STRINGSTRING
ERC2 ERC2 SNAP47 SNAP47 PRRT2 PRRT2 DOC2B DOC2B UNC13C UNC13C SYNDIG1 SYNDIG1 OTOF OTOF NOSTRIN NOSTRIN RIMS1 RIMS1 ITSN1 ITSN1 SNCG SNCG AP3D1 AP3D1 SLC17A7 SLC17A7 UNC13B UNC13B SH3GL3 SH3GL3 CADPS CADPS OPHN1 OPHN1 SLC18A1 SLC18A1 VAMP2 VAMP2 RIMS2 RIMS2 SNAP25 SNAP25 DNM2 DNM2 RAP1A RAP1A RIMS3 RIMS3 A0A287AZ68_PIG A0A287AZ68_PIG CANX CANX DENND1A DENND1A CADPS2 CADPS2 FCHO2 FCHO2 UNC13A UNC13A CPLX2 CPLX2 STX4 STX4 PACSIN1 PACSIN1 SNAP23 SNAP23 STX3 STX3 LOC100624109-2 LOC100624109-2 ACTG1 ACTG1 A0A287AA37_PIG A0A287AA37_PIG NLGN3 NLGN3 DNM3 DNM3 GIT2 GIT2 STXBP1 STXBP1 SYNJ1 SYNJ1 BRAF BRAF ACTB ACTB SNAP91 SNAP91 DNAJC6 DNAJC6 SNAPIN SNAPIN CLCN3 CLCN3 RAB5A RAB5A STON2 STON2 SYNPR SYNPR LOC100624109 LOC100624109 TBC1D24 TBC1D24 PPFIA3 PPFIA3 SLC17A8 SLC17A8 SNCA SNCA CTNNB1 CTNNB1 STX2 STX2 SYN1 SYN1 SYT5 SYT5 STX1B STX1B PCLO PCLO DNM1 DNM1 SYT8 SYT8 AMPH AMPH SYNJ2 SYNJ2 SLC18A2 SLC18A2 GIT1 GIT1 PICALM PICALM SYT9 SYT9 AP3B1 AP3B1 SNCB SNCB RAB3A RAB3A SH3GL1 SH3GL1 SLC17A6 SLC17A6 SYP SYP NLGN1 NLGN1 SYT2 SYT2 CTBP2 CTBP2 SNAP29 SNAP29 P2RX7 P2RX7 STX1A STX1A SLC32A1 SLC32A1 SV2A SV2A SH3GL2 SH3GL2 CPLX4 CPLX4 STX11 STX11 PSEN1 PSEN1 CPLX3 CPLX3 LRRC1 LRRC1 SYT1 SYT1 LRRK2 LRRK2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ERC2ELKS/RAB6-interacting/CAST family member 2. (969 aa)
SNAP47Synaptosome associated protein 47. (449 aa)
PRRT2Proline-rich transmembrane protein 2 isoform 3. (406 aa)
DOC2BDouble C2-like domain-containing protein. (412 aa)
UNC13CUnc-13 homolog C. (2214 aa)
SYNDIG1Synapse differentiation-inducing gene protein 1 isoform X2. (258 aa)
OTOFOtoferlin. (1997 aa)
NOSTRINNitric oxide synthase trafficking. (504 aa)
RIMS1Regulating synaptic membrane exocytosis 1. (1684 aa)
ITSN1Intersectin 1. (1485 aa)
SNCGGamma-synuclein; Belongs to the synuclein family. (153 aa)
AP3D1Adaptor related protein complex 3 subunit delta 1. (1232 aa)
SLC17A7Solute carrier family 17 member 7. (567 aa)
UNC13BUncharacterized protein. (4266 aa)
SH3GL3SH3 domain containing GRB2 like 3, endophilin A3. (512 aa)
CADPSUncharacterized protein. (1370 aa)
OPHN1Oligophrenin 1. (808 aa)
SLC18A1Solute carrier family 18 member A1. (524 aa)
VAMP2V-SNARE coiled-coil homology domain-containing protein. (189 aa)
RIMS2Regulating synaptic membrane exocytosis 2. (1348 aa)
SNAP25Synaptosomal-associated protein; Belongs to the SNAP-25 family. (206 aa)
DNM2Dynamin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (877 aa)
RAP1ARAP1A, member of RAS oncogene family. (184 aa)
RIMS3Regulating synaptic membrane exocytosis 3. (312 aa)
A0A287AZ68_PIGPDZ domain-containing protein. (909 aa)
CANXCalnexin. (615 aa)
DENND1ADENN domain-containing protein 1A isoform 3. (1069 aa)
CADPS2Calcium dependent secretion activator 2. (1297 aa)
FCHO2F-BAR domain only protein 2 isoform X1. (809 aa)
UNC13AUncharacterized protein. (1581 aa)
CPLX2Complexin 2. (163 aa)
STX4Syntaxin 4; Belongs to the syntaxin family. (338 aa)
PACSIN1Protein kinase C and casein kinase substrate in neurons 1. (376 aa)
SNAP23Synaptosomal-associated protein; Belongs to the SNAP-25 family. (222 aa)
STX3Syntaxin 3; Belongs to the syntaxin family. (347 aa)
LOC100624109-2COesterase domain-containing protein. (836 aa)
ACTG1Actin gamma 1. (381 aa)
A0A287AA37_PIGENTH domain-containing protein. (274 aa)
NLGN3Neuroligin-3 isoform 1. (848 aa)
DNM3Dynamin 3; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (863 aa)
GIT2GIT ArfGAP 2. (853 aa)
STXBP1Syntaxin binding protein 1; Belongs to the STXBP/unc-18/SEC1 family. (609 aa)
SYNJ1Synaptojanin 1. (1576 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (804 aa)
ACTBActin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (375 aa)
SNAP91Synaptosome associated protein 91. (906 aa)
DNAJC6DnaJ heat shock protein family (Hsp40) member C6. (973 aa)
SNAPINSNARE-associated protein Snapin; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling; Belongs to t [...] (136 aa)
CLCN3Chloride channel protein. (866 aa)
RAB5ARas-related protein Rab-5A; Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Active GTP-bound form is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes. Contributes to the regulati [...] (215 aa)
STON2Stonin-2; Adapter protein involved in endocytic machinery. Involved in the synaptic vesicle recycling. May facilitate clathrin-coated vesicle uncoating; Belongs to the Stoned B family. (955 aa)
SYNPRSynaptoporin. (288 aa)
LOC100624109COesterase domain-containing protein. (835 aa)
TBC1D24Uncharacterized protein. (559 aa)
PPFIA3PTPRF interacting protein alpha 3. (1235 aa)
SLC17A8Solute carrier family 17 member 8. (544 aa)
SNCAAlpha-synuclein; Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs [...] (142 aa)
CTNNB1Catenin beta 1. (808 aa)
STX2Syntaxin 2; Belongs to the syntaxin family. (347 aa)
SYN1Synapsin-1 isoform Ia. (712 aa)
SYT5Synaptotagmin 5. (385 aa)
STX1BSyntaxin 1B; Belongs to the syntaxin family. (288 aa)
PCLOPiccolo presynaptic cytomatrix protein. (5107 aa)
DNM1Dynamin 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (880 aa)
SYT8Synaptotagmin 8. (381 aa)
AMPHUncharacterized protein. (678 aa)
SYNJ2Synaptojanin 2. (1402 aa)
SLC18A2MFS domain-containing protein. (517 aa)
GIT1GIT ArfGAP 1. (761 aa)
PICALMPhosphatidylinositol binding clathrin assembly protein. (700 aa)
SYT9Synaptotagmin-9. (491 aa)
AP3B1AP-3 complex subunit beta; Belongs to the adaptor complexes large subunit family. (1130 aa)
SNCBBeta-synuclein; Belongs to the synuclein family. (183 aa)
RAB3ARas-related protein Rab-3A; Small GTP-binding protein that plays a central role in regulated exocytosis and secretion. Controls the recruitment, tethering and docking of secretory vesicles to the plasma membrane (By similarity). Upon stimulation, switches to its active GTP-bound form, cycles to vesicles and recruits effectors such as RIMS1, RIMS2, Rabphilin-3A/RPH3A, RPH3AL or SYTL4 to help the docking of vesicules onto the plasma membrane (By similarity). Upon GTP hydrolysis by GTPase-activating protein, dissociates from the vesicle membrane allowing the exocytosis to proceed (By simi [...] (254 aa)
SH3GL1SH3 domain containing GRB2 like 1, endophilin A2. (405 aa)
SLC17A6Solute carrier family 17 member 6. (582 aa)
SYPSynaptophysin. (319 aa)
NLGN1Neuroligin 1. (823 aa)
SYT2Synaptotagmin 2. (417 aa)
CTBP2C-terminal binding protein 2. (982 aa)
SNAP29Synaptosome associated protein 29. (258 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (595 aa)
STX1ASyntaxin 1A; Belongs to the syntaxin family. (295 aa)
SLC32A1Vesicular inhibitory amino acid transporter. (526 aa)
SV2ASynaptic vesicle glycoprotein 2A isoform 1. (742 aa)
SH3GL2SH3 domain containing GRB2 like 2, endophilin A1. (352 aa)
CPLX4Complexin 4. (160 aa)
STX11Syntaxin-11 isoform X1; Belongs to the syntaxin family. (287 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (463 aa)
CPLX3Complexin 3. (158 aa)
LRRC1Leucine rich repeat containing 1. (524 aa)
SYT1Synaptotagmin 1. (379 aa)
LRRK2Uncharacterized protein. (2501 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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