STRINGSTRING
DSG4 DSG4 DSP DSP DSC1 DSC1 VCL VCL KLHL35 KLHL35 JUP JUP DSG1 DSG1 ACTN1 ACTN1 DSG3 DSG3 PKP3 PKP3 PNN PNN DSC2 DSC2 KAZN KAZN KLHL24 KLHL24 PKP4 PKP4 DSG2 DSG2 TMEM255B TMEM255B KLHL6 KLHL6 TMEM255A TMEM255A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DSG4Desmoglein 4; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. (1042 aa)
DSPDesmoplakin. (2883 aa)
DSC1Desmocollin 1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. (897 aa)
VCLVinculin; Actin filament (F-actin)-binding protein involved in cell- matrix adhesion and cell-cell adhesion. Regulates cell-surface E- cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion; Belongs to the vinculin/alpha-catenin family. (1135 aa)
KLHL35Kelch like family member 35. (564 aa)
JUPJunction plakoglobin; Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE- cadherin function in endothelial cells. Can replace beta-catenin in E- cadherin/catenin adhes [...] (744 aa)
DSG1Desmoglein-1; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion (By similarity). (1045 aa)
ACTN1Uncharacterized protein. (888 aa)
DSG3Desmoglein 3. (989 aa)
PKP3Plakophilin 3. (1145 aa)
PNNUncharacterized protein. (736 aa)
DSC2Desmocollin 2; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. (911 aa)
KAZNKazrin, periplakin interacting protein. (864 aa)
KLHL24Kelch-like protein 24 isoform b. (600 aa)
PKP4Plakophilin 4. (1234 aa)
DSG2Desmoglein 2. (1127 aa)
TMEM255BTransmembrane protein 255B isoform 1. (329 aa)
KLHL6BTB domain-containing protein. (620 aa)
TMEM255ATransmembrane protein 255A. (349 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
Server load: low (40%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.