(27 nodes) Regulation of glycogen metabolic process network (Sus scrofa)

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Your Input:
	INPP5K	Inositol polyphosphate-5-phosphatase K. (480 aa)
	GCGR	G_PROTEIN_RECEP_F2_4 domain-containing protein; Belongs to the G-protein coupled receptor 2 family. (602 aa)
	PPP1R3B	Protein phosphatase 1 regulatory subunit. (339 aa)
	PPP1R3F	Protein phosphatase 1 regulatory subunit 3F. (790 aa)
	KHK	Ketohexokinase. (339 aa)
	IRS1	Insulin receptor substrate 1. (1241 aa)
	IRS2	Insulin receptor substrate 2. (1092 aa)
	A0A287B5K4_PIG	Protein kinase domain-containing protein. (62 aa)
	AKT1	Non-specific serine/threonine protein kinase. (785 aa)
	GCK	Glucokinase. (659 aa)
	AKT2	Non-specific serine/threonine protein kinase. (525 aa)
	INS	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (108 aa)
	PASK	PAS domain containing serine/threonine kinase. (1320 aa)
	DYRK2	Dual specificity tyrosine-phosphorylation-regulated kinase 2 isoform 2. (601 aa)
	EPM2AIP1	EPM2A interacting protein 1. (608 aa)
	ENPP1	Ectonucleotide pyrophosphatase/phosphodiesterase 1. (878 aa)
	A0A287ABS1_PIG	Uncharacterized protein. (178 aa)
	PPP1R3E	Protein phosphatase 1 regulatory subunit 3E. (279 aa)
	INSR	Tyrosine-protein kinase receptor. (1382 aa)
	PPP1R3D	Protein phosphatase 1 regulatory subunit. (299 aa)
	RUBCNL	Rubicon like autophagy enhancer. (664 aa)
	PPP1R3C	Protein phosphatase 1 regulatory subunit 3C; Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown. (317 aa)
	PTH	Parathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D- glucose (2DG) transport and glycogen synthesis in osteoblastic cells (By similarity). (115 aa)
	PPP1R3G	Protein phosphatase 1 regulatory subunit 3G. (353 aa)
	PPP1R3A	Protein phosphatase 1 regulatory subunit 3A. (1096 aa)
	IGF1	Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (230 aa)
	PHLDA2	Pleckstrin homology-like domain family A member 2. (131 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKT1	AKT2	ENSSSCP00000050721	ENSSSCP00000046221	Non-specific serine/threonine protein kinase.	Non-specific serine/threonine protein kinase.	0.902
AKT1	IGF1	ENSSSCP00000050721	ENSSSCP00000000915	Non-specific serine/threonine protein kinase.	Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...]	0.520
AKT1	INS	ENSSSCP00000050721	ENSSSCP00000044635	Non-specific serine/threonine protein kinase.	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.510
AKT1	IRS1	ENSSSCP00000050721	ENSSSCP00000061240	Non-specific serine/threonine protein kinase.	Insulin receptor substrate 1.	0.417
AKT2	AKT1	ENSSSCP00000046221	ENSSSCP00000050721	Non-specific serine/threonine protein kinase.	Non-specific serine/threonine protein kinase.	0.902
AKT2	IGF1	ENSSSCP00000046221	ENSSSCP00000000915	Non-specific serine/threonine protein kinase.	Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...]	0.411
AKT2	INS	ENSSSCP00000046221	ENSSSCP00000044635	Non-specific serine/threonine protein kinase.	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.618
AKT2	IRS1	ENSSSCP00000046221	ENSSSCP00000061240	Non-specific serine/threonine protein kinase.	Insulin receptor substrate 1.	0.625
AKT2	IRS2	ENSSSCP00000046221	ENSSSCP00000052323	Non-specific serine/threonine protein kinase.	Insulin receptor substrate 2.	0.487
EPM2AIP1	PPP1R3D	ENSSSCP00000039040	ENSSSCP00000008042	EPM2A interacting protein 1.	Protein phosphatase 1 regulatory subunit.	0.490
EPM2AIP1	PPP1R3E	ENSSSCP00000039040	ENSSSCP00000002208	EPM2A interacting protein 1.	Protein phosphatase 1 regulatory subunit 3E.	0.493
EPM2AIP1	PPP1R3G	ENSSSCP00000039040	ENSSSCP00000001065	EPM2A interacting protein 1.	Protein phosphatase 1 regulatory subunit 3G.	0.497
GCGR	INS	ENSSSCP00000070968	ENSSSCP00000044635	G_PROTEIN_RECEP_F2_4 domain-containing protein; Belongs to the G-protein coupled receptor 2 family.	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.596
GCGR	PTH	ENSSSCP00000070968	ENSSSCP00000014236	G_PROTEIN_RECEP_F2_4 domain-containing protein; Belongs to the G-protein coupled receptor 2 family.	Parathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D- glucose (2DG) transport and glycogen synthesis in osteoblastic cells (By similarity).	0.425
GCK	INS	ENSSSCP00000048940	ENSSSCP00000044635	Glucokinase.	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.794
GCK	IRS1	ENSSSCP00000048940	ENSSSCP00000061240	Glucokinase.	Insulin receptor substrate 1.	0.457
GCK	IRS2	ENSSSCP00000048940	ENSSSCP00000052323	Glucokinase.	Insulin receptor substrate 2.	0.462
GCK	KHK	ENSSSCP00000048940	ENSSSCP00000063487	Glucokinase.	Ketohexokinase.	0.456
IGF1	AKT1	ENSSSCP00000000915	ENSSSCP00000050721	Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...]	Non-specific serine/threonine protein kinase.	0.520
IGF1	AKT2	ENSSSCP00000000915	ENSSSCP00000046221	Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...]	Non-specific serine/threonine protein kinase.	0.411