STRINGSTRING
PDZD3 PDZD3 PDK2 PDK2 NCS1 NCS1 PDK1 PDK1 PDK4 PDK4 FLCN FLCN GUCA1A GUCA1A GUCA1B GUCA1B GUCA2B GUCA2B SPHK2 SPHK2 ADORA2B ADORA2B PARP1 PARP1 PPARGC1A PPARGC1A RD3 RD3 PID1 PID1 TREM2 TREM2 ENO1 ENO1 ATPSCKMT ATPSCKMT NOS3 NOS3 PPARA PPARA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PDZD3Na(+)/H(+) exchange regulatory cofactor NHE-RF4 isoform 1. (506 aa)
PDK2Protein-serine/threonine kinase. (437 aa)
NCS1Neuronal calcium sensor 1. (190 aa)
PDK1Protein-serine/threonine kinase. (454 aa)
PDK4Protein-serine/threonine kinase. (411 aa)
FLCNUDENN FLCN/SMCR8-type domain-containing protein. (611 aa)
GUCA1AUncharacterized protein. (205 aa)
GUCA1BGuanylate cyclase activator 1B. (203 aa)
GUCA2BGuanylate cyclase activator 2B; Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins. May be a potent physiological regulator of intestinal fluid and electrolyte transport. May be an autocrine/paracrine regulator of intestinal salt and water transport (By similarity); Belongs to the guanylin family. (113 aa)
SPHK2Sphingosine kinase 2. (653 aa)
ADORA2BAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (332 aa)
PARP1Poly [ADP-ribose] polymerase. (1017 aa)
PPARGC1APeroxisome proliferator-activated receptor gamma coactivator 1-alpha; Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. Induces the expression of PERM1 in [...] (796 aa)
RD3Retinal degeneration 3, GUCY2D regulator. (195 aa)
PID1PID domain-containing protein. (223 aa)
TREM2Ig-like domain-containing protein. (248 aa)
ENO1Alpha-enolase isoform X1. (434 aa)
ATPSCKMTATP synthase c subunit lysine N-methyltransferase. (228 aa)
NOS3Nitric oxide synthase, endothelial; Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets (By similarity). (1239 aa)
PPARAUncharacterized protein. (469 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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