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| | PCID2 | PCI domain-containing protein 2 isoform X1. (399 aa) |
| | GLI3 | GLI family zinc finger 3. (1586 aa) |
| | DROSHA | Drosha ribonuclease III. (1397 aa) |
| | FOXJ1 | Forkhead box J1. (421 aa) |
| | PRKCA | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (669 aa) |
| | STAT5A | Signal transducer and activator of transcription 5A; Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the GAS element and activates PRL-induced transcription. Regulates the expression of milk proteins during lactation (By similarity). (799 aa) |
| | STAT5B | Signal transducer and activator of transcription 5B; Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Binds to the GAS element and activates PRL-induced transcription. Positively regulates hematopoietic/erythroid differentiation. (787 aa) |
| | KAT2A | Lysine acetyltransferase 2A. (857 aa) |
| | ERBB2 | Receptor protein-tyrosine kinase. (1255 aa) |
| | TBX21 | Uncharacterized protein. (535 aa) |
| | NF1 | Neurofibromin 1. (2847 aa) |
| | FOXN1 | Forkhead box N1. (671 aa) |
| | CD4 | CD4 molecule. (494 aa) |
| | POU4F2 | POU domain protein. (408 aa) |
| | TNFAIP6 | Uncharacterized protein. (277 aa) |
| | FSHR | Follicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. (695 aa) |
| | OCSTAMP | Osteoclast stimulatory transmembrane protein. (503 aa) |
| | IL1RL2 | Interleukin 1 receptor like 2. (644 aa) |
| | TNFSF9 | Tumor necrosis factor ligand superfamily member 9; Belongs to the tumor necrosis factor family. (259 aa) |
| | FBXW7 | F-box and WD repeat domain containing 7. (779 aa) |
| | MMP14 | Matrix metalloproteinase-14; Endopeptidase that degrades various components of the extracellular matrix, such as collagen. Activates progelatinase A. Essential for pericellular collagenolysis and modeling of skeletal and extraskeletal connective tissues during development. May be involved in actin cytoskeleton reorganization by cleaving PTK7. Acts as a positive regulator of cell growth and migration via activation of MMP15 in association with pro-MMP2. Involved in the formation of the fibrovascular tissues in association with pro-MMP2. Cleaves ADGRB1 to release vasculostatin-40 which i [...] (606 aa) |
| | TMEM178A | Transmembrane protein 178A. (297 aa) |
| | FANCA | FA complementation group A. (1484 aa) |
| | HOXA7 | Homeobox A7. (234 aa) |
| | SOCS1 | Suppressor of cytokine signaling 1. (220 aa) |
| | PIK3R1 | Phosphoinositide-3-kinase regulatory subunit 1. (766 aa) |
| | CASP8 | Caspase-8 isoform X2; Belongs to the peptidase C14A family. (486 aa) |
| | CASP10 | Caspase 10; Belongs to the peptidase C14A family. (520 aa) |
| | LTF | Lactotransferrin; Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. The lactotransferrin transferrin-like domain 1 functions as a serine protease of the peptidase S60 family that cuts arginine rich regions. This function contributes to the antimicrobial activity. Shows a preferential cleavage at -Arg-Ser-Arg-Arg-|- and -Arg-Arg-Ser-Arg-|-, and of Z-Phe-Arg-|-aminomethylcoumarin sites. (704 aa) |
| | PRKCZ | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (629 aa) |
| | PGLYRP2 | N-acetylmuramoyl-L-alanine amidase; May play a scavenger role by digesting biologically active peptidoglycan (PGN) into biologically inactive fragments. Has no direct bacteriolytic activity. (598 aa) |
| | RIPK2 | Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (533 aa) |
| | IL7R | Fibronectin type-III domain-containing protein. (458 aa) |
| | CD101 | CD101 molecule. (1018 aa) |
| | ZEB1 | Zinc finger E-box binding homeobox 1. (1128 aa) |
| | GNAS | Guanine nucleotide-binding protein G(s) subunit alpha; Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein- coupled receptors (GPCRs). Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP. GNAS functions downstream of several GPCRs, including beta-adrenergic receptors. Stimulates the Ras signaling pathway via RAPGEF2. (1045 aa) |
| | PCK1 | Phosphoenolpyruvate carboxykinase 1. (841 aa) |
| | ADAM8 | Disintegrin and metalloproteinase domain-containing protein 8. (835 aa) |
| | SFRP1 | Secreted frizzled-related protein 1. (308 aa) |
| | IL15 | Interleukin-15; Cytokine that stimulates the proliferation of T-lymphocytes. Stimulation by IL15 requires interaction of IL15 with components of the IL2 receptor, including IL2RB and probably IL2RG but not IL2RA (By similarity). In neutrophils, stimulates phagocytosis probably by signaling through the IL15 receptor, composed of the subunits IL15RA, IL2RB and IL2RG, which results in kinase SYK activation (By similarity); Belongs to the IL-15/IL-21 family. (182 aa) |
| | MALT1 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 isoform X1. (850 aa) |
| | TGFB1 | Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa) |
| | FADD | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (211 aa) |
| | ZAP70 | Tyrosine-protein kinase. (615 aa) |
| | CDK6 | Cyclin-dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa) |
| | CTLA4 | Cytotoxic T-lymphocyte protein 4; Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28. (223 aa) |
| | GPR68 | G protein-coupled receptor 68; Belongs to the G-protein coupled receptor 1 family. (370 aa) |
| | CTNNB1 | Catenin beta 1. (808 aa) |
| | SYK | 40 kDa tyrosine-protein kinase SYK; Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and vascular development. Assembles into signaling complexes with activated receptors at the plasma membrane via interaction between its SH2 domains and the receptor tyrosine-phosphorylated ITAM domains. The association with the recepto [...] (628 aa) |
| | FCRL3 | Fc receptor-like protein 3 isoform 1. (729 aa) |
| | LEF1 | Lymphoid enhancer binding factor 1. (429 aa) |
| | TRAF6 | TNF receptor-associated factor 6; E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Mediates activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to [...] (541 aa) |
| | ZBTB16 | Zinc finger and BTB domain containing 16. (673 aa) |
| | C1QC | Complement C1q subcomponent subunit C isoform 1. (245 aa) |
| | HSF1 | Heat shock transcription factor 1. (590 aa) |
| | APCS | Serum amyloid P-component; Belongs to the pentraxin family. (224 aa) |
| | RARA | Retinoic acid receptor alpha isoform X1. (462 aa) |
| | BRAF | B-Raf proto-oncogene, serine/threonine kinase. (804 aa) |
| | CREB1 | Cyclic AMP-responsive element-binding protein 1 isoform B. (341 aa) |
| | A0A286ZWW0_PIG | AIG1-type G domain-containing protein. (321 aa) |
| | LIF | Leukemia inhibitory factor isoform X1. (202 aa) |
| | IFNG | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (166 aa) |
| | TAL1 | TAL bHLH transcription factor 1, erythroid differentiation factor. (331 aa) |
| | PTPN6 | Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (612 aa) |
| | CLPTM1 | CLPTM1 regulator of GABA type A receptor forward trafficking. (647 aa) |
| | TREM2 | Ig-like domain-containing protein. (248 aa) |
| | RNF41 | E3 ubiquitin-protein ligase NRDP1 isoform 1. (317 aa) |
| | CRTAM | Cytotoxic and regulatory T cell molecule. (400 aa) |
| | PPP2R3C | Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1. (453 aa) |
| | EVI2B | Ecotropic viral integration site 2B. (459 aa) |
| | CARD11 | Caspase recruitment domain family member 11. (1154 aa) |
| | RHOH | Rho-related GTP-binding protein RhoH. (191 aa) |
| | GPR55 | G-protein coupled receptor 55; Belongs to the G-protein coupled receptor 1 family. (361 aa) |
| | IL23A | Interleukin-23 subunit alpha; Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tu [...] (193 aa) |
| | IL34 | Interleukin 34. (243 aa) |
| | PTPRC | Protein tyrosine phosphatase receptor type C. (1092 aa) |
| | AXL | Uncharacterized protein. (871 aa) |
| | GATA3 | Trans-acting T-cell-specific transcription factor GATA-3. (444 aa) |
| | INPP5D | Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 isoform X1. (1199 aa) |
| | RUNX1 | Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (480 aa) |
| | CTNNBIP1 | Beta-catenin-interacting protein 1. (81 aa) |
| | RC3H1 | Ring finger and CCCH-type domains 1. (1132 aa) |
| | BAD | BCL2 associated agonist of cell death. (209 aa) |
| | TCTA | T-cell leukemia translocation-altered gene protein homolog; May be required for cellular fusion during osteoclastogenesis; Belongs to the TCTA family. (106 aa) |
| | FOXP1 | Forkhead box P1. (692 aa) |
| | SLC46A2 | Solute carrier family 46 member 2. (494 aa) |
| | RHOA | Transforming protein RhoA isoform 1. (193 aa) |
| | CEBPB | CCAAT/enhancer-binding protein. (346 aa) |
| | IL12B | Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Belongs to the IL-12B family. (324 aa) |
| | TMEM64 | Transmembrane protein 64. (387 aa) |
| | ADIPOQ | C1q domain-containing protein. (332 aa) |
| | FSTL3 | Follistatin-related protein 3. (262 aa) |
| | XBP1 | BZIP domain-containing protein. (378 aa) |
| | GAS6 | Uncharacterized protein. (682 aa) |
| | ZFPM1 | Zinc finger protein, FOG family member 1. (965 aa) |
| | NDFIP1 | Uncharacterized protein. (254 aa) |
| | FOXP3 | Forkhead box protein P3 isoform a. (475 aa) |
| | CD74 | Thyroglobulin type-1 domain-containing protein. (347 aa) |
| | ZBTB46 | Zinc finger and BTB domain-containing protein 46. (589 aa) |
| | RASSF2 | Ras association domain-containing protein 2 isoform X2. (326 aa) |
| | MITF | Microphthalmia-associated transcription factor isoform 1. (520 aa) |
| | IL27 | Interleukin-27 subunit alpha; Associates with EBI3 to form the IL-27 interleukin, a heterodimeric cytokine which functions in innate immunity. Cytokine with pro- and anti-inflammatory properties, that can regulate T-helper cell development, suppress T-cell proliferation, stimulate cytotoxic T- cell activity, induce isotype switching in B-cells, and that has diverse effects on innate immune cells. Among its target cells are CD4 T-helper cells which can differentiate in type 1 effector cells (TH1), type 2 effector cells (TH2) and IL17 producing helper T-cells (TH17). It drives rapid clon [...] (239 aa) |
| | GPR137B | G protein-coupled receptor 137B. (415 aa) |
| | POU4F1 | POU domain protein. (421 aa) |
| | EGR3 | Early growth response protein 3 isoform 1. (387 aa) |
| | PRXL2A | Peroxiredoxin like 2A. (229 aa) |
| | TOX | Thymocyte selection associated high mobility group box. (541 aa) |
| | UBASH3B | Ubiquitin associated and SH3 domain containing B. (638 aa) |
| | ABL1 | Tyrosine-protein kinase. (1146 aa) |
| | ITPKB | Kinase; Belongs to the inositol phosphokinase (IPK) family. (650 aa) |
| | FBXO7 | F-box protein 7. (606 aa) |
| | WNT10B | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa) |
| | LAG3 | Uncharacterized protein. (507 aa) |
| | CD27 | CD27. (249 aa) |
| | NEDD9 | Neural precursor cell expressed, developmentally down-regulated 9. (829 aa) |
| | AGER | Advanced glycosylation end-product specific receptor. (487 aa) |
| | SLA-DOA | Ig-like domain-containing protein; Belongs to the MHC class II family. (360 aa) |
| | IL17A | Interleukin-17A; Ligand for IL17RA and IL17RC. The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC. Involved in inducing stromal cells to produce proinflammatory and hematopoietic cytokines. Belongs to the IL-17 family. (153 aa) |
| | FES | Tyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (822 aa) |
| | IL4I1 | Amine oxidase. (578 aa) |
| | MTOR | Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2548 aa) |
| | VNN1 | Pantetheinase; Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cysteamine. (512 aa) |
| | FOXO3 | Forkhead box protein O3 isoform X1. (672 aa) |
| | SMAD7 | Mothers against decapentaplegic homolog. (426 aa) |
| | FBN1 | Fibrillin-1; [Fibrillin-1]: Structural component of the 10-12 nm diameter microfibrils of the extracellular matrix, which conveys both structural and regulatory properties to load-bearing connective tissues. Fibrillin-1-containing microfibrils provide long-term force bearing structural support. In tissues such as the lung, blood vessels and skin, microfibrils form the periphery of the elastic fiber, acting as a scaffold for the deposition of elastin. In addition, microfibrils can occur as elastin-independent networks in tissues such as the ciliary zonule, tendon, cornea and glomerulus [...] (2871 aa) |
| | RASGRP1 | RAS guanyl releasing protein 1. (797 aa) |
| | SOS2 | SOS Ras/Rho guanine nucleotide exchange factor 2. (1332 aa) |
| | BMP4 | Bone morphogenetic protein 4. (409 aa) |
| | ANXA1 | Annexin A1; Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity. Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response. Promotes resolution of inflammation and wound healing (By similarity). Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (By similarity). Contribut [...] (346 aa) |
| | SHB | SH2 domain-containing protein. (507 aa) |
| | NRARP | NOTCH regulated ankyrin repeat protein. (114 aa) |
| | DCSTAMP | Dendrocyte expressed seven transmembrane protein. (487 aa) |
| | KLF10 | Kruppel-like factor 10. (480 aa) |
| | LYN | Tyrosine-protein kinase. (512 aa) |
| | SLAMF8 | SLAM family member 8 isoform X1. (295 aa) |
| | HAX1 | HCLS1-associated protein X-1; Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex. Slows down the rate of inactivation of KCNC3 channels. Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools; Belongs to the HAX1 family. (284 aa) |
| | PIAS3 | Protein inhibitor of activated STAT 3. (628 aa) |
| | NOTCH2 | Neurogenic locus notch homolog protein 2 isoform 1 preproprotein. (2471 aa) |
| | CYP26B1 | Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family. (512 aa) |
| | SOS1 | SOS Ras/Rac guanine nucleotide exchange factor 1. (1369 aa) |
| | TMEM131L | Transmembrane 131 like. (1682 aa) |
| | PPP3CA | Serine/threonine-protein phosphatase. (523 aa) |
| | RB1 | RB transcriptional corepressor 1. (938 aa) |
| | TNFSF11 | TNF superfamily member 11; Belongs to the tumor necrosis factor family. (319 aa) |
| | SH3RF1 | E3 ubiquitin-protein ligase SH3RF1 isoform X1. (849 aa) |
| | TESC | Calcineurin B homologous protein 3 isoform 1. (240 aa) |
| | PLA2G3 | Phospholipase A2 group III. (501 aa) |
| | VSIR | V-set immunoregulatory receptor. (310 aa) |
| | ZMIZ1 | Zinc finger MIZ-type containing 1. (1065 aa) |
| | DUSP10 | Dual specificity protein phosphatase 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (482 aa) |
| | CCL19 | C-C motif chemokine. (100 aa) |
| | TLR9 | Toll-like receptor 9; Key component of innate and adaptive immunity. TLRs (Toll- like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine- phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production (By similarity). (1030 aa) |
| | CLDN18 | Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (261 aa) |
| | BCL6 | B-cell lymphoma 6 protein isoform X1. (706 aa) |
| | TFE3 | Transcription factor binding to IGHM enhancer 3. (575 aa) |
| | VSIG1 | Uncharacterized protein. (1377 aa) |
| | SASH3 | SAM and SH3 domain containing 3. (420 aa) |
| | SART1 | Spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP. (803 aa) |
| | GPR137 | G protein-coupled receptor 137. (423 aa) |
| | AMBRA1 | Activating molecule in BECN1-regulated autophagy protein 1 isoform X1. (1296 aa) |
| | FSHB | Follitropin subunit beta; Together with the alpha chain CGA constitutes follitropin, the follicle-stimulating hormone, and provides its biological specificity to the hormone heterodimer. Binds FSHR, a G protein-coupled receptor, on target cells to activate downstream signaling pathways. Follitropin is involved in follicle development and spermatogenesis in reproductive organs. (129 aa) |
| | FBXW9 | F-box and WD repeat domain containing 9. (458 aa) |
| | AP3B1 | AP-3 complex subunit beta; Belongs to the adaptor complexes large subunit family. (1130 aa) |
| | IRF1 | Interferon regulatory factor 1; Transcriptional regulator which displays a remarkable functional diversity in the regulation of cellular responses. These include the regulation of IFN and IFN-inducible genes, host response to viral and bacterial infections, regulation of many genes expressed during hematopoiesis, inflammation, immune responses and cell proliferation and differentiation, regulation of the cell cycle and induction of growth arrest and programmed cell death following DNA damage. Stimulates both innate and acquired immune responses through the activation of specific target [...] (320 aa) |
| | IL4 | Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (133 aa) |
| | PPARGC1B | Peroxisome proliferator-activated receptor gamma coactivator 1-beta isoform 1. (1028 aa) |
| | FGL2 | Fibroleukin. (495 aa) |
| | IL10 | Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (219 aa) |
| | IHH | Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (454 aa) |
| | SHH | Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (440 aa) |
| | ZC3H12A | Zinc finger CCCH-type containing 12A. (582 aa) |
| | PGLYRP3 | Uncharacterized protein. (378 aa) |
| | TOB2 | Protein Tob2 isoform X1. (353 aa) |
| | SLC9B2 | Solute carrier family 9 member B2. (537 aa) |
| | ZNF683 | Zinc finger protein 683. (496 aa) |
| | LRRC17 | Leucine rich repeat containing 17. (438 aa) |
| | RC3H2 | Ring finger and CCCH-type domains 2. (1192 aa) |
| | ZC3H8 | Zinc finger CCCH-type containing 8. (309 aa) |
| | PRDM1 | PR/SET domain 1. (842 aa) |
| | NFAM1 | NFAT activating protein with ITAM motif 1. (261 aa) |
| | IKZF3 | IKAROS family zinc finger 3. (509 aa) |
| | PTPN2 | Tyrosine-protein phosphatase non-receptor type. (447 aa) |
| | CSF1 | Colony stimulating factor 1. (656 aa) |
| | ZBTB7B | Zinc finger and BTB domain-containing protein 7B isoform X1. (543 aa) |
| | IL2 | Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family. (154 aa) |
| | RIPK1 | Receptor interacting serine/threonine kinase 1. (668 aa) |
| | SOX13 | SRY-box transcription factor 13. (676 aa) |
| | ZFP36L1 | ZFP36 ring finger protein like 1. (348 aa) |
| | FANCD2 | Fanconi anemia group D2 protein isoform b. (1459 aa) |
| | TMEM176B | Uncharacterized protein. (341 aa) |
| | CD83 | Ig-like domain-containing protein. (365 aa) |
| | IL7 | Interleukin-7; Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation; Belongs to the IL-7/IL-9 family. (176 aa) |
| | A0A5G2QKY7_PIG | Kinase; Belongs to the inositol phosphokinase (IPK) family. (363 aa) |
| | KAT5 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (576 aa) |
| | NCKAP1L | NCK associated protein 1 like. (1128 aa) |
| | LOXL3 | Lysyl oxidase like 3. (814 aa) |
| | CUL4A | Cullin 4A; Belongs to the cullin family. (712 aa) |
| | PRELID1 | PRELI domain-containing protein 1, mitochondrial isoform 1. (219 aa) |
| | TMEM176A | Transmembrane protein 176A. (248 aa) |
| | MYB | MYB proto-oncogene, transcription factor. (744 aa) |
| | ZFP36L2 | ZFP36 ring finger protein like 2. (564 aa) |
| | CLEC4G | C-type lectin domain-containing protein. (358 aa) |
| | TRIB1 | Tribbles pseudokinase 1. (372 aa) |
| | SLA-DQA1 | SLA class II histocompatibility antigen, DQ haplotype D alpha chain. (255 aa) |
| | ADA | Adenosine deaminase. (409 aa) |
| | HCLS1 | Hematopoietic cell-specific Lyn substrate 1. (525 aa) |
| | NFKBIZ | NFKB inhibitor zeta. (747 aa) |
| | IL20 | Interleukin 20. (175 aa) |
| | CBFB | Core-binding factor subunit beta. (204 aa) |
| | CD28 | IGv domain-containing protein. (222 aa) |
| | NKAP | NFKB activating protein. (431 aa) |
| | HLX | H2.0 like homeobox. (556 aa) |
| | PIK3R6 | Phosphoinositide-3-kinase regulatory subunit 6. (942 aa) |
| | SOCS5 | Suppressor of cytokine signaling 5. (536 aa) |
| | MYC | Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). (452 aa) |
| | ZBTB1 | Zinc finger and BTB domain-containing protein 1 isoform X1. (713 aa) |
