(27 nodes) Extrinsic apoptotic signaling pathway in absence of ligand network (Sus scrofa)

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	BCL2A1	Bcl-2-related protein A1 isoform 1. (175 aa)
	ITGAV	Integrin subunit alpha V; Belongs to the integrin alpha chain family. (1052 aa)
	FADD	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (211 aa)
	ERBB3	Erb-b2 receptor tyrosine kinase 3. (1342 aa)
	NF1	Neurofibromin 1. (2847 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
	CTNNA1	Catenin alpha 1. (1090 aa)
	IL4	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (133 aa)
	BAG3	BCL2 associated athanogene 3. (609 aa)
	BCL2L11	Uncharacterized protein. (433 aa)
	IL1A	Interleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. (270 aa)
	BCL2L10	Uncharacterized protein. (184 aa)
	FOXO3	Forkhead box protein O3 isoform X1. (672 aa)
	BAX	Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase; Belongs to the Gfo/Idh/MocA family. (480 aa)
	GSK3A	Protein kinase domain-containing protein. (566 aa)
	EYA2	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (583 aa)
	COL2A1	Collagen type II alpha 1 chain. (1486 aa)
	EYA1	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (618 aa)
	BAD	BCL2 associated agonist of cell death. (209 aa)
	BOK	BCL2 family apoptosis regulator BOK. (288 aa)
	GSK3B	Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (414 aa)
	MCL1	Induced myeloid leukemia cell differentiation protein Mcl-1. (351 aa)
	IL2	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family. (154 aa)
	FAS	Tumor necrosis factor receptor superfamily member 6; Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen- stimulated suicide of mature T-cells, or both (By similarity). (428 aa)
	ENSA	Alpha-endosulfine; Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-67 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. Also acts as a stimulator of insulin secretion by interacting with sulfonylurea receptor (ABCC8), thereby preventing sulfonylurea from binding to its receptor and reducing K(ATP) channel currents (By similarity); Belongs to the endosulfine [...] (137 aa)
	BCL2L1	Bcl-2-like protein 1; Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage- dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis. Regulates presynaptic plasticity, including neurotransmitter release and recovery, number of axonal mitochondria as well as size and number of synaptic vesicle clusters. During synaptic stimulation, increases ATP availab [...] (233 aa)
	BAK1	Uncharacterized protein. (266 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BAD	BAK1	ENSSSCP00000042395	ENSSSCP00000032742	BCL2 associated agonist of cell death.	Uncharacterized protein.	0.805
BAD	BCL2A1	ENSSSCP00000042395	ENSSSCP00000034483	BCL2 associated agonist of cell death.	Bcl-2-related protein A1 isoform 1.	0.647
BAD	BCL2L1	ENSSSCP00000042395	ENSSSCP00000033436	BCL2 associated agonist of cell death.	Bcl-2-like protein 1; Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage- dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis. Regulates presynaptic plasticity, including neurotransmitter release and recovery, number of axonal mitochondria as well as size and number of synaptic vesicle clusters. During synaptic stimulation, increases ATP availab [...]	0.998
BAD	BCL2L10	ENSSSCP00000042395	ENSSSCP00000004982	BCL2 associated agonist of cell death.	Uncharacterized protein.	0.706
BAD	BCL2L11	ENSSSCP00000042395	ENSSSCP00000008657	BCL2 associated agonist of cell death.	Uncharacterized protein.	0.870
BAD	BOK	ENSSSCP00000042395	ENSSSCP00000044300	BCL2 associated agonist of cell death.	BCL2 family apoptosis regulator BOK.	0.751
BAD	FADD	ENSSSCP00000042395	ENSSSCP00000030483	BCL2 associated agonist of cell death.	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	0.528
BAD	MCL1	ENSSSCP00000042395	ENSSSCP00000056528	BCL2 associated agonist of cell death.	Induced myeloid leukemia cell differentiation protein Mcl-1.	0.686
BAK1	BAD	ENSSSCP00000032742	ENSSSCP00000042395	Uncharacterized protein.	BCL2 associated agonist of cell death.	0.805
BAK1	BAX	ENSSSCP00000032742	ENSSSCP00000003404	Uncharacterized protein.	Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase; Belongs to the Gfo/Idh/MocA family.	0.901
BAK1	BCL2A1	ENSSSCP00000032742	ENSSSCP00000034483	Uncharacterized protein.	Bcl-2-related protein A1 isoform 1.	0.917
BAK1	BCL2L1	ENSSSCP00000032742	ENSSSCP00000033436	Uncharacterized protein.	Bcl-2-like protein 1; Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage- dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis. Regulates presynaptic plasticity, including neurotransmitter release and recovery, number of axonal mitochondria as well as size and number of synaptic vesicle clusters. During synaptic stimulation, increases ATP availab [...]	0.998
BAK1	BCL2L10	ENSSSCP00000032742	ENSSSCP00000004982	Uncharacterized protein.	Uncharacterized protein.	0.633
BAK1	BCL2L11	ENSSSCP00000032742	ENSSSCP00000008657	Uncharacterized protein.	Uncharacterized protein.	0.896
BAK1	FADD	ENSSSCP00000032742	ENSSSCP00000030483	Uncharacterized protein.	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	0.470
BAK1	MCL1	ENSSSCP00000032742	ENSSSCP00000056528	Uncharacterized protein.	Induced myeloid leukemia cell differentiation protein Mcl-1.	0.874
BAX	BAK1	ENSSSCP00000003404	ENSSSCP00000032742	Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase; Belongs to the Gfo/Idh/MocA family.	Uncharacterized protein.	0.901
BAX	BCL2L1	ENSSSCP00000003404	ENSSSCP00000033436	Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase; Belongs to the Gfo/Idh/MocA family.	Bcl-2-like protein 1; Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage- dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis. Regulates presynaptic plasticity, including neurotransmitter release and recovery, number of axonal mitochondria as well as size and number of synaptic vesicle clusters. During synaptic stimulation, increases ATP availab [...]	0.901
BAX	ENSA	ENSSSCP00000003404	ENSSSCP00000069445	Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase; Belongs to the Gfo/Idh/MocA family.	Alpha-endosulfine; Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-67 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. Also acts as a stimulator of insulin secretion by interacting with sulfonylurea receptor (ABCC8), thereby preventing sulfonylurea from binding to its receptor and reducing K(ATP) channel currents (By similarity); Belongs to the endosulfine [...]	0.404
BCL2A1	BAD	ENSSSCP00000034483	ENSSSCP00000042395	Bcl-2-related protein A1 isoform 1.	BCL2 associated agonist of cell death.	0.647