STRINGSTRING
LSM14A LSM14A WDFY4 WDFY4 SMAD3 SMAD3 NFKB1 NFKB1 IFI6 IFI6 RIOK3 RIOK3 HIF1A HIF1A ATF2 ATF2 LGALS8 LGALS8 ZC3H12A ZC3H12A POU2F2 POU2F2 BAX BAX EXT1 EXT1 CHUK CHUK CCL19 CCL19 TLR8 TLR8 DDX3X DDX3X VWCE VWCE TLR3 TLR3 DHX58 DHX58 PHB PHB RNF135 RNF135 RRP1B RRP1B IKBKE IKBKE S100A6 S100A6 PHB2 PHB2 TRIM6 TRIM6 IRF3 IRF3 TGFB1 TGFB1 FMR1 FMR1 MAPK11 MAPK11 CXCL10 CXCL10 CLPB CLPB GSDME GSDME IL21 IL21 IFIH1 IFIH1 DDX58 DDX58 HSP90AA1 HSP90AA1 PRPS2 PRPS2 ADAR ADAR POU2AF1 POU2AF1 TOMM70 TOMM70
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LSM14AUncharacterized protein. (475 aa)
WDFY4WDFY family member 4. (1979 aa)
SMAD3Mothers against decapentaplegic homolog. (434 aa)
NFKB1Uncharacterized protein. (898 aa)
IFI6Interferon alpha inducible protein 6. (171 aa)
RIOK3Serine/threonine-protein kinase RIO3; Involved in regulation of type I interferon (IFN)-dependent immune response which plays a critical role in the innate immune response against DNA and RNA viruses. (519 aa)
HIF1AHypoxia-inducible factor 1-alpha isoform 1. (824 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
LGALS8Galectin. (368 aa)
ZC3H12AZinc finger CCCH-type containing 12A. (582 aa)
POU2F2POU domain, class 2, transcription factor 2; Transcription factor that specifically binds to the octamer motif (5'-ATTTGCAT-3'). Regulates transcription in a number of tissues in addition to activating immunoglobulin gene expression. Modulates transcription transactivation by NR3C1, AR and PGR (By similarity). Belongs to the POU transcription factor family. Class-2 subfamily. (711 aa)
BAXTrans-1,2-dihydrobenzene-1,2-diol dehydrogenase; Belongs to the Gfo/Idh/MocA family. (480 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
CHUKProtein kinase domain-containing protein. (580 aa)
CCL19C-C motif chemokine. (100 aa)
TLR8Toll like receptor 8; Belongs to the Toll-like receptor family. (1117 aa)
DDX3XATP-dependent RNA helicase DDX3X isoform 1; Belongs to the DEAD box helicase family. (662 aa)
VWCEVon Willebrand factor C and EGF domains. (941 aa)
TLR3TIR domain-containing protein; Belongs to the Toll-like receptor family. (903 aa)
DHX58DExH-box helicase 58. (681 aa)
PHBProhibitin. (272 aa)
RNF135E3 ubiquitin-protein ligase RNF135 isoform 1. (423 aa)
RRP1BRibosomal RNA processing 1B. (739 aa)
IKBKEInhibitor of nuclear factor kappa-B kinase subunit epsilon isoform 1. (718 aa)
S100A6Protein S100-A6; May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes such as the reorganization of the actin cytoskeleton and in cell motility. Binds 2 calcium ions. Calcium binding is cooperative (By similarity). (90 aa)
PHB2Prohibitin. (299 aa)
TRIM6Tripartite motif containing 6. (487 aa)
IRF3Interferon regulatory factor 3; Key transcriptional regulator of type I interferon (IFN)- dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN- stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction. Found in an inactiv [...] (452 aa)
TGFB1Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa)
FMR1Fragile X mental retardation protein 1. (632 aa)
MAPK11Mitogen-activated protein kinase. (364 aa)
CXCL10C-X-C motif chemokine. (104 aa)
CLPBClpB homolog, mitochondrial AAA ATPase chaperonin. (721 aa)
GSDMEGasdermin E. (495 aa)
IL21Interleukin-21; Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells. May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells (By similarity). During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation; Belongs to the IL-1 [...] (160 aa)
IFIH1Interferon induced with helicase C domain 1. (1023 aa)
DDX58Antiviral innate immune response receptor RIG-I; Innate immune receptor that senses cytoplasmic viral nucleic acids and activates a downstream signaling cascade leading to the production of type I interferons and proinflammatory cytokines. Forms a ribonucleoprotein complex with viral RNAs on which it homooligomerizes to form filaments. The homooligomerization allows the recruitment of RNF135 an E3 ubiquitin-protein ligase that activates and amplifies the RIG-I-mediated antiviral signaling in an RNA length-dependent manner through ubiquitination-dependent and -independent mechanisms. Up [...] (943 aa)
HSP90AA1Heat shock protein HSP 90-alpha; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a ra [...] (789 aa)
PRPS2TIR domain-containing protein. (1337 aa)
ADARAdenosine deaminase RNA specific. (1169 aa)
POU2AF1Uncharacterized protein. (255 aa)
TOMM70Translocase of outer mitochondrial membrane 70. (609 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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