(16 nodes) Cochlea morphogenesis network (Sus scrofa)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PTK7	Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family. (1070 aa)
	DVL1	Dishevelled segment polarity protein 1. (700 aa)
	SIX1	Six homeobox 1. (284 aa)
	CTHRC1	Collagen triple helix repeat containing 1. (244 aa)
	NEUROG1	Neurogenin 1. (246 aa)
	SOX9	Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (511 aa)
	DVL2	Dishevelled segment polarity protein 2. (794 aa)
	TBX2	T-box 2 protein. (714 aa)
	ZEB1	Zinc finger E-box binding homeobox 1. (1128 aa)
	WNT5A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
	EYA1	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (618 aa)
	FZD2	Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (558 aa)
	FRZB	Secreted frizzled-related protein 3. (325 aa)
	TIFAB	TIFA inhibitor. (197 aa)
	HPN	Hepsin; Belongs to the peptidase S1 family. (449 aa)
	GRHL3	Grainyhead like transcription factor 3. (607 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DVL1	DVL2	ENSSSCP00000003625	ENSSSCP00000019910	Dishevelled segment polarity protein 1.	Dishevelled segment polarity protein 2.	0.955
DVL1	FZD2	ENSSSCP00000003625	ENSSSCP00000042537	Dishevelled segment polarity protein 1.	Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family.	0.946
DVL1	PTK7	ENSSSCP00000003625	ENSSSCP00000001804	Dishevelled segment polarity protein 1.	Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.468
DVL1	WNT5A	ENSSSCP00000003625	ENSSSCP00000037791	Dishevelled segment polarity protein 1.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.721
DVL2	DVL1	ENSSSCP00000019910	ENSSSCP00000003625	Dishevelled segment polarity protein 2.	Dishevelled segment polarity protein 1.	0.955
DVL2	FZD2	ENSSSCP00000019910	ENSSSCP00000042537	Dishevelled segment polarity protein 2.	Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family.	0.953
DVL2	PTK7	ENSSSCP00000019910	ENSSSCP00000001804	Dishevelled segment polarity protein 2.	Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.537
DVL2	WNT5A	ENSSSCP00000019910	ENSSSCP00000037791	Dishevelled segment polarity protein 2.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.919
EYA1	NEUROG1	ENSSSCP00000038801	ENSSSCP00000015220	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	Neurogenin 1.	0.522
EYA1	SIX1	ENSSSCP00000038801	ENSSSCP00000005467	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	Six homeobox 1.	0.933
FRZB	WNT5A	ENSSSCP00000043537	ENSSSCP00000037791	Secreted frizzled-related protein 3.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.582
FZD2	DVL1	ENSSSCP00000042537	ENSSSCP00000003625	Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family.	Dishevelled segment polarity protein 1.	0.946
FZD2	DVL2	ENSSSCP00000042537	ENSSSCP00000019910	Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family.	Dishevelled segment polarity protein 2.	0.953
FZD2	PTK7	ENSSSCP00000042537	ENSSSCP00000001804	Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family.	Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.555
FZD2	WNT5A	ENSSSCP00000042537	ENSSSCP00000037791	Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.989
GRHL3	PTK7	ENSSSCP00000074183	ENSSSCP00000001804	Grainyhead like transcription factor 3.	Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.442
NEUROG1	EYA1	ENSSSCP00000015220	ENSSSCP00000038801	Neurogenin 1.	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	0.522
NEUROG1	SIX1	ENSSSCP00000015220	ENSSSCP00000005467	Neurogenin 1.	Six homeobox 1.	0.555
PTK7	DVL1	ENSSSCP00000001804	ENSSSCP00000003625	Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family.	Dishevelled segment polarity protein 1.	0.468
PTK7	DVL2	ENSSSCP00000001804	ENSSSCP00000019910	Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family.	Dishevelled segment polarity protein 2.	0.537