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| | WNT10B | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa) |
| | RACGAP1 | Rac GTPase activating protein 1. (634 aa) |
| | NCAPH2 | Uncharacterized protein. (610 aa) |
| | XRCC3 | DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (357 aa) |
| | CDC20 | Cell division cycle protein 20 homolog; Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may confer substrate specificity upon the complex. Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentia [...] (499 aa) |
| | FBXO5 | F-box protein 5. (462 aa) |
| | OOEP | Oocyte-expressed protein homolog. (148 aa) |
| | INO80 | INO80 complex ATPase subunit. (1566 aa) |
| | ANXA1 | Annexin A1; Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity. Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response. Promotes resolution of inflammation and wound healing (By similarity). Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (By similarity). Contribut [...] (346 aa) |
| | SMC2 | Structural maintenance of chromosomes protein. (1191 aa) |
| | MTBP | MDM2 binding protein. (919 aa) |
| | RAD21 | Double-strand-break repair protein rad21 homolog. (631 aa) |
| | CSPP1 | Centrosome and spindle pole associated protein 1. (1240 aa) |
| | CDC14A | Cell division cycle 14A. (626 aa) |
| | NSFL1C | NSFL1 cofactor. (370 aa) |
| | UBE2C | Ubiquitin conjugating enzyme E2 C; Belongs to the ubiquitin-conjugating enzyme family. (179 aa) |
| | PPP1R35 | Protein phosphatase 1 regulatory subunit 35. (268 aa) |
| | SH2B1 | SH2B adaptor protein 1. (757 aa) |
| | IL1B2 | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (267 aa) |
| | LOC110258578 | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (267 aa) |
| | IL1A | Interleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. (270 aa) |
| | FAM178B | Uncharacterized protein. (569 aa) |
| | TGFA | Protransforming growth factor alpha; TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar. (160 aa) |
| | PRKCE | Protein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa) |
| | MSX1 | Homeobox domain-containing protein. (303 aa) |
| | NCAPG | Non-SMC condensin I complex subunit G. (1034 aa) |
| | RB1 | RB transcriptional corepressor 1. (938 aa) |
| | PCID2 | PCI domain-containing protein 2 isoform X1. (399 aa) |
| | PBK | Lymphokine-activated killer T-cell-originated protein kinase isoform X1. (322 aa) |
| | ANAPC5 | Anaphase-promoting complex subunit 5 isoform X1. (755 aa) |
| | RANBP1 | RAN binding protein 1. (206 aa) |
| | CDC73 | Cell division cycle 73. (531 aa) |
| | DRD3 | Dopamine receptor D3; Belongs to the G-protein coupled receptor 1 family. (447 aa) |
| | APP | Gamma-secretase C-terminal fragment 50; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] (756 aa) |
| | DDX3X | ATP-dependent RNA helicase DDX3X isoform 1; Belongs to the DEAD box helicase family. (662 aa) |
| | ATRX | ATRX chromatin remodeler. (2486 aa) |
| | CUL4B | Cullin 4B; Belongs to the cullin family. (1056 aa) |
| | LRP5 | Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1614 aa) |
| | INSR | Tyrosine-protein kinase receptor. (1382 aa) |
| | SLF1 | SMC5-SMC6 complex localization factor 1. (1055 aa) |
| | NEUROG1 | Neurogenin 1. (246 aa) |
| | CDC23 | Cell division cycle protein 23 homolog. (594 aa) |
| | CDC25C | M-phase inducer phosphatase 3; Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle. Directly dephosphorylates CDK1 and activates its kinase activity. When phosphorylated, highly effective in activating G2 cells into prophase (By similarity). (501 aa) |
| | CXCR5 | C-X-C chemokine receptor type 5 isoform 1; Belongs to the G-protein coupled receptor 1 family. (373 aa) |
| | DTL | Denticleless E3 ubiquitin protein ligase homolog. (729 aa) |
| | STRA8 | Stimulated by retinoic acid 8. (365 aa) |
| | FGF10 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa) |
| | SPHK1 | Sphingosine kinase 1 isoform 2. (481 aa) |
| | BECN1 | Beclin-1-C 35 kDa; Plays a central role in autophagy. Acts as core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3- phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2. Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex f [...] (461 aa) |
| | CDC6 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (560 aa) |
| | MED1 | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1517 aa) |
| | SPAG5 | Uncharacterized protein. (1193 aa) |
| | CENPV | Centromere protein V. (259 aa) |
| | MEPCE | Methylphosphate capping enzyme. (744 aa) |
| | FEN1 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa) |
| | NUP62CL | Nucleoporin 62 C-terminal like. (183 aa) |
| | ANAPC7 | Anaphase promoting complex subunit 7. (597 aa) |
| | RPTOR | Regulatory associated protein of MTOR complex 1. (1351 aa) |
| | TBX2 | T-box 2 protein. (714 aa) |
| | GPSM2 | G-protein-signaling modulator 2 isoform X1. (680 aa) |
| | PIWIL2 | Piwi like RNA-mediated gene silencing 2; Belongs to the argonaute family. (985 aa) |
| | CDK4 | Cyclin-dependent kinase 4; Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. [...] (303 aa) |
| | CDCA5 | Cell division cycle associated 5. (301 aa) |
| | KMT2E | Myeloid/lymphoid or mixed-lineage leukemia 5. (1859 aa) |
| | RAD51C | RAD51 paralog C. (371 aa) |
| | CENPJ | Centromere protein J. (1353 aa) |
| | PHB2 | Prohibitin. (299 aa) |
| | HOXA13 | Homeobox A13. (388 aa) |
| | KAT2B | Histone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (831 aa) |
| | MTA3 | Metastasis associated 1 family member 3. (593 aa) |
| | NRM | Nurim. (203 aa) |
| | FBXO42 | F-box only protein 42. (717 aa) |
| | I3LV77_PIG | Uncharacterized protein. (135 aa) |
| | EGF | Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6 (By similarity). (1194 aa) |
| | UBE2E2 | Ubiquitin conjugating enzyme E2 E2; Belongs to the ubiquitin-conjugating enzyme family. (201 aa) |
| | CDC42 | Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...] (197 aa) |
| | PPP1R10 | Serine/threonine-protein phosphatase 1 regulatory subunit 10; Scaffold protein which mediates the formation of the PTW/PP1 phosphatase complex by providing a binding platform to each component of the complex. The PTW/PP1 phosphatase complex plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Mediates interaction of WDR82 and PPP1CA. Inhibitor of PPP1CA and PPP1CC phosphatase activities. Has inhibitory activity on PPP1CA only when phosphorylated. Binds to mRNA, single-stranded DNA (ssDNA), poly(A) and poly(G) [...] (925 aa) |
| | DDX39B | Spliceosome RNA helicase DDX39B; Involved in nuclear export of spliced and unspliced mRNA. Assembling component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pat [...] (467 aa) |
| | MAD2L1 | Mitotic arrest deficient 2 like 1. (205 aa) |
| | TPR | Translocated promoter region, nuclear basket protein. (2518 aa) |
| | ECT2 | Epithelial cell transforming 2. (1028 aa) |
| | PKN2 | Serine/threonine-protein kinase N2 isoform 1. (983 aa) |
| | LOC110258125 | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (268 aa) |
| | RAD51AP1 | RAD51 associated protein 1. (345 aa) |
| | SASS6 | Spindle assembly abnormal protein 6 homolog isoform X1. (741 aa) |
| | TFDP1 | Transcription factor. (415 aa) |
| | CEP295 | Centrosomal protein 295. (2552 aa) |
| | SMC4 | Structural maintenance of chromosomes protein. (1250 aa) |
| | CDC14B | Uncharacterized protein. (542 aa) |
| | KLHL18 | Kelch like family member 18. (619 aa) |
| | HNRNPU | Heterogeneous nuclear ribonucleoprotein U isoform a. (825 aa) |
| | RAB11A | Ras-related protein Rab-11A; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. The small Rab GTPase RAB11A regulates endocytic recycling. Acts as a major regulator of membrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial c [...] (216 aa) |
| | ZNF16 | Zinc finger protein 16. (576 aa) |
| | AURKA | Aurora kinase A; Mitotic serine/threonine kinase that contributes to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. Required for normal spindle positioning during mitosis and for the localization of NUMA1 and DCTN1 to the cell cortex during metaphase. Required for initial activation [...] (408 aa) |
| | AIF1 | Allograft inflammatory factor 1; Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage activation and function. Promotes the proliferation of vascular smooth muscle cells and of T-lymphocytes. Enhances lymphocyte migration. Plays a role in vascular inflammation (By similarity). Has a dual influence on glucose-induced insulin secretion: inhibition at low concentration and stimulation at high concentrations. (147 aa) |
| | STOX1 | Storkhead box 1. (987 aa) |
| | BTC | EGF-like domain-containing protein. (342 aa) |
| | WNT5A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa) |
| | ZNF112 | Uncharacterized protein. (807 aa) |
| | CUL3 | Cullin 3; Belongs to the cullin family. (773 aa) |
| | DBF4 | DBF4-type domain-containing protein. (675 aa) |
| | LSM11 | LSM11, U7 small nuclear RNA associated. (357 aa) |
| | GIPC3 | GIPC PDZ domain containing family member 3. (314 aa) |
| | MAD1L1 | Mitotic arrest deficient 1 like 1. (737 aa) |
| | SFPQ | Splicing factor, proline-and glutamine-rich isoform X1. (702 aa) |
| | LOC110258582 | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (245 aa) |
| | STIL | STIL centriolar assembly protein. (1288 aa) |
| | RRM1 | Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (790 aa) |
| | DBF4B | DBF4 zinc finger B. (640 aa) |
| | SIN3A | SIN3 transcription regulator family member A. (1274 aa) |
| | PDGFB | Platelet-derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (240 aa) |
| | BIRC5 | Baculoviral IAP repeat-containing protein 5; Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis (By similarity). Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis (By similarity). Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with p [...] (142 aa) |
| | PRKAR2A | cAMP-dependent protein kinase type II-alpha regulatory subunit; Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase. (389 aa) |
| | GEN1 | GEN1 Holliday junction 5' flap endonuclease. (906 aa) |
| | IL1B-2 | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (244 aa) |
| | TAS1R2 | Taste 1 receptor member 2. (836 aa) |
| | EDN1 | Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides. Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. (203 aa) |
| | PKP4 | Plakophilin 4. (1234 aa) |
| | DYNC1LI1 | Dynein light intermediate chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. (524 aa) |
| | RRM2 | Uncharacterized protein. (439 aa) |
| | LOC102159347 | CULLIN_2 domain-containing protein; Belongs to the cullin family. (647 aa) |
| | CDK1 | Cyclin-dependent kinase 1 isoform 1; Belongs to the protein kinase superfamily. (297 aa) |
| | LOC110258579 | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (272 aa) |
| | INS | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (108 aa) |
| | CRNN | Cornulin. (659 aa) |
| | UBE2B | Ubiquitin-conjugating enzyme E2 B; Belongs to the ubiquitin-conjugating enzyme family. (152 aa) |
| | RCC2 | Regulator of chromosome condensation 2. (554 aa) |
| | RHOA | Transforming protein RhoA isoform 1. (193 aa) |
| | MAD2L1BP | MAD2L1 binding protein. (274 aa) |
| | PRDM7 | PR/SET domain 7. (466 aa) |
| | NUDT16 | Nudix hydrolase 16. (211 aa) |
| | THOC5 | THO complex subunit 5 homolog isoform X1. (694 aa) |
| | NPM2 | Nucleoplasmin domain-containing protein. (260 aa) |
| | EZH2 | Enhancer of zeste 2 polycomb repressive complex 2 subunit. (762 aa) |
| | SMPD3 | Sphingomyelin phosphodiesterase 3. (656 aa) |
| | UBXN2B | UBX domain protein 2B. (369 aa) |
| | NUP62 | Nucleoporin 62. (478 aa) |
| | DRD2 | Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family. (455 aa) |
| | CDC25B | M-phase inducer phosphatase 2 isoform 1. (631 aa) |
| | CDC25A | M-phase inducer phosphatase 1 isoform a. (524 aa) |
| | LSM10 | LSM10, U7 small nuclear RNA associated. (121 aa) |
| | CEP120 | Centrosomal protein 120. (992 aa) |
| | LOC110255300 | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (267 aa) |
| | KIF14 | Kinesin family member 14; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1532 aa) |
| | A0A287B846_PIG | DBF4-type domain-containing protein. (317 aa) |
| | NUSAP1 | Uncharacterized protein. (439 aa) |
| | EIF4G1 | Eukaryotic translation initiation factor 4 gamma 1. (1613 aa) |
| | CDT1 | PI-PLC Y-box domain-containing protein. (815 aa) |
| | RHNO1 | RAD9-HUS1-RAD1 interacting nuclear orphan 1. (240 aa) |
| | DYNC1H1 | Dynein cytoplasmic 1 heavy chain 1. (4645 aa) |
| | VPS4B | Vacuolar protein sorting-associated protein 4B; Belongs to the AAA ATPase family. (444 aa) |
| | CCND2 | G1/S-specific cyclin-D2; Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. A [...] (288 aa) |
| | PLK4 | Polo like kinase 4. (964 aa) |
| | ATAD5 | ATPase family AAA domain containing 5. (1891 aa) |
| | SMC5 | AAA_23 domain-containing protein. (1106 aa) |
| | SLF2 | SMC5-SMC6 complex localization factor 2. (1169 aa) |
| | RRM2B | Ribonucleotide reductase regulatory TP53 inducible subunit M2B. (385 aa) |
| | CDC27 | Cell division cycle 27. (825 aa) |
| | HYAL1 | Hyaluronidase-1; May have a role in promoting tumor progression. May block the TGFB1-enhanced cell growth (By similarity); Belongs to the glycosyl hydrolase 56 family. (650 aa) |
| | DYRK3 | Dual specificity tyrosine phosphorylation regulated kinase 3. (545 aa) |
| | GLI1 | Zinc finger protein GLI1 isoform X1. (1106 aa) |
| | ANKRD17 | Ankyrin repeat domain 17. (2499 aa) |
| | NUMA1 | Nuclear mitotic apparatus protein 1. (2134 aa) |
| | DDX39A | DExD-box helicase 39A. (452 aa) |
| | BHMG1 | Basic helix-loop-helix and HMG-box containing 1. (550 aa) |
| | GIPC2 | PDZ domain-containing protein GIPC2 isoform 1. (313 aa) |
| | LOC110259156 | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (267 aa) |
| | E2F8 | E2F transcription factor 8. (859 aa) |
| | CCND1 | Cyclin D1; Belongs to the cyclin family. (295 aa) |
| | SVIL | Supervillin. (2229 aa) |
| | CPSF3 | Cleavage and polyadenylation specificity factor subunit 3 isoform X1. (684 aa) |
| | ROCK2 | Rho-associated protein kinase 2; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of ADD1, BRCA2, CNN1, EZR, DPYSL2, EP300, MSN, MYL9/MLC2, NPM1, RDX, PPP1R12A and VIM. Phosphorylates SORL1 and IRF4. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Positively regulates the activation of p42/MAPK1- p44/MAPK3 and of p90RSK/RPS6K [...] (1397 aa) |
| | CCND3 | Cyclin D3; Belongs to the cyclin family. (331 aa) |
| | NCAPG2 | Non-SMC condensin II complex subunit G2. (1164 aa) |
| | AURKB | Aurora kinase B; Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Involved in the bipolar attachment of spindle microtubules to kinetochores and is a key regulator for the onset of cytokinesis during mitosis. Required for central/midzone spindle assembly and cleavage furrow formation. Key component of [...] (443 aa) |
| | MECP2 | Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (489 aa) |
| | FAM83D | Family with sequence similarity 83 member D. (583 aa) |
| | NSMCE2 | NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase. (275 aa) |
| | SIRT2 | NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (392 aa) |
| | MACROH2A1 | Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (372 aa) |
| | PAF1 | PAF1 homolog, Paf1/RNA polymerase II complex component. (560 aa) |
| | MBLAC1 | Metallo-beta-lactamase domain containing 1. (271 aa) |
| | MAP3K20 | Mitogen-activated protein kinase kinase kinase 20. (799 aa) |
| | ANAPC11 | RING-type domain-containing protein. (411 aa) |
| | E2F7 | E2F transcription factor 7. (908 aa) |
| | KAT5 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (576 aa) |
| | PRAP1 | Uncharacterized protein. (151 aa) |
| | ANKHD1 | ANK_REP_REGION domain-containing protein. (2652 aa) |
| | FGF8 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa) |
| | MAPK15 | Mitogen-activated protein kinase. (578 aa) |
| | NDC80 | NDC80 kinetochore complex component. (677 aa) |
| | DMRT1 | Doublesex- and mab-3-related transcription factor 1; Transcription factor that plays a key role in male sex determination and differentiation by controlling testis development and male germ cell proliferation. Plays a central role in spermatogonia by inhibiting meiosis in undifferentiated spermatogonia and promoting mitosis, leading to spermatogonial development and allowing abundant and continuous production of sperm. Acts both as a transcription repressor and activator: prevents meiosis by restricting retinoic acid (RA)-dependent transcription and repressing STRA8 expression and prom [...] (375 aa) |
| | CUL4A | Cullin 4A; Belongs to the cullin family. (712 aa) |
| | EREG | Epiregulin. (168 aa) |
| | THOC1 | THO complex 1. (702 aa) |
| | EGFR | Receptor protein-tyrosine kinase. (1205 aa) |
| | CDC7 | Cell division cycle 7-related protein kinase isoform X1. (576 aa) |
| | TMOD3 | Uncharacterized protein. (386 aa) |
| | ADAMTS1 | Peptidase M12B domain-containing protein. (963 aa) |
| | CDC16 | TPR_REGION domain-containing protein. (680 aa) |
| | CD28 | IGv domain-containing protein. (222 aa) |
| | CIT | Citron Rho-interacting kinase; Plays a role in cytokinesis. Displays serine/threonine protein kinase activity; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (2104 aa) |
| | RAD51B | RAD51 paralog B. (365 aa) |
| | STXBP4 | Syntaxin-binding protein 4 isoform X3. (573 aa) |
| | GIPC1 | GIPC PDZ domain containing family member 1. (405 aa) |
