STRINGSTRING
SMDT1 SMDT1 KCTD17 KCTD17 KCNA1 KCNA1 MCUR1 MCUR1 HCRTR2 HCRTR2 PKHD1 PKHD1 PML PML PSEN1 PSEN1 CALB2 CALB2 APOE APOE BAX BAX HRC HRC GRIK2 GRIK2 TRPM7 TRPM7 SLC24A5 SLC24A5 SLC24A2 SLC24A2 CALB1 CALB1 TRPA1 TRPA1 SV2A SV2A CASQ2 CASQ2 SYPL2 SYPL2 MICU3 MICU3 SLC24A3 SLC24A3 F1RNR1_PIG F1RNR1_PIG UMOD UMOD CNNM4 CNNM4 ATP6V1B1 ATP6V1B1 FKBP1B FKBP1B LETM1 LETM1 SLC30A9 SLC30A9 EDNRA EDNRA TRPC3 TRPC3 MCUB MCUB PKD2 PKD2 GPR12 GPR12 KL KL TNFSF11 TNFSF11 STC1 STC1 SLC8B1 SLC8B1 CDH23 CDH23 MCU MCU PDZD8 PDZD8 ATP2B2 ATP2B2 ATP13A4 ATP13A4 DRD3 DRD3 APP APP TCIRG1 TCIRG1 SLC39A13 SLC39A13 F2 F2 CSRP3 CSRP3 CRSP3 CRSP3 CRSP-2 CRSP-2 PTH PTH F1SA33_PIG F1SA33_PIG HEXB HEXB AP3B1 AP3B1 F1SUY7_PIG F1SUY7_PIG HTR2B HTR2B TRIM24 TRIM24 CAV2 CAV2 SNX10 SNX10 ANKH ANKH STC2 STC2 SGCD SGCD ANXA6 ANXA6 FAM20A FAM20A LOC100739663 LOC100739663 RMDN2 RMDN2 CCDC47 CCDC47 SLC35G1 SLC35G1 CALCB CALCB MT-2B MT-2B CYP27B1 CYP27B1 TMEM178A TMEM178A MT1A MT1A GPER1 GPER1 SLC39A6 SLC39A6 GRM5 GRM5 ATP13A5 ATP13A5 SLC39A14 SLC39A14 SLC39A4 SLC39A4 ATP2B3 ATP2B3 KDR KDR BCAP31 BCAP31 TGFB1 TGFB1 NT5E NT5E HTR2C HTR2C CAV1 CAV1 SLC8A2 SLC8A2 DHRS7C DHRS7C MICU1 MICU1 SLC30A7 SLC30A7 BAK1 BAK1 STIM2 STIM2 CAV3 CAV3 SLC30A4 SLC30A4 CCL8 CCL8 MT1D MT1D HTR2A HTR2A MT3 MT3 PACS2 PACS2 ATP2A3 ATP2A3 GRIA1 GRIA1 STOML2 STOML2 C19orf12 C19orf12 SLC25A23 SLC25A23 PRKCB PRKCB MAIP1 MAIP1 ATP13A3 ATP13A3 TMTC4 TMTC4 HCRTR1 HCRTR1 ATP2A2 ATP2A2 WNT5A WNT5A EDN2 EDN2 ATP2B1 ATP2B1 SLC39A8 SLC39A8 TMEM203 TMEM203 TFAP2B TFAP2B DMPK DMPK NPTN NPTN CALCB-2 CALCB-2 CASR CASR GCM2 GCM2 CHERP CHERP FIS1 FIS1 SLC11A1 SLC11A1 A0A287AEK4_PIG A0A287AEK4_PIG SLC39A12 SLC39A12 SLC30A10 SLC30A10 ATP1B1 ATP1B1 EDN1 EDN1 LCK LCK ATP13A2 ATP13A2 SLC39A5 SLC39A5 SLC30A8 SLC30A8 SLC24A1 SLC24A1 BOK BOK ATP2A1 ATP2A1 GRINA GRINA SLC30A5 SLC30A5 CNNM2 CNNM2 ATP2B4 ATP2B4 SELENOK SELENOK SLC39A10 SLC39A10 TMC8 TMC8 TMEM64 TMEM64 CDH5 CDH5 FATE1 FATE1 GRM1 GRM1 ADCY8 ADCY8 TRPV5 TRPV5 FGF23 FGF23 CIB3 CIB3 MYH7B MYH7B MICU2 MICU2 CLN3 CLN3 CD40 CD40 TMCO1 TMCO1 RMDN3 RMDN3 STIM1 STIM1 WFS1 WFS1 MT4 MT4 VDR VDR HERPUD1 HERPUD1 ATF4 ATF4 SLC30A1 SLC30A1 SLC8A1 SLC8A1 TRPC1 TRPC1 CNNM3 CNNM3 SLC37A4 SLC37A4 ALPL ALPL ATP13A1 ATP13A1 VAPB VAPB A0A5G2QS04_PIG A0A5G2QS04_PIG SLC41A1 SLC41A1 SLC24A4 SLC24A4 SCGN SCGN SLC39A7 SLC39A7 IMMT IMMT TRPV4 TRPV4 TNNI3 TNNI3 ITPR1 ITPR1 TGM2 TGM2 TRPC4 TRPC4 TMTC2 TMTC2 A0A5G2QXZ6_PIG A0A5G2QXZ6_PIG TRPC7 TRPC7 EDN3 EDN3 ATP2C2 ATP2C2 SLC10A7 SLC10A7 A0A5G2QUX5_PIG A0A5G2QUX5_PIG CHRNA7 CHRNA7 TPCN2 TPCN2 KEL KEL BBC3 BBC3 RYR2 RYR2 CNNM1 CNNM1 ATP2C1 ATP2C1 PTH1R PTH1R SELENON SELENON TMEM165 TMEM165 TRPC6 TRPC6
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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SMDT1Single-pass membrane protein with aspartate rich tail 1. (107 aa)
KCTD17Potassium channel tetramerization domain containing 17. (356 aa)
KCNA1Potassium voltage-gated channel subfamily A member 1; Belongs to the potassium channel family. (495 aa)
MCUR1Mitochondrial calcium uniporter regulator 1. (437 aa)
HCRTR2Orexin receptor type 2; Nonselective, high-affinity receptor for both orexin-A and orexin-B neuropeptides. Triggers an increase in cytoplasmic Ca(2+) levels in response to orexin-A binding. (444 aa)
PKHD1PKHD1 ciliary IPT domain containing fibrocystin/polyductin. (4075 aa)
PMLPromyelocytic leukemia. (827 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (463 aa)
CALB2Uncharacterized protein. (348 aa)
APOEApolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] (292 aa)
BAXTrans-1,2-dihydrobenzene-1,2-diol dehydrogenase; Belongs to the Gfo/Idh/MocA family. (480 aa)
HRCSarcoplasmic reticulum histidine-rich calcium-binding protein. (620 aa)
GRIK2Glutamate ionotropic receptor kainate type subunit 2. (908 aa)
TRPM7Transient receptor potential cation channel subfamily M member 7. (1886 aa)
SLC24A5Solute carrier family 24 member 5; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (501 aa)
SLC24A2Sodium/potassium/calcium exchanger 2 isoform X1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (664 aa)
CALB1Calbindin 1. (261 aa)
TRPA1Transient receptor potential cation channel subfamily A member 1; Belongs to the transient receptor (TC 1.A.4) family. (1145 aa)
SV2ASynaptic vesicle glycoprotein 2A isoform 1. (742 aa)
CASQ2Calsequestrin-2; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic residues at the protein surface, especially at the interface between subunits. Can bind around 60 Ca(2+) ions. Regulates the release of lumenal Ca(2+) via the calcium release channel RYR2; this plays an important role in triggering muscle contraction. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats. (405 aa)
SYPL2Synaptophysin like 2. (278 aa)
MICU3Mitochondrial calcium uptake family member 3. (527 aa)
SLC24A3Solute carrier family 24 member 3; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (743 aa)
F1RNR1_PIGG_PROTEIN_RECEP_F3_4 domain-containing protein. (379 aa)
UMODUromodulin. (642 aa)
CNNM4Cyclin and CBS domain divalent metal cation transport mediator 4. (775 aa)
ATP6V1B1Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (395 aa)
FKBP1BPeptidylprolyl isomerase. (108 aa)
LETM1Leucine zipper and EF-hand containing transmembrane protein 1. (791 aa)
SLC30A9Uncharacterized protein. (541 aa)
EDNRAEndothelin-1 receptor; Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3 (By similarity). (427 aa)
TRPC3Transient receptor potential cation channel subfamily C member 3; Belongs to the transient receptor (TC 1.A.4) family. (921 aa)
MCUBCalcium uniporter regulatory subunit MCUb, mitochondrial isoform X1. (335 aa)
PKD2Polycystin 2, transient receptor potential cation channel. (970 aa)
GPR12G protein-coupled receptor 12; Belongs to the G-protein coupled receptor 1 family. (334 aa)
KLKlotho. (1011 aa)
TNFSF11TNF superfamily member 11; Belongs to the tumor necrosis factor family. (319 aa)
STC1Stanniocalcin 1. (247 aa)
SLC8B1Solute carrier family 8 member B1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (604 aa)
CDH23Cadherin related 23. (3354 aa)
MCUCalcium uniporter protein, mitochondrial isoform 1. (351 aa)
PDZD8PDZ domain-containing protein 8. (1154 aa)
ATP2B2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1235 aa)
ATP13A4Uncharacterized protein. (212 aa)
DRD3Dopamine receptor D3; Belongs to the G-protein coupled receptor 1 family. (447 aa)
APPGamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] (756 aa)
TCIRG1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (862 aa)
SLC39A13Zinc transporter SLC39A7; Zinc transporter, that transports Zn(2+) from the endoplasmic reticulum/Golgi apparatus to the cytosol; Belongs to the ZIP transporter (TC 2.A.5) family. KE4/Catsup subfamily. (372 aa)
F2Activation peptide fragment 1; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity). (623 aa)
CSRP3Uncharacterized protein. (200 aa)
CRSP3Calcitonin receptor-stimulating peptide 3; Belongs to the calcitonin family. (125 aa)
CRSP-2Calcitonin receptor-stimulating peptide 2; Belongs to the calcitonin family. (117 aa)
PTHParathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D- glucose (2DG) transport and glycogen synthesis in osteoblastic cells (By similarity). (115 aa)
F1SA33_PIGG_PROTEIN_RECEP_F3_4 domain-containing protein. (349 aa)
HEXBBeta-hexosaminidase subunit beta; Responsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines, in the brain and other tissues. (538 aa)
AP3B1AP-3 complex subunit beta; Belongs to the adaptor complexes large subunit family. (1130 aa)
F1SUY7_PIGUncharacterized protein; Belongs to the transient receptor (TC 1.A.4) family. (888 aa)
HTR2B5-hydroxytryptamine receptor 2B; G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various ergot alkaloid derivatives and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide- binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity [...] (481 aa)
TRIM24Transcription intermediary factor 1-alpha isoform X1. (1050 aa)
CAV2Caveolin-2; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression (By similarity); Belongs to the caveolin family. (162 aa)
SNX10Sorting nexin-10 isoform 1. (200 aa)
ANKHANKH inorganic pyrophosphate transport regulator. (494 aa)
STC2Stanniocalcin-2. (301 aa)
SGCDSarcoglycan delta. (290 aa)
ANXA6Annexin. (672 aa)
FAM20AFAM20A golgi associated secretory pathway pseudokinase. (541 aa)
LOC100739663Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (61 aa)
RMDN2Regulator of microtubule dynamics 2. (569 aa)
CCDC47Coiled-coil domain-containing protein 47. (483 aa)
SLC35G1Solute carrier family 35 member G1 isoform 1. (366 aa)
CALCBCalcitonin; Causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones; Belongs to the calcitonin family. (141 aa)
MT-2BMetallothionein-2A; Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids. (61 aa)
CYP27B1Cytochrome P450 family 27 subfamily B member 1; Belongs to the cytochrome P450 family. (500 aa)
TMEM178ATransmembrane protein 178A. (297 aa)
MT1AMetallothionein-1A; Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids. (113 aa)
GPER1G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (360 aa)
SLC39A6Solute carrier family 39 member 6. (811 aa)
GRM5Glutamate metabotropic receptor 5. (1212 aa)
ATP13A5Cation-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. (1219 aa)
SLC39A14Solute carrier family 39 member 14. (531 aa)
SLC39A4Solute carrier family 39 member 4. (816 aa)
ATP2B3Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1193 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1360 aa)
BCAP31B-cell receptor-associated protein 31 isoform b. (246 aa)
TGFB1Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa)
NT5E5'-nucleotidase ecto; Belongs to the 5'-nucleotidase family. (574 aa)
HTR2C5-hydroxytryptamine receptor 2C. (457 aa)
CAV1Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (177 aa)
SLC8A2Solute carrier family 8 member A2; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (1002 aa)
DHRS7CDehydrogenase/reductase 7C; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (308 aa)
MICU1Mitochondrial calcium uptake 1. (509 aa)
SLC30A7Solute carrier family 30 member 7. (376 aa)
BAK1Uncharacterized protein. (266 aa)
STIM2Stromal interaction molecule 2. (483 aa)
CAV3Caveolin-3; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. May also regulate voltage-gated potassium channels. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress. Mediates the recruitment of CAVIN2 and CAVIN3 proteins to the caveolae. (151 aa)
SLC30A4Solute carrier family 30 member 4. (429 aa)
CCL8C-C motif chemokine 8; Chemotactic factor that attracts monocytes. This protein can bind heparin. (99 aa)
MT1DMetallothionein-1C; Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids. (61 aa)
HTR2A5-hydroxytryptamine receptor 2A; G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5- dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. S [...] (470 aa)
MT3Metallothionein-3; Binds heavy metals. Contains three zinc and three copper atoms per polypeptide chain and only a negligible amount of cadmium. Inhibits survival and neurite formation of cortical neurons in vitro (By similarity); Belongs to the metallothionein superfamily. Type 1 family. (95 aa)
PACS2Phosphofurin acidic cluster sorting protein 2 isoform X1. (889 aa)
ATP2A3Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1020 aa)
GRIA1Glutamate ionotropic receptor AMPA type subunit 1. (906 aa)
STOML2Stomatin like 2. (356 aa)
C19orf12Chromosome 19 open reading frame 12. (108 aa)
SLC25A23Solute carrier family 25 member 23; Belongs to the mitochondrial carrier (TC 2.A.29) family. (524 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
MAIP1Matrix AAA peptidase interacting protein 1. (288 aa)
ATP13A3Cation-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. (1312 aa)
TMTC4Transmembrane O-mannosyltransferase targeting cadherins 4. (762 aa)
HCRTR1Orexin receptor type 1; Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide. Triggers an increase in cytoplasmic Ca(2+) levels in response to orexin-A binding. (425 aa)
ATP2A2Sarcoplasmic/endoplasmic reticulum calcium ATPase 2; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Isoform SERCA2A is involved in the regulation of the contraction/relaxation cycle. Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathways via its interaction with TMEM64 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation. Association between TMEM64 and SERCA2 in the ER leads to cytos [...] (1042 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
EDN2Endothelin 2. (180 aa)
ATP2B1Plasma membrane calcium-transporting ATPase 1; Catalyzes the hydrolysis of ATP coupled with the transport of calcium from the cytoplasm to the extracellular space thereby maintaining intracellular calcium homeostasis. Plays a role in blood pressure regulation through regulation of intracellular calcium concentration and nitric oxide production leading to regulation of vascular smooth muscle cells vasoconstriction. Positively regulates bone mineralization through absorption of calcium from the intestine. Plays dual roles in osteoclast differentiation and survival by regulating RANKL-ind [...] (1249 aa)
SLC39A8Solute carrier family 39 member 8. (461 aa)
TMEM203Transmembrane protein 203. (136 aa)
TFAP2BTranscription factor AP-2 beta. (469 aa)
DMPKDM1 protein kinase. (590 aa)
NPTNNeuroplastin. (412 aa)
CALCB-2Calcitonin receptor-stimulating peptide 1; Stimulates cAMP production in porcine kidney cell line LLC- PK1 via the calcitonin receptor (CT) but not via the CT-like (CL) receptor. (259 aa)
CASRExtracellular calcium-sensing receptor; G-protein-coupled receptor that senses changes in the extracellular concentration of calcium ions and plays a key role in maintaining calcium homeostasis. Senses fluctuations in the circulating calcium concentration and modulates the production of parathyroid hormone (PTH) in parathyroid glands (By similarity). The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. The G-protein- coupled receptor activity is activated by a co-agonist mechanism: aromatic amino acids, such as [...] (1089 aa)
GCM2Glial cells missing transcription factor 2. (503 aa)
CHERPCalcium homeostasis endoplasmic reticulum protein. (916 aa)
FIS1Mitochondrial fission 1 protein; Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. (152 aa)
SLC11A1Natural resistance-associated macrophage protein 1; Divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Macrophage-specific membrane transport function. Controls natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe(2+) and Mn(2+), cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis [...] (538 aa)
A0A287AEK4_PIGUncharacterized protein. (85 aa)
SLC39A12Solute carrier family 39 member 12. (728 aa)
SLC30A10Uncharacterized protein. (260 aa)
ATP1B1Sodium/potassium-transporting ATPase subunit beta-1; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. (325 aa)
EDN1Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides. Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. (203 aa)
LCKTyrosine-protein kinase. (520 aa)
ATP13A2Cation-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. (1131 aa)
SLC39A5Solute carrier family 39 member 5. (554 aa)
SLC30A8Solute carrier family 30 member 8. (369 aa)
SLC24A1Solute carrier family 24 member 1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (1088 aa)
BOKBCL2 family apoptosis regulator BOK. (288 aa)
ATP2A1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1021 aa)
GRINAGlutamate ionotropic receptor NMDA type subunit associated protein 1. (356 aa)
SLC30A5Uncharacterized protein. (793 aa)
CNNM2Cyclin and CBS domain divalent metal cation transport mediator 2. (875 aa)
ATP2B4Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1171 aa)
SELENOKSelenoprotein K; Required for Ca(2+) flux in immune cells and plays a role in T-cell proliferation and in T-cell and neutrophil migration (By similarity). Involved in endoplasmic reticulum-associated degradation (ERAD) of soluble glycosylated proteins (By similarity). Required for palmitoylation and cell surface expression of CD36 and involved in macrophage uptake of low-density lipoprotein and in foam cell formation (By similarity). Together with ZDHHC6, required for palmitoylation of ITPR1 in immune cells, leading to regulate ITPR1 stability and function. Plays a role in protection o [...] (93 aa)
SLC39A10Solute carrier family 39 member 10. (837 aa)
TMC8Transmembrane channel-like protein. (699 aa)
TMEM64Transmembrane protein 64. (387 aa)
CDH5Cadherin-5; Cadherins are calcium-dependent cell adhesion proteins (By similarity). They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types (By similarity). This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions (By similarity). It associates with alpha-catenin forming a link to the cytoskeleton (By similarity). Acts in concert with KRIT1 and MPP5 to establish and maintain correct endotheli [...] (782 aa)
FATE1Fetal and adult testis-expressed transcript protein homolog; Involved in the regulation of endoplasmic reticulum (ER)- mitochondria coupling. Negatively regulates the ER-mitochondria distance and Ca(2+) transfer from ER to mitochondria possibly implicating it in the regulation of apoptosis. May collaborate with RNF183 to restrain BIK protein levels thus regulating apoptotic signaling. (171 aa)
GRM1Glutamate metabotropic receptor 1. (1195 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1250 aa)
TRPV5Transient receptor potential cation channel subfamily V member 5; Belongs to the transient receptor (TC 1.A.4) family. (792 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (243 aa)
CIB3Calcium and integrin binding family member 3. (206 aa)
MYH7BMyosin heavy chain 7B; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1748 aa)
MICU2Calcium uptake protein 2, mitochondrial isoform X1. (430 aa)
CLN3Battenin. (414 aa)
CD40Tumor necrosis factor receptor superfamily member 5; Receptor for TNFSF5/CD40LG (By similarity). Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion (By similarity). (278 aa)
TMCO1Calcium load-activated calcium channel; Calcium-selective channel required to prevent calcium stores from overfilling, thereby playing a key role in calcium homeostasis. In response to endoplasmic reticulum overloading, assembles into a homotetramer, forming a functional calcium-selective channel, regulating the calcium content in endoplasmic reticulum store. Belongs to the TMCO1 family. (246 aa)
RMDN3Regulator of microtubule dynamics 3. (470 aa)
STIM1Stromal interaction molecule 1. (791 aa)
WFS1Wolframin ER transmembrane glycoprotein. (889 aa)
MT4Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (62 aa)
VDRVitamin D3 receptor; Nuclear receptor for calcitriol, the active form of vitamin D3 which mediates the action of this vitamin on cells (By similarity). Enters the nucleus upon vitamin D3 binding where it forms heterodimers with the retinoid X receptor/RXR (By similarity). The VDR-RXR heterodimers bind to specific response elements on DNA and activate the transcription of vitamin D3-responsive target genes (By similarity). Plays a central role in calcium homeostasis (By similarity). (520 aa)
HERPUD1Homocysteine inducible ER protein with ubiquitin like domain 1. (389 aa)
ATF4Activating transcription factor 4. (329 aa)
SLC30A1Solute carrier family 30 member 1. (506 aa)
SLC8A1Solute carrier family 8 member A1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (972 aa)
TRPC1Transient receptor potential cation channel subfamily C member 1; Belongs to the transient receptor (TC 1.A.4) family. (794 aa)
CNNM3Cyclin and CBS domain divalent metal cation transport mediator 3. (863 aa)
SLC37A4Solute carrier family 37 member 4. (451 aa)
ALPLAlkaline phosphatase. (834 aa)
ATP13A1Cation-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. (1252 aa)
VAPBVesicle-associated membrane protein-associated protein B; Participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity. Involved in cellular calcium homeostasis regulation. (309 aa)
A0A5G2QS04_PIGXRCC1_N domain-containing protein. (137 aa)
SLC41A1Solute carrier family 41 member 1 isoform X1. (514 aa)
SLC24A4Solute carrier family 24 member 4; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (637 aa)
SCGNSecretagogin. (278 aa)
SLC39A7Zinc transporter SLC39A7. (472 aa)
IMMTMICOS complex subunit MIC60; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. (753 aa)
TRPV4Transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (924 aa)
TNNI3Troponin I3, cardiac type. (273 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (2759 aa)
TGM2Transglutaminase 2. (696 aa)
TRPC4Transient receptor potential cation channel subfamily C member 4; Belongs to the transient receptor (TC 1.A.4) family. (982 aa)
TMTC2Transmembrane O-mannosyltransferase targeting cadherins 2. (827 aa)
A0A5G2QXZ6_PIGProtein kinase domain-containing protein. (408 aa)
TRPC7Uncharacterized protein; Belongs to the transient receptor (TC 1.A.4) family. (862 aa)
EDN3Endothelin-3; Endothelins are endothelium-derived vasoconstrictor peptides. Belongs to the endothelin/sarafotoxin family. (231 aa)
ATP2C2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (947 aa)
SLC10A7Sodium/bile acid cotransporter; Does not show transport activity towards bile acids or steroid sulfates; Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family. (359 aa)
A0A5G2QUX5_PIGUncharacterized protein. (201 aa)
CHRNA7Uncharacterized protein. (585 aa)
TPCN2Uncharacterized protein. (765 aa)
KELKell metallo-endopeptidase (Kell blood group). (763 aa)
BBC3Uncharacterized protein. (361 aa)
RYR2Ryanodine receptor 2. (4966 aa)
CNNM1Cyclin and CBS domain divalent metal cation transport mediator 1. (973 aa)
ATP2C1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (949 aa)
PTH1RParathyroid hormone/parathyroid hormone-related peptide receptor; Receptor for parathyroid hormone and for parathyroid hormone- related peptide. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system. Belongs to the G-protein coupled receptor 2 family. (641 aa)
SELENONSelenoprotein N. (556 aa)
TMEM165GDT1 family protein. (350 aa)
TRPC6Transient receptor potential cation channel subfamily C member 6; Belongs to the transient receptor (TC 1.A.4) family. (939 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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