node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BMP2 | IL6 | ENSSSCP00000037008 | ENSSSCP00000023819 | Bone morphogenetic protein 2 preproprotein. | Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] | 0.496 |
BMP2 | SMAD3 | ENSSSCP00000037008 | ENSSSCP00000073915 | Bone morphogenetic protein 2 preproprotein. | Mothers against decapentaplegic homolog. | 0.461 |
BMP2 | SOX9 | ENSSSCP00000037008 | ENSSSCP00000018278 | Bone morphogenetic protein 2 preproprotein. | Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. | 0.691 |
COLGALT1 | COLGALT2 | ENSSSCP00000048658 | ENSSSCP00000059431 | Glycosyltransferase 25 domain containing 1. | Procollagen galactosyltransferase 2 isoform 1precursor. | 0.901 |
COLGALT2 | COLGALT1 | ENSSSCP00000059431 | ENSSSCP00000048658 | Procollagen galactosyltransferase 2 isoform 1precursor. | Glycosyltransferase 25 domain containing 1. | 0.901 |
IL6 | BMP2 | ENSSSCP00000023819 | ENSSSCP00000037008 | Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] | Bone morphogenetic protein 2 preproprotein. | 0.496 |
IL6 | SMAD3 | ENSSSCP00000023819 | ENSSSCP00000073915 | Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] | Mothers against decapentaplegic homolog. | 0.636 |
IL6 | SOX9 | ENSSSCP00000023819 | ENSSSCP00000018278 | Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] | Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. | 0.649 |
SMAD3 | BMP2 | ENSSSCP00000073915 | ENSSSCP00000037008 | Mothers against decapentaplegic homolog. | Bone morphogenetic protein 2 preproprotein. | 0.461 |
SMAD3 | IL6 | ENSSSCP00000073915 | ENSSSCP00000023819 | Mothers against decapentaplegic homolog. | Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] | 0.636 |
SMAD3 | SOX9 | ENSSSCP00000073915 | ENSSSCP00000018278 | Mothers against decapentaplegic homolog. | Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. | 0.619 |
SOX9 | BMP2 | ENSSSCP00000018278 | ENSSSCP00000037008 | Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. | Bone morphogenetic protein 2 preproprotein. | 0.691 |
SOX9 | IL6 | ENSSSCP00000018278 | ENSSSCP00000023819 | Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. | Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] | 0.649 |
SOX9 | SMAD3 | ENSSSCP00000018278 | ENSSSCP00000073915 | Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. | Mothers against decapentaplegic homolog. | 0.619 |