STRINGSTRING
CCNO CCNO PRKAA1 PRKAA1 CCNB1 CCNB1 RB1CC1 RB1CC1 CCNL1 CCNL1 CDK4 CDK4 CDK5R2 CDK5R2 SNW1 SNW1 CDK5 CDK5 CCNG1 CCNG1 CDK13 CDK13 PRKAG2 PRKAG2 CDK5R1 CDK5R1 CAB39 CAB39 PRKAG3 PRKAG3 ACVR1C ACVR1C CCNT2 CCNT2 CCNI2 CCNI2 INSR INSR STK11 STK11 GTF2H1 GTF2H1 ATG13 ATG13 CCNQ CCNQ PHKA1 PHKA1 LAS1L LAS1L PRKCI PRKCI NEK10 NEK10 CHUK CHUK PRKAB1 PRKAB1 RB1 RB1 CCNA1 CCNA1 PHKG2 PHKG2 PHKG1 PHKG1 IKBKB IKBKB PRKAB2 PRKAB2 INSRR INSRR PRKDC PRKDC CCNE2 CCNE2 CDK9 CDK9 MNAT1 MNAT1 IGF1R IGF1R CCNB2 CCNB2 CNTD2 CNTD2 CCNE1 CCNE1 CCNK CCNK CDKN1A CDKN1A CDK2 CDK2 PRKAG1 PRKAG1 ACVR1B ACVR1B CDK7 CDK7 CCNT1 CCNT1 CDK16 CDK16 A0A5G2RI12_PIG A0A5G2RI12_PIG A0A5G2R9C4_PIG A0A5G2R9C4_PIG GTF2H5 GTF2H5 WDR41 WDR41 XRCC6 XRCC6 BCCIP BCCIP CDK3 CDK3 CCNJ CCNJ ACVR2B ACVR2B PARD6A PARD6A SESN2 SESN2 PARD3 PARD3 XRCC5 XRCC5 AMHR2 AMHR2 STRADB STRADB CCND3 CCND3 CCNJL CCNJL CCND1 CCND1 CCNI CCNI MAP3K7 MAP3K7 ACVR1 ACVR1 PRKAA2 PRKAA2 CCNL2 CCNL2 CDK12 CDK12 SMCR8 SMCR8 CCND2 CCND2 ULK1 ULK1 PHKA2 PHKA2 C9orf72 C9orf72 TRIM40 TRIM40 PYCARD PYCARD IKBKG IKBKG LOC110259300 LOC110259300 ERCC3 ERCC3 CNPPD1 CNPPD1 ERC1 ERC1 CDK1 CDK1 PRKAR1A PRKAR1A ATG101 ATG101 GTF2H3 GTF2H3 PHKB PHKB PRKAR2A PRKAR2A PCNA PCNA CDK14 CDK14 GTF2H2 GTF2H2 ZBTB7A ZBTB7A CCNH CCNH CCNG2 CCNG2 VARS2 VARS2 CCNB3 CCNB3 ERCC2 ERCC2 STRADA STRADA MAP3K5 MAP3K5 CDKN2D CDKN2D UVRAG UVRAG CCNY CCNY A0A286ZHX0_PIG A0A286ZHX0_PIG TGFBR1 TGFBR1 CDK6 CDK6 MAP3K6 MAP3K6 DAPK1 DAPK1 CKS2 CKS2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CCNOCyclin-O; Belongs to the cyclin family. (351 aa)
PRKAA1Non-specific serine/threonine protein kinase. (559 aa)
CCNB1Cyclin B1 transcript variant 1; Belongs to the cyclin family. (435 aa)
RB1CC1RB1 inducible coiled-coil 1. (1608 aa)
CCNL1Cyclin-L1 isoform 1; Belongs to the cyclin family. (526 aa)
CDK4Cyclin-dependent kinase 4; Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. [...] (303 aa)
CDK5R2Cyclin-dependent kinase 5 activator. (365 aa)
SNW1SNW domain-containing protein 1 isoform 2. (536 aa)
CDK5Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (361 aa)
CCNG1Cyclin-G1; May play a role in growth regulation. Is associated with G2/M phase arrest in response to DNA damage. May be an intermediate by which p53 mediates its role as an inhibitor of cellular proliferation (By similarity); Belongs to the cyclin family. Cyclin G subfamily. (161 aa)
CDK13Cyclin dependent kinase 13. (1513 aa)
PRKAG2Protein kinase AMP-activated non-catalytic subunit gamma 2. (619 aa)
CDK5R1Cyclin-dependent kinase 5 activator. (315 aa)
CAB39Calcium-binding protein 39. (341 aa)
PRKAG35'-AMP-activated protein kinase subunit gamma-3; AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a [...] (499 aa)
ACVR1CReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (500 aa)
CCNT2Cyclin T2; Belongs to the cyclin family. (618 aa)
CCNI2CYCLIN domain-containing protein; Belongs to the cyclin family. (223 aa)
INSRTyrosine-protein kinase receptor. (1382 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (438 aa)
GTF2H1General transcription factor IIH subunit 1. (674 aa)
ATG13Autophagy-related protein 13; Belongs to the ATG13 family. Metazoan subfamily. (550 aa)
CCNQCyclin Q; Belongs to the cyclin family. (250 aa)
PHKA1Phosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. (1227 aa)
LAS1LLAS1 like, ribosome biogenesis factor. (721 aa)
PRKCIProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (636 aa)
NEK10NIMA related kinase 10. (1116 aa)
CHUKProtein kinase domain-containing protein. (580 aa)
PRKAB15'-AMP-activated protein kinase subunit beta-1; Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a reg [...] (271 aa)
RB1RB transcriptional corepressor 1. (938 aa)
CCNA1Cyclin-A1 isoform X1; Belongs to the cyclin family. (421 aa)
PHKG2Phosphorylase kinase catalytic subunit gamma 2; Belongs to the protein kinase superfamily. (406 aa)
PHKG1Phosphorylase kinase gamma 1; Belongs to the protein kinase superfamily. (388 aa)
IKBKBInhibitor of kappa light chain gene enhancer in B cells, kinase beta. (755 aa)
PRKAB2Protein kinase AMP-activated non-catalytic subunit beta 2. (272 aa)
INSRRTyrosine-protein kinase receptor. (1315 aa)
PRKDCProtein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4136 aa)
CCNE2G1/S-specific cyclin-E2 isoform X1; Belongs to the cyclin family. (405 aa)
CDK9Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (488 aa)
MNAT1CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. (309 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
CCNB2G2/mitotic-specific cyclin-B2; Belongs to the cyclin family. (396 aa)
CNTD2Cyclin N-terminal domain containing 2; Belongs to the cyclin family. (201 aa)
CCNE1Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (410 aa)
CCNKCyclin K; Belongs to the cyclin family. (605 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (163 aa)
CDK2Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (381 aa)
PRKAG15'-AMP-activated protein kinase subunit gamma-1; AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a [...] (298 aa)
ACVR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (547 aa)
CDK7Cyclin dependent kinase 7; Belongs to the protein kinase superfamily. (361 aa)
CCNT1Cyclin T1; Belongs to the cyclin family. (727 aa)
CDK16Cyclin dependent kinase 16. (620 aa)
A0A5G2RI12_PIGUncharacterized protein. (55 aa)
A0A5G2R9C4_PIGUncharacterized protein. (69 aa)
GTF2H5Uncharacterized protein. (88 aa)
WDR41WD repeat-containing protein 41 isoform X1. (459 aa)
XRCC6X-ray repair cross complementing 6. (606 aa)
BCCIPBRCA2 and CDKN1A interacting protein. (327 aa)
CDK3Cyclin dependent kinase 3; Belongs to the protein kinase superfamily. (467 aa)
CCNJCyclin J; Belongs to the cyclin family. (452 aa)
ACVR2BActivin receptor type-2B; Transmembrane serine/threonine kinase activin type-2 receptor forming an activin receptor complex with activin type-1 serine/threonine kinase receptors (ACVR1, ACVR1B or ACVR1c). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to [...] (565 aa)
PARD6APar-6 family cell polarity regulator alpha. (354 aa)
SESN2Sestrin 2. (471 aa)
PARD3Par-3 family cell polarity regulator. (1355 aa)
XRCC5X-ray repair cross complementing 5. (1011 aa)
AMHR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (583 aa)
STRADBSTE20 related adaptor beta. (430 aa)
CCND3Cyclin D3; Belongs to the cyclin family. (331 aa)
CCNJLCyclin J like; Belongs to the cyclin family. (536 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
CCNICyclin-I isoform X2; Belongs to the cyclin family. (377 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
ACVR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (729 aa)
PRKAA25'-AMP-activated protein kinase catalytic subunit alpha-2; Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts a [...] (552 aa)
CCNL2Cyclin-L2 isoform A; Belongs to the cyclin family. (530 aa)
CDK12Cyclin dependent kinase 12. (1483 aa)
SMCR8SMCR8-C9orf72 complex subunit. (935 aa)
CCND2G1/S-specific cyclin-D2; Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. A [...] (288 aa)
ULK1Unc-51 like autophagy activating kinase 1. (1176 aa)
PHKA2Phosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. (1237 aa)
C9orf72C9orf72-SMCR8 complex subunit. (489 aa)
TRIM40Tripartite motif containing 40. (300 aa)
PYCARDApoptosis-associated speck-like protein containing a CARD isoform a. (196 aa)
IKBKGNF-kappa-B essential modulator; Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Its binding to scaffolding polyubiquitin seems to play a role in IKK activation by multiple signaling receptor pathways. However, the specific type of polyubiquitin recognized upon cell stimulation (either 'Lys-63'-linked or linear polyubiquitin) and its functional importance is reported conflictingly. Also considered to be a mediator for TAX activati [...] (451 aa)
LOC110259300Uncharacterized protein; Belongs to the cyclin family. (347 aa)
ERCC3ERCC excision repair 3, TFIIH core complex helicase subunit. (801 aa)
CNPPD1Cyclin Pas1/PHO80 domain containing 1. (440 aa)
ERC1ELKS/RAB6-interacting/CAST family member 1. (1092 aa)
CDK1Cyclin-dependent kinase 1 isoform 1; Belongs to the protein kinase superfamily. (297 aa)
PRKAR1AcAMP-dependent protein kinase type I-alpha regulatory subunit, N-terminally processed; Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. (433 aa)
ATG101Autophagy-related protein 101 isoform X1. (218 aa)
GTF2H3General transcription factor IIH subunit 3 isoform a. (321 aa)
PHKBPhosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. Belongs to the phosphorylase b kinase regulatory chain family. (1090 aa)
PRKAR2AcAMP-dependent protein kinase type II-alpha regulatory subunit; Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase. (389 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (270 aa)
CDK14Cyclin dependent kinase 14. (526 aa)
GTF2H2VWFA domain-containing protein. (613 aa)
ZBTB7AZinc finger and BTB domain containing 7A. (596 aa)
CCNHCyclin-H isoform 1; Belongs to the cyclin family. (328 aa)
CCNG2Cyclin G2; Belongs to the cyclin family. (344 aa)
VARS2Valine--tRNA ligase, mitochondrial; Belongs to the class-I aminoacyl-tRNA synthetase family. (1139 aa)
CCNB3Cyclin B3; Belongs to the cyclin family. (1338 aa)
ERCC2General transcription and DNA repair factor IIH helicase subunit XPD isoform 1. (763 aa)
STRADASTE20 related adaptor alpha. (432 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1425 aa)
CDKN2DCyclin dependent kinase inhibitor 2D. (166 aa)
UVRAGUV radiation resistance associated. (748 aa)
CCNYCyclin Y; Belongs to the cyclin family. (416 aa)
A0A286ZHX0_PIGCyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (117 aa)
TGFBR1TGF-beta receptor type-1; Transmembrane serine/threonine kinase forming with the TGF- beta type II serine/threonine kinase receptor, TGFBR2, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinog [...] (560 aa)
CDK6Cyclin-dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
MAP3K6Mitogen-activated protein kinase kinase kinase 6. (1295 aa)
DAPK1Death associated protein kinase 1. (1442 aa)
CKS2Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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