20 items (Sus scrofa) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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Predicted Interactions

gene neighborhood

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Your Input:
	PDZD3	Na(+)/H(+) exchange regulatory cofactor NHE-RF4 isoform 1. (506 aa)
	PDK2	Protein-serine/threonine kinase. (437 aa)
	NCS1	Neuronal calcium sensor 1. (190 aa)
	PDK1	Protein-serine/threonine kinase. (454 aa)
	PDK4	Protein-serine/threonine kinase. (411 aa)
	FLCN	UDENN FLCN/SMCR8-type domain-containing protein. (611 aa)
	GUCA1A	Uncharacterized protein. (205 aa)
	GUCA1B	Guanylate cyclase activator 1B. (203 aa)
	GUCA2B	Guanylate cyclase activator 2B; Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins. May be a potent physiological regulator of intestinal fluid and electrolyte transport. May be an autocrine/paracrine regulator of intestinal salt and water transport (By similarity); Belongs to the guanylin family. (113 aa)
	SPHK2	Sphingosine kinase 2. (653 aa)
	ADORA2B	Adenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (332 aa)
	PARP1	Poly [ADP-ribose] polymerase. (1017 aa)
	PPARGC1A	Peroxisome proliferator-activated receptor gamma coactivator 1-alpha; Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. Induces the expression of PERM1 in [...] (796 aa)
	RD3	Retinal degeneration 3, GUCY2D regulator. (195 aa)
	PID1	PID domain-containing protein. (223 aa)
	TREM2	Ig-like domain-containing protein. (248 aa)
	ENO1	Alpha-enolase isoform X1. (434 aa)
	ATPSCKMT	ATP synthase c subunit lysine N-methyltransferase. (228 aa)
	NOS3	Nitric oxide synthase, endothelial; Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets (By similarity). (1239 aa)
	PPARA	Uncharacterized protein. (469 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
GUCA1A	GUCA1B	ENSSSCP00000001774	ENSSSCP00000001775	Uncharacterized protein.	Guanylate cyclase activator 1B.	0.925
GUCA1A	RD3	ENSSSCP00000001774	ENSSSCP00000034069	Uncharacterized protein.	Retinal degeneration 3, GUCY2D regulator.	0.468
GUCA1B	GUCA1A	ENSSSCP00000001775	ENSSSCP00000001774	Guanylate cyclase activator 1B.	Uncharacterized protein.	0.925
GUCA1B	RD3	ENSSSCP00000001775	ENSSSCP00000034069	Guanylate cyclase activator 1B.	Retinal degeneration 3, GUCY2D regulator.	0.448
GUCA2B	PDZD3	ENSSSCP00000004292	ENSSSCP00000058848	Guanylate cyclase activator 2B; Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins. May be a potent physiological regulator of intestinal fluid and electrolyte transport. May be an autocrine/paracrine regulator of intestinal salt and water transport (By similarity); Belongs to the guanylin family.	Na(+)/H(+) exchange regulatory cofactor NHE-RF4 isoform 1.	0.603
PDK1	PDK2	ENSSSCP00000066226	ENSSSCP00000059052	Protein-serine/threonine kinase.	Protein-serine/threonine kinase.	0.788
PDK2	PDK1	ENSSSCP00000059052	ENSSSCP00000066226	Protein-serine/threonine kinase.	Protein-serine/threonine kinase.	0.788
PDK2	PDK4	ENSSSCP00000059052	ENSSSCP00000066529	Protein-serine/threonine kinase.	Protein-serine/threonine kinase.	0.515
PDK4	PDK2	ENSSSCP00000066529	ENSSSCP00000059052	Protein-serine/threonine kinase.	Protein-serine/threonine kinase.	0.515
PDK4	PPARA	ENSSSCP00000066529	ENSSSCP00000000007	Protein-serine/threonine kinase.	Uncharacterized protein.	0.562
PDK4	PPARGC1A	ENSSSCP00000066529	ENSSSCP00000032437	Protein-serine/threonine kinase.	Peroxisome proliferator-activated receptor gamma coactivator 1-alpha; Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. Induces the expression of PERM1 in [...]	0.696
PDZD3	GUCA2B	ENSSSCP00000058848	ENSSSCP00000004292	Na(+)/H(+) exchange regulatory cofactor NHE-RF4 isoform 1.	Guanylate cyclase activator 2B; Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins. May be a potent physiological regulator of intestinal fluid and electrolyte transport. May be an autocrine/paracrine regulator of intestinal salt and water transport (By similarity); Belongs to the guanylin family.	0.603
PPARA	PDK4	ENSSSCP00000000007	ENSSSCP00000066529	Uncharacterized protein.	Protein-serine/threonine kinase.	0.562
PPARA	PPARGC1A	ENSSSCP00000000007	ENSSSCP00000032437	Uncharacterized protein.	Peroxisome proliferator-activated receptor gamma coactivator 1-alpha; Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. Induces the expression of PERM1 in [...]	0.999
PPARGC1A	PDK4	ENSSSCP00000032437	ENSSSCP00000066529	Peroxisome proliferator-activated receptor gamma coactivator 1-alpha; Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. Induces the expression of PERM1 in [...]	Protein-serine/threonine kinase.	0.696
PPARGC1A	PPARA	ENSSSCP00000032437	ENSSSCP00000000007	Peroxisome proliferator-activated receptor gamma coactivator 1-alpha; Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. Induces the expression of PERM1 in [...]	Uncharacterized protein.	0.999
RD3	GUCA1A	ENSSSCP00000034069	ENSSSCP00000001774	Retinal degeneration 3, GUCY2D regulator.	Uncharacterized protein.	0.468
RD3	GUCA1B	ENSSSCP00000034069	ENSSSCP00000001775	Retinal degeneration 3, GUCY2D regulator.	Guanylate cyclase activator 1B.	0.448