21 items (Sus scrofa) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

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Your Input:
	NPPC	C-type natriuretic peptide; Hormone which plays a role in endochondral ossification through regulation of cartilaginous growth plate chondrocytes proliferation and differentiation. May also be vasoactive and natriuretic. Specifically binds and stimulates the cGMP production of the NPR2 receptor. Binds the clearance receptor NPR3 (By similarity). (126 aa)
	EXT1	Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
	DDR2	Discoidin domain receptor tyrosine kinase 2. (866 aa)
	COMP	Cartilage oligomeric matrix protein. (756 aa)
	MMP13	Matrix metallopeptidase 13. (470 aa)
	ANXA6	Annexin. (672 aa)
	SOX9	Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (511 aa)
	MATN1	Matrilin 1. (496 aa)
	IFT80	Intraflagellar transport 80. (767 aa)
	ECM1	Extracellular matrix protein 1. (559 aa)
	LEPR	Leptin receptor; Receptor for hormone LEP/leptin (By similarity). On ligand binding, mediates LEP central and peripheral effects through the activation of different signaling pathways such as JAK2/STAT3 and MAPK cascade/FOS. In the hypothalamus, LEP acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, increases basal metabolism, influences reproductiv [...] (1165 aa)
	BNC2	Basonuclin 2. (1085 aa)
	ZMPSTE24	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (475 aa)
	RARG	Retinoic acid receptor gamma. (554 aa)
	RARA	Retinoic acid receptor alpha isoform X1. (462 aa)
	OSTN	Musclin. (132 aa)
	THBS3	Thrombospondin-3 isoform 1. (973 aa)
	SMPD3	Sphingomyelin phosphodiesterase 3. (656 aa)
	EVC	Ellis-van Creveld syndrome protein isoform 2. (991 aa)
	ATF2	Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
	LEP	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] (192 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
COMP	ECM1	ENSSSCP00000014796	ENSSSCP00000021637	Cartilage oligomeric matrix protein.	Extracellular matrix protein 1.	0.415
COMP	MATN1	ENSSSCP00000014796	ENSSSCP00000019357	Cartilage oligomeric matrix protein.	Matrilin 1.	0.620
COMP	MMP13	ENSSSCP00000014796	ENSSSCP00000015912	Cartilage oligomeric matrix protein.	Matrix metallopeptidase 13.	0.609
COMP	SOX9	ENSSSCP00000014796	ENSSSCP00000018278	Cartilage oligomeric matrix protein.	Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219.	0.615
ECM1	COMP	ENSSSCP00000021637	ENSSSCP00000014796	Extracellular matrix protein 1.	Cartilage oligomeric matrix protein.	0.415
EVC	IFT80	ENSSSCP00000049939	ENSSSCP00000020004	Ellis-van Creveld syndrome protein isoform 2.	Intraflagellar transport 80.	0.414
IFT80	EVC	ENSSSCP00000020004	ENSSSCP00000049939	Intraflagellar transport 80.	Ellis-van Creveld syndrome protein isoform 2.	0.414
LEP	LEPR	ENSSSCP00000056831	ENSSSCP00000022838	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...]	Leptin receptor; Receptor for hormone LEP/leptin (By similarity). On ligand binding, mediates LEP central and peripheral effects through the activation of different signaling pathways such as JAK2/STAT3 and MAPK cascade/FOS. In the hypothalamus, LEP acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, increases basal metabolism, influences reproductiv [...]	0.999
LEPR	LEP	ENSSSCP00000022838	ENSSSCP00000056831	Leptin receptor; Receptor for hormone LEP/leptin (By similarity). On ligand binding, mediates LEP central and peripheral effects through the activation of different signaling pathways such as JAK2/STAT3 and MAPK cascade/FOS. In the hypothalamus, LEP acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, increases basal metabolism, influences reproductiv [...]	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...]	0.999
MATN1	COMP	ENSSSCP00000019357	ENSSSCP00000014796	Matrilin 1.	Cartilage oligomeric matrix protein.	0.620
MMP13	COMP	ENSSSCP00000015912	ENSSSCP00000014796	Matrix metallopeptidase 13.	Cartilage oligomeric matrix protein.	0.609
MMP13	SOX9	ENSSSCP00000015912	ENSSSCP00000018278	Matrix metallopeptidase 13.	Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219.	0.769
RARA	RARG	ENSSSCP00000035518	ENSSSCP00000032642	Retinoic acid receptor alpha isoform X1.	Retinoic acid receptor gamma.	0.414
RARG	RARA	ENSSSCP00000032642	ENSSSCP00000035518	Retinoic acid receptor gamma.	Retinoic acid receptor alpha isoform X1.	0.414
SOX9	COMP	ENSSSCP00000018278	ENSSSCP00000014796	Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219.	Cartilage oligomeric matrix protein.	0.615
SOX9	MMP13	ENSSSCP00000018278	ENSSSCP00000015912	Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219.	Matrix metallopeptidase 13.	0.769