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| | MCRS1 | Microspherule protein 1. (487 aa) |
| | TIMELESS | Timeless circadian regulator. (1206 aa) |
| | ACRBP | Acrosin-binding protein; May be involved in packaging and condensation of the acrosin zymogen in the acrosomal matrix via its association with proacrosin. (539 aa) |
| | PARPBP | PARP1 binding protein. (599 aa) |
| | WRNIP1 | WRN helicase interacting protein 1. (638 aa) |
| | PML | Promyelocytic leukemia. (827 aa) |
| | OTUB2 | OTU deubiquitinase, ubiquitin aldehyde binding 2. (234 aa) |
| | SPIRE2 | Spire type actin nucleation factor 2. (763 aa) |
| | TERF2IP | TERF2 interacting protein. (401 aa) |
| | RFWD3 | E3 ubiquitin-protein ligase RFWD3 isoform X1. (781 aa) |
| | RUVBL2 | RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (525 aa) |
| | BCL2L12 | BCL2 like 12. (255 aa) |
| | PRKCG | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (759 aa) |
| | TFPT | TCF3 fusion partner isoform 1. (253 aa) |
| | CASP9 | Caspase 9; Belongs to the peptidase C14A family. (438 aa) |
| | KDM1A | Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (875 aa) |
| | AUNIP | Aurora kinase A and ninein interacting protein. (385 aa) |
| | EYA3 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (573 aa) |
| | FBXO5 | F-box protein 5. (462 aa) |
| | ARMT1 | DUF89 domain-containing protein. (443 aa) |
| | KHDC3L | MOEP19 domain-containing protein. (142 aa) |
| | OOEP | Oocyte-expressed protein homolog. (148 aa) |
| | ELL3 | Elongation factor for RNA polymerase II 3. (374 aa) |
| | INO80 | INO80 complex ATPase subunit. (1566 aa) |
| | RAD51 | DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa) |
| | LOC100359361 | Uncharacterized protein. (108 aa) |
| | TRIM32 | Tripartite motif containing 32. (652 aa) |
| | CDK9 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (488 aa) |
| | ENDOG | Endonuclease. (299 aa) |
| | PRKDC | Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4136 aa) |
| | MUC1 | SEA domain-containing protein. (638 aa) |
| | POGZ | Pogo transposable element with ZNF domain isoform X1. (1412 aa) |
| | BCL7B | BAF chromatin remodeling complex subunit BCL7B. (249 aa) |
| | ERCC4 | ERCC excision repair 4, endonuclease catalytic subunit. (914 aa) |
| | NPAS2 | Neuronal PAS domain protein 2. (796 aa) |
| | FAM178B | Uncharacterized protein. (569 aa) |
| | NSD2 | Histone-lysine N-methyltransferase NSD2 isoform 1. (1338 aa) |
| | ABRAXAS1 | Abraxas 1, BRCA1 A complex subunit. (405 aa) |
| | HELQ | Helicase, POLQ like. (1076 aa) |
| | CCAR2 | DBC1 domain-containing protein. (916 aa) |
| | PBK | Lymphokine-activated killer T-cell-originated protein kinase isoform X1. (322 aa) |
| | MIF | Macrophage migration inhibitory factor; Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity (By simi [...] (115 aa) |
| | ZNF365 | Zinc finger protein 365. (407 aa) |
| | SIRT1 | NAD-dependent protein deacetylase sirtuin-1 isoform a. (742 aa) |
| | ERCC6 | ERCC excision repair 6, chromatin remodeling factor. (1462 aa) |
| | PARG | Poly(ADP-ribose) glycohydrolase. (976 aa) |
| | MMS19 | MMS19 homolog, cytosolic iron-sulfur assembly component. (1039 aa) |
| | NSMCE4A | Non-structural maintenance of chromosomes element 4; Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids. (382 aa) |
| | UCHL5 | Ubiquitin carboxyl-terminal hydrolase isozyme L5; Protease that specifically cleaves 'Lys-48'-linked polyubiquitin chains. Deubiquitinating enzyme associated with the 19S regulatory subunit of the 26S proteasome. Putative regulatory component of the INO80 complex; however is inactive in the INO80 complex and is activated by a transient interaction of the INO80 complex with the proteasome via ADRM1 (By similarity). (327 aa) |
| | ACTR8 | Actin-related protein 8; Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize; Belongs to the actin family. ARP8 subfamily. (624 aa) |
| | OGG1 | OGG_N domain-containing protein. (195 aa) |
| | ATR | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2643 aa) |
| | SKIL | Ski-like protein isoform X1. (661 aa) |
| | ACTL6A | Actin-like protein 6A isoform X1; Belongs to the actin family. (429 aa) |
| | MAGEF1 | MAGE family member F1. (315 aa) |
| | MORF4L2 | Mortality factor 4 like 2. (288 aa) |
| | RADX | RPA1 related single stranded DNA binding protein, X-linked. (857 aa) |
| | RAD9A | Cell cycle checkpoint control protein; Belongs to the rad9 family. (443 aa) |
| | OTUB1 | Ubiquitin thioesterase. (271 aa) |
| | CD44 | CD44 molecule (Indian blood group). (767 aa) |
| | SIRT6 | Deacetylase sirtuin-type domain-containing protein. (327 aa) |
| | HDGFL2 | HDGF like 2. (667 aa) |
| | MRNIP | Uncharacterized protein. (216 aa) |
| | SLF1 | SMC5-SMC6 complex localization factor 1. (1055 aa) |
| | DDIAS | DNA damage induced apoptosis suppressor. (991 aa) |
| | ATM | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospec [...] (3057 aa) |
| | CHEK1 | Serine/threonine-protein kinase Chk1 isoform X2; Belongs to the protein kinase superfamily. (476 aa) |
| | SMYD2 | N-lysine methyltransferase SMYD2; Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. Specifically trimethylates histone H3 'Lys-4' (H3K4me3) in vivo. The activity requires interaction with HSP90alpha. Shows even higher methyltransferase activity on p53/TP53. Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates RB1 at 'Lys-860'; Belongs to the class V-like SAM-binding methyltransferase superfamily. (538 aa) |
| | EPC2 | Enhancer of polycomb homolog. (807 aa) |
| | TEX15 | Uncharacterized protein. (237 aa) |
| | ACKR3 | Atypical chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (362 aa) |
| | RIF1 | Replication timing regulatory factor 1. (2466 aa) |
| | POT1 | Protection of telomeres 1. (813 aa) |
| | FGF10 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa) |
| | MBTD1 | Mbt domain containing 1. (715 aa) |
| | WRAP53 | WD repeat containing antisense to TP53. (539 aa) |
| | FXR2 | FMR1 autosomal homolog 2. (667 aa) |
| | SMCHD1 | Structural maintenance of chromosomes flexible hinge domain containing 1. (1997 aa) |
| | FEM1B | Protein fem-1 homolog B. (627 aa) |
| | RUVBL1 | RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (463 aa) |
| | EP400 | E1A binding protein p400. (3210 aa) |
| | FBH1 | F-box DNA helicase 1 isoform X1. (1045 aa) |
| | RMI2 | RecQ-mediated genome instability protein 2. (150 aa) |
| | TIGAR | TP53 induced glycolysis regulatory phosphatase. (269 aa) |
| | BRD8 | Bromodomain containing 8. (1236 aa) |
| | PARP1 | Poly [ADP-ribose] polymerase. (1017 aa) |
| | UBR5 | Ubiquitin protein ligase E3 component n-recognin 5. (2759 aa) |
| | HIC1 | Hypermethylated in cancer 1 protein isoform 2. (733 aa) |
| | FXR1 | Fragile X mental retardation syndrome-related protein 1 isoform X1. (677 aa) |
| | PARP3 | Poly [ADP-ribose] polymerase. (539 aa) |
| | HDAC10 | Histone deacetylase 10. (671 aa) |
| | CGAS | Cyclic GMP-AMP synthase; Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (cGAMP) from ATP and GTP and plays a key role in innate immunity. Catalysis involves both the formation of a 2',5' phosphodiester linkage at the GpA step and the formation of a 3',5' phosphodiester linkage at the ApG step, producing c[G(2',5')pA(3',5')p]. Acts as a key cytosolic DNA sensor, the presence of double-stranded DNA (dsDNA) in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second m [...] (495 aa) |
| | MARCHF7 | Membrane associated ring-CH-type finger 7. (708 aa) |
| | MAD2L2 | Mitotic spindle assembly checkpoint protein MAD2B. (211 aa) |
| | UIMC1 | BRCA1-A complex subunit RAP80; Ubiquitin-binding protein. Specifically recognizes and binds 'Lys-63'-linked ubiquitin. Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. M [...] (622 aa) |
| | ZMPSTE24 | CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (475 aa) |
| | RNF169 | E3 ubiquitin-protein ligase RNF169. (708 aa) |
| | DTX3L | Deltex E3 ubiquitin ligase 3L. (737 aa) |
| | FIGNL1 | Fidgetin-like protein 1 isoform 1; Belongs to the AAA ATPase family. (675 aa) |
| | PMAIP1 | Uncharacterized protein. (121 aa) |
| | FANCB | FA complementation group B. (855 aa) |
| | IER3 | Immediate early response 3. (214 aa) |
| | DHX9 | ATP-dependent RNA helicase A. (1384 aa) |
| | PPP1R10 | Serine/threonine-protein phosphatase 1 regulatory subunit 10; Scaffold protein which mediates the formation of the PTW/PP1 phosphatase complex by providing a binding platform to each component of the complex. The PTW/PP1 phosphatase complex plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Mediates interaction of WDR82 and PPP1CA. Inhibitor of PPP1CA and PPP1CC phosphatase activities. Has inhibitory activity on PPP1CA only when phosphorylated. Binds to mRNA, single-stranded DNA (ssDNA), poly(A) and poly(G) [...] (925 aa) |
| | FMR1 | Fragile X mental retardation protein 1. (632 aa) |
| | PLA2R1 | Phospholipase A2 receptor 1. (1435 aa) |
| | FUS | FUS RNA binding protein. (518 aa) |
| | DDX39B | Spliceosome RNA helicase DDX39B; Involved in nuclear export of spliced and unspliced mRNA. Assembling component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pat [...] (467 aa) |
| | ZNHIT1 | Zinc finger HIT-type containing 1. (154 aa) |
| | YY1 | YY1 transcription factor. (438 aa) |
| | EYA2 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (583 aa) |
| | SHLD2 | Shieldin complex subunit 2. (907 aa) |
| | RBBP8 | RB binding protein 8, endonuclease. (897 aa) |
| | CRY1 | Cryptochrome circadian regulator 1. (588 aa) |
| | RAD51AP1 | RAD51 associated protein 1. (345 aa) |
| | ETAA1 | Ewing's tumor-associated antigen 1 isoform X2. (899 aa) |
| | BCL2L1 | Bcl-2-like protein 1; Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage- dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis. Regulates presynaptic plasticity, including neurotransmitter release and recovery, number of axonal mitochondria as well as size and number of synaptic vesicle clusters. During synaptic stimulation, increases ATP availab [...] (233 aa) |
| | BABAM1 | BRISC and BRCA1 A complex member 1. (332 aa) |
| | CDKN2D | Cyclin dependent kinase inhibitor 2D. (166 aa) |
| | ANKLE1 | Ankyrin repeat and LEM domain containing 1. (503 aa) |
| | BRCA1 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1865 aa) |
| | HSF1 | Heat shock transcription factor 1. (590 aa) |
| | RECQL5 | ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (984 aa) |
| | TRIM28 | Tripartite motif containing 28. (868 aa) |
| | XRCC1 | X-ray repair cross complementing 1. (617 aa) |
| | ACTB | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (375 aa) |
| | EPC1 | Enhancer of polycomb homolog. (841 aa) |
| | A0A286ZVL9_PIG | RING-type domain-containing protein. (137 aa) |
| | EEF1E1 | Eukaryotic translation elongation factor 1 epsilon-1 isoform 1. (174 aa) |
| | UBQLN4 | Ubiquilin-4 isoform 1. (601 aa) |
| | INO80E | INO80 complex subunit E isoform 1. (244 aa) |
| | WDR76 | WD repeat-containing protein 76; Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC. Belongs to the WD repeat DDB2/WDR76 family. (678 aa) |
| | PAXIP1 | PAX interacting protein 1. (1030 aa) |
| | YEATS4 | YEATS domain containing 4. (227 aa) |
| | TP53BP1 | Tumor protein p53 binding protein 1. (1931 aa) |
| | SNAI2 | Snail family transcriptional repressor 2. (268 aa) |
| | SIRT7 | Sirtuin 7. (447 aa) |
| | KLHL15 | Kelch like family member 15. (614 aa) |
| | EYA1 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (618 aa) |
| | ARID2 | AT-rich interaction domain 2. (1833 aa) |
| | MEAF6 | MYST/Esa1 associated factor 6. (216 aa) |
| | ING3 | Inhibitor of growth protein. (418 aa) |
| | USP1 | Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (784 aa) |
| | SPIRE1 | Spire type actin nucleation factor 1. (802 aa) |
| | HELB | DNA helicase B isoform X1. (1082 aa) |
| | PIAS4 | Protein inhibitor of activated STAT 4. (566 aa) |
| | PCNA | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (270 aa) |
| | CEBPG | CCAAT enhancer binding protein gamma. (164 aa) |
| | A0A287AFM3_PIG | Reverse transcriptase domain-containing protein. (831 aa) |
| | FOXM1 | Forkhead box M1. (766 aa) |
| | CLUL1 | Clusterin; Belongs to the clusterin family. (469 aa) |
| | FAM168A | Family with sequence similarity 168 member A. (234 aa) |
| | DYRK1A | Dual specificity tyrosine phosphorylation regulated kinase 1A. (764 aa) |
| | TMEM161A | Transmembrane protein 161A. (479 aa) |
| | RAD52 | RAD52 homolog, DNA repair protein. (406 aa) |
| | A0A287AMB0_PIG | TCTP domain-containing protein; Belongs to the TCTP family. (186 aa) |
| | ANKRD1 | Ankyrin repeat domain-containing protein 1; May play an important role in endothelial cell activation. May act as a nuclear transcription factor that negatively regulates the expression of cardiac genes (By similarity). (339 aa) |
| | TTI2 | TELO2 interacting protein 2. (507 aa) |
| | EYA4 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (645 aa) |
| | SELENOK | Selenoprotein K; Required for Ca(2+) flux in immune cells and plays a role in T-cell proliferation and in T-cell and neutrophil migration (By similarity). Involved in endoplasmic reticulum-associated degradation (ERAD) of soluble glycosylated proteins (By similarity). Required for palmitoylation and cell surface expression of CD36 and involved in macrophage uptake of low-density lipoprotein and in foam cell formation (By similarity). Together with ZDHHC6, required for palmitoylation of ITPR1 in immune cells, leading to regulate ITPR1 stability and function. Plays a role in protection o [...] (93 aa) |
| | FH | Fumarate hydratase, mitochondrial; Catalyzes the reversible stereospecific interconversion of fumarate to L-malate. Experiments in different species have demonstrated that specific isoforms of this protein act in defined pathways and favor one direction over the other (Probable). [Isoform Cytoplasmic]: Catalyzes the dehydration of L-malate to fumarate. Fumarate metabolism in the cytosol plays a role during urea cycle and arginine metabolism; fumarate being a by-product of the urea cycle and amino-acid catabolism (By similarity). Also plays a role in DNA repair by promoting non-homolog [...] (466 aa) |
| | THOC5 | THO complex subunit 5 homolog isoform X1. (694 aa) |
| | INO80D | INO80 complex subunit D. (1028 aa) |
| | SPIDR | DNA repair-scaffolding protein isoform 1. (924 aa) |
| | CCDC117 | Coiled-coil domain containing 117. (279 aa) |
| | PPP4R2 | Protein phosphatase 4 regulatory subunit 2. (414 aa) |
| | DMAP1 | DNA methyltransferase 1-associated protein 1 isoform X1. (468 aa) |
| | SNAI1 | Snail family transcriptional repressor 1. (264 aa) |
| | WAS | WASP actin nucleation promoting factor. (500 aa) |
| | CD74 | Thyroglobulin type-1 domain-containing protein. (347 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (442 aa) |
| | VPS72 | Vacuolar protein sorting-associated protein 72 homolog isoform 2. (364 aa) |
| | NSMCE1 | NSE1 homolog, SMC5-SMC6 complex component. (324 aa) |
| | SMG1 | SMG1 nonsense mediated mRNA decay associated PI3K related kinase; Belongs to the PI3/PI4-kinase family. (3646 aa) |
| | PARP9 | Poly(ADP-ribose) polymerase family member 9. (847 aa) |
| | TPT1 | Translationally-controlled tumor protein; Involved in calcium binding and microtubule stabilization. (245 aa) |
| | NACC2 | NACC family member 2. (588 aa) |
| | SETD2 | SET domain containing 2, histone lysine methyltransferase. (2557 aa) |
| | CLU | Clusterin alpha chain; Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysos [...] (472 aa) |
| | ABL1 | Tyrosine-protein kinase. (1146 aa) |
| | PRKCD | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (723 aa) |
| | TRIP12 | Thyroid hormone receptor interactor 12. (2026 aa) |
| | BABAM2 | BRISC and BRCA1 A complex member 2. (383 aa) |
| | ATAD5 | ATPase family AAA domain containing 5. (1891 aa) |
| | AXIN2 | Axin-2. (843 aa) |
| | ZNF385A | Zinc finger protein 385A. (406 aa) |
| | SLF2 | SMC5-SMC6 complex localization factor 2. (1169 aa) |
| | ZCWPW1 | Zinc finger CW-type and PWWP domain containing 1. (653 aa) |
| | RTEL1 | Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1349 aa) |
| | DYRK3 | Dual specificity tyrosine phosphorylation regulated kinase 3. (545 aa) |
| | DDX5 | DEAD-box helicase 5; Belongs to the DEAD box helicase family. (617 aa) |
| | NKX3-1 | Homeobox protein Nkx-3.1 isoform 1. (247 aa) |
| | BCLAF1 | BCL2 associated transcription factor 1. (933 aa) |
| | DDX39A | DExD-box helicase 39A. (452 aa) |
| | MGMT | O-6-methylguanine-DNA methyltransferase. (265 aa) |
| | KMT5B | Lysine methyltransferase 5B. (915 aa) |
| | A0A287BQB1_PIG | zf-C3HC4 domain-containing protein. (282 aa) |
| | POLQ | DNA polymerase theta isoform X1. (2600 aa) |
| | PPP4C | Serine/threonine-protein phosphatase. (307 aa) |
| | KMT5C | Lysine methyltransferase 5C. (455 aa) |
| | PSMD10 | Proteasome 26S subunit, non-ATPase 10. (226 aa) |
| | COPS3 | COP9 signalosome subunit 3. (426 aa) |
| | KMT5A | Lysine methyltransferase 5A. (496 aa) |
| | HMGA2 | Uncharacterized protein. (143 aa) |
| | NUDT16L1 | Nudix hydrolase 16 like 1. (212 aa) |
| | DEK | DEK proto-oncogene. (383 aa) |
| | RPS3 | 40S ribosomal protein S3; Involved in translation as a component of the 40S small ribosomal subunit. Has endonuclease activity and plays a role in repair of damaged DNA. Cleaves phosphodiester bonds of DNAs containing altered bases with broad specificity and cleaves supercoiled DNA more efficiently than relaxed DNA. Displays high binding affinity for 7,8- dihydro-8-oxoguanine (8-oxoG), a common DNA lesion caused by reactive oxygen species (ROS). Has also been shown to bind with similar affinity to intact and damaged DNA. Stimulates the N-glycosylase activity of the base excision protei [...] (259 aa) |
| | USP47 | Ubiquitin specific peptidase 47; Belongs to the peptidase C19 family. (1356 aa) |
| | UBE2V2 | UBIQUITIN_CONJUGAT_2 domain-containing protein. (159 aa) |
| | MAP3K20 | Mitogen-activated protein kinase kinase kinase 20. (799 aa) |
| | A0A5G2R3X2_PIG | Reverse transcriptase domain-containing protein. (774 aa) |
| | CCDC197 | Coiled-coil domain containing 197. (289 aa) |
| | KAT5 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (576 aa) |
| | ING4 | Inhibitor of growth family member 4. (277 aa) |
| | CXCL12 | C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. (119 aa) |
| | A0A5G2QSK7_PIG | Reverse transcriptase domain-containing protein. (680 aa) |
| | BCL7A | BAF chromatin remodeling complex subunit BCL7A. (260 aa) |
| | PNKP | Polynucleotide kinase 3'-phosphatase. (578 aa) |
| | CUL4A | Cullin 4A; Belongs to the cullin family. (712 aa) |
| | BRCC3 | BRCA1/BRCA2-containing complex subunit 3. (316 aa) |
| | THOC1 | THO complex 1. (702 aa) |
| | EGFR | Receptor protein-tyrosine kinase. (1205 aa) |
| | WDR48 | WD repeat domain 48. (740 aa) |
| | A0A5G2R3D3_PIG | Reverse transcriptase domain-containing protein. (1014 aa) |
| | SPRED1 | Sprouty related EVH1 domain containing 1. (445 aa) |
| | FBXO4 | F-box only protein 4. (387 aa) |
| | A0A5G2QVU0_PIG | Reverse transcriptase domain-containing protein. (742 aa) |
| | ENSA | Alpha-endosulfine; Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-67 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. Also acts as a stimulator of insulin secretion by interacting with sulfonylurea receptor (ABCC8), thereby preventing sulfonylurea from binding to its receptor and reducing K(ATP) channel currents (By similarity); Belongs to the endosulfine [...] (137 aa) |
| | KAT7 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (613 aa) |
| | A0A5G2R4M1_PIG | Reverse transcriptase domain-containing protein. (784 aa) |
| | NFRKB | Nuclear factor related to kappaB binding protein. (1333 aa) |
| | ERCC8 | ERCC excision repair 8, CSA ubiquitin ligase complex subunit. (396 aa) |
| | NEK4 | NIMA related kinase 4. (796 aa) |
| | MFSD11 | Major facilitator superfamily domain containing 11. (491 aa) |
| | A0A5G2RES6_PIG | Reverse transcriptase domain-containing protein. (356 aa) |
| | ENSSSCP00000073725 | annotation not available (332 aa) |
| | SHLD1 | Shieldin complex subunit 1. (276 aa) |
| | BCL7C | BAF chromatin remodeling complex subunit BCL7C. (243 aa) |
| | RNF168 | E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (575 aa) |
| | A0A5G2RGJ5_PIG | Uncharacterized protein. (102 aa) |
| | MYC | Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). (452 aa) |
