STRINGSTRING
SARNP SARNP SRPK1 SRPK1 SRSF3 SRSF3 YLPM1 YLPM1 NRDE2 NRDE2 SRSF11 SRSF11 VIRMA VIRMA SCNM1 SCNM1 RBM15 RBM15 EPAS1 EPAS1 ZC3H13 ZC3H13 SMU1 SMU1 RAD54L2 RAD54L2 ZCCHC18 ZCCHC18 TUT1 TUT1 F1S6T5_PIG F1S6T5_PIG MAML1 MAML1 MEF2C MEF2C RBM27 RBM27 INPPL1 INPPL1 FAM76B FAM76B WT1 WT1 I3L661_PIG I3L661_PIG FYTTD1 FYTTD1 NOC3L NOC3L PNISR PNISR GLIS2 GLIS2 DHX36 DHX36 DDX39B DDX39B A0A286ZI50_PIG A0A286ZI50_PIG DDX17 DDX17 NSRP1 NSRP1 RBM23 RBM23 SRSF5 SRSF5 HSPB3 HSPB3 TCIM TCIM ALKBH5 ALKBH5 CPSF6 CPSF6 WTAP WTAP SRSF2 SRSF2 SF3A1 SF3A1 AKAP17A AKAP17A DYRK1A DYRK1A SNRNP70 SNRNP70 U2AF1 U2AF1 RBM11 RBM11 BASP1 BASP1 WBP4 WBP4 HABP4 HABP4 NR3C1 NR3C1 A0A287AT02_PIG A0A287AT02_PIG FTO FTO DUSP11 DUSP11 FASTK FASTK YTHDC1 YTHDC1 RBM14 RBM14 SRSF10 SRSF10 SRPK2 SRPK2 RBM39 RBM39 ZC3H14 ZC3H14 SON SON DDX5 DDX5 SRSF1 SRSF1 DDX39A DDX39A RBM25 RBM25 SRSF4 SRSF4 APEX1 APEX1 CSNK1A1 CSNK1A1 RSRC1 RSRC1 WBP11 WBP11 DGKQ DGKQ ZNF830 ZNF830 AKAP17B AKAP17B ELL ELL SRPK3 SRPK3 PIP5K1A PIP5K1A POLDIP3 POLDIP3 A0A5G2R6G8_PIG A0A5G2R6G8_PIG TRIM69 TRIM69 ZC3H18 ZC3H18
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SARNPSAP domain containing ribonucleoprotein. (238 aa)
SRPK1SRSF protein kinase 1. (831 aa)
SRSF3Serine and arginine rich splicing factor 3. (164 aa)
YLPM1YLP motif-containing protein 1. (2149 aa)
NRDE2NRDE-2, necessary for RNA interference, domain containing. (1166 aa)
SRSF11Uncharacterized protein. (423 aa)
VIRMAVir like m6A methyltransferase associated. (1812 aa)
SCNM1Sodium channel modifier 1. (230 aa)
RBM15RNA binding motif protein 15. (1006 aa)
EPAS1Uncharacterized protein. (870 aa)
ZC3H13Zinc finger CCCH-type containing 13. (1640 aa)
SMU1Uncharacterized protein. (511 aa)
RAD54L2RAD54 like 2. (1468 aa)
ZCCHC18Zinc finger CCHC-type containing 18. (378 aa)
TUT1RRM domain-containing protein. (871 aa)
F1S6T5_PIGUncharacterized protein. (97 aa)
MAML1Mastermind like transcriptional coactivator 1. (1014 aa)
MEF2CMyocyte-specific enhancer factor 2C; Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Enhances transcriptional activation mediated by SOX18. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex [...] (483 aa)
RBM27RNA-binding protein 27 isoform X7. (962 aa)
INPPL1Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2; Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. Plays a central role in regulation of PI3K-dependent insulin signaling, although the precise molecular mechanisms and signaling pathways remain unclear. While overexpression reduces both insulin-stimulated MAP kinase and Akt activation, its absence does not affect insulin signaling [...] (1265 aa)
FAM76BFamily with sequence similarity 76 member B. (339 aa)
WT1Wilms tumor protein homolog; Transcription factor that plays an important role in cellular development and cell survival. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'. Regulates the expression of numerous target genes, including EPO. Plays an essential role for development of the urogenital system. It has a tumor suppressor as well as an oncogenic role in tumor formation. Function may be isoform-specific: isoforms lacking the KTS motif may act as transcription factors. Isoforms containing the KTS motif may bind mRNA and play a role in mRNA metabolism or splicing. Isofor [...] (523 aa)
I3L661_PIGUncharacterized protein. (107 aa)
FYTTD1Forty-two-three domain containing 1. (317 aa)
NOC3LNucleolar complex protein 3 homolog. (799 aa)
PNISRPNN interacting serine and arginine rich protein. (814 aa)
GLIS2GLIS family zinc finger 2. (596 aa)
DHX36DEAH (Asp-Glu-Ala-His) box polypeptide 36 tv1. (1012 aa)
DDX39BSpliceosome RNA helicase DDX39B; Involved in nuclear export of spliced and unspliced mRNA. Assembling component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pat [...] (467 aa)
A0A286ZI50_PIGRRM domain-containing protein. (184 aa)
DDX17DEAD-box helicase 17; Belongs to the DEAD box helicase family. (588 aa)
NSRP1Nuclear speckle splicing regulatory protein 1. (614 aa)
RBM23RNA binding motif protein 23. (429 aa)
SRSF5Serine and arginine rich splicing factor 5. (271 aa)
HSPB3Heat shock protein family B (small) member 3; Belongs to the small heat shock protein (HSP20) family. (150 aa)
TCIMTranscriptional and immune response regulator. (106 aa)
ALKBH5AlkB homolog 5, RNA demethylase. (394 aa)
CPSF6Cleavage and polyadenylation specificity factor subunit 6 isoform 2. (588 aa)
WTAPUncharacterized protein. (649 aa)
SRSF2Serine/arginine-rich splicing factor 2; Necessary for the splicing of pre-mRNA. It is required for formation of the earliest ATP-dependent splicing complex and interacts with spliceosomal components bound to both the 5'- and 3'-splice sites during spliceosome assembly. It also is required for ATP-dependent interactions of both U1 and U2 snRNPs with pre-mRNA. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Binds to purine-rich RNA sequences, either 5'-AGSAGAGTA-3' (S=C or G) or 5 [...] (221 aa)
SF3A1Splicing factor 3a subunit 1. (722 aa)
AKAP17AA-kinase anchoring protein 17A. (733 aa)
DYRK1ADual specificity tyrosine phosphorylation regulated kinase 1A. (764 aa)
SNRNP70Small nuclear ribonucleoprotein U1 subunit 70. (436 aa)
U2AF1Splicing factor U2AF 35 kDa subunit; Plays a critical role in both constitutive and enhancer- dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection. Recruits U2 snRNP to the branch point. Directly mediates interactions between U2AF2 and proteins bound to the enhancers and thus may function as a bridge between U2AF2 and the enhancer complex to recruit it to the adjacent intron (By similarity). (239 aa)
RBM11Splicing regulator RBM11 isoform X1. (237 aa)
BASP1Uncharacterized protein. (228 aa)
WBP4WW domain-binding protein 4. (373 aa)
HABP4Intracellular hyaluronan-binding protein 4. (418 aa)
NR3C1Glucocorticoid receptor; Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling. Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP [...] (810 aa)
A0A287AT02_PIGUncharacterized protein. (116 aa)
FTOFTO_NTD domain-containing protein. (509 aa)
DUSP11Dual specificity phosphatase 11. (314 aa)
FASTKFas activated serine/threonine kinase. (668 aa)
YTHDC1YTH domain containing 1. (743 aa)
RBM14RNA-binding protein 14 isoform 1. (669 aa)
SRSF10Serine and arginine rich splicing factor 10. (261 aa)
SRPK2SRSF protein kinase 2. (763 aa)
RBM39RNA-binding protein 39 isoform a. (530 aa)
ZC3H14Zinc finger CCCH-type containing 14. (736 aa)
SONSON DNA binding protein. (2447 aa)
DDX5DEAD-box helicase 5; Belongs to the DEAD box helicase family. (617 aa)
SRSF1Serine/arginine-rich splicing factor 1; Plays a role in preventing exon skipping, ensuring the accuracy of splicing and regulating alternative splicing. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Can stimulate binding of U1 snRNP to a 5'-splice site- containing pre-mRNA. Binds to purine-rich RNA sequences, either the octamer, 5'-RGAAGAAC-3' (r=A or G) or the decamers, AGGACAGAGC/AGGACGAAGC. Binds preferentially to the 5'-CGAGGCG-3' motif in vitro. Three copies of the octame [...] (253 aa)
DDX39ADExD-box helicase 39A. (452 aa)
RBM25RNA binding motif protein 25. (862 aa)
SRSF4Serine and arginine rich splicing factor 4. (489 aa)
APEX1DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (318 aa)
CSNK1A1Casein kinase I isoform alpha; Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 at 'Ser-45'. May phosphorylate PER1 and PER2. May play a role in segregating chromosomes during mitosis. May play a role in keratin cytoskeleton disassembly and thereby, it may regulate epithelial cell migration. (359 aa)
RSRC1Arginine and serine rich coiled-coil 1. (334 aa)
WBP11WW domain-binding protein 11. (641 aa)
DGKQDiacylglycerol kinase. (987 aa)
ZNF830Zinc finger protein 830. (367 aa)
AKAP17BRRM domain-containing protein. (955 aa)
ELLElongation factor for RNA polymerase II. (657 aa)
SRPK3SRSF protein kinase 3; Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains. Phosphorylates the SR splicing factor SRSF1 and the lamin-B receptor (LBR) in vitro. Required for normal muscle development (By similarity). (604 aa)
PIP5K1APhosphatidylinositol-4-phosphate 5-kinase type 1 alpha. (584 aa)
POLDIP3Polymerase delta-interacting protein 3 isoform X1. (420 aa)
A0A5G2R6G8_PIGUncharacterized protein. (157 aa)
TRIM69Tripartite motif containing 69. (500 aa)
ZC3H18Zinc finger CCCH domain-containing protein 18 isoform X1. (949 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.