STRINGSTRING
FGF9 FGF9 CITED1 CITED1 LTBP3 LTBP3 FGF2 FGF2 IRS2 IRS2 ATXN1L ATXN1L LOC110259300 LOC110259300 PTPRC PTPRC WNT5A WNT5A WNT1 WNT1 WNT10B WNT10B HMX2 HMX2 TBX3 TBX3 PRRX1 PRRX1 HNRNPU HNRNPU YAP1 YAP1 SOX11 SOX11 CTNNB1 CTNNB1 TGFB1 TGFB1 KDR KDR NR2E1 NR2E1 THPO THPO SHOX2 SHOX2 SOX9 SOX9 TERT TERT FGF10 FGF10 HOXA3 HOXA3 VEGFC VEGFC FGF4 FGF4 OSR2 OSR2 LOC100359361 LOC100359361 ELL3 ELL3 GJA1 GJA1 CCNE1 CCNE1 RUNX2 RUNX2 KAT7 KAT7 FGF8 FGF8 TP63 TP63 FERMT2 FERMT2 HMGA2 HMGA2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FGF9Fibroblast growth factor 9; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. May have a role in glial cell growth and differentiation during development, gliosis during repair and regeneration of brain tissue after damage, differentiation and survival of neuronal cells, and growth stimulation of glial tumors (By similarity). (228 aa)
CITED1Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1. (221 aa)
LTBP3Latent transforming growth factor beta binding protein 3. (1332 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (316 aa)
IRS2Insulin receptor substrate 2. (1092 aa)
ATXN1LAtaxin 1 like. (688 aa)
LOC110259300Uncharacterized protein; Belongs to the cyclin family. (347 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (1092 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
HMX2H6 family homeobox 2. (281 aa)
TBX3T-box transcription factor TBX3 isoform 2. (745 aa)
PRRX1Paired mesoderm homeobox protein 1 isoform pmx-1b. (245 aa)
HNRNPUHeterogeneous nuclear ribonucleoprotein U isoform a. (825 aa)
YAP1Yes associated protein 1. (432 aa)
SOX11Transcription factor SOX. (447 aa)
CTNNB1Catenin beta 1. (808 aa)
TGFB1Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1360 aa)
NR2E1Nuclear receptor subfamily 2 group E member 1. (385 aa)
THPOThrombopoietin; Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets. (477 aa)
SHOX2Short stature homeobox 2. (321 aa)
SOX9Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (511 aa)
TERTTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1130 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
HOXA3Homeobox protein Hox-A3 isoform a. (443 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (418 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
OSR2Odd-skipped related transciption factor 2. (312 aa)
LOC100359361Uncharacterized protein. (108 aa)
ELL3Elongation factor for RNA polymerase II 3. (374 aa)
GJA1Gap junction alpha-1 protein; Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph. Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli a [...] (382 aa)
CCNE1Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (410 aa)
RUNX2Runt-related transcription factor 2 isoform a. (625 aa)
KAT7Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (613 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
FERMT2Fermitin family member 2. (776 aa)
HMGA2Uncharacterized protein. (143 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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