STRINGSTRING
MAP1LC3B MAP1LC3B PIK3C3 PIK3C3 ATG14 ATG14 MAP1LC3A MAP1LC3A MFSD8 MFSD8 RUBCNL RUBCNL SNAP29 SNAP29 CHMP5 CHMP5 CHMP2B CHMP2B CHMP6 CHMP6 BECN1 BECN1 CHMP4C CHMP4C VAMP8 VAMP8 LIX1 LIX1 LIX1L LIX1L EPG5 EPG5 CHMP2A CHMP2A CHMP1A CHMP1A VPS33A VPS33A UVRAG UVRAG CHMP4A CHMP4A STX17 STX17 SNAPIN SNAPIN VCP VCP MCOLN1 MCOLN1 ATP2A2 ATP2A2 VMP1 VMP1 MAP1LC3C MAP1LC3C CHMP7 CHMP7 UBQLN1 UBQLN1 CLN3 CLN3 TECPR1 TECPR1 LAMP2 LAMP2 PIK3R4 PIK3R4 VPS16 VPS16 SNX14 SNX14 CHMP3 CHMP3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAP1LC3BMicrotubule-associated protein 1 light chain 3 beta. (125 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3; Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2. Involved in the transport of lysosomal enzyme precursors to lysosomes. Requ [...] (863 aa)
ATG14Autophagy related 14. (510 aa)
MAP1LC3AMicrotubule-associated protein 1 light chain 3 alpha. (121 aa)
MFSD8Major facilitator superfamily domain containing 8. (517 aa)
RUBCNLRubicon like autophagy enhancer. (664 aa)
SNAP29Synaptosome associated protein 29. (258 aa)
CHMP5Uncharacterized protein. (219 aa)
CHMP2BCharged multivesicular body protein 2B. (213 aa)
CHMP6Charged multivesicular body protein 6. (201 aa)
BECN1Beclin-1-C 35 kDa; Plays a central role in autophagy. Acts as core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3- phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2. Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex f [...] (461 aa)
CHMP4CCharged multivesicular body protein 4C. (237 aa)
VAMP8V-SNARE coiled-coil homology domain-containing protein. (143 aa)
LIX1Limb and CNS expressed 1. (281 aa)
LIX1LLimb and CNS expressed 1 like. (337 aa)
EPG5Ectopic P-granules autophagy protein 5 homolog. (2577 aa)
CHMP2ACharged multivesicular body protein 2A. (222 aa)
CHMP1AUncharacterized protein. (196 aa)
VPS33AVacuolar protein sorting 33A homolog; Belongs to the STXBP/unc-18/SEC1 family. (596 aa)
UVRAGUV radiation resistance associated. (748 aa)
CHMP4ACharged multivesicular body protein 4A. (229 aa)
STX17Syntaxin-17 isoform X1; Belongs to the syntaxin family. (302 aa)
SNAPINSNARE-associated protein Snapin; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling; Belongs to t [...] (136 aa)
VCPTransitional endoplasmic reticulum ATPase; Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is neces [...] (878 aa)
MCOLN1Mucolipin 1. (663 aa)
ATP2A2Sarcoplasmic/endoplasmic reticulum calcium ATPase 2; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Isoform SERCA2A is involved in the regulation of the contraction/relaxation cycle. Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathways via its interaction with TMEM64 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation. Association between TMEM64 and SERCA2 in the ER leads to cytos [...] (1042 aa)
VMP1Vacuole membrane protein 1. (417 aa)
MAP1LC3CMicrotubule associated protein 1 light chain 3 gamma. (147 aa)
CHMP7Charged multivesicular body protein 7. (505 aa)
UBQLN1Ubiquilin 1. (582 aa)
CLN3Battenin. (414 aa)
TECPR1Tectonin beta-propeller repeat containing 1. (1070 aa)
LAMP2Lysosome-associated membrane glycoprotein 2 isoform A. (411 aa)
PIK3R4Phosphoinositide-3-kinase regulatory subunit 4. (1302 aa)
VPS16Vacuolar protein sorting-associated protein 16 homolog; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes. Belongs to the VPS16 family. (842 aa)
SNX14Sorting nexin 14. (944 aa)
CHMP3Uncharacterized protein. (251 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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