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| | RNF165 | Ring finger protein 165. (365 aa) |
| | EMILIN1 | Elastin microfibril interfacer 1. (1292 aa) |
| | VWC2L | Von Willebrand factor C domain-containing protein 2-like isoform 1. (222 aa) |
| | DSTYK | Dual serine/threonine and tyrosine protein kinase. (1049 aa) |
| | ADGRA2 | Adhesion G protein-coupled receptor A2; Belongs to the G-protein coupled receptor 2 family. (1336 aa) |
| | UBL3 | Ubiquitin-like domain-containing protein. (275 aa) |
| | STRAP | Serine-threonine kinase receptor-associated protein. (350 aa) |
| | HTRA1 | HtrA serine peptidase 1. (479 aa) |
| | FBN2 | Fibrillin 2. (2910 aa) |
| | ADAMTS3 | ADAM metallopeptidase with thrombospondin type 1 motif 3. (1220 aa) |
| | SOSTDC1 | Sclerostin domain containing 1. (229 aa) |
| | CCN1 | Cellular communication network factor 1. (382 aa) |
| | FLCN | UDENN FLCN/SMCR8-type domain-containing protein. (611 aa) |
| | ROBO1 | Roundabout guidance receptor 1. (1687 aa) |
| | LRIT3 | Leucine rich repeat, Ig-like and transmembrane domains 3. (621 aa) |
| | MYOCD | Myocardin; Smooth muscle cells (SM) and cardiac muscle cells-specific transcriptional factor which uses the canonical single or multiple CArG boxes DNA sequence. Acts as a cofactor of serum response factor (SRF) with the potential to modulate SRF-target genes. Plays a crucial role in cardiogenesis and differentiation of the smooth muscle cell lineage (myogenesis) (By similarity). (993 aa) |
| | SPRY1 | Sprouty RTK signaling antagonist 1. (319 aa) |
| | TWSG1 | Twisted gastrulation BMP signaling modulator 1. (291 aa) |
| | VEPH1 | Ventricular zone-expressed PH domain-containing protein homolog 1 isoform X2. (833 aa) |
| | SPRED1 | Sprouty related EVH1 domain containing 1. (445 aa) |
| | NRP1 | Neuropilin; Belongs to the neuropilin family. (924 aa) |
| | BMPER | BMP binding endothelial regulator. (699 aa) |
| | SPRY2 | Sprouty RTK signaling antagonist 2. (315 aa) |
| | SMURF1 | E3 ubiquitin-protein ligase. (859 aa) |
| | SPRY4 | Sprouty RTK signaling antagonist 4. (325 aa) |
| | TGFBR3 | Transforming growth factor beta receptor type 3; Binds to TGF-beta. Could be involved in capturing and retaining TGF-beta for presentation to the signaling receptors. (952 aa) |
| | RUNX2 | Runt-related transcription factor 2 isoform a. (625 aa) |
| | CHRDL2 | Chordin like 2. (452 aa) |
| | BMPR2 | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1085 aa) |
| | CASK | Calcium/calmodulin dependent serine protein kinase; Belongs to the MAGUK family. (925 aa) |
| | CCBE1 | Collagen and calcium binding EGF domains 1. (407 aa) |
| | AXIN1 | Axin 1. (867 aa) |
| | SDCBP | Syndecan binding protein. (300 aa) |
| | CREB3L1 | cAMP responsive element binding protein 3 like 1. (520 aa) |
| | CIDEA | CIDE-N domain-containing protein. (376 aa) |
| | SMAD3 | Mothers against decapentaplegic homolog. (434 aa) |
| | GIPC1 | GIPC PDZ domain containing family member 1. (405 aa) |
| | NRROS | Negative regulator of reactive oxygen species. (704 aa) |
| | HSPA5 | Endoplasmic reticulum chaperone BiP; Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (By similarity). Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate (By similarity). Acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to dis [...] (657 aa) |
| | NANOG | Homeobox domain-containing protein. (304 aa) |
| | PBLD | Phenazine biosynthesis like protein domain containing. (322 aa) |
| | C20orf27 | Chromosome 20 open reading frame 27. (198 aa) |
| | VWC2 | Von Willebrand factor C domain containing 2. (325 aa) |
| | NUMA1 | Nuclear mitotic apparatus protein 1. (2134 aa) |
| | CITED1 | Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1. (221 aa) |
| | SPART | Spartin. (666 aa) |
| | FGFBP3 | Fibroblast growth factor binding protein 3. (256 aa) |
| | PPARA | Uncharacterized protein. (469 aa) |
| | WNT1 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa) |
| | ACVRL1 | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (595 aa) |
| | ZDHHC17 | Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (610 aa) |
| | ZNF451 | Zinc finger protein 451. (1061 aa) |
| | MPP5 | MAGUK p55 subfamily member 5 isoform X1; Belongs to the MAGUK family. (675 aa) |
| | FUZ | Fuzzy planar cell polarity protein. (418 aa) |
| | SMOC2 | SPARC related modular calcium binding 2. (613 aa) |
| | CITED2 | Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (278 aa) |
| | LOC100520342 | Nephrocan-like. (512 aa) |
| | SMAD7 | Mothers against decapentaplegic homolog. (426 aa) |
| | SMAD4 | Mothers against decapentaplegic homolog 4; Common SMAD (co-SMAD) is the coactivator and mediator of signal transduction by TGF-beta (transforming growth factor). Component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling. Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. Component of the multimeric SMAD3/SMAD4/JUN/FOS complex which forms at the AP1 promoter site; required for synergistic transcriptional activity in r [...] (552 aa) |
| | ONECUT2 | One cut domain family member. (694 aa) |
| | ONECUT1 | One cut domain family member. (465 aa) |
| | FBN1 | Fibrillin-1; [Fibrillin-1]: Structural component of the 10-12 nm diameter microfibrils of the extracellular matrix, which conveys both structural and regulatory properties to load-bearing connective tissues. Fibrillin-1-containing microfibrils provide long-term force bearing structural support. In tissues such as the lung, blood vessels and skin, microfibrils form the periphery of the elastic fiber, acting as a scaffold for the deposition of elastin. In addition, microfibrils can occur as elastin-independent networks in tissues such as the ciliary zonule, tendon, cornea and glomerulus [...] (2871 aa) |
| | THBS1 | Uncharacterized protein. (1170 aa) |
| | SMAD6 | Mothers against decapentaplegic homolog. (496 aa) |
| | SKOR1 | SKI family transcriptional corepressor 1. (934 aa) |
| | BMP4 | Bone morphogenetic protein 4. (409 aa) |
| | PPM1A | Protein phosphatase, Mg2+/Mn2+ dependent 1A. (490 aa) |
| | CDKN2B | Cyclin dependent kinase inhibitor 2B. (131 aa) |
| | DAB2IP | DAB2 interacting protein. (1196 aa) |
| | CRB2 | Crumbs cell polarity complex component 2. (1283 aa) |
| | SKOR2 | SKI family transcriptional corepressor 2. (1009 aa) |
| | PRDM14 | PR/SET domain 14. (571 aa) |
| | SULF1 | Sulfatase 1. (1108 aa) |
| | NOTCH2 | Neurogenic locus notch homolog protein 2 isoform 1 preproprotein. (2471 aa) |
| | FERMT1 | Fermitin family member 1. (676 aa) |
| | SULF2 | Extracellular sulfatase; Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C- 6 position of glucosamine within specific subregions of intact heparin. Belongs to the sulfatase family. (906 aa) |
| | DOK5 | IRS-type PTB domain-containing protein. (316 aa) |
| | CREBBP | CREB-binding protein isoform a. (2440 aa) |
| | TMEM204 | Transmembrane protein 204. (226 aa) |
| | ASPN | Asporin. (370 aa) |
| | CRIM1 | Cysteine rich transmembrane BMP regulator 1. (1031 aa) |
| | XDH | Xanthine dehydrogenase/oxidase. (1336 aa) |
| | SOX11 | Transcription factor SOX. (447 aa) |
| | HTRA3 | Uncharacterized protein. (577 aa) |
| | MSX1 | Homeobox domain-containing protein. (303 aa) |
| | SLIT2 | Slit guidance ligand 2. (1542 aa) |
| | RASL11B | RAS like family 11 member B. (248 aa) |
| | SFRP2 | Uncharacterized protein. (294 aa) |
| | SIRT1 | NAD-dependent protein deacetylase sirtuin-1 isoform a. (742 aa) |
| | GDF2 | Growth differentiation factor 2. (427 aa) |
| | SFRP5 | Uncharacterized protein. (315 aa) |
| | BAMBI | BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (260 aa) |
| | JCAD | Junctional cadherin 5 associated. (1378 aa) |
| | IL17RD | Interleukin-17 receptor D isoform a. (737 aa) |
| | TMEM108 | Transmembrane protein 108. (575 aa) |
| | SKIL | Ski-like protein isoform X1. (661 aa) |
| | HRG | Uncharacterized protein. (561 aa) |
| | FGF4 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa) |
| | MEN1 | Menin 1. (704 aa) |
| | STK11 | Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (438 aa) |
| | LINGO3 | Leucine rich repeat and Ig domain containing 3. (592 aa) |
| | LOX | Protein-lysine 6-oxidase, short form; Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Regulator of Ras expression. May play a role in tumor suppression. Plays a role in the aortic wall architecture (By similarity); Belongs to the lysyl oxidase family. (419 aa) |
| | IL4 | Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (133 aa) |
| | KIAA1324L | KIAA1324 like. (1276 aa) |
| | SNX25 | Sorting nexin 25. (556 aa) |
| | ZNF703 | Zinc finger protein 703. (591 aa) |
| | KCP | Kielin cysteine rich BMP regulator. (1783 aa) |
| | CAV2 | Caveolin-2; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression (By similarity); Belongs to the caveolin family. (162 aa) |
| | TBX20 | T-box transcription factor TBX20 isoform 1. (449 aa) |
| | FGF10 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa) |
| | PELO | Protein pelota homolog; May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non- functional ribosomes and degrade damaged mRNAs. (384 aa) |
| | FST | Follistatin; Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH). (343 aa) |
| | NGFR | Nerve growth factor receptor. (414 aa) |
| | WFIKKN2 | WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2. (580 aa) |
| | TMPRSS6 | Transmembrane serine protease 6; Belongs to the peptidase S1 family. (812 aa) |
| | TNFAIP6 | Uncharacterized protein. (277 aa) |
| | SNW1 | SNW domain-containing protein 1 isoform 2. (536 aa) |
| | FGF16 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa) |
| | PRDM16 | PR/SET domain 16. (1278 aa) |
| | ILK | Integrin linked kinase. (479 aa) |
| | EP300 | E1A binding protein p300. (2420 aa) |
| | PRKD2 | Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (889 aa) |
| | EID2 | EP300 interacting inhibitor of differentiation 2. (178 aa) |
| | ADAMTSL2 | ADAMTS like 2. (958 aa) |
| | TRIM33 | E3 ubiquitin-protein ligase TRIM33 isoform alpha. (1127 aa) |
| | GDF5 | Growth differentiation factor 5. (499 aa) |
| | HIPK2 | Homeodomain interacting protein kinase 2. (1208 aa) |
| | PIN1 | Peptidyl-prolyl cis-trans isomerase. (163 aa) |
| | SHISA2 | Protein shisa-2 homolog. (294 aa) |
| | GREM2 | Gremlin 2, DAN family BMP antagonist. (166 aa) |
| | DLL1 | Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (729 aa) |
| | GLG1 | Golgi glycoprotein 1. (1210 aa) |
| | ADAMTS12 | ADAM metallopeptidase with thrombospondin type 1 motif 12. (1598 aa) |
| | HOXA13 | Homeobox A13. (388 aa) |
| | FGF18 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (251 aa) |
| | ING2 | Inhibitor of growth protein. (280 aa) |
| | ITGA3 | Integrin subunit alpha 3; Belongs to the integrin alpha chain family. (1085 aa) |
| | CD109 | CD109 antigen isoform 1 preproprotein. (1449 aa) |
| | ZEB1 | Zinc finger E-box binding homeobox 1. (1128 aa) |
| | KDR | Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1360 aa) |
| | SFRP1 | Secreted frizzled-related protein 1. (308 aa) |
| | CD63 | Tetraspanin. (237 aa) |
| | AGT | Angiotensinogen; Belongs to the serpin family. (482 aa) |
| | GPC3 | Glypican-3 isoform 2; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (579 aa) |
| | ENG | Endoglin; Vascular endothelium glycoprotein that plays an important role in the regulation of angiogenesis. Required for normal structure and integrity of adult vasculature. Regulates the migration of vascular endothelial cells (By similarity). Required for normal extraembryonic angiogenesis and for embryonic heart development (By similarity). May regulate endothelial cell shape changes in response to blood flow, which drive vascular remodeling and establishment of normal vascular morphology during angiogenesis (By similarity). May play a role in the binding of endothelial cells to int [...] (619 aa) |
| | FGFR1 | Fibroblast growth factor receptor. (820 aa) |
| | IL17F | Interleukin 17F. (165 aa) |
| | TGFB1 | Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa) |
| | CHRDL1 | Chordin like 1. (526 aa) |
| | GRB10 | Growth factor receptor-bound protein 10; Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin [...] (589 aa) |
| | CAV1 | Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (177 aa) |
| | CTNNB1 | Catenin beta 1. (808 aa) |
| | MYO1C | Unconventional myosin-Ic isoform a; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1067 aa) |
| | NBL1 | CTCK domain-containing protein. (364 aa) |
| | CAV3 | Caveolin-3; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. May also regulate voltage-gated potassium channels. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress. Mediates the recruitment of CAVIN2 and CAVIN3 proteins to the caveolae. (151 aa) |
| | P14ARF | ANK_REP_REGION domain-containing protein. (159 aa) |
| | MT3 | Metallothionein-3; Binds heavy metals. Contains three zinc and three copper atoms per polypeptide chain and only a negligible amount of cadmium. Inhibits survival and neurite formation of cortical neurons in vitro (By similarity); Belongs to the metallothionein superfamily. Type 1 family. (95 aa) |
| | NEO1 | Neogenin 1. (1465 aa) |
| | WFIKKN1 | WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1. (548 aa) |
| | PDPK1 | 3-phosphoinositide dependent protein kinase 1. (668 aa) |
| | A0A286ZVP0_PIG | ENTH domain-containing protein. (70 aa) |
| | PTP4A3 | Protein tyrosine phosphatase 4A3. (173 aa) |
| | LTBP1 | Latent transforming growth factor beta binding protein 1. (1708 aa) |
| | PRKCB | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa) |
| | DLX1 | Homeobox protein DLX-1 isoform 1. (255 aa) |
| | CTDSPL2 | CTD small phosphatase like 2. (437 aa) |
| | BMP2 | Bone morphogenetic protein 2 preproprotein. (395 aa) |
| | FGF1 | Fibroblast growth factor 1; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrin ITGAV:ITGB3. Its binding to integrin, subsequent ternary complex formation with int [...] (182 aa) |
| | WNT5A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa) |
| | PTPN1 | Tyrosine-protein phosphatase non-receptor type. (435 aa) |
| | GREM1 | Gremlin 1, DAN family BMP antagonist. (240 aa) |
| | GIPC3 | GIPC PDZ domain containing family member 3. (314 aa) |
| | TFAP2B | Transcription factor AP-2 beta. (469 aa) |
| | SPRY3 | Sprouty RTK signaling antagonist 3. (288 aa) |
| | NPTN | Neuroplastin. (412 aa) |
| | CXCL13 | C-X-C motif chemokine. (111 aa) |
| | ZBTB7A | Zinc finger and BTB domain containing 7A. (596 aa) |
| | CDKN1C | Cyclin dependent kinase inhibitor 1C. (262 aa) |
| | SCUBE3 | Signal peptide, CUB domain and EGF like domain containing 3. (1008 aa) |
| | DAB2 | DAB adaptor protein 2. (769 aa) |
| | GATA3 | Trans-acting T-cell-specific transcription factor GATA-3. (444 aa) |
| | LOC110256054 | WH2 domain-containing protein. (558 aa) |
| | TGFBR3L | Transforming growth factor beta receptor 3 like. (285 aa) |
| | SKI | SKI proto-oncogene. (728 aa) |
| | LEMD3 | Inner nuclear membrane protein Man1 isoform 1. (911 aa) |
| | FAM89B | Family with sequence similarity 89 member B. (192 aa) |
| | LATS1 | Large tumor suppressor kinase 1. (1146 aa) |
| | PDCD6 | Programmed cell death 6. (292 aa) |
| | SOST | Sclerostin. (212 aa) |
| | IL12B | Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Belongs to the IL-12B family. (324 aa) |
| | ATP2B4 | Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1171 aa) |
| | WASF1 | WH2 domain-containing protein. (559 aa) |
| | A0A287AS64_PIG | Uncharacterized protein. (72 aa) |
| | CDH5 | Cadherin-5; Cadherins are calcium-dependent cell adhesion proteins (By similarity). They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types (By similarity). This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions (By similarity). It associates with alpha-catenin forming a link to the cytoskeleton (By similarity). Acts in concert with KRIT1 and MPP5 to establish and maintain correct endotheli [...] (782 aa) |
| | GPC1 | Glypican 1; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (559 aa) |
| | LEMD2 | LEM domain containing 2. (527 aa) |
| | SMURF2 | E3 ubiquitin-protein ligase. (748 aa) |
| | HES1 | Uncharacterized protein. (280 aa) |
| | CYFIP2 | Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1278 aa) |
| | FSTL3 | Follistatin-related protein 3. (262 aa) |
| | SLC2A10 | Solute carrier family 2 member 10; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (540 aa) |
| | HJV | Hemojuvelin BMP co-receptor. (432 aa) |
| | ZNF423 | Zinc finger protein 423 isoform X2. (1292 aa) |
| | LRP2 | Low-density lipoprotein receptor-related protein 2; Multiligand endocytic receptor (By similarity). Acts together with CUBN to mediate endocytosis of high-density lipoproteins (By similarity). Mediates receptor-mediated uptake of polybasic drugs such as aprotinin, aminoglycosides and polymyxin B (By similarity). In the kidney, mediates the tubular uptake and clearance of leptin (By similarity). Also mediates transport of leptin across the blood-brain barrier through endocytosis at the choroid plexus epithelium (By similarity). Endocytosis of leptin in neuronal cells is required for hyp [...] (4626 aa) |
| | LDLRAD4 | Low density lipoprotein receptor class A domain containing 4. (321 aa) |
| | NOTCH1 | Neurogenic locus notch homolog protein 1 preproprotein. (2560 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (442 aa) |
| | HIF1A | Hypoxia-inducible factor 1-alpha isoform 1. (824 aa) |
| | VASN | Vasorin isoform X2. (677 aa) |
| | RNF111 | Ring finger protein 111. (992 aa) |
| | CHRD | Chordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes. (1028 aa) |
| | SEMA6A | Semaphorin-6A isoform 1; Belongs to the semaphorin family. (1047 aa) |
| | TGFB1I1 | Transforming growth factor beta-1-induced transcript 1 protein; Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. (519 aa) |
| | FBXL15 | F-box and leucine rich repeat protein 15. (371 aa) |
| | UBE2O | Ubiquitin conjugating enzyme E2 O. (1296 aa) |
| | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1; Belongs to the PI3/PI4-kinase family. (1070 aa) |
| | EPN2 | Epsin 2. (704 aa) |
| | HHIP | Hedgehog-interacting protein. (700 aa) |
| | MMRN2 | Multimerin 2. (931 aa) |
| | PMEPA1 | Prostate transmembrane protein, androgen induced 1. (288 aa) |
| | NOG | Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa) |
| | ABL1 | Tyrosine-protein kinase. (1146 aa) |
| | HES5 | Hes family bHLH transcription factor 5. (226 aa) |
| | CHST11 | Carbohydrate sulfotransferase. (352 aa) |
| | LATS2 | Serine/threonine-protein kinase LATS2 isoform X1. (1041 aa) |
| | TSPAN12 | Tetraspanin. (305 aa) |
| | NKX2-1 | NK2 homeobox 1. (399 aa) |
| | FGF2 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (316 aa) |
| | GIPC2 | PDZ domain-containing protein GIPC2 isoform 1. (313 aa) |
| | NREP | Neuronal regeneration-related protein. (70 aa) |
| | FSTL1 | Follistatin like 1. (307 aa) |
| | SORL1 | Sortilin related receptor 1. (2213 aa) |
| | BCL9L | BCL9 like. (1526 aa) |
| | FZD4 | Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (536 aa) |
| | FGF9 | Fibroblast growth factor 9; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. May have a role in glial cell growth and differentiation during development, gliosis during repair and regeneration of brain tissue after damage, differentiation and survival of neuronal cells, and growth stimulation of glial tumors (By similarity). (228 aa) |
| | HGS | Hepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] (908 aa) |
