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| | RAMP2 | Receptor activity-modifying protein 2. (177 aa) |
| | HAVCR1 | Hepatitis A virus cellular receptor 1 isoform X1. (349 aa) |
| | CD180 | Lymphocyte antigen 64-like protein. (661 aa) |
| | ACKR3 | Atypical chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (362 aa) |
| | AAMP | Angio associated migratory cell protein. (388 aa) |
| | LCT | Uncharacterized protein. (1898 aa) |
| | CD36 | Platelet glycoprotein 4 isoform X1; Belongs to the CD36 family. (472 aa) |
| | IZUMO1R | IZUMO1 receptor, JUNO. (243 aa) |
| | CLEC17A | C-type lectin domain family 17, member A isoform X1. (327 aa) |
| | CD209 | CD209 antigen isoform X1. (240 aa) |
| | CD44 | CD44 molecule (Indian blood group). (767 aa) |
| | CBLIF | Cobalamin binding intrinsic factor. (425 aa) |
| | SRPX2 | Sushi repeat containing protein X-linked 2. (465 aa) |
| | CD80 | CD80 molecule. (297 aa) |
| | GHSR | Growth hormone secretagogue receptor type 1; Receptor for ghrelin, coupled to G-alpha-11 proteins. Stimulates growth hormone secretion. Binds also other growth hormone releasing peptides (GHRP) (e.g. Met-enkephalin and GHRP-6) as well as non-peptide, low molecular weight secretagogues (e.g. L-692,429, MK- 0677, adenosine). (366 aa) |
| | P2RY12 | Purinergic receptor P2Y12. (339 aa) |
| | LRP2 | Low-density lipoprotein receptor-related protein 2; Multiligand endocytic receptor (By similarity). Acts together with CUBN to mediate endocytosis of high-density lipoproteins (By similarity). Mediates receptor-mediated uptake of polybasic drugs such as aprotinin, aminoglycosides and polymyxin B (By similarity). In the kidney, mediates the tubular uptake and clearance of leptin (By similarity). Also mediates transport of leptin across the blood-brain barrier through endocytosis at the choroid plexus epithelium (By similarity). Endocytosis of leptin in neuronal cells is required for hyp [...] (4626 aa) |
| | CCL19 | C-C motif chemokine. (100 aa) |
| | MIF | Macrophage migration inhibitory factor; Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity (By simi [...] (115 aa) |
| | LOC100624226 | Uncharacterized protein. (446 aa) |
| | AREG | Amphiregulin long form. (247 aa) |
| | TMPRSS11F | Transmembrane protease serine; Belongs to the peptidase S1 family. (438 aa) |
| | TGFA | Protransforming growth factor alpha; TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar. (160 aa) |
| | ADRA2B | Alpha-2B adrenergic receptor. (446 aa) |
| | ITGAM | Integrin subunit alpha M; Belongs to the integrin alpha chain family. (1272 aa) |
| | PDGFA | Platelet derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (286 aa) |
| | SULF2 | Extracellular sulfatase; Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C- 6 position of glucosamine within specific subregions of intact heparin. Belongs to the sulfatase family. (906 aa) |
| | PGB | Pepsin B; Belongs to the peptidase A1 family. (391 aa) |
| | WNT2B | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (392 aa) |
| | CD58 | Uncharacterized protein. (243 aa) |
| | ADAM15 | Disintegrin and metalloproteinase domain-containing protein 15 isoform 6 preproprotein. (866 aa) |
| | SLAMF9 | SLAM family member 9. (369 aa) |
| | CD244 | CD244 molecule. (369 aa) |
| | SELE | E-selectin; Cell-surface glycoprotein having a role in immunoadhesion. Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with SELPLG/PSGL1. May have a role in capillary morphogenesis (By similarity). Belongs to the selectin/LECAM family. (484 aa) |
| | SULF1 | Sulfatase 1. (1108 aa) |
| | FZD6 | Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (711 aa) |
| | PCSK6 | Proprotein convertase subtilisin/kexin type 6 isoform PACE4-AI preproprotein; Belongs to the peptidase S8 family. (965 aa) |
| | ANXA1 | Annexin A1; Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity. Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response. Promotes resolution of inflammation and wound healing (By similarity). Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (By similarity). Contribut [...] (346 aa) |
| | CD274 | CD274 molecule. (311 aa) |
| | TEK | TEK receptor tyrosine kinase. (1147 aa) |
| | WNT4 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa) |
| | EPHA2 | Ephrin type-A receptor 2 isoform 1. (975 aa) |
| | LOC100515551 | Uncharacterized protein. (551 aa) |
| | BSPH1 | Binder of sperm protein homolog 1. (127 aa) |
| | TYROBP | TYRO protein tyrosine kinase-binding protein; Adapter protein which non-covalently associates with activating receptors found on the surface of a variety of immune cells to mediate signaling and cell activation following ligand binding by the receptors (By similarity). TYROBP is tyrosine-phosphorylated in the ITAM domain following ligand binding by the associated receptors which leads to activation of additional tyrosine kinases and subsequent cell activation (By similarity). Also has an inhibitory role in some cells (By similarity). Non-covalently associates with activating receptors [...] (109 aa) |
| | TREML1 | Triggering receptor expressed on myeloid cells like 1. (310 aa) |
| | LOC100513868 | Uncharacterized protein. (522 aa) |
| | NOTCH4 | Uncharacterized protein. (1993 aa) |
| | STAB2 | Uncharacterized protein. (2550 aa) |
| | CD27 | CD27. (249 aa) |
| | CD69 | C-type lectin domain-containing protein. (200 aa) |
| | CLEC7A | C-type lectin domain containing 7A. (247 aa) |
| | TMX3 | Thioredoxin related transmembrane protein 3. (454 aa) |
| | LDLR | Low-density lipoprotein receptor; Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. (878 aa) |
| | HPN | Hepsin; Belongs to the peptidase S1 family. (449 aa) |
| | PLA2G1B | Phospholipase A2, major isoenzyme; PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides, this releases glycerophospholipids and arachidonic acid that serve as the precursors of signal molecules. Belongs to the phospholipase A2 family. (146 aa) |
| | RSPO2 | Uncharacterized protein. (242 aa) |
| | CCR5 | C-C motif chemokine receptor 5 (gene/pseudogene); Belongs to the G-protein coupled receptor 1 family. (361 aa) |
| | CYTH1 | Cytohesin 1. (400 aa) |
| | A0A287B199_PIG | Ig-like domain-containing protein. (313 aa) |
| | THY1 | Thy-1 cell surface antigen. (165 aa) |
| | WNT2 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa) |
| | CD40 | Tumor necrosis factor receptor superfamily member 5; Receptor for TNFSF5/CD40LG (By similarity). Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion (By similarity). (278 aa) |
| | HCST | Hematopoietic cell signal transducer; Transmembrane adapter protein which associates with KLRK1 to form an activation receptor KLRK1-HCST in lymphoid and myeloid cells; this receptor plays a major role in triggering cytotoxicity against target cells expressing cell surface ligands such as MHC class I chain- related MICA and MICB, and UL16-binding proteins (ULBPs); these ligands are up-regulated by stress conditions and pathological state such as viral infection and tumor transformation. Functions as docking site for PI3-kinase PIK3R1 and GRB2. Interaction of ULBPs with KLRK1-HCST trigg [...] (281 aa) |
| | ABCG1 | ATP binding cassette subfamily G member 1. (679 aa) |
| | VEGFA | Vascular endothelial growth factor A; Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin (By similarity). Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By s [...] (451 aa) |
| | NRROS | Negative regulator of reactive oxygen species. (704 aa) |
| | HAVCR2 | Hepatitis A virus cellular receptor 2. (283 aa) |
| | K7GLG1_PIG | Uncharacterized protein. (449 aa) |
| | CD200R1L | Ig-like domain-containing protein. (300 aa) |
| | CD86 | T-lymphocyte activation antigen CD86 isoform 1. (337 aa) |
| | FCER1A | Fc fragment of IgE receptor Ia. (261 aa) |
| | K7GMK8_PIG | Signal transducer CD24 isoform a preproprotein. (78 aa) |
| | CXCR3 | C-X-C chemokine receptor type 3 isoform 1; Belongs to the G-protein coupled receptor 1 family. (361 aa) |
| | ENPP3 | Ectonucleotide pyrophosphatase/phosphodiesterase family member 3. (874 aa) |
| | SDC1 | Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (309 aa) |
| | TFRC | Transferrin receptor protein 1; Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). Positively regulates T and B cell proliferation through iron uptake (By similarity). (794 aa) |
| | BGN | Biglycan; May be involved in collagen fiber assembly. (338 aa) |
| | MPL | MPL proto-oncogene, thrombopoietin receptor. (630 aa) |
| | ENG | Endoglin; Vascular endothelium glycoprotein that plays an important role in the regulation of angiogenesis. Required for normal structure and integrity of adult vasculature. Regulates the migration of vascular endothelial cells (By similarity). Required for normal extraembryonic angiogenesis and for embryonic heart development (By similarity). May regulate endothelial cell shape changes in response to blood flow, which drive vascular remodeling and establishment of normal vascular morphology during angiogenesis (By similarity). May play a role in the binding of endothelial cells to int [...] (619 aa) |
| | TGFB1 | Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa) |
| | ITGB1 | Integrin beta-1; Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G- E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha- 4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha- 11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha- 4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin [...] (853 aa) |
| | K7GSB8_PIG | Ig-like domain-containing protein. (331 aa) |
| | TGFBR1 | TGF-beta receptor type-1; Transmembrane serine/threonine kinase forming with the TGF- beta type II serine/threonine kinase receptor, TGFBR2, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinog [...] (560 aa) |
| | CTLA4 | Cytotoxic T-lymphocyte protein 4; Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28. (223 aa) |
| | ITGAV | Integrin subunit alpha V; Belongs to the integrin alpha chain family. (1052 aa) |
| | PRND | Prion like protein doppel. (178 aa) |
| | TIGIT | T cell immunoreceptor with Ig and ITIM domains. (223 aa) |
| | EFNA5 | Ephrin A5; Belongs to the ephrin family. (228 aa) |
| | KLRK1 | NKG2-D type II integral membrane protein; Functions as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress- inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-exp [...] (221 aa) |
| | GFRAL | GDNF family receptor alpha like. (457 aa) |
| | CYTH3 | Cytohesin 3. (407 aa) |
| | EMP2 | Epithelial membrane protein 2; Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion; Belongs to the PMP-22/EMP/MP20 family. (167 aa) |
| | SMIM1 | Small integral membrane protein 1 (Vel blood group). (79 aa) |
| | CD34 | CD34 molecule. (393 aa) |
| | LOC100524773 | Uncharacterized protein. (2024 aa) |
| | ENPP1 | Ectonucleotide pyrophosphatase/phosphodiesterase 1. (878 aa) |
| | NPTN | Neuroplastin. (412 aa) |
| | LRRC32 | Leucine rich repeat containing 32. (688 aa) |
| | BMPR1A | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa) |
| | CD19 | CD19 molecule. (645 aa) |
| | AXL | Uncharacterized protein. (871 aa) |
| | CD200 | OX-2 membrane glycoprotein isoform X2. (301 aa) |
| | LOC100625897 | Uncharacterized protein. (1920 aa) |
| | TMEM123 | Transmembrane protein 123. (246 aa) |
| | LRP4 | LDL receptor related protein 4. (1918 aa) |
| | RTBDN | Retbindin. (252 aa) |
| | FAM234A | Family with sequence similarity 234 member A. (551 aa) |
| | GUSB | Beta-glucuronidase; Plays an important role in the degradation of dermatan and keratan sulfates. (652 aa) |
| | CD163 | Scavenger receptor cysteine-rich type 1 protein M130; Involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH- dependent manner. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion [...] (1113 aa) |
| | LOC100517427 | Uncharacterized protein. (299 aa) |
| | ADIPOQ | C1q domain-containing protein. (332 aa) |
| | CPM | Carboxypeptidase M. (500 aa) |
| | LPAR1 | Lysophosphatidic acid receptor 1; Belongs to the G-protein coupled receptor 1 family. (364 aa) |
| | SERPINE2 | SERPIN domain-containing protein; Belongs to the serpin family. (378 aa) |
| | FGF22 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (170 aa) |
| | HSPA5 | Endoplasmic reticulum chaperone BiP; Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (By similarity). Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate (By similarity). Acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to dis [...] (657 aa) |
| | INTU | Inturned planar cell polarity protein. (937 aa) |
| | FOLR1 | Folate receptor alpha. (346 aa) |
| | LOC110259119 | Uncharacterized protein. (674 aa) |
| | HFE | Homeostatic iron regulator; Belongs to the MHC class I family. (395 aa) |
| | CXCR4 | C-X-C chemokine receptor type 4; Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Involved in the AKT signaling cascade (By similarity). Plays a role in regulation of cell migration, e.g. during wound healing. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Binds bacterial lipopolysaccharide (LPS) et mediates LPS- induced inflammatory response, including TNF secretion by monocytes (By similarity). Inv [...] (353 aa) |
| | RTP1 | Receptor-transporting protein 1. (263 aa) |
| | CCR10 | G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (375 aa) |
| | DPP4 | Dipeptidyl peptidase 4 membrane form; Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T- cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the mi [...] (833 aa) |
| | CD79A | Ig-like domain-containing protein. (234 aa) |
| | FZD4 | Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (536 aa) |
| | HBEGF | Proheparin-binding EGF-like growth factor; Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor (By similarity). (276 aa) |
| | NECTIN2 | Uncharacterized protein. (616 aa) |
| | RTN4R | Reticulon 4 receptor. (548 aa) |
| | L1CAM | L1 cell adhesion molecule. (1256 aa) |
| | A0A5G2QG99_PIG | Uncharacterized protein. (2082 aa) |
| | ASTN1 | Astrotactin 1. (1269 aa) |
| | FOLR2 | Folate receptor beta. (319 aa) |
| | MCAM | Melanoma cell adhesion molecule. (667 aa) |
| | IGSF21 | Immunoglobin superfamily member 21. (490 aa) |
| | A0A5G2R217_PIG | Uncharacterized protein. (1028 aa) |
| | SPN | Uncharacterized protein. (463 aa) |
| | CCR2 | C-C chemokine receptor type 2 isoform B; Belongs to the G-protein coupled receptor 1 family. (373 aa) |
| | CLEC5A | C-type lectin domain family 5 member A; Functions as a positive regulator of osteoclastogenesis (By similarity). Cell surface receptor that signals via TYROBP. Regulates inflammatory responses (By similarity). (185 aa) |
| | TMEM102 | Transmembrane protein 102. (495 aa) |
| | ATP5IF1 | ATPase inhibitor, mitochondrial; Endogenous F(1)F(o)-ATPase inhibitor limiting ATP depletion when the mitochondrial membrane potential falls below a threshold and the F(1)F(o)-ATP synthase starts hydrolyzing ATP to pump protons out of the mitochondrial matrix. Required to avoid the consumption of cellular ATP when the F(1)F(o)-ATP synthase enzyme acts as an ATP hydrolase. Indirectly acts as a regulator of heme synthesis in erythroid tissues: regulates heme synthesis by modulating the mitochondrial pH and redox potential, allowing FECH to efficiently catalyze the incorporation of iron i [...] (108 aa) |
| | CDH4 | Cadherin 4; Cadherins are calcium-dependent cell adhesion proteins. (914 aa) |
| | SEMA7A | Semaphorin 7A (John Milton Hagen blood group); Belongs to the semaphorin family. (615 aa) |
| | CCR6 | C-C motif chemokine receptor 6; Belongs to the G-protein coupled receptor 1 family. (376 aa) |
| | CX3CR1 | CX3C chemokine receptor 1 isoform a; Belongs to the G-protein coupled receptor 1 family. (356 aa) |
| | I3L9Z6_PIG | Uncharacterized protein. (335 aa) |
| | CEACAM1 | Uncharacterized protein. (438 aa) |
| | CD40LG | CD40 ligand, membrane form; Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (By similarity). Induces the activation of NF-kappa-B (By similarity). Induces the activation of kinases MAPK8 and PAK2 in T-cells (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of [...] (261 aa) |
| | LOC100519314 | C-type lectin domain-containing protein. (247 aa) |
| | FCN2 | Ficolin-2. (429 aa) |
| | CD4 | CD4 molecule. (494 aa) |
| | CCR7 | G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (477 aa) |
