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| | MESP1 | Mesoderm posterior bHLH transcription factor 1. (256 aa) |
| | CCDC88C | Coiled-coil domain containing 88C. (1906 aa) |
| | GSK3A | Protein kinase domain-containing protein. (566 aa) |
| | APOE | Apolipoprotein E; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density [...] (292 aa) |
| | RUVBL2 | RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (525 aa) |
| | FUZ | Fuzzy planar cell polarity protein. (418 aa) |
| | DRAXIN | Draxin; Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway. (416 aa) |
| | FOXO3 | Forkhead box protein O3 isoform X1. (672 aa) |
| | TLE3 | TLE family member 3, transcriptional corepressor. (808 aa) |
| | INVS | Inversin. (1076 aa) |
| | DAB2IP | DAB2 interacting protein. (1196 aa) |
| | RAPGEF1 | Rap guanine nucleotide exchange factor 1. (1093 aa) |
| | CTHRC1 | Collagen triple helix repeat containing 1. (244 aa) |
| | FZD6 | Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (711 aa) |
| | SOX17 | SRY-box transcription factor 17. (407 aa) |
| | DKK4 | Dickkopf WNT signaling pathway inhibitor 4. (223 aa) |
| | FERMT1 | Fermitin family member 1. (676 aa) |
| | SFRP2 | Uncharacterized protein. (294 aa) |
| | TMEM131L | Transmembrane 131 like. (1682 aa) |
| | KREMEN1 | Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. (464 aa) |
| | DKK1 | Dickkopf_N domain-containing protein. (357 aa) |
| | SFRP5 | Uncharacterized protein. (315 aa) |
| | TCF7L2 | Transcription factor 7 like 2. (669 aa) |
| | RBMS3 | RNA binding motif single stranded interacting protein 3. (458 aa) |
| | LIMD1 | LIM domain-containing protein 1. (671 aa) |
| | WWTR1 | WW domain containing transcription regulator 1. (398 aa) |
| | CTNND1 | Catenin delta 1. (940 aa) |
| | STK11 | Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (438 aa) |
| | EGR1 | Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (542 aa) |
| | SHH | Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (440 aa) |
| | GLI3 | GLI family zinc finger 3. (1586 aa) |
| | ISL1 | Insulin gene enhancer protein ISL-1. (349 aa) |
| | SOX9 | Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (511 aa) |
| | WNT11 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (536 aa) |
| | I3L6Y1_PIG | WD_REPEATS_REGION domain-containing protein. (391 aa) |
| | OTUD5 | OTU deubiquitinase 5. (571 aa) |
| | AMER2 | APC membrane recruitment protein 2. (533 aa) |
| | HDAC1 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (491 aa) |
| | PTPRO | Protein tyrosine phosphatase receptor type O. (1186 aa) |
| | NPHP4 | Nephrocystin 4. (1466 aa) |
| | MAD2L2 | Mitotic spindle assembly checkpoint protein MAD2B. (211 aa) |
| | LZTS2 | Leucine zipper putative tumor suppressor 2; Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta- catenin. (667 aa) |
| | SFRP1 | Secreted frizzled-related protein 1. (308 aa) |
| | AMER1 | APC membrane recruitment protein 1. (1108 aa) |
| | GPC3 | Glypican-3 isoform 2; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (579 aa) |
| | CAV1 | Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (177 aa) |
| | CTNNB1 | Catenin beta 1. (808 aa) |
| | TLE4 | TLE family member 4, transcriptional corepressor. (774 aa) |
| | TMEM88 | Transmembrane protein 88. (168 aa) |
| | G3BP1 | G3BP stress granule assembly factor 1. (495 aa) |
| | NOTUM | Notum, palmitoleoyl-protein carboxylesterase. (570 aa) |
| | DKKL1 | Dickkopf-like protein 1 isoform X2. (233 aa) |
| | JADE1 | Jade family PHD finger 1. (857 aa) |
| | LMBR1L | Limb development membrane protein 1 like; Belongs to the LIMR family. (524 aa) |
| | SOX10 | Transcription factor SOX-10; Transcription factor that plays a central role in developing and mature glia. Specifically activates expression of myelin genes, during oligodendrocyte (OL) maturation, such as DUSP15 and MYRF, thereby playing a central role in oligodendrocyte maturation and CNS myelination. Once induced, MYRF cooperates with SOX10 to implement the myelination program. Transcriptional activator of MITF, acting synergistically with PAX3 (By similarity). (542 aa) |
| | CHD8 | Chromodomain-helicase-DNA-binding protein 8; DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive [...] (2583 aa) |
| | TMEM170B | Transmembrane protein 170B. (132 aa) |
| | BMP2 | Bone morphogenetic protein 2 preproprotein. (395 aa) |
| | APC2 | Uncharacterized protein. (2292 aa) |
| | BICC1 | BicC family RNA binding protein 1. (1086 aa) |
| | NKD1 | NKD inhibitor of WNT signaling pathway 1. (482 aa) |
| | SNAI2 | Snail family transcriptional repressor 2. (268 aa) |
| | APC | APC_basic domain-containing protein. (2713 aa) |
| | WNT5A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa) |
| | GREM1 | Gremlin 1, DAN family BMP antagonist. (240 aa) |
| | SFRP4 | Secreted frizzled-related protein 4. (346 aa) |
| | TLE5 | TLE family member 5, transcriptional modulator. (197 aa) |
| | DAB2 | DAB adaptor protein 2. (769 aa) |
| | CYLD | CYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. (955 aa) |
| | CTNNBIP1 | Beta-catenin-interacting protein 1. (81 aa) |
| | LRP4 | LDL receptor related protein 4. (1918 aa) |
| | AMFR | Autocrine motility factor receptor. (731 aa) |
| | PRICKLE1 | Prickle planar cell polarity protein 1. (856 aa) |
| | FRZB | Secreted frizzled-related protein 3. (325 aa) |
| | ANKRD6 | Ankyrin repeat domain-containing protein 6 isoform X2. (727 aa) |
| | DDIT3 | DNA-damage-inducible transcript 3. (167 aa) |
| | LATS1 | Large tumor suppressor kinase 1. (1146 aa) |
| | TLE1 | TLE family member 1, transcriptional corepressor. (770 aa) |
| | DKK2 | Dickkopf WNT signaling pathway inhibitor 2. (259 aa) |
| | SOST | Sclerostin. (212 aa) |
| | GSK3B | Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (414 aa) |
| | SIAH2 | E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (324 aa) |
| | STK3 | Serine/threonine kinase 3. (542 aa) |
| | NOTCH1 | Neurogenic locus notch homolog protein 1 preproprotein. (2560 aa) |
| | SDHAF2 | Succinate dehydrogenase assembly factor 2, mitochondrial; Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SDHA of the SDH catalytic dimer. (172 aa) |
| | SCYL2 | SCY1 like pseudokinase 2. (934 aa) |
| | NOG | Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa) |
| | SHISA3 | Shisa family member 3. (337 aa) |
| | LATS2 | Serine/threonine-protein kinase LATS2 isoform X1. (1041 aa) |
| | NPHP3 | TPR_REGION domain-containing protein. (1368 aa) |
| | AXIN2 | Axin-2. (843 aa) |
| | TNN | Tenascin N. (1472 aa) |
| | DACT1 | Dishevelled binding antagonist of beta catenin 1. (807 aa) |
| | PTPRU | Protein tyrosine phosphatase receptor type U. (1446 aa) |
| | GLI1 | Zinc finger protein GLI1 isoform X1. (1106 aa) |
| | MLLT3 | MLLT3 super elongation complex subunit. (624 aa) |
| | SOX13 | SRY-box transcription factor 13. (676 aa) |
| | FZD4 | Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (536 aa) |
| | CSNK1A1 | Casein kinase I isoform alpha; Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 at 'Ser-45'. May phosphorylate PER1 and PER2. May play a role in segregating chromosomes during mitosis. May play a role in keratin cytoskeleton disassembly and thereby, it may regulate epithelial cell migration. (359 aa) |
| | PRKN | E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (461 aa) |
| | NKD2 | Uncharacterized protein. (611 aa) |
| | FRMD8 | FERM domain containing 8. (477 aa) |
| | DKK3 | Dickkopf WNT signaling pathway inhibitor 3. (433 aa) |
| | UBAC2 | UBA domain containing 2. (373 aa) |
| | PFDN5 | Prefoldin subunit 5. (109 aa) |
| | TPBG | Trophoblast glycoprotein. (419 aa) |
| | SOSTDC1 | Sclerostin domain containing 1. (229 aa) |
| | SLC9A3R1 | Na(+)/H(+) exchange regulatory cofactor NHE-RF; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. (365 aa) |
| | TLE2 | TLE family member 2, transcriptional corepressor. (750 aa) |
| | EMD | LEM domain-containing protein. (400 aa) |
| | MCC | MCC regulator of WNT signaling pathway. (982 aa) |
| | STK4 | Serine/threonine kinase 4. (502 aa) |
| | AXIN1 | Axin 1. (867 aa) |
| | TLE7 | TLE family member 7. (433 aa) |
| | DACT3 | Dishevelled binding antagonist of beta catenin 3. (741 aa) |
