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| | LRRK2 | Uncharacterized protein. (2501 aa) |
| | ARMC12 | Armadillo repeat containing 12. (363 aa) |
| | LOC100525346 | Uncharacterized protein. (459 aa) |
| | DNAJC11 | DnaJ heat shock protein family (Hsp40) member C11. (559 aa) |
| | TOMM20L | Translocase of outer mitochondrial membrane 20 like. (152 aa) |
| | TOMM5 | Mitochondrial import receptor subunit TOM5. (51 aa) |
| | ARMC1 | Armadillo repeat-containing protein 1. (282 aa) |
| | TOMM40L | Translocase of outer mitochondrial membrane 40 like. (308 aa) |
| | MTX1 | Metaxin-1; Involved in transport of proteins into the mitochondrion. Essential for embryonic development (By similarity); Belongs to the metaxin family. (463 aa) |
| | HAX1 | HCLS1-associated protein X-1; Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex. Slows down the rate of inactivation of KCNC3 channels. Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools; Belongs to the HAX1 family. (284 aa) |
| | PI4KB | Phosphatidylinositol 4-kinase beta; Belongs to the PI3/PI4-kinase family. (841 aa) |
| | VDAC3 | Voltage-dependent anion-selective channel protein 3; Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules; Belongs to the eukaryotic mitochondrial porin family. (284 aa) |
| | FAM210B | Family with sequence similarity 210 member B. (239 aa) |
| | F1SU50_PIG | Uncharacterized protein. (722 aa) |
| | HK2 | Hexokinase-2; Catalyzes the phosphorylation of hexose, such as D-glucose and D-fructose, to hexose 6-phosphate (D-glucose 6-phosphate and D- fructose 6-phosphate, respectively). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6- phosphate. Plays a key role in maintaining the integrity of the outer mitochondrial membrane by preventing the release of apoptogenic molecules from the intermembrane space and subsequent apoptosis. Belongs to the hexokinase family. (917 aa) |
| | MGARP | AIF-MLS domain-containing protein. (238 aa) |
| | CISD2 | CDGSH iron-sulfur domain-containing protein 2. (135 aa) |
| | LOC100520401 | ZnF_CDGSH domain-containing protein. (106 aa) |
| | VDAC2 | Voltage-dependent anion-selective channel protein 2; Forms a channel through the cell membrane that allows diffusion from small hydrophilic molecules. (294 aa) |
| | SFXN2 | Sidoreflexin. (322 aa) |
| | GPAM | Glycerol-3-phosphate acyltransferase 1, mitochondrial; Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis. (825 aa) |
| | PDZD8 | PDZ domain-containing protein 8. (1154 aa) |
| | MARC2 | Mitochondrial amidoxime reducing component 2; Catalyzes the reduction of N-oxygenated molecules, acting as a counterpart of cytochrome P450 and flavin-containing monooxygenases in metabolic cycles. As a component of prodrug-converting system, reduces a multitude of N-hydroxylated prodrugs particularly amidoximes, leading to increased drug bioavailability. May be involved in mitochondrial N(omega)-hydroxy-L-arginine (NOHA) reduction, regulating endogenous nitric oxide levels and biosynthesis. Postulated to cleave the N-OH bond of N-hydroxylated substrates in concert with electron transf [...] (339 aa) |
| | MAOA | Amine oxidase [flavin-containing] A; Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine (By similarity). (946 aa) |
| | CPT1A | Uncharacterized protein; Belongs to the carnitine/choline acetyltransferase family. (771 aa) |
| | TOMM7 | Mitochondrial import receptor subunit TOM7 homolog; Required for assembly and stability of the TOM complex (By similarity). Positive regulator of PRKN translocation to damaged mitochondria. Acts probably by stabilizing PINK1 on the outer membrane of depolarized mitochondria (By similarity). (55 aa) |
| | UBB | Ubiquitin B. (229 aa) |
| | SYNJ2BP | Synaptojanin 2 binding protein. (164 aa) |
| | VAT1 | Synaptic vesicle membrane protein VAT-1 homolog. (400 aa) |
| | TIGAR | TP53 induced glycolysis regulatory phosphatase. (269 aa) |
| | SPATA19 | Spermatogenesis-associated protein 19, mitochondrial. (154 aa) |
| | BNIP3 | BCL2 interacting protein 3. (202 aa) |
| | PODN | LRRNT domain-containing protein. (697 aa) |
| | MAOB | Amine oxidase [flavin-containing] B; Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine (By similarity). (518 aa) |
| | MUL1 | Mitochondrial E3 ubiquitin protein ligase 1. (305 aa) |
| | GPAT2 | PlsC domain-containing protein. (800 aa) |
| | MTX3 | Metaxin. (320 aa) |
| | MTX2 | Metaxin-2; Involved in transport of proteins into the mitochondrion. (284 aa) |
| | PGRMC1 | Membrane-associated progesterone receptor component 1; Component of a progesterone-binding protein complex. Binds progesterone. Has many reported cellular functions (heme homeostasis, interaction with CYPs). (194 aa) |
| | FUNDC1 | FUN14 domain containing 1. (158 aa) |
| | A0A286ZLQ1_PIG | Miff domain-containing protein. (121 aa) |
| | BAK1 | Uncharacterized protein. (266 aa) |
| | GDAP1L1 | Ganglioside-induced differentiation-associated protein 1-like 1 isoform 2. (367 aa) |
| | BCL2L1 | Bcl-2-like protein 1; Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage- dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis. Regulates presynaptic plasticity, including neurotransmitter release and recovery, number of axonal mitochondria as well as size and number of synaptic vesicle clusters. During synaptic stimulation, increases ATP availab [...] (233 aa) |
| | LOC100739656 | Uncharacterized protein. (128 aa) |
| | HKDC1 | Hexokinase domain containing 1. (917 aa) |
| | MTCH2 | Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (334 aa) |
| | PLD6 | Phospholipase D family member 6. (221 aa) |
| | SOX10 | Transcription factor SOX-10; Transcription factor that plays a central role in developing and mature glia. Specifically activates expression of myelin genes, during oligodendrocyte (OL) maturation, such as DUSP15 and MYRF, thereby playing a central role in oligodendrocyte maturation and CNS myelination. Once induced, MYRF cooperates with SOX10 to implement the myelination program. Transcriptional activator of MITF, acting synergistically with PAX3 (By similarity). (542 aa) |
| | GDAP1 | Ganglioside induced differentiation associated protein 1; Belongs to the GST superfamily. (362 aa) |
| | RHOT1 | Ras homolog family member T1. (752 aa) |
| | MFN1 | Mitochondrial mitofusin 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (741 aa) |
| | MARCHF5 | Membrane associated ring-CH-type finger 5. (145 aa) |
| | SAMM50 | SAMM50 sorting and assembly machinery component. (469 aa) |
| | MSTO1 | Misato mitochondrial distribution and morphology regulator 1. (566 aa) |
| | SPIRE1 | Spire type actin nucleation factor 1. (802 aa) |
| | FIS1 | Mitochondrial fission 1 protein; Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. (152 aa) |
| | BAD | BCL2 associated agonist of cell death. (209 aa) |
| | ACSL1 | Acyl-CoA synthetase long chain family member 1. (771 aa) |
| | BNIP3L | BCL2 interacting protein 3 like. (204 aa) |
| | CPT1B | Carnitine O-palmitoyltransferase 1, muscle isoform. (807 aa) |
| | A0A287AS79_PIG | Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (232 aa) |
| | VDAC1 | Voltage-dependent anion-selective channel protein 1; Forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. May participate in the formation of the permeability transition p [...] (302 aa) |
| | BID | BH3-interacting domain death agonist p11; Induces caspases and apoptosis. Counters the protective effect of Bcl-2. The major proteolytic product p15 BID allows the release of cytochrome c (By similarity). (205 aa) |
| | MIEF2 | Mitochondrial elongation factor 2. (472 aa) |
| | ATF2 | Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa) |
| | TMEM205 | Transmembrane protein 205. (199 aa) |
| | USP30 | Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (516 aa) |
| | TAZ | Tafazzin family protein; Some isoforms may be involved in cardiolipin metabolism. (395 aa) |
| | A0A287BBW3_PIG | ZnF_CDGSH domain-containing protein. (123 aa) |
| | TOMM6 | Translocase of outer mitochondrial membrane 6. (74 aa) |
| | RAB38 | Ras-related protein Rab-32; Acts as an A-kinase anchoring protein by binding to the type II regulatory subunit of protein kinase A and anchoring it to the mitochondrion. Also involved in synchronization of mitochondrial fission. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and Mycobacterium. Plays an important role in the control of melanin production and melanosome biogenesis. In concert with RAB38, regulates the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes. Belongs to the small GTPase superfam [...] (211 aa) |
| | MFN2 | Mitofusin-2 isoform X1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (757 aa) |
| | TOMM34 | Translocase of outer mitochondrial membrane 34. (309 aa) |
| | SPART | Spartin. (666 aa) |
| | A0A287BQP7_PIG | Mab-21 domain-containing protein. (155 aa) |
| | A0A5G2QGL4_PIG | Uncharacterized protein. (51 aa) |
| | MFF | Miff domain-containing protein. (341 aa) |
| | UBC | Ubiquitin-related; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repa [...] (837 aa) |
| | FUNDC2 | FUN14 domain-containing protein 2; Belongs to the FUN14 family. (215 aa) |
| | TOMM70 | Translocase of outer mitochondrial membrane 70. (609 aa) |
| | TOMM40 | Translocase of outer mitochondrial membrane 40. (400 aa) |
| | CISD1 | ZnF_CDGSH domain-containing protein. (135 aa) |
| | CYB5B | Cytochrome b5 heme-binding domain-containing protein; Belongs to the cytochrome b5 family. (148 aa) |
| | RTN4IP1 | Reticulon 4 interacting protein 1. (476 aa) |
| | A0A5G2QRP7_PIG | Uncharacterized protein. (104 aa) |
| | KMO | Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract. Belongs to the aromatic-ring hydroxylase family. KMO subfamily. (547 aa) |
| | TOMM20 | Translocase of outer mitochondrial membrane 20. (152 aa) |
| | HK1 | Uncharacterized protein. (919 aa) |
| | TOMM22 | Uncharacterized protein. (207 aa) |
| | MFSD11 | Major facilitator superfamily domain containing 11. (491 aa) |
| | SPATA18 | Mitochondria-eating protein; Key regulator of mitochondrial quality that mediates the repairing or degradation of unhealthy mitochondria in response to mitochondrial damage. Mediator of mitochondrial protein catabolic process (also named MALM) by mediating the degradation of damaged proteins inside mitochondria by promoting the accumulation in the mitochondrial matrix of hydrolases that are characteristic of the lysosomal lumen. Also involved in mitochondrion degradation of damaged mitochondria by promoting the formation of vacuole-like structures (named MIV), which engulf and degrade [...] (577 aa) |
