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| | INHBB | Inhibin beta B chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins. (407 aa) |
| | RAB12 | RAB12, member RAS oncogene family. (332 aa) |
| | AHCYL1 | Adenosylhomocysteinase-like protein 1; Belongs to the adenosylhomocysteinase family. (530 aa) |
| | JAK1 | Tyrosine-protein kinase. (1154 aa) |
| | A0A286ZLG7_PIG | Uncharacterized protein. (135 aa) |
| | CAV1 | Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (177 aa) |
| | GRB10 | Growth factor receptor-bound protein 10; Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin [...] (589 aa) |
| | AGTR1 | Type-1 angiotensin II receptor; Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. (359 aa) |
| | JAK3 | Tyrosine-protein kinase. (1103 aa) |
| | FOXO4 | Forkhead box protein O4 isoform 1. (531 aa) |
| | SRC | Tyrosine-protein kinase. (559 aa) |
| | FOXO1 | Forkhead box protein O1; Transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress. Binds to the insulin response element (IRE) with consensus sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16 family binding element (DBE) with consensus sequence 5'-TT[G/A]TTTAC-3'. Activity suppressed by insulin. Main regulator of redox balance and osteoblast numbers and controls bone mass. Orchestrates the endocrine function of the skeleton in regulating glucose metabolism. Acts synergistically with ATF4 to suppress osteocalc [...] (662 aa) |
| | SH2B2 | SH2B adaptor protein 2. (695 aa) |
| | PCK1 | Phosphoenolpyruvate carboxykinase 1. (841 aa) |
| | JAK2 | Tyrosine-protein kinase JAK2; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN- beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors [...] (1131 aa) |
| | SHC1 | SHC adaptor protein 1. (583 aa) |
| | IRS4 | Insulin receptor substrate 4. (1175 aa) |
| | SLC39A14 | Solute carrier family 39 member 14. (531 aa) |
| | GPER1 | G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (360 aa) |
| | KAT2B | Histone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (831 aa) |
| | INPP5K | Inositol polyphosphate-5-phosphatase K. (480 aa) |
| | PIK3R1 | Phosphoinositide-3-kinase regulatory subunit 1. (766 aa) |
| | FER | Tyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (822 aa) |
| | CYP11A1 | Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R-hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the sec [...] (520 aa) |
| | PCSK9 | Proprotein convertase subtilisin/kexin type 9. (678 aa) |
| | CDK4 | Cyclin-dependent kinase 4; Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. [...] (303 aa) |
| | PARP1 | Poly [ADP-ribose] polymerase. (1017 aa) |
| | UMODL1 | Uromodulin like 1. (1360 aa) |
| | DPEP1 | Dipeptidase 1; Hydrolyzes a wide range of dipeptides. Implicated in the renal metabolism of glutathione and its conjugates. Converts leukotriene D4 to leukotriene E4; it may play an important role in the regulation of leukotriene activity; Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family. (409 aa) |
| | STAT6 | Signal transducer and activator of transcription. (847 aa) |
| | POU4F2 | POU domain protein. (408 aa) |
| | SLC2A4 | Solute carrier family 2, facilitated glucose transporter member 4; Insulin-regulated facilitative glucose transporter, which plays a key role in removal of glucose from circulation. Response to insulin is regulated by its intracellular localization: in the absence of insulin, it is efficiently retained intracellularly within storage compartments in muscle and fat cells. Upon insulin stimulation, translocates from these compartments to the cell surface where it transports glucose from the extracellular milieu into the cell. (509 aa) |
| | TUSC5 | Uncharacterized protein. (259 aa) |
| | STAT5B | Signal transducer and activator of transcription 5B; Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Binds to the GAS element and activates PRL-induced transcription. Positively regulates hematopoietic/erythroid differentiation. (787 aa) |
| | STAT5A | Signal transducer and activator of transcription 5A; Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the GAS element and activates PRL-induced transcription. Regulates the expression of milk proteins during lactation (By similarity). (799 aa) |
| | STAT3 | Signal transducer and activator of transcription 3; Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors. Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA (By similarity). Acts as a regulator of inflammatory response by regul [...] (772 aa) |
| | CRHR1 | Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family. (415 aa) |
| | GRB2 | Growth factor receptor-bound protein 2 isoform 1. (217 aa) |
| | GHRHR | Growth hormone-releasing hormone receptor; Receptor for GRF, coupled to G proteins which activate adenylyl cyclase. Stimulates somatotroph cell growth, growth hormone gene transcription and growth hormone secretion. (451 aa) |
| | CAV2 | Caveolin-2; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression (By similarity); Belongs to the caveolin family. (162 aa) |
| | F1SS05_PIG | G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (343 aa) |
| | CAMK2A | Calcium/calmodulin-dependent protein kinase type II subunit alpha isoform 1; Belongs to the protein kinase superfamily. (489 aa) |
| | CRHBP | Corticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family. (322 aa) |
| | INSR | Tyrosine-protein kinase receptor. (1382 aa) |
| | CSRP3 | Uncharacterized protein. (200 aa) |
| | RELA | Transcription factor p65 isoform 1. (573 aa) |
| | AGTR2 | Angiotensin II receptor type 2; Belongs to the G-protein coupled receptor 1 family. (362 aa) |
| | GHSR | Growth hormone secretagogue receptor type 1; Receptor for ghrelin, coupled to G-alpha-11 proteins. Stimulates growth hormone secretion. Binds also other growth hormone releasing peptides (GHRP) (e.g. Met-enkephalin and GHRP-6) as well as non-peptide, low molecular weight secretagogues (e.g. L-692,429, MK- 0677, adenosine). (366 aa) |
| | PRKCI | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (636 aa) |
| | PPARG | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (528 aa) |
| | GOT1 | Aspartate aminotransferase, cytoplasmic; Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-m [...] (413 aa) |
| | RB1 | RB transcriptional corepressor 1. (938 aa) |
| | KL | Klotho. (1011 aa) |
| | MGARP | AIF-MLS domain-containing protein. (238 aa) |
| | EDNRA | Endothelin-1 receptor; Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3 (By similarity). (427 aa) |
| | OTOP1 | Otopetrin 1. (612 aa) |
| | LHCGR | Lutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (696 aa) |
| | LOC100515824 | Insulin receptor substrate 1-like isoform X2. (512 aa) |
| | NCOA5 | Nuclear receptor coactivator 5 isoform 1. (585 aa) |
| | LPIN3 | LNS2 domain-containing protein. (826 aa) |
| | SOGA1 | Suppressor of glucose, autophagy associated 1. (1661 aa) |
| | F1SER7_PIG | ANK_REP_REGION domain-containing protein. (858 aa) |
| | F1SER8_PIG | ANK_REP_REGION domain-containing protein. (697 aa) |
| | GNRHR2 | Gonadotropin-releasing hormone receptor isoform 1. (293 aa) |
| | RAB13 | Uncharacterized protein. (203 aa) |
| | INSRR | Tyrosine-protein kinase receptor. (1315 aa) |
| | PRKDC | Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4136 aa) |
| | IGF1R | Tyrosine-protein kinase receptor. (1367 aa) |
| | MAS1 | MAS1 proto-oncogene, G protein-coupled receptor; Belongs to the G-protein coupled receptor 1 family. (292 aa) |
| | RPE65 | Retinoid isomerohydrolase RPE65. (533 aa) |
| | GSK3A | Protein kinase domain-containing protein. (566 aa) |
| | GPLD1 | Glycosylphosphatidylinositol specific phospholipase D1. (906 aa) |
| | STXBP4 | Syntaxin-binding protein 4 isoform X3. (573 aa) |
| | CRHR2 | Corticotropin releasing hormone receptor 2; Belongs to the G-protein coupled receptor 2 family. (482 aa) |
| | PLA2G1B | Phospholipase A2, major isoenzyme; PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides, this releases glycerophospholipids and arachidonic acid that serve as the precursors of signal molecules. Belongs to the phospholipase A2 family. (146 aa) |
| | GCGR | G_PROTEIN_RECEP_F2_4 domain-containing protein; Belongs to the G-protein coupled receptor 2 family. (602 aa) |
| | GLP1R | Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family. (468 aa) |
| | AGTRAP | Uncharacterized protein. (270 aa) |
| | PHIP | Pleckstrin homology domain interacting protein. (1825 aa) |
| | EIF4EBP2 | Eukaryotic translation initiation factor 4E binding protein 2. (123 aa) |
| | LPIN1 | Lipin 1. (957 aa) |
| | SLC27A4 | Solute carrier family 27 member 4. (673 aa) |
| | RPS6KB1 | Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa) |
| | PPP1R12A | Protein phosphatase 1 regulatory subunit. (1028 aa) |
| | PDK4 | Protein-serine/threonine kinase. (411 aa) |
| | ACTN2 | Uncharacterized protein. (933 aa) |
| | COMMD6 | Uncharacterized protein. (1300 aa) |
| | SLC2A8 | Solute carrier family 2, facilitated glucose transporter member 8 isoform X1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (478 aa) |
| | RAB31 | RAB31, member RAS oncogene family. (195 aa) |
| | DENND4C | DENN domain containing 4C. (1996 aa) |
| | IRS1 | Insulin receptor substrate 1. (1241 aa) |
| | RAB10 | Uncharacterized protein. (201 aa) |
| | PIK3R2 | Uncharacterized protein. (772 aa) |
| | ZFP36L1 | ZFP36 ring finger protein like 1. (348 aa) |
| | UBA6 | Gonadotropin-releasing hormone receptor; Receptor for gonadotropin releasing hormone (GnRH) that mediates the action of GnRH to stimulate the secretion of the gonadotropic hormones luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This receptor mediates its action by association with G- proteins that activate a phosphatidylinositol-calcium second messenger system. (1396 aa) |
| | PDK2 | Protein-serine/threonine kinase. (437 aa) |
| | TRIB3 | Tribbles pseudokinase 3. (373 aa) |
| | PTPN2 | Tyrosine-protein phosphatase non-receptor type. (447 aa) |
| | NR4A3 | Nuclear receptor subfamily 4 group A member 3 isoform b. (643 aa) |
| | SLC25A33 | Solute carrier family 25 member 33; Belongs to the mitochondrial carrier (TC 2.A.29) family. (321 aa) |
| | LEP | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] (192 aa) |
| | BCAR3 | BCAR3 adaptor protein, NSP family member. (860 aa) |
| | ZNF106 | Zinc finger protein 106. (1903 aa) |
| | PRKCD | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (723 aa) |
| | GRB14 | Growth factor receptor-bound protein 14 isoform 1. (540 aa) |
| | TSHR | Thyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. (764 aa) |
| | LOC100511937 | Uncharacterized protein. (532 aa) |
| | PTPRA | Protein tyrosine phosphatase receptor type A. (850 aa) |
| | NDEL1 | NudE neurodevelopment protein 1 like 1. (394 aa) |
| | IRS2 | Insulin receptor substrate 2. (1092 aa) |
| | RARRES2 | Retinoic acid receptor responder 2. (177 aa) |
| | CA2 | Carbonic anhydrase 2; Belongs to the alpha-carbonic anhydrase family. (305 aa) |
| | A0A287B5K4_PIG | Protein kinase domain-containing protein. (62 aa) |
| | GH1 | Somatotropin; Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues; Belongs to the somatotropin/prolactin family. (217 aa) |
| | AKT1 | Non-specific serine/threonine protein kinase. (785 aa) |
| | WDTC1 | WD and tetratricopeptide repeats 1. (733 aa) |
| | ZDHHC7 | Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (389 aa) |
| | SLC27A1 | Solute carrier family 27 (Fatty acid transporter), member 1. (646 aa) |
| | C2CD5 | C2 calcium dependent domain containing 5. (1148 aa) |
| | XBP1 | BZIP domain-containing protein. (378 aa) |
| | SYAP1 | Synapse-associated protein 1. (358 aa) |
| | NFKB1 | Uncharacterized protein. (898 aa) |
| | ADIPOQ | C1q domain-containing protein. (332 aa) |
| | GSK3B | Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (414 aa) |
| | AKT2 | Non-specific serine/threonine protein kinase. (525 aa) |
| | NR4A1 | Nuclear receptor subfamily 4 group A member 1 isoform 2. (598 aa) |
| | SMARCC1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1. (1175 aa) |
| | INS | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (108 aa) |
| | GHR | Growth hormone-binding protein; Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway. (660 aa) |
| | USF1 | Upstream transcription factor 1. (317 aa) |
| | LOC110260194 | Cytochrome P450 11B1, mitochondrial; A cytochrome P450 monooxygenase involved in the biosynthesis of adrenal corticoids. Catalyzes the hydroxylation of carbon hydrogen bond at 11-beta position of 11-deoxycortisol and 11- deoxycorticosterone/21-hydroxyprogesterone yielding cortisol or corticosterone, respectively. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) [...] (503 aa) |
| | EDN1 | Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides. Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. (203 aa) |
| | YME1L1 | ANK_REP_REGION domain-containing protein. (2031 aa) |
| | SLC30A10 | Uncharacterized protein. (260 aa) |
| | PCK2 | Phosphoenolpyruvate carboxykinase 2, mitochondrial. (673 aa) |
| | A0A287ABS1_PIG | Uncharacterized protein. (178 aa) |
| | INSIG2 | Insulin-induced gene 2 protein; Mediates feedback control of cholesterol synthesis by controlling SCAP and HMGCR. Functions by blocking the processing of sterol regulatory element-binding proteins (SREBPs). Capable of retaining the SCAP-SREBF2 complex in the ER thus preventing it from escorting SREBPs to the Golgi. Seems to regulate the ubiquitin-mediated proteasomal degradation of HMGCR (By similarity). (225 aa) |
| | ENPP1 | Ectonucleotide pyrophosphatase/phosphodiesterase 1. (878 aa) |
| | RHOQ | Rho-related GTP-binding protein RhoQ. (205 aa) |
| | APPL1 | Adaptor protein phosphotyrosine interaction PH domain and leucine zipper containing 1. (708 aa) |
| | RAB15 | RAB15, member RAS oncogene family. (197 aa) |
| | NR4A2 | Nuclear receptor subfamily 4 group A member 2 isoform X1. (609 aa) |
| | PTPN1 | Tyrosine-protein phosphatase non-receptor type. (435 aa) |
| | APC | APC_basic domain-containing protein. (2713 aa) |
| | CPEB2 | Cytoplasmic polyadenylation element binding protein 2. (1035 aa) |
| | SP1 | Transcription factor Sp1 isoform a. (786 aa) |
| | PKLR | Pyruvate kinase; Belongs to the pyruvate kinase family. (565 aa) |
| | INSIG1 | Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (308 aa) |
| | TYK2 | Tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1226 aa) |
| | A0A286ZVA3_PIG | CCDC144C domain-containing protein. (323 aa) |
| | PDPK1 | 3-phosphoinositide dependent protein kinase 1. (668 aa) |
| | CAPN10 | Calpain 10; Belongs to the peptidase C2 family. (734 aa) |
| | EPRS1 | Glutamyl-prolyl-tRNA synthetase. (1519 aa) |
| | DNAI1 | Dynein axonemal intermediate chain 1. (704 aa) |
| | GLP2R | Glucagon like peptide 2 receptor; Belongs to the G-protein coupled receptor 2 family. (556 aa) |
| | LPIN2 | Lipin 2. (937 aa) |
| | STAT1 | Signal transducer and activator of transcription 1; Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other cytokines and other growth factors. Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to [...] (856 aa) |
