STRINGSTRING
PWP1 PWP1 SOX5 SOX5 GATA6 GATA6 TACSTD2 TACSTD2 SOX17 SOX17 JAG1 JAG1 SETD1A SETD1A TBX3 TBX3 TBX5 TBX5 PUS7 PUS7 CDK13 CDK13 SOX9 SOX9 STAT3 STAT3 HOXB4 HOXB4 WNT3A WNT3A ZFP36 ZFP36 SLC4A11 SLC4A11 DHX36 DHX36 TMSB4X TMSB4X TRIM6 TRIM6 CDK6 CDK6 YAP1 YAP1 TEAD2 TEAD2 RBM24 RBM24 TCF15 TCF15 MTCH2 MTCH2 TGFB2 TGFB2 HNRNPU HNRNPU KDM3A KDM3A PTN PTN HSPA9 HSPA9 SOX6 SOX6 PRICKLE1 PRICKLE1 GSK3B GSK3B A0A287AS79_PIG A0A287AS79_PIG HES1 HES1 EZH2 EZH2 PDGFRA PDGFRA NOTCH1 NOTCH1 SP7 SP7 HES5 HES5 FGF2 FGF2 CDK12 CDK12 NANOG NANOG LTBP3 LTBP3 EIF2AK2 EIF2AK2 NELFB NELFB SMYD5 SMYD5 NSUN2 NSUN2 NFE2L2 NFE2L2 NUDT21 NUDT21 YTHDF2 YTHDF2 KAT5 KAT5 ZFP36L2 ZFP36L2 BBS12 BBS12 REST REST
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PWP1PWP1 homolog, endonuclein. (499 aa)
SOX5SRY-box transcription factor 5. (763 aa)
GATA6Transcription factor GATA-6; Transcriptional activator that regulates SEMA3C and PLXNA2. May regulate genes that protect epithelial cells from bacterial infection. Involved in gene regulation specifically in the gastric epithelium. Involved in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression. Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions. (592 aa)
TACSTD2Tumor-associated calcium signal transducer 2. (323 aa)
SOX17SRY-box transcription factor 17. (407 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1211 aa)
SETD1ASET domain containing 1A, histone lysine methyltransferase. (1703 aa)
TBX3T-box transcription factor TBX3 isoform 2. (745 aa)
TBX5T-box transcription factor 5. (535 aa)
PUS7Pseudouridine synthase 7. (816 aa)
CDK13Cyclin dependent kinase 13. (1513 aa)
SOX9Transcription factor SOX-9; Transcriptional regulator that plays a role in chondrocytes differentiation and skeletal development. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219. (511 aa)
STAT3Signal transducer and activator of transcription 3; Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors. Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA (By similarity). Acts as a regulator of inflammatory response by regul [...] (772 aa)
HOXB4Homeobox B4. (278 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
ZFP36Uncharacterized protein. (372 aa)
SLC4A11Solute carrier family 4 member 11. (933 aa)
DHX36DEAH (Asp-Glu-Ala-His) box polypeptide 36 tv1. (1012 aa)
TMSB4XHematopoietic system regulatory peptide; Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization; Belongs to the thymosin beta family. (44 aa)
TRIM6Tripartite motif containing 6. (487 aa)
CDK6Cyclin-dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
YAP1Yes associated protein 1. (432 aa)
TEAD2TEA domain transcription factor 2. (457 aa)
RBM24RRM domain-containing protein. (528 aa)
TCF15Transcription factor 15. (197 aa)
MTCH2Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (334 aa)
TGFB2Transforming growth factor beta-2 proprotein; Transforming growth factor beta-2 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively. Transforming growth factor beta-2: Multifunctional protein that regulates various processes such as angiogenesis and heart development (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transfor [...] (443 aa)
HNRNPUHeterogeneous nuclear ribonucleoprotein U isoform a. (825 aa)
KDM3ALysine demethylase 3A. (1323 aa)
PTNPleiotrophin; Secreted growth factor that mediates its signal through cell- surface proteoglycan and non-proteoglycan receptors. Binds cell-surface proteoglycan receptor via their chondroitin sulfate (CS) groups. Thereby regulates many processes like cell proliferation, cell survival, cell growth, cell differentiation and cell migration in several tissues namely neuron and bone (By similarity). Also plays a role in synaptic plasticity and learning-related behavior by inhibiting long-term synaptic potentiation (By similarity). Binds PTPRZ1, leading to neutralization of the negative char [...] (215 aa)
HSPA9Heat shock protein family A (Hsp70) member 9; Belongs to the heat shock protein 70 family. (679 aa)
SOX6SRY-box transcription factor 6. (859 aa)
PRICKLE1Prickle planar cell polarity protein 1. (856 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (414 aa)
A0A287AS79_PIGUncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (232 aa)
HES1Uncharacterized protein. (280 aa)
EZH2Enhancer of zeste 2 polycomb repressive complex 2 subunit. (762 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1088 aa)
NOTCH1Neurogenic locus notch homolog protein 1 preproprotein. (2560 aa)
SP7Sp7 transcription factor. (432 aa)
HES5Hes family bHLH transcription factor 5. (226 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (316 aa)
CDK12Cyclin dependent kinase 12. (1483 aa)
NANOGHomeobox domain-containing protein. (304 aa)
LTBP3Latent transforming growth factor beta binding protein 3. (1332 aa)
EIF2AK2Eukaryotic translation initiation factor 2 alpha kinase 2. (546 aa)
NELFBUncharacterized protein. (757 aa)
SMYD5SET and MYND domain-containing protein 5 isoform X1. (596 aa)
NSUN2NOP2/Sun RNA methyltransferase 2; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (992 aa)
NFE2L2Nuclear factor, erythroid 2 like 2. (656 aa)
NUDT21Cleavage and polyadenylation specificity factor subunit 5; Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The [...] (237 aa)
YTHDF2YTH N6-methyladenosine RNA binding protein 2. (600 aa)
KAT5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (576 aa)
ZFP36L2ZFP36 ring finger protein like 2. (564 aa)
BBS12Bardet-Biedl syndrome 12. (714 aa)
RESTRE1 silencing transcription factor. (1108 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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