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| | BCLAF1 | BCL2 associated transcription factor 1. (933 aa) |
| | MGMT | O-6-methylguanine-DNA methyltransferase. (265 aa) |
| | KMT5B | Lysine methyltransferase 5B. (915 aa) |
| | A0A287BQB1_PIG | zf-C3HC4 domain-containing protein. (282 aa) |
| | KMT5C | Lysine methyltransferase 5C. (455 aa) |
| | RPS3 | 40S ribosomal protein S3; Involved in translation as a component of the 40S small ribosomal subunit. Has endonuclease activity and plays a role in repair of damaged DNA. Cleaves phosphodiester bonds of DNAs containing altered bases with broad specificity and cleaves supercoiled DNA more efficiently than relaxed DNA. Displays high binding affinity for 7,8- dihydro-8-oxoguanine (8-oxoG), a common DNA lesion caused by reactive oxygen species (ROS). Has also been shown to bind with similar affinity to intact and damaged DNA. Stimulates the N-glycosylase activity of the base excision protei [...] (259 aa) |
| | UBE2V2 | UBIQUITIN_CONJUGAT_2 domain-containing protein. (159 aa) |
| | MAP3K20 | Mitogen-activated protein kinase kinase kinase 20. (799 aa) |
| | A0A5G2R3X2_PIG | Reverse transcriptase domain-containing protein. (774 aa) |
| | KAT5 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (576 aa) |
| | ING4 | Inhibitor of growth family member 4. (277 aa) |
| | A0A5G2QSK7_PIG | Reverse transcriptase domain-containing protein. (680 aa) |
| | BCL7A | BAF chromatin remodeling complex subunit BCL7A. (260 aa) |
| | PNKP | Polynucleotide kinase 3'-phosphatase. (578 aa) |
| | BRCC3 | BRCA1/BRCA2-containing complex subunit 3. (316 aa) |
| | EGFR | Receptor protein-tyrosine kinase. (1205 aa) |
| | WDR48 | WD repeat domain 48. (740 aa) |
| | A0A5G2R3D3_PIG | Reverse transcriptase domain-containing protein. (1014 aa) |
| | SPRED1 | Sprouty related EVH1 domain containing 1. (445 aa) |
| | A0A5G2QVU0_PIG | Reverse transcriptase domain-containing protein. (742 aa) |
| | A0A5G2R4M1_PIG | Reverse transcriptase domain-containing protein. (784 aa) |
| | NFRKB | Nuclear factor related to kappaB binding protein. (1333 aa) |
| | ERCC8 | ERCC excision repair 8, CSA ubiquitin ligase complex subunit. (396 aa) |
| | A0A5G2RES6_PIG | Reverse transcriptase domain-containing protein. (356 aa) |
| | MFSD11 | Major facilitator superfamily domain containing 11. (491 aa) |
| | ENSSSCP00000073725 | annotation not available (332 aa) |
| | SHLD1 | Shieldin complex subunit 1. (276 aa) |
| | BCL7C | BAF chromatin remodeling complex subunit BCL7C. (243 aa) |
| | RNF168 | E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (575 aa) |
| | A0A5G2RGJ5_PIG | Uncharacterized protein. (102 aa) |
| | MYC | Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). (452 aa) |
| | MCRS1 | Microspherule protein 1. (487 aa) |
| | TIMELESS | Timeless circadian regulator. (1206 aa) |
| | ACRBP | Acrosin-binding protein; May be involved in packaging and condensation of the acrosin zymogen in the acrosomal matrix via its association with proacrosin. (539 aa) |
| | SPIRE2 | Spire type actin nucleation factor 2. (763 aa) |
| | RUVBL2 | RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (525 aa) |
| | PRKCG | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (759 aa) |
| | TFPT | TCF3 fusion partner isoform 1. (253 aa) |
| | EYA3 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (573 aa) |
| | KHDC3L | MOEP19 domain-containing protein. (142 aa) |
| | OOEP | Oocyte-expressed protein homolog. (148 aa) |
| | INO80 | INO80 complex ATPase subunit. (1566 aa) |
| | ENDOG | Endonuclease. (299 aa) |
| | PRKDC | Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4136 aa) |
| | POGZ | Pogo transposable element with ZNF domain isoform X1. (1412 aa) |
| | BCL7B | BAF chromatin remodeling complex subunit BCL7B. (249 aa) |
| | NPAS2 | Neuronal PAS domain protein 2. (796 aa) |
| | FAM178B | Uncharacterized protein. (569 aa) |
| | ABRAXAS1 | Abraxas 1, BRCA1 A complex subunit. (405 aa) |
| | HELQ | Helicase, POLQ like. (1076 aa) |
| | CCAR2 | DBC1 domain-containing protein. (916 aa) |
| | PBK | Lymphokine-activated killer T-cell-originated protein kinase isoform X1. (322 aa) |
| | SIRT1 | NAD-dependent protein deacetylase sirtuin-1 isoform a. (742 aa) |
| | ERCC6 | ERCC excision repair 6, chromatin remodeling factor. (1462 aa) |
| | MMS19 | MMS19 homolog, cytosolic iron-sulfur assembly component. (1039 aa) |
| | NSMCE4A | Non-structural maintenance of chromosomes element 4; Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids. (382 aa) |
| | UCHL5 | Ubiquitin carboxyl-terminal hydrolase isozyme L5; Protease that specifically cleaves 'Lys-48'-linked polyubiquitin chains. Deubiquitinating enzyme associated with the 19S regulatory subunit of the 26S proteasome. Putative regulatory component of the INO80 complex; however is inactive in the INO80 complex and is activated by a transient interaction of the INO80 complex with the proteasome via ADRM1 (By similarity). (327 aa) |
| | ACTR8 | Actin-related protein 8; Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize; Belongs to the actin family. ARP8 subfamily. (624 aa) |
| | ATR | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2643 aa) |
| | SKIL | Ski-like protein isoform X1. (661 aa) |
| | ACTL6A | Actin-like protein 6A isoform X1; Belongs to the actin family. (429 aa) |
| | MORF4L2 | Mortality factor 4 like 2. (288 aa) |
| | RAD9A | Cell cycle checkpoint control protein; Belongs to the rad9 family. (443 aa) |
| | SIRT6 | Deacetylase sirtuin-type domain-containing protein. (327 aa) |
| | HDGFL2 | HDGF like 2. (667 aa) |
| | MRNIP | Uncharacterized protein. (216 aa) |
| | SLF1 | SMC5-SMC6 complex localization factor 1. (1055 aa) |
| | ATM | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospec [...] (3057 aa) |
| | EPC2 | Enhancer of polycomb homolog. (807 aa) |
| | RIF1 | Replication timing regulatory factor 1. (2466 aa) |
| | FGF10 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa) |
| | MBTD1 | Mbt domain containing 1. (715 aa) |
| | WRAP53 | WD repeat containing antisense to TP53. (539 aa) |
| | FXR2 | FMR1 autosomal homolog 2. (667 aa) |
| | SMCHD1 | Structural maintenance of chromosomes flexible hinge domain containing 1. (1997 aa) |
| | RUVBL1 | RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (463 aa) |
| | EP400 | E1A binding protein p400. (3210 aa) |
| | FBH1 | F-box DNA helicase 1 isoform X1. (1045 aa) |
| | TIGAR | TP53 induced glycolysis regulatory phosphatase. (269 aa) |
| | BRD8 | Bromodomain containing 8. (1236 aa) |
| | PARP1 | Poly [ADP-ribose] polymerase. (1017 aa) |
| | HIC1 | Hypermethylated in cancer 1 protein isoform 2. (733 aa) |
| | FXR1 | Fragile X mental retardation syndrome-related protein 1 isoform X1. (677 aa) |
| | PARP3 | Poly [ADP-ribose] polymerase. (539 aa) |
| | HDAC10 | Histone deacetylase 10. (671 aa) |
| | MAD2L2 | Mitotic spindle assembly checkpoint protein MAD2B. (211 aa) |
| | UIMC1 | BRCA1-A complex subunit RAP80; Ubiquitin-binding protein. Specifically recognizes and binds 'Lys-63'-linked ubiquitin. Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. M [...] (622 aa) |
| | DTX3L | Deltex E3 ubiquitin ligase 3L. (737 aa) |
| | PMAIP1 | Uncharacterized protein. (121 aa) |
| | FANCB | FA complementation group B. (855 aa) |
| | DHX9 | ATP-dependent RNA helicase A. (1384 aa) |
| | FMR1 | Fragile X mental retardation protein 1. (632 aa) |
| | PLA2R1 | Phospholipase A2 receptor 1. (1435 aa) |
| | FUS | FUS RNA binding protein. (518 aa) |
| | ZNHIT1 | Zinc finger HIT-type containing 1. (154 aa) |
| | YY1 | YY1 transcription factor. (438 aa) |
| | EYA2 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (583 aa) |
| | SHLD2 | Shieldin complex subunit 2. (907 aa) |
| | RBBP8 | RB binding protein 8, endonuclease. (897 aa) |
| | RAD51AP1 | RAD51 associated protein 1. (345 aa) |
| | BABAM1 | BRISC and BRCA1 A complex member 1. (332 aa) |
| | ANKLE1 | Ankyrin repeat and LEM domain containing 1. (503 aa) |
| | BRCA1 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1865 aa) |
| | TRIM28 | Tripartite motif containing 28. (868 aa) |
| | XRCC1 | X-ray repair cross complementing 1. (617 aa) |
| | ACTB | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (375 aa) |
| | EPC1 | Enhancer of polycomb homolog. (841 aa) |
| | A0A286ZVL9_PIG | RING-type domain-containing protein. (137 aa) |
| | EEF1E1 | Eukaryotic translation elongation factor 1 epsilon-1 isoform 1. (174 aa) |
| | INO80E | INO80 complex subunit E isoform 1. (244 aa) |
| | PAXIP1 | PAX interacting protein 1. (1030 aa) |
| | YEATS4 | YEATS domain containing 4. (227 aa) |
| | EYA1 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (618 aa) |
| | ARID2 | AT-rich interaction domain 2. (1833 aa) |
| | MEAF6 | MYST/Esa1 associated factor 6. (216 aa) |
| | ING3 | Inhibitor of growth protein. (418 aa) |
| | SPIRE1 | Spire type actin nucleation factor 1. (802 aa) |
| | PIAS4 | Protein inhibitor of activated STAT 4. (566 aa) |
| | PCNA | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (270 aa) |
| | CEBPG | CCAAT enhancer binding protein gamma. (164 aa) |
| | A0A287AFM3_PIG | Reverse transcriptase domain-containing protein. (831 aa) |
| | FOXM1 | Forkhead box M1. (766 aa) |
| | FAM168A | Family with sequence similarity 168 member A. (234 aa) |
| | TMEM161A | Transmembrane protein 161A. (479 aa) |
| | ANKRD1 | Ankyrin repeat domain-containing protein 1; May play an important role in endothelial cell activation. May act as a nuclear transcription factor that negatively regulates the expression of cardiac genes (By similarity). (339 aa) |
| | TTI2 | TELO2 interacting protein 2. (507 aa) |
| | EYA4 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (645 aa) |
| | SELENOK | Selenoprotein K; Required for Ca(2+) flux in immune cells and plays a role in T-cell proliferation and in T-cell and neutrophil migration (By similarity). Involved in endoplasmic reticulum-associated degradation (ERAD) of soluble glycosylated proteins (By similarity). Required for palmitoylation and cell surface expression of CD36 and involved in macrophage uptake of low-density lipoprotein and in foam cell formation (By similarity). Together with ZDHHC6, required for palmitoylation of ITPR1 in immune cells, leading to regulate ITPR1 stability and function. Plays a role in protection o [...] (93 aa) |
| | FH | Fumarate hydratase, mitochondrial; Catalyzes the reversible stereospecific interconversion of fumarate to L-malate. Experiments in different species have demonstrated that specific isoforms of this protein act in defined pathways and favor one direction over the other (Probable). [Isoform Cytoplasmic]: Catalyzes the dehydration of L-malate to fumarate. Fumarate metabolism in the cytosol plays a role during urea cycle and arginine metabolism; fumarate being a by-product of the urea cycle and amino-acid catabolism (By similarity). Also plays a role in DNA repair by promoting non-homolog [...] (466 aa) |
| | INO80D | INO80 complex subunit D. (1028 aa) |
| | SPIDR | DNA repair-scaffolding protein isoform 1. (924 aa) |
| | CCDC117 | Coiled-coil domain containing 117. (279 aa) |
| | DMAP1 | DNA methyltransferase 1-associated protein 1 isoform X1. (468 aa) |
| | WAS | WASP actin nucleation promoting factor. (500 aa) |
| | VPS72 | Vacuolar protein sorting-associated protein 72 homolog isoform 2. (364 aa) |
| | NSMCE1 | NSE1 homolog, SMC5-SMC6 complex component. (324 aa) |
| | PARP9 | Poly(ADP-ribose) polymerase family member 9. (847 aa) |
| | NACC2 | NACC family member 2. (588 aa) |
| | PRKCD | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (723 aa) |
| | BABAM2 | BRISC and BRCA1 A complex member 2. (383 aa) |
| | ZNF385A | Zinc finger protein 385A. (406 aa) |
| | SLF2 | SMC5-SMC6 complex localization factor 2. (1169 aa) |
| | ZCWPW1 | Zinc finger CW-type and PWWP domain containing 1. (653 aa) |
| | DDX5 | DEAD-box helicase 5; Belongs to the DEAD box helicase family. (617 aa) |
| | NKX3-1 | Homeobox protein Nkx-3.1 isoform 1. (247 aa) |
