8 CCL19 CCL19 MYD88 MYD88 HYAL2 HYAL2 IRAK1 IRAK1 RELA RELA EGR1 EGR1 SMPD1 SMPD1 SOX9 SOX9 PRKCA PRKCA CCL1 CCL1 CCL11 CCL11 CCL2 CCL2 CCL17 CCL17 IL1RL2 IL1RL2 RPS6KA5 RPS6KA5 ADAMTS12 ADAMTS12 RPS6KA4 RPS6KA4 CCL5 CCL5 RIPK2 RIPK2 TNFRSF11A TNFRSF11A SFRP1 SFRP1 RBMX RBMX SRC SRC CCL20 CCL20 MAPK11 MAPK11 CCL24 CCL24 CCL8 CCL8 LOC110258125 LOC110258125 LOC100515857 LOC100515857 TRAF6 TRAF6 NR1D1 NR1D1 LOC100516039 LOC100516039 CCL21 CCL21 UPF1 UPF1 TOLLIP TOLLIP LOC110258582 LOC110258582 RC3H1 RC3H1 IRAK2 IRAK2 IL1B-2 IL1B-2 LOC110258579 LOC110258579 ANKRD1 ANKRD1 NFKB1 NFKB1 PYCARD PYCARD YTHDC2 YTHDC2 HIF1A HIF1A LOC110255300 LOC110255300 HYAL3 HYAL3 CD40 CD40 MYLK3 MYLK3 SHAS2 SHAS2 CCL14 CCL14 ZC3H12A ZC3H12A HYAL1 HYAL1 CACTIN CACTIN CHI3L1 CHI3L1 NKX3-1 NKX3-1 CCL26 CCL26 MAPK3 MAPK3 LOC110259156 LOC110259156 CCL16 CCL16 IRAK3 IRAK3 TAF9 TAF9 PLCB1 PLCB1 CCL4 CCL4 IL1R1 IL1R1 CCL25 CCL25 MAPK13 MAPK13
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
I3L9Z6_PIGUncharacterized protein. (335 aa)
IL17AInterleukin-17A; Ligand for IL17RA and IL17RC. The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC. Involved in inducing stromal cells to produce proinflammatory and hematopoietic cytokines. Belongs to the IL-17 family. (153 aa)
ADAMTS7ADAM metallopeptidase with thrombospondin type 1 motif 7. (1660 aa)
USP10Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (805 aa)
CCL22C-C motif chemokine. (93 aa)
RORARAR related orphan receptor A. (530 aa)
ANXA1Annexin A1; Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity. Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response. Promotes resolution of inflammation and wound healing (By similarity). Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (By similarity). Contribut [...] (346 aa)
DAB2IPDAB2 interacting protein. (1196 aa)
PTGESMicrosomal prostaglandin E synthase-1. (153 aa)
XCL1Lymphotactin isoform X1. (110 aa)
IKBKBInhibitor of kappa light chain gene enhancer in B cells, kinase beta. (755 aa)
PTGISProstacyclin synthase; Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2); Belongs to the cytochrome P450 family. (503 aa)
IL1B2Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (267 aa)
LOC110258578Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (267 aa)
CXCL8Interleukin-8; IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus; Belongs to the intercrine alpha (chemokine CxC) family. (103 aa)
CCL19C-C motif chemokine. (100 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] (323 aa)
HYAL2Hyaluronidase. (476 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (691 aa)
RELATranscription factor p65 isoform 1. (573 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (542 aa)
SMPD1Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. (640 aa)
SOX9Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (511 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (669 aa)
CCL1C-C motif chemokine. (94 aa)
CCL11C-C motif chemokine. (97 aa)
CCL2C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...] (99 aa)
CCL17C-C motif chemokine. (102 aa)
IL1RL2Interleukin 1 receptor like 2. (644 aa)
RPS6KA5Non-specific serine/threonine protein kinase. (957 aa)
ADAMTS12ADAM metallopeptidase with thrombospondin type 1 motif 12. (1598 aa)
RPS6KA4Ribosomal protein S6 kinase. (806 aa)
CCL5C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Belongs to the intercrine beta (chemokine CC) family. (91 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (533 aa)
TNFRSF11ATNF receptor superfamily member 11a. (629 aa)
SFRP1Secreted frizzled-related protein 1. (308 aa)
RBMXRNA binding motif protein X-linked. (408 aa)
SRCTyrosine-protein kinase. (559 aa)
CCL20C-C motif chemokine. (153 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
CCL24SCY domain-containing protein. (183 aa)
CCL8C-C motif chemokine 8; Chemotactic factor that attracts monocytes. This protein can bind heparin. (99 aa)
LOC110258125Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (268 aa)
LOC100515857C-C motif chemokine. (132 aa)
TRAF6TNF receptor-associated factor 6; E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Mediates activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to [...] (541 aa)
NR1D1Nuclear receptor subfamily 1 group D member 1 isoform X2. (616 aa)
LOC100516039C-C motif chemokine. (243 aa)
CCL21Putative CCL21 chemokine. (134 aa)
UPF1UPF1 RNA helicase and ATPase. (1127 aa)
TOLLIPCUE domain-containing protein. (272 aa)
LOC110258582Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (245 aa)
RC3H1Ring finger and CCCH-type domains 1. (1132 aa)
IRAK2Interleukin-1 receptor-associated kinase-like 2. (621 aa)
IL1B-2Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (244 aa)
LOC110258579Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (272 aa)
ANKRD1Ankyrin repeat domain-containing protein 1; May play an important role in endothelial cell activation. May act as a nuclear transcription factor that negatively regulates the expression of cardiac genes (By similarity). (339 aa)
NFKB1Uncharacterized protein. (898 aa)
PYCARDApoptosis-associated speck-like protein containing a CARD isoform a. (196 aa)
YTHDC2YTH domain containing 2. (1430 aa)
HIF1AHypoxia-inducible factor 1-alpha isoform 1. (824 aa)
LOC110255300Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (267 aa)
HYAL3Hyaluronidase-3; Facilitates sperm penetration into the layer of cumulus cells surrounding the egg by digesting hyaluronic acid. Involved in induction of the acrosome reaction in the sperm. Involved in follicular atresia, the breakdown of immature ovarian follicles that are not selected to ovulate. Induces ovarian granulosa cell apoptosis, possibly via apoptotic signaling pathway involving CASP8 and CASP3 activation, and poly(ADP-ribose) polymerase (PARP) cleavage. Has no hyaluronidase activity in embryonic fibroblasts in vitro. Has no hyaluronidase activity in granulosa cells in vitro. (490 aa)
CD40Tumor necrosis factor receptor superfamily member 5; Receptor for TNFSF5/CD40LG (By similarity). Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion (By similarity). (278 aa)
MYLK3Myosin light chain kinase 3. (797 aa)
SHAS2Uncharacterized protein. (553 aa)
CCL14C-C motif chemokine. (99 aa)
ZC3H12AZinc finger CCCH-type containing 12A. (582 aa)
HYAL1Hyaluronidase-1; May have a role in promoting tumor progression. May block the TGFB1-enhanced cell growth (By similarity); Belongs to the glycosyl hydrolase 56 family. (650 aa)
CACTINCactin, spliceosome C complex subunit. (755 aa)
CHI3L1Chitinase-3-like protein 1; Carbohydrate-binding lectin with a preference for chitin. Has no chitinase activity. May play a role in tissue remodeling and in the capacity of cells to respond to and cope with changes in their environment. Plays a role in T-helper cell type 2 (Th2) inflammatory response and IL-13-induced inflammation, regulating allergen sensitization, inflammatory cell apoptosis, dendritic cell accumulation and M2 macrophage differentiation. Facilitates invasion of pathogenic enteric bacteria into colonic mucosa and lymphoid organs. Mediates activation of AKT1 signaling [...] (427 aa)
NKX3-1Homeobox protein Nkx-3.1 isoform 1. (247 aa)
CCL26C-C motif chemokine. (94 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (361 aa)
LOC110259156Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (267 aa)
CCL16C-C motif chemokine. (120 aa)
IRAK3Interleukin 1 receptor associated kinase 3. (752 aa)
TAF9Transcription initiation factor TFIID subunit 9. (265 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1173 aa)
CCL4C-C motif chemokine 4; Monokine with inflammatory and chemokinetic properties. (96 aa)
IL1R1Interleukin-1 receptor type 1 isoform 1. (572 aa)
CCL25C-C motif chemokine 25; Potentially involved in T-cell development. Recombinant protein shows chemotactic activity on thymocytes, macrophages, THP-1 cells, and dendritics cells but is inactive on peripheral blood lymphocytes and neutrophils. Binds to CCR9. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4 (By similarity); Belongs to the intercrine beta (chemokine CC) family. (220 aa)
MAPK13Mitogen-activated protein kinase. (435 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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