STRINGSTRING
WNT10B WNT10B LRRK2 LRRK2 PTK7 PTK7 WLS WLS PPM1A PPM1A NRARP NRARP SULF2 SULF2 PPM1B PPM1B SFRP2 SFRP2 SCEL SCEL CCAR2 CCAR2 TNKS2 TNKS2 FAM53B FAM53B BAMBI BAMBI DDX3X DDX3X LGR4 LGR4 TTC21B TTC21B FGF10 FGF10 CTDNEP1 CTDNEP1 RUVBL1 RUVBL1 ILK ILK WNT3A WNT3A CDH3 CDH3 UBR5 UBR5 PIN1 PIN1 TMEM198 TMEM198 FZD9 FZD9 CAPRIN2 CAPRIN2 EGF EGF SFRP1 SFRP1 AMER1 AMER1 SRC SRC EDA EDA GPC3 GPC3 TBL1X TBL1X CAV1 CAV1 RSPO3 RSPO3 HHEX HHEX YAP1 YAP1 LOC100624648 LOC100624648 USP8 USP8 TNKS TNKS LOC100523244 LOC100523244 SFRP4 SFRP4 FRAT1 FRAT1 XIAP XIAP GSKIP GSKIP LRRK1 LRRK1 PPM1M PPM1M LOC100523964 LOC100523964 NLE1 NLE1 USP34 USP34 DLX5 DLX5 GPC5 GPC5 TBL1XR1 TBL1XR1 UBE2B UBE2B DKK2 DKK2 TRPM4 TRPM4 RSPO1 RSPO1 NFKB1 NFKB1 GID8 GID8 CSNK1G1 CSNK1G1 ANKRD39 ANKRD39 FGF2 FGF2 KANK1 KANK1 LGR5 LGR5 DACT1 DACT1 PPM1N PPM1N JRK JRK RNF146 RNF146 PRDM15 PRDM15 CSNK1G2 CSNK1G2 FGF9 FGF9 USP47 USP47 RECK RECK DAAM2 DAAM2 ADGRA2 ADGRA2 COL1A1 COL1A1 TMEM9 TMEM9 RNF220 RNF220 EGFR EGFR PLEKHA4 PLEKHA4 CSNK1D CSNK1D ZBED3 ZBED3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
LRRK2Uncharacterized protein. (2501 aa)
PTK7Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family. (1070 aa)
WLSWnt ligand secretion mediator. (545 aa)
PPM1AProtein phosphatase, Mg2+/Mn2+ dependent 1A. (490 aa)
NRARPNOTCH regulated ankyrin repeat protein. (114 aa)
SULF2Extracellular sulfatase; Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C- 6 position of glucosamine within specific subregions of intact heparin. Belongs to the sulfatase family. (906 aa)
PPM1BPPM-type phosphatase domain-containing protein. (473 aa)
SFRP2Uncharacterized protein. (294 aa)
SCELSciellin. (684 aa)
CCAR2DBC1 domain-containing protein. (916 aa)
TNKS2Poly [ADP-ribose] polymerase. (1316 aa)
FAM53BFamily with sequence similarity 53 member B. (430 aa)
BAMBIBMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (260 aa)
DDX3XATP-dependent RNA helicase DDX3X isoform 1; Belongs to the DEAD box helicase family. (662 aa)
LGR4Leucine-rich repeat-containing G-protein coupled receptor 4 isoform 1. (951 aa)
TTC21BTetratricopeptide repeat protein 21B. (1315 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
CTDNEP1CTD nuclear envelope phosphatase 1. (244 aa)
RUVBL1RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (463 aa)
ILKIntegrin linked kinase. (479 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
CDH3Cadherin-3; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. (826 aa)
UBR5Ubiquitin protein ligase E3 component n-recognin 5. (2759 aa)
PIN1Peptidyl-prolyl cis-trans isomerase. (163 aa)
TMEM198Transmembrane protein 198. (360 aa)
FZD9Frizzled class receptor 9; Belongs to the G-protein coupled receptor Fz/Smo family. (591 aa)
CAPRIN2Caprin family member 2. (1069 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6 (By similarity). (1194 aa)
SFRP1Secreted frizzled-related protein 1. (308 aa)
AMER1APC membrane recruitment protein 1. (1108 aa)
SRCTyrosine-protein kinase. (559 aa)
EDAEctodysplasin A; Belongs to the tumor necrosis factor family. (389 aa)
GPC3Glypican-3 isoform 2; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (579 aa)
TBL1XUncharacterized protein. (615 aa)
CAV1Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (177 aa)
RSPO3Uncharacterized protein. (280 aa)
HHEXHematopoietically-expressed homeobox protein HHEX. (269 aa)
YAP1Yes associated protein 1. (432 aa)
LOC100624648F-box-like/WD repeat-containing protein TBL1X isoform a. (529 aa)
USP8Ubiquitin specific peptidase 8; Belongs to the peptidase C19 family. (1115 aa)
TNKSPoly [ADP-ribose] polymerase. (1327 aa)
LOC100523244Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (454 aa)
SFRP4Secreted frizzled-related protein 4. (346 aa)
FRAT1Uncharacterized protein. (279 aa)
XIAPX-linked inhibitor of apoptosis. (514 aa)
GSKIPDUF727 domain-containing protein. (282 aa)
LRRK1Leucine rich repeat kinase 1. (2030 aa)
PPM1MPPM-type phosphatase domain-containing protein. (535 aa)
LOC100523964Uncharacterized protein. (349 aa)
NLE1Notchless homolog 1. (487 aa)
USP34Ubiquitin specific peptidase 34; Belongs to the peptidase C19 family. (3522 aa)
DLX5Homeobox protein DLX-5. (290 aa)
GPC5Glypican 5; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (571 aa)
TBL1XR1Transducin beta like 1 X-linked receptor 1. (526 aa)
UBE2BUbiquitin-conjugating enzyme E2 B; Belongs to the ubiquitin-conjugating enzyme family. (152 aa)
DKK2Dickkopf WNT signaling pathway inhibitor 2. (259 aa)
TRPM4Transient receptor potential cation channel subfamily M member 4 isoform X1. (1213 aa)
RSPO1R-spondin 1. (262 aa)
NFKB1Uncharacterized protein. (898 aa)
GID8GID complex subunit 8 homolog. (296 aa)
CSNK1G1Casein kinase 1 gamma 1; Belongs to the protein kinase superfamily. (466 aa)
ANKRD39Ankyrin repeat domain 39. (273 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (316 aa)
KANK1KN motif and ankyrin repeat domains 1. (1331 aa)
LGR5Leucine-rich repeat-containing G-protein coupled receptor 5 isoform 1. (907 aa)
DACT1Dishevelled binding antagonist of beta catenin 1. (807 aa)
PPM1NProtein phosphatase, Mg2+/Mn2+ dependent 1N (putative). (415 aa)
JRKJrk helix-turn-helix protein. (518 aa)
RNF146Ring finger protein 146. (369 aa)
PRDM15PR/SET domain 15. (1266 aa)
CSNK1G2Casein kinase I isoform gamma-2; Belongs to the protein kinase superfamily. (414 aa)
FGF9Fibroblast growth factor 9; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. May have a role in glial cell growth and differentiation during development, gliosis during repair and regeneration of brain tissue after damage, differentiation and survival of neuronal cells, and growth stimulation of glial tumors (By similarity). (228 aa)
USP47Ubiquitin specific peptidase 47; Belongs to the peptidase C19 family. (1356 aa)
RECKReversion-inducing cysteine-rich protein with Kazal motifs isoform 1. (971 aa)
DAAM2Dishevelled associated activator of morphogenesis 2. (1075 aa)
ADGRA2Adhesion G protein-coupled receptor A2; Belongs to the G-protein coupled receptor 2 family. (1336 aa)
COL1A1Collagen type I alpha 1 chain. (1477 aa)
TMEM9Transmembrane protein 9. (273 aa)
RNF220Ring finger protein 220. (565 aa)
EGFRReceptor protein-tyrosine kinase. (1205 aa)
PLEKHA4Pleckstrin homology domain containing A4. (682 aa)
CSNK1DCasein kinase 1 delta. (459 aa)
ZBED3Uncharacterized protein. (218 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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