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| | PDK2 | Protein-serine/threonine kinase. (437 aa) |
| | IL2 | Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family. (154 aa) |
| | RIPK1 | Receptor interacting serine/threonine kinase 1. (668 aa) |
| | SIVA1 | Apoptosis regulatory protein Siva; Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl- x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis. (199 aa) |
| | MAPK9 | Mitogen-activated protein kinase 9. (461 aa) |
| | TNF | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (233 aa) |
| | USP47 | Ubiquitin specific peptidase 47; Belongs to the peptidase C19 family. (1356 aa) |
| | MLLT11 | Protein AF1q. (90 aa) |
| | TNFRSF1B | TNF receptor superfamily member 1B. (461 aa) |
| | IL7 | Interleukin-7; Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation; Belongs to the IL-7/IL-9 family. (176 aa) |
| | ITPR1 | Inositol 1,4,5-trisphosphate receptor type 1. (2759 aa) |
| | LOC100627067 | Uncharacterized protein. (518 aa) |
| | FAS | Tumor necrosis factor receptor superfamily member 6; Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen- stimulated suicide of mature T-cells, or both (By similarity). (428 aa) |
| | TP63 | Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa) |
| | TIMM50 | Mitochondrial import inner membrane translocase subunit TIM50; Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. (355 aa) |
| | CASP1 | Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracell [...] (406 aa) |
| | PDK1 | Protein-serine/threonine kinase. (454 aa) |
| | NFATC4 | Nuclear factor of activated T cells 4. (937 aa) |
| | FLCN | UDENN FLCN/SMCR8-type domain-containing protein. (611 aa) |
| | A0A5G2QRP7_PIG | Uncharacterized protein. (104 aa) |
| | TMEM109 | Transmembrane protein 109. (295 aa) |
| | KRT18 | Keratin 18; Belongs to the intermediate filament family. (423 aa) |
| | ITPRIP | Inositol 1,4,5-trisphosphate receptor interacting protein. (583 aa) |
| | FAIM2 | Fas apoptotic inhibitory molecule 2; Belongs to the BI1 family. (316 aa) |
| | CD27 | CD27. (249 aa) |
| | BAG6 | Large proline-rich protein BAG6; ATP-independent molecular chaperone preventing the aggregation of misfolded and hydrophobic patches-containing proteins. Functions as part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, which maintains these client proteins in a soluble state and participates to their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation. The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endo [...] (1163 aa) |
| | DAXX | Death domain associated protein. (751 aa) |
| | PPARD | Peroxisome proliferator-activated receptor delta. (441 aa) |
| | CDKN1A | Cyclin dependent kinase inhibitor 1A. (163 aa) |
| | PML | Promyelocytic leukemia. (827 aa) |
| | PARP2 | Poly [ADP-ribose] polymerase. (567 aa) |
| | PSEN1 | Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (463 aa) |
| | GSK3A | Protein kinase domain-containing protein. (566 aa) |
| | BAX | Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase; Belongs to the Gfo/Idh/MocA family. (480 aa) |
| | TFPT | TCF3 fusion partner isoform 1. (253 aa) |
| | UBE4B | Ubiquitination factor E4B. (1297 aa) |
| | CASP9 | Caspase 9; Belongs to the peptidase C14A family. (438 aa) |
| | EPHA2 | Ephrin type-A receptor 2 isoform 1. (975 aa) |
| | CASP8AP2 | Caspase 8 associated protein 2. (1974 aa) |
| | FOXO3 | Forkhead box protein O3 isoform X1. (672 aa) |
| | BCL2L10 | Uncharacterized protein. (184 aa) |
| | ELL3 | Elongation factor for RNA polymerase II 3. (374 aa) |
| | PDIA3 | Protein disulfide-isomerase. (504 aa) |
| | AEN | Apoptosis enhancing nuclease. (325 aa) |
| | DAB2IP | DAB2 interacting protein. (1196 aa) |
| | PRKDC | Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4136 aa) |
| | HIPK1 | Homeodomain-interacting protein kinase 1 isoform 1. (1210 aa) |
| | E2F1 | E2F transcription factor 1. (435 aa) |
| | PTGIS | Prostacyclin synthase; Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2); Belongs to the cytochrome P450 family. (503 aa) |
| | HIP1 | Huntingtin interacting protein 1. (990 aa) |
| | UMOD | Uromodulin. (642 aa) |
| | CDIP1 | Cell death inducing p53 target 1. (213 aa) |
| | IL1A | Interleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. (270 aa) |
| | BCL2L11 | Uncharacterized protein. (433 aa) |
| | MSH2 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (920 aa) |
| | LOC100624226 | Uncharacterized protein. (446 aa) |
| | HMGB2 | High mobility group protein B2; Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. In the nucleus is an abundant chromatin-associated non-histone protein involved in transcription, chromatin remodeling and V(D)J recombination and probably other processes (By similarity). Binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters by enhancing transcription factor bindi [...] (210 aa) |
| | DIABLO | Uncharacterized protein. (237 aa) |
| | P2RX7 | P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (595 aa) |
| | ADORA2A | Adenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (414 aa) |
| | PPM1F | Protein phosphatase, Mg2+/Mn2+ dependent 1F. (436 aa) |
| | SIRT1 | NAD-dependent protein deacetylase sirtuin-1 isoform a. (742 aa) |
| | VDAC2 | Voltage-dependent anion-selective channel protein 2; Forms a channel through the cell membrane that allows diffusion from small hydrophilic molecules. (294 aa) |
| | ERCC6 | ERCC excision repair 6, chromatin remodeling factor. (1462 aa) |
| | BAG3 | BCL2 associated athanogene 3. (609 aa) |
| | BMI1 | RING-type domain-containing protein. (336 aa) |
| | SKIL | Ski-like protein isoform X1. (661 aa) |
| | DDX3X | ATP-dependent RNA helicase DDX3X isoform 1; Belongs to the DEAD box helicase family. (662 aa) |
| | AIFM1 | Apoptosis inducing factor mitochondria associated 1. (613 aa) |
| | RAD9A | Cell cycle checkpoint control protein; Belongs to the rad9 family. (443 aa) |
| | LGALS12 | Galectin. (330 aa) |
| | CD5 | T-cell surface glycoprotein CD5 isoform 1. (497 aa) |
| | STK11 | Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (438 aa) |
| | NANOS3 | Nanos C2HC-type zinc finger 3; Belongs to the nanos family. (261 aa) |
| | NDUFA13 | Uncharacterized protein. (144 aa) |
| | IL4 | Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (133 aa) |
| | CTNNA1 | Catenin alpha 1. (1090 aa) |
| | DELE1 | DAP3 binding cell death enhancer 1. (517 aa) |
| | F1SV37_PIG | Uncharacterized protein; Belongs to the peptidase C14A family. (332 aa) |
| | LOC100522887 | Uncharacterized protein; Belongs to the peptidase C14A family. (376 aa) |
| | ATM | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospec [...] (3057 aa) |
| | TLR3 | TIR domain-containing protein; Belongs to the Toll-like receptor family. (903 aa) |
| | DAPL1 | Uncharacterized protein. (97 aa) |
| | STK25 | Serine/threonine kinase 25. (476 aa) |
| | SHH | Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (440 aa) |
| | ZNF622 | Zinc finger protein 622. (473 aa) |
| | FGF10 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa) |
| | ANXA6 | Annexin. (672 aa) |
| | ERN1 | Uncharacterized protein. (1029 aa) |
| | NF1 | Neurofibromin 1. (2847 aa) |
| | SGPP1 | Sphingosine-1-phosphate phosphatase 1. (443 aa) |
| | FASLG | Tumor necrosis factor ligand superfamily member 6, membrane form; Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. Involved in cytotoxic T-cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development. Initiates fratricidal/suicidal activation-induced cell death (AICD) in antigen-activated T-cells contributing to the termination of immune responses (By similarity). TNFRSF6/FAS-mediated apoptosis has also a role in the induction of peripheral tolerance (By similarity). Binds to TNFRSF6B/DcR3, a decoy receptor tha [...] (282 aa) |
| | IKBKE | Inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform 1. (718 aa) |
| | ERBB3 | Erb-b2 receptor tyrosine kinase 3. (1342 aa) |
| | SNW1 | SNW domain-containing protein 1 isoform 2. (536 aa) |
| | EP300 | E1A binding protein p300. (2420 aa) |
| | RAF1 | RAF proto-oncogene serine/threonine-protein kinase isoform a. (668 aa) |
| | BNIP3 | BCL2 interacting protein 3. (202 aa) |
| | DEDD2 | Death effector domain containing 2. (204 aa) |
| | RB1CC1 | RB1 inducible coiled-coil 1. (1608 aa) |
| | HIC1 | Hypermethylated in cancer 1 protein isoform 2. (733 aa) |
| | HIPK2 | Homeodomain interacting protein kinase 2. (1208 aa) |
| | PIK3R1 | Phosphoinositide-3-kinase regulatory subunit 1. (766 aa) |
| | BDKRB2 | B2 bradykinin receptor; Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system (By similarity). (440 aa) |
| | TP73 | Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (640 aa) |
| | ZNF385B | Zinc finger protein 385B. (486 aa) |
| | RRP8 | Ribosomal RNA-processing protein 8; Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone- modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and pr [...] (593 aa) |
| | CASP8 | Caspase-8 isoform X2; Belongs to the peptidase C14A family. (486 aa) |
| | CASP10 | Caspase 10; Belongs to the peptidase C14A family. (520 aa) |
| | I3LSU6_PIG | Uncharacterized protein; Belongs to the BI1 family. (302 aa) |
| | DAPK1 | Death associated protein kinase 1. (1442 aa) |
| | PMAIP1 | Uncharacterized protein. (121 aa) |
| | MSH6 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1363 aa) |
| | BRCA2 | Tower domain-containing protein. (1163 aa) |
| | JAK2 | Tyrosine-protein kinase JAK2; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN- beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors [...] (1131 aa) |
| | SFRP1 | Secreted frizzled-related protein 1. (308 aa) |
| | TGFB1 | Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa) |
| | NOX1 | NADPH oxidase 1 isoform 1. (564 aa) |
| | FADD | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (211 aa) |
| | PIDD1 | P53-induced death domain protein 1. (954 aa) |
| | BCL3 | ANK_REP_REGION domain-containing protein. (453 aa) |
| | ITGAV | Integrin subunit alpha V; Belongs to the integrin alpha chain family. (1052 aa) |
| | G0S2 | G0/G1 switch 2 protein. (103 aa) |
| | CAV1 | Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (177 aa) |
| | CTNNB1 | Catenin beta 1. (808 aa) |
| | PDCD10 | Programmed cell death protein 10. (212 aa) |
| | EYA2 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (583 aa) |
| | ERN2 | Endoplasmic reticulum to nucleus signaling 2. (989 aa) |
| | BAK1 | Uncharacterized protein. (266 aa) |
| | YAP1 | Yes associated protein 1. (432 aa) |
| | POLB | DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (334 aa) |
| | BCL2L1 | Bcl-2-like protein 1; Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage- dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis. Regulates presynaptic plasticity, including neurotransmitter release and recovery, number of axonal mitochondria as well as size and number of synaptic vesicle clusters. During synaptic stimulation, increases ATP availab [...] (233 aa) |
| | ATP2A3 | Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1020 aa) |
| | DAP | Uncharacterized protein. (102 aa) |
| | E2F2 | E2F transcription factor 2. (437 aa) |
| | MAP3K5 | Mitogen-activated protein kinase kinase kinase 5. (1425 aa) |
| | TP53BP2 | Apoptosis-stimulating of p53 protein 2 isoform 1. (1157 aa) |
| | BRCA1 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1865 aa) |
| | BCL2A1 | Bcl-2-related protein A1 isoform 1. (175 aa) |
| | TGFB2 | Transforming growth factor beta-2 proprotein; Transforming growth factor beta-2 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively. Transforming growth factor beta-2: Multifunctional protein that regulates various processes such as angiogenesis and heart development (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transfor [...] (443 aa) |
| | PDPK1 | 3-phosphoinositide dependent protein kinase 1. (668 aa) |
| | TNFRSF1A | Tumor necrosis factor receptor superfamily member 1A; Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis (By similarity). (464 aa) |
| | ISG12(A) | Uncharacterized protein. (217 aa) |
| | COL2A1 | Collagen type II alpha 1 chain. (1486 aa) |
| | IFNG | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (166 aa) |
| | P2RX4 | P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (388 aa) |
| | PCGF2 | Polycomb group RING finger protein 2 isoform X1. (344 aa) |
| | RNF41 | E3 ubiquitin-protein ligase NRDP1 isoform 1. (317 aa) |
| | MYBBP1A | MYB binding protein 1a. (1594 aa) |
| | DYRK2 | Dual specificity tyrosine-phosphorylation-regulated kinase 2 isoform 2. (601 aa) |
| | CFLAR | CASP8 and FADD-like apoptosis regulator isoform 1; Belongs to the peptidase C14A family. (509 aa) |
| | CHAC1 | Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family. (219 aa) |
| | RHOT1 | Ras homolog family member T1. (752 aa) |
| | SORT1 | Sortilin. (963 aa) |
| | EYA1 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (618 aa) |
| | TM2D1 | TM2 domain containing 1. (214 aa) |
| | HTRA2 | HtrA serine peptidase 2. (444 aa) |
| | GSKIP | DUF727 domain-containing protein. (282 aa) |
| | DDX47 | Putative ATP-dependent RNA helicase DDX47; Belongs to the DEAD box helicase family. (493 aa) |
| | CHEK2 | Serine/threonine-protein kinase Chk2 isoform X4. (553 aa) |
| | PTPRC | Protein tyrosine phosphatase receptor type C. (1092 aa) |
| | DDIT4 | Uncharacterized protein. (231 aa) |
| | FIS1 | Mitochondrial fission 1 protein; Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. (152 aa) |
| | APAF1 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1249 aa) |
| | BAD | BCL2 associated agonist of cell death. (209 aa) |
| | FGFR3 | Fibroblast growth factor receptor. (855 aa) |
| | DIDO1 | Death inducer-obliterator 1. (2242 aa) |
| | BNIP3L | BCL2 interacting protein 3 like. (204 aa) |
| | BOK | BCL2 family apoptosis regulator BOK. (288 aa) |
| | DDIT3 | DNA-damage-inducible transcript 3. (167 aa) |
| | ATP2A1 | Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1021 aa) |
| | TOPORS | TOP1 binding arginine/serine rich protein. (1049 aa) |
| | A0A287ANP8_PIG | Uncharacterized protein. (89 aa) |
| | CEBPB | CCAAT/enhancer-binding protein. (346 aa) |
| | GSK3B | Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (414 aa) |
| | KRT8 | Keratin, type II cytoskeletal 8 isoform 2; Belongs to the intermediate filament family. (461 aa) |
| | PAWR | Pro-apoptotic WT1 regulator. (336 aa) |
| | STK3 | Serine/threonine kinase 3. (542 aa) |
| | TNFSF12 | TNF superfamily member 12; Belongs to the tumor necrosis factor family. (386 aa) |
| | SHISA5 | Shisa family member 5. (242 aa) |
| | PYCARD | Apoptosis-associated speck-like protein containing a CARD isoform a. (196 aa) |
| | IFI6 | Interferon alpha inducible protein 6. (171 aa) |
| | NBN | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (752 aa) |
| | FHIT | Fragile histidine triad diadenosine triphosphatase. (150 aa) |
| | RNF186 | Ring finger protein 186. (191 aa) |
| | CASP3 | Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). (266 aa) |
| | NOL3 | Nucleolar protein 3. (237 aa) |
| | A0A287B1R4_PIG | Uncharacterized protein. (34 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (442 aa) |
| | HRAS | HRas proto-oncogene, GTPase. (189 aa) |
| | INHBA | Inhibin beta A chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins. (424 aa) |
| | IVNS1ABP | Influenza virus NS1A binding protein. (668 aa) |
| | ERO1A | ERO1-like protein alpha; Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation. Following P4HB reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell. Required for the proper folding of immunoglobulins. Plays an important role in ER stress-induced, CHOP-dependent apoptosis by activating the inositol 1,4,5-trisphosphate recep [...] (486 aa) |
| | UACA | Uveal autoantigen with coiled-coil domains and ankyrin repeats. (1566 aa) |
| | TMEM117 | Transmembrane protein 117 isoform X1. (514 aa) |
| | ATF2 | Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa) |
| | CLU | Clusterin alpha chain; Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysos [...] (472 aa) |
| | A0A287B8J8_PIG | Uncharacterized protein. (617 aa) |
| | PDX1 | Homeobox domain-containing protein. (284 aa) |
| | POU4F1 | POU domain protein. (421 aa) |
| | SGPL1 | Sphingosine-1-phosphate lyase 1. (609 aa) |
| | ATAD5 | ATPase family AAA domain containing 5. (1891 aa) |
| | ITPRIPL2 | Inositol 1,4,5-trisphosphate receptor-interacting protein-like 2. (532 aa) |
| | CYP1B1 | Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. (543 aa) |
| | SENP1 | SUMO specific peptidase 1. (677 aa) |
| | MCL1 | Induced myeloid leukemia cell differentiation protein Mcl-1. (351 aa) |
| | NGF | Beta-nerve growth factor; Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades to regulate neuronal proliferation, differentiation and survival (By similarity). The immature NGF precursor (proNGF) functions as ligand for the heterodimeric receptor formed by SORCS2 and NGFR, and activates cellular signaling cascades that lead to inactivation of RAC1 and/or RAC2, reorganization of the actin cytoskeleton and neuronal growth cone colla [...] (385 aa) |
| | DDX5 | DEAD-box helicase 5; Belongs to the DEAD box helicase family. (617 aa) |
| | MELK | Non-specific serine/threonine protein kinase. (655 aa) |
| | ATF4 | Activating transcription factor 4. (329 aa) |
| | TRADD | Tumor necrosis factor receptor type 1-associated DEATH domain protein. (304 aa) |
| | PPP1R13B | Protein phosphatase 1 regulatory subunit 13B. (1196 aa) |
| | TRIB3 | Tribbles pseudokinase 3. (373 aa) |
| | INHBB | Inhibin beta B chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins. (407 aa) |
| | JMY | Junction mediating and regulatory protein, p53 cofactor. (991 aa) |
| | WWOX | WW domain containing oxidoreductase. (414 aa) |
| | CASP6 | Caspase 6; Belongs to the peptidase C14A family. (292 aa) |
| | INCA1 | Uncharacterized protein. (295 aa) |
| | CTTN | Cortactin. (685 aa) |
| | ENSA | Alpha-endosulfine; Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-67 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. Also acts as a stimulator of insulin secretion by interacting with sulfonylurea receptor (ABCC8), thereby preventing sulfonylurea from binding to its receptor and reducing K(ATP) channel currents (By similarity); Belongs to the endosulfine [...] (137 aa) |
| | IL18 | Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (201 aa) |
| | BBC3 | Uncharacterized protein. (361 aa) |
| | CD28 | IGv domain-containing protein. (222 aa) |
| | STK4 | Serine/threonine kinase 4. (502 aa) |
| | GGCT | Uncharacterized protein. (188 aa) |
| | ACVR1B | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (547 aa) |
| | SMAD3 | Mothers against decapentaplegic homolog. (434 aa) |
| | MYC | Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). (452 aa) |
