36 items (Sus scrofa) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	CACNA1H	Voltage-dependent T-type calcium channel subunit alpha-1H isoform a. (2328 aa)
	CACNA1S	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1873 aa)
	CACNG8	Voltage-dependent calcium channel gamma-8 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (423 aa)
	CACNG6	Voltage-dependent calcium channel gamma-6 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (259 aa)
	TMEM249	Transmembrane protein 249. (237 aa)
	CASQ1	Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (402 aa)
	FKBP1A	Peptidylprolyl isomerase. (240 aa)
	CACNA1D	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2211 aa)
	CATSPERZ	Uncharacterized protein. (289 aa)
	CATSPERD	Cation channel sperm associated auxiliary subunit delta. (790 aa)
	CACNA1E	Voltage-dependent R-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. (2447 aa)
	EFCAB9	Uncharacterized protein. (328 aa)
	CACNG1	Voltage-dependent calcium channel gamma-1 subunit; Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Regulates channel inactivation kinetics; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (224 aa)
	CACNA2D4	Calcium voltage-gated channel auxiliary subunit alpha2delta 4. (1114 aa)
	CATSPER3	Ion_trans domain-containing protein. (425 aa)
	CATSPER4	Cation channel sperm associated 4. (471 aa)
	CATSPERB	Cation channel sperm associated auxiliary subunit beta. (1030 aa)
	CACNA2D2	Calcium voltage-gated channel auxiliary subunit alpha2delta 2. (1068 aa)
	CACNB3	Voltage-dependent L-type calcium channel subunit beta-3 isoform 1. (484 aa)
	CACNA1A	Uncharacterized protein. (434 aa)
	CACNA1C	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1291 aa)
	CACNA2D3	Calcium voltage-gated channel auxiliary subunit alpha2delta 3. (1092 aa)
	CACNB4	SH3 domain-containing protein. (519 aa)
	CACNB2	Calcium voltage-gated channel auxiliary subunit beta 2. (656 aa)
	CACNA1B	Voltage-dependent N-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. (2329 aa)
	CACNA1F	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1977 aa)
	CACNA2D1	Calcium voltage-gated channel auxiliary subunit alpha2delta 1. (1110 aa)
	CATSPER2	Cation channel sperm associated 2. (538 aa)
	A0A5G2Q7N9_PIG	Ion_trans domain-containing protein. (292 aa)
	CATSPERE	Catsper channel auxiliary subunit epsilon. (951 aa)
	TMEM262	Transmembrane protein 262. (116 aa)
	RYR3	Ryanodine receptor 3. (4871 aa)
	CALM3	Uncharacterized protein; Belongs to the calmodulin family. (214 aa)
	RYR2	Ryanodine receptor 2. (4966 aa)
	PDE4B	Phosphodiesterase. (736 aa)
	CATSPER1	Ion_trans domain-containing protein. (724 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A5G2Q7N9_PIG	CACNB4	ENSSSCP00000060119	ENSSSCP00000043421	Ion_trans domain-containing protein.	SH3 domain-containing protein.	0.433
A0A5G2Q7N9_PIG	CACNG1	ENSSSCP00000060119	ENSSSCP00000018299	Ion_trans domain-containing protein.	Voltage-dependent calcium channel gamma-1 subunit; Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Regulates channel inactivation kinetics; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.	0.441
A0A5G2Q7N9_PIG	CATSPER3	ENSSSCP00000060119	ENSSSCP00000025936	Ion_trans domain-containing protein.	Ion_trans domain-containing protein.	0.467
A0A5G2Q7N9_PIG	CATSPER4	ENSSSCP00000060119	ENSSSCP00000028118	Ion_trans domain-containing protein.	Cation channel sperm associated 4.	0.539
CACNA1A	CACNA1B	ENSSSCP00000038048	ENSSSCP00000045750	Uncharacterized protein.	Voltage-dependent N-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents.	0.913
CACNA1A	CACNA1C	ENSSSCP00000038048	ENSSSCP00000041051	Uncharacterized protein.	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.	0.913
CACNA1A	CACNA1E	ENSSSCP00000038048	ENSSSCP00000016478	Uncharacterized protein.	Voltage-dependent R-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents.	0.923
CACNA1A	CACNA2D1	ENSSSCP00000038048	ENSSSCP00000052639	Uncharacterized protein.	Calcium voltage-gated channel auxiliary subunit alpha2delta 1.	0.754
CACNA1A	CACNA2D2	ENSSSCP00000038048	ENSSSCP00000032994	Uncharacterized protein.	Calcium voltage-gated channel auxiliary subunit alpha2delta 2.	0.800
CACNA1A	CACNA2D3	ENSSSCP00000038048	ENSSSCP00000041566	Uncharacterized protein.	Calcium voltage-gated channel auxiliary subunit alpha2delta 3.	0.650
CACNA1A	CACNA2D4	ENSSSCP00000038048	ENSSSCP00000021944	Uncharacterized protein.	Calcium voltage-gated channel auxiliary subunit alpha2delta 4.	0.569
CACNA1A	CACNB2	ENSSSCP00000038048	ENSSSCP00000045516	Uncharacterized protein.	Calcium voltage-gated channel auxiliary subunit beta 2.	0.816
CACNA1A	CACNB3	ENSSSCP00000038048	ENSSSCP00000033312	Uncharacterized protein.	Voltage-dependent L-type calcium channel subunit beta-3 isoform 1.	0.669
CACNA1A	CACNB4	ENSSSCP00000038048	ENSSSCP00000043421	Uncharacterized protein.	SH3 domain-containing protein.	0.640
CACNA1A	CACNG1	ENSSSCP00000038048	ENSSSCP00000018299	Uncharacterized protein.	Voltage-dependent calcium channel gamma-1 subunit; Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Regulates channel inactivation kinetics; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.	0.469
CACNA1B	CACNA1A	ENSSSCP00000045750	ENSSSCP00000038048	Voltage-dependent N-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents.	Uncharacterized protein.	0.913
CACNA1B	CACNA1C	ENSSSCP00000045750	ENSSSCP00000041051	Voltage-dependent N-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents.	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.	0.515
CACNA1B	CACNA1D	ENSSSCP00000045750	ENSSSCP00000012208	Voltage-dependent N-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents.	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.	0.646
CACNA1B	CACNA1E	ENSSSCP00000045750	ENSSSCP00000016478	Voltage-dependent N-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents.	Voltage-dependent R-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents.	0.940
CACNA1B	CACNA1F	ENSSSCP00000045750	ENSSSCP00000048418	Voltage-dependent N-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents.	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.	0.585