18 items (Sus scrofa) - STRING interaction network

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Your Input:
	CTTN	Cortactin. (685 aa)
	VPS13C	Vacuolar protein sorting 13 homolog C. (3757 aa)
	PRKN	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (461 aa)
	HIF1A	Hypoxia-inducible factor 1-alpha isoform 1. (824 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (442 aa)
	PARL	Rhomboid domain-containing protein. (502 aa)
	VDAC1	Voltage-dependent anion-selective channel protein 1; Forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. May participate in the formation of the permeability transition p [...] (302 aa)
	RNF41	E3 ubiquitin-protein ligase NRDP1 isoform 1. (317 aa)
	FBXW7	F-box and WD repeat domain containing 7. (779 aa)
	TIGAR	TP53 induced glycolysis regulatory phosphatase. (269 aa)
	FBXW9	F-box and WD repeat domain containing 9. (458 aa)
	AMBRA1	Activating molecule in BECN1-regulated autophagy protein 1 isoform X1. (1296 aa)
	HTT	Huntingtin. (3138 aa)
	PINK1	PTEN induced kinase 1. (588 aa)
	VPS13D	Vacuolar protein sorting 13 homolog D. (4389 aa)
	GSK3A	Protein kinase domain-containing protein. (566 aa)
	FBXO7	F-box protein 7. (606 aa)
	TSPO	Translocator protein; Promotes the transport of cholesterol across mitochondrial membranes and may play a role in lipid metabolism, but its precise physiological role is controversial. It is apparently not required for steroid hormone biosynthesis. Can bind protoporphyrin IX and may play a role in the transport of porphyrins and heme. Was initially identified as peripheral-type benzodiazepine receptor; can also bind isoquinoline carboxamides (By similarity); Belongs to the TspO/BZRP family. (169 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AMBRA1	PINK1	ENSSSCP00000014094	ENSSSCP00000003807	Activating molecule in BECN1-regulated autophagy protein 1 isoform X1.	PTEN induced kinase 1.	0.586
AMBRA1	PRKN	ENSSSCP00000014094	ENSSSCP00000061874	Activating molecule in BECN1-regulated autophagy protein 1 isoform X1.	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily.	0.632
FBXO7	PINK1	ENSSSCP00000000162	ENSSSCP00000003807	F-box protein 7.	PTEN induced kinase 1.	0.614
FBXO7	PRKN	ENSSSCP00000000162	ENSSSCP00000061874	F-box protein 7.	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily.	0.503
FBXO7	VPS13C	ENSSSCP00000000162	ENSSSCP00000062501	F-box protein 7.	Vacuolar protein sorting 13 homolog C.	0.407
FBXW7	PRKN	ENSSSCP00000022261	ENSSSCP00000061874	F-box and WD repeat domain containing 7.	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily.	0.631
FBXW7	TP53	ENSSSCP00000022261	ENSSSCP00000050664	F-box and WD repeat domain containing 7.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]	0.707
GSK3A	TP53	ENSSSCP00000003288	ENSSSCP00000050664	Protein kinase domain-containing protein.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]	0.467
HIF1A	TP53	ENSSSCP00000050717	ENSSSCP00000050664	Hypoxia-inducible factor 1-alpha isoform 1.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]	0.882
HTT	PINK1	ENSSSCP00000009271	ENSSSCP00000003807	Huntingtin.	PTEN induced kinase 1.	0.537
HTT	PRKN	ENSSSCP00000009271	ENSSSCP00000061874	Huntingtin.	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily.	0.654
HTT	TP53	ENSSSCP00000009271	ENSSSCP00000050664	Huntingtin.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]	0.924
PARL	PINK1	ENSSSCP00000049967	ENSSSCP00000003807	Rhomboid domain-containing protein.	PTEN induced kinase 1.	0.825
PARL	PRKN	ENSSSCP00000049967	ENSSSCP00000061874	Rhomboid domain-containing protein.	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily.	0.743
PINK1	AMBRA1	ENSSSCP00000003807	ENSSSCP00000014094	PTEN induced kinase 1.	Activating molecule in BECN1-regulated autophagy protein 1 isoform X1.	0.586
PINK1	FBXO7	ENSSSCP00000003807	ENSSSCP00000000162	PTEN induced kinase 1.	F-box protein 7.	0.614
PINK1	HTT	ENSSSCP00000003807	ENSSSCP00000009271	PTEN induced kinase 1.	Huntingtin.	0.537
PINK1	PARL	ENSSSCP00000003807	ENSSSCP00000049967	PTEN induced kinase 1.	Rhomboid domain-containing protein.	0.825
PINK1	PRKN	ENSSSCP00000003807	ENSSSCP00000061874	PTEN induced kinase 1.	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily.	0.999
PINK1	VDAC1	ENSSSCP00000003807	ENSSSCP00000047193	PTEN induced kinase 1.	Voltage-dependent anion-selective channel protein 1; Forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. May participate in the formation of the permeability transition p [...]	0.726