STRINGSTRING
SOX9 SOX9 WNT10B WNT10B WNT1 WNT1 KDF1 KDF1 CDKN2C CDKN2C ELL3 ELL3 SHB SHB OSR2 OSR2 GBA GBA WNT2B WNT2B SIX2 SIX2 SFRP2 SFRP2 LIG4 LIG4 TBX3 TBX3 HMX2 HMX2 FGF4 FGF4 YJEFN3 YJEFN3 SHH SHH HOXA3 HOXA3 GLI3 GLI3 FGF10 FGF10 HOXB4 HOXB4 NF1 NF1 WNT11 WNT11 SHOX2 SHOX2 I3LA07_PIG I3LA07_PIG BYSL BYSL IFT20 IFT20 NES NES NR2E1 NR2E1 BRCA2 BRCA2 PTCH1 PTCH1 CD109 CD109 KDR KDR TGFB1 TGFB1 CTNNB1 CTNNB1 RARG RARG NFIB NFIB YAP1 YAP1 BABAM1 BABAM1 ERCC2 ERCC2 SART3 SART3 ETV6 ETV6 PRRX1 PRRX1 WNT5A WNT5A IRF6 IRF6 SCRG1 SCRG1 WNT3 WNT3 TRIM71 TRIM71 TP53 TP53 CEP120 CEP120 RNF43 RNF43 ARIH2 ARIH2 IRS2 IRS2 A0A287B8J8_PIG A0A287B8J8_PIG AXIN2 AXIN2 FGF2 FGF2 OVOL1 OVOL1 FGF9 FGF9 XRCC5 XRCC5 TP63 TP63 YTHDF2 YTHDF2 FGF8 FGF8 RUNX2 RUNX2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SOX9Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (511 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
KDF1Keratinocyte differentiation factor 1. (398 aa)
CDKN2CCyclin-dependent kinase 4 inhibitor C. (168 aa)
ELL3Elongation factor for RNA polymerase II 3. (374 aa)
SHBSH2 domain-containing protein. (507 aa)
OSR2Odd-skipped related transciption factor 2. (312 aa)
GBALysosomal acid glucosylceramidase; Glucosylceramidase that catalyzes, within the lysosomal compartment, the hydrolysis of glucosylceramide/GlcCer into free ceramide and glucose. Thereby, plays a central role in the degradation of complex lipids and the turnover of cellular membranes. Through the production of ceramides, participates to the PKC-activated salvage pathway of ceramide formation. Also plays a role in cholesterol metabolism. May either catalyze the glucosylation of cholesterol, through a transglucosylation reaction that transfers glucose from glucosylceramide to cholesterol. [...] (536 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (392 aa)
SIX2SIX homeobox 2. (296 aa)
SFRP2Uncharacterized protein. (294 aa)
LIG4DNA ligase. (910 aa)
TBX3T-box transcription factor TBX3 isoform 2. (745 aa)
HMX2H6 family homeobox 2. (281 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
YJEFN3YjeF N-terminal domain-containing protein. (269 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (440 aa)
HOXA3Homeobox protein Hox-A3 isoform a. (443 aa)
GLI3GLI family zinc finger 3. (1586 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
HOXB4Homeobox B4. (278 aa)
NF1Neurofibromin 1. (2847 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (536 aa)
SHOX2Short stature homeobox 2. (321 aa)
I3LA07_PIGUncharacterized protein. (398 aa)
BYSLUncharacterized protein. (435 aa)
IFT20Intraflagellar transport protein 20 homolog isoform X1. (158 aa)
NESNestin; Belongs to the intermediate filament family. (1699 aa)
NR2E1Nuclear receptor subfamily 2 group E member 1. (385 aa)
BRCA2Tower domain-containing protein. (1163 aa)
PTCH1Protein patched homolog 1 isoform L. (1452 aa)
CD109CD109 antigen isoform 1 preproprotein. (1449 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1360 aa)
TGFB1Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa)
CTNNB1Catenin beta 1. (808 aa)
RARGRetinoic acid receptor gamma. (554 aa)
NFIBNuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (570 aa)
YAP1Yes associated protein 1. (432 aa)
BABAM1BRISC and BRCA1 A complex member 1. (332 aa)
ERCC2General transcription and DNA repair factor IIH helicase subunit XPD isoform 1. (763 aa)
SART3Spliceosome associated factor 3, U4/U6 recycling protein. (972 aa)
ETV6Transcription factor ETV6. (452 aa)
PRRX1Paired mesoderm homeobox protein 1 isoform pmx-1b. (245 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
IRF6Interferon regulatory factor 6. (467 aa)
SCRG1Stimulator of chondrogenesis 1. (98 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (453 aa)
TRIM71E3 ubiquitin-protein ligase TRIM71. (869 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (442 aa)
CEP120Centrosomal protein 120. (992 aa)
RNF43RING-type domain-containing protein. (743 aa)
ARIH2RBR-type E3 ubiquitin transferase. (491 aa)
IRS2Insulin receptor substrate 2. (1092 aa)
A0A287B8J8_PIGUncharacterized protein. (617 aa)
AXIN2Axin-2. (843 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (316 aa)
OVOL1Ovo like transcriptional repressor 1. (313 aa)
FGF9Fibroblast growth factor 9; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. May have a role in glial cell growth and differentiation during development, gliosis during repair and regeneration of brain tissue after damage, differentiation and survival of neuronal cells, and growth stimulation of glial tumors (By similarity). (228 aa)
XRCC5X-ray repair cross complementing 5. (1011 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
YTHDF2YTH N6-methyladenosine RNA binding protein 2. (600 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
RUNX2Runt-related transcription factor 2 isoform a. (625 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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