STRINGSTRING
KLHL3 KLHL3 WNT1 WNT1 GDF11 GDF11 IQGAP1 IQGAP1 ARG2 ARG2 IRX3 IRX3 SALL1 SALL1 GREB1L GREB1L SMAD7 SMAD7 SMAD4 SMAD4 SMAD6 SMAD6 BMP4 BMP4 SIX1 SIX1 EXT1 EXT1 CALB1 CALB1 NOTCH2 NOTCH2 JAG1 JAG1 GZF1 GZF1 ASXL1 ASXL1 BMP7 BMP7 UMOD UMOD SIX2 SIX2 SLIT2 SLIT2 EDNRA EDNRA PKD2 PKD2 EDNRB EDNRB RET RET POU3F4 POU3F4 LGR4 LGR4 TMEM59L TMEM59L MEF2C MEF2C AQP11 AQP11 NPHS2 NPHS2 EPHA4 EPHA4 SHH SHH SMO SMO HOXA11 HOXA11 GLI3 GLI3 ADAMTS16 ADAMTS16 FOXJ1 FOXJ1 SOX9 SOX9 WNT11 WNT11 WT1 WT1 ILK ILK GREB1 GREB1 PTPRO PTPRO DLL1 DLL1 KIF26B KIF26B POU3F3 POU3F3 LZTS2 LZTS2 DCHS1 DCHS1 PTCH1 PTCH1 SFRP1 SFRP1 GPC3 GPC3 TGFB1 TGFB1 DLG1 DLG1 PAX2 PAX2 LHX1 LHX1 CTNNB1 CTNNB1 SMAD1 SMAD1 SMAD5 SMAD5 HEYL HEYL SOX8 SOX8 RARA RARA OSR1 OSR1 NPHS1 NPHS1 BMP2 BMP2 FGF1 FGF1 GREM1 GREM1 KANK2 KANK2 EYA1 EYA1 TFAP2B TFAP2B HS3ST3A1 HS3ST3A1 COMMD5 COMMD5 GATA3 GATA3 HS2ST1 HS2ST1 CTNNBIP1 CTNNBIP1 CRLF1 CRLF1 IRX1 IRX1 GDNF GDNF PECAM1 PECAM1 HES1 HES1 LAMB2 LAMB2 NOTCH1 NOTCH1 PROM1 PROM1 TCF21 TCF21 FMN1 FMN1 EPHA7 EPHA7 NOG NOG HES5 HES5 IRX2 IRX2 FGF2 FGF2 WNT9B WNT9B AHI1 AHI1 WNT6 WNT6 AQP1 AQP1 DLG2 DLG2 PKD1 PKD1 MTSS1 MTSS1 FGF8 FGF8 A0A5G2QXZ6_PIG A0A5G2QXZ6_PIG SPRY1 SPRY1 BMPER BMPER MYO1E MYO1E SMAD3 SMAD3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
KLHL3Kelch like family member 3. (601 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
GDF11Growth/differentiation factor 11 preproprotein. (404 aa)
IQGAP1IQ motif containing GTPase activating protein 1. (1709 aa)
ARG2Arginase. (354 aa)
IRX3Iroquois-class homeodomain protein IRX-3 isoform X2. (502 aa)
SALL1Spalt like transcription factor 1. (1326 aa)
GREB1LGREB1 like retinoic acid receptor coactivator. (1909 aa)
SMAD7Mothers against decapentaplegic homolog. (426 aa)
SMAD4Mothers against decapentaplegic homolog 4; Common SMAD (co-SMAD) is the coactivator and mediator of signal transduction by TGF-beta (transforming growth factor). Component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling. Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. Component of the multimeric SMAD3/SMAD4/JUN/FOS complex which forms at the AP1 promoter site; required for synergistic transcriptional activity in r [...] (552 aa)
SMAD6Mothers against decapentaplegic homolog. (496 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
SIX1Six homeobox 1. (284 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
CALB1Calbindin 1. (261 aa)
NOTCH2Neurogenic locus notch homolog protein 2 isoform 1 preproprotein. (2471 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1211 aa)
GZF1Uncharacterized protein. (235 aa)
ASXL1ASXL transcriptional regulator 1. (1542 aa)
BMP7Bone morphogenetic protein 7. (650 aa)
UMODUromodulin. (642 aa)
SIX2SIX homeobox 2. (296 aa)
SLIT2Slit guidance ligand 2. (1542 aa)
EDNRAEndothelin-1 receptor; Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3 (By similarity). (427 aa)
PKD2Polycystin 2, transient receptor potential cation channel. (970 aa)
EDNRBEndothelin receptor type B; Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRB sub-subfamily. (443 aa)
RETProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1111 aa)
POU3F4POU domain protein. (352 aa)
LGR4Leucine-rich repeat-containing G-protein coupled receptor 4 isoform 1. (951 aa)
TMEM59LTransmembrane protein 59-like. (349 aa)
MEF2CMyocyte-specific enhancer factor 2C; Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Enhances transcriptional activation mediated by SOX18. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex [...] (483 aa)
AQP11Aquaporin; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes. (271 aa)
NPHS2NPHS2 stomatin family member, podocin. (378 aa)
EPHA4EPH receptor A4. (986 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (440 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (783 aa)
HOXA11Homeobox protein Hox-A11. (317 aa)
GLI3GLI family zinc finger 3. (1586 aa)
ADAMTS16ADAM metallopeptidase with thrombospondin type 1 motif 16. (1202 aa)
FOXJ1Forkhead box J1. (421 aa)
SOX9Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (511 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (536 aa)
WT1Wilms tumor protein homolog; Transcription factor that plays an important role in cellular development and cell survival. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'. Regulates the expression of numerous target genes, including EPO. Plays an essential role for development of the urogenital system. It has a tumor suppressor as well as an oncogenic role in tumor formation. Function may be isoform-specific: isoforms lacking the KTS motif may act as transcription factors. Isoforms containing the KTS motif may bind mRNA and play a role in mRNA metabolism or splicing. Isofor [...] (523 aa)
ILKIntegrin linked kinase. (479 aa)
GREB1Uncharacterized protein. (1970 aa)
PTPROProtein tyrosine phosphatase receptor type O. (1186 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (729 aa)
KIF26BKinesin family member 26B; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (2109 aa)
POU3F3POU domain, class 3, transcription factor 3; Transcription factor that acts synergistically with SOX11 and SOX4. Plays a role in neuronal development. Is implicated in an enhancer activity at the embryonic met-mesencephalic junction; the enhancer element contains the octamer motif (5'-ATTTGCAT-3') (By similarity); Belongs to the POU transcription factor family. Class-3 subfamily. (501 aa)
LZTS2Leucine zipper putative tumor suppressor 2; Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta- catenin. (667 aa)
DCHS1Dachsous cadherin-related 1. (3294 aa)
PTCH1Protein patched homolog 1 isoform L. (1452 aa)
SFRP1Secreted frizzled-related protein 1. (308 aa)
GPC3Glypican-3 isoform 2; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (579 aa)
TGFB1Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa)
DLG1Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (939 aa)
PAX2Paired box 2. (416 aa)
LHX1LIM homeobox 1. (436 aa)
CTNNB1Catenin beta 1. (808 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
SMAD5Mothers against decapentaplegic homolog. (465 aa)
HEYLHairy/enhancer-of-split related with YRPW motif-like protein isoform X1. (328 aa)
SOX8SRY-box transcription factor 8. (460 aa)
RARARetinoic acid receptor alpha isoform X1. (462 aa)
OSR1Odd-skipped related transcription factor 1. (267 aa)
NPHS1NPHS1 adhesion molecule, nephrin. (1239 aa)
BMP2Bone morphogenetic protein 2 preproprotein. (395 aa)
FGF1Fibroblast growth factor 1; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrin ITGAV:ITGB3. Its binding to integrin, subsequent ternary complex formation with int [...] (182 aa)
GREM1Gremlin 1, DAN family BMP antagonist. (240 aa)
KANK2KN motif and ankyrin repeat domains 2. (981 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (618 aa)
TFAP2BTranscription factor AP-2 beta. (469 aa)
HS3ST3A1Sulfotransferase; Belongs to the sulfotransferase 1 family. (405 aa)
COMMD5COMM domain containing 5. (260 aa)
GATA3Trans-acting T-cell-specific transcription factor GATA-3. (444 aa)
HS2ST1Uncharacterized protein. (356 aa)
CTNNBIP1Beta-catenin-interacting protein 1. (81 aa)
CRLF1Cytokine receptor like factor 1. (421 aa)
IRX1Iroquois homeobox 1. (478 aa)
GDNFGlial cell line-derived neurotrophic factor isoform 1. (211 aa)
PECAM1Platelet endothelial cell adhesion molecule; Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions. Tyr-692 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes. Trans-homophilic interaction may play a role in endothelial cell-cell adhesion via cell junctions. Heterophilic interaction with CD177 plays a role in transendothelial migration of neutr [...] (740 aa)
HES1Uncharacterized protein. (280 aa)
LAMB2Laminin subunit beta-2. (1881 aa)
NOTCH1Neurogenic locus notch homolog protein 1 preproprotein. (2560 aa)
PROM1Prominin 1. (838 aa)
TCF21Transcription factor 21. (179 aa)
FMN1Formin 1. (1195 aa)
EPHA7Ephrin type-A receptor 7 isoform 1. (998 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
HES5Hes family bHLH transcription factor 5. (226 aa)
IRX2Iroquois-class homeodomain protein IRX-2. (473 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (316 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (357 aa)
AHI1Abelson helper integration site 1. (1114 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (364 aa)
AQP1Aquaporin-1; Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. (280 aa)
DLG2Discs large MAGUK scaffold protein 2. (1012 aa)
PKD1Polycystin 1, transient receptor potential channel interacting. (4383 aa)
MTSS1MTSS I-BAR domain containing 1. (766 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
A0A5G2QXZ6_PIGProtein kinase domain-containing protein. (408 aa)
SPRY1Sprouty RTK signaling antagonist 1. (319 aa)
BMPERBMP binding endothelial regulator. (699 aa)
MYO1EMyosin IE; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1116 aa)
SMAD3Mothers against decapentaplegic homolog. (434 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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