STRINGSTRING
VTI1B VTI1B SYT1 SYT1 SEC23A SEC23A SEC13 SEC13 SEC31B SEC31B PEF1 PEF1 VAMP2 VAMP2 MCTP1 MCTP1 AP1G1 AP1G1 RAB3C RAB3C SEC31A SEC31A SLC17A7 SLC17A7 WDR86 WDR86 RPH3A RPH3A SYN2 SYN2 SYNRG SYNRG RASSF9 RASSF9 KLHL12 KLHL12 DOC2A DOC2A SEMA4C SEMA4C SEC24A SEC24A SEC23B SEC23B SV2B SV2B PDCD6 PDCD6 SAR1B SAR1B STX6 STX6 CDKN2AIPNL CDKN2AIPNL LOC100525027 LOC100525027 CLBA1 CLBA1 SAR1A SAR1A ATP2B1 ATP2B1 VMA21 VMA21 RAB5A RAB5A SYN3 SYN3 SYNPR SYNPR CACFD1 CACFD1 SLC17A8 SLC17A8 SLC18A3 SLC18A3 SYN1 SYN1 PRRT1 PRRT1 AFTPH AFTPH STX12 STX12 PHLPP2 PHLPP2 AMPH AMPH SYNJ2 SYNJ2 TMEM163 TMEM163 RAB3A RAB3A STX10 STX10 SLC17A6 SLC17A6 SYP SYP SEC24C SEC24C SEC24B SEC24B SEC24D SEC24D SLC32A1 SLC32A1 AP1G2 AP1G2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
VTI1Bt-SNARE coiled-coil homology domain-containing protein. (232 aa)
SYT1Synaptotagmin 1. (379 aa)
SEC23AProtein transport protein SEC23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules; Belongs to the SEC23/SEC24 family. SEC23 subfamily. (765 aa)
SEC13SEC13 homolog, nuclear pore and COPII coat complex component; Belongs to the WD repeat SEC13 family. (341 aa)
SEC31BSEC31 homolog B, COPII coat complex component. (1210 aa)
PEF1Penta-EF-hand domain containing 1. (334 aa)
VAMP2V-SNARE coiled-coil homology domain-containing protein. (189 aa)
MCTP1Multiple C2 and transmembrane domain containing 1. (995 aa)
AP1G1AP-1 complex subunit gamma. (825 aa)
RAB3CRAB3C, member RAS oncogene family. (235 aa)
SEC31ASEC31 homolog A, COPII coat complex component. (1251 aa)
SLC17A7Solute carrier family 17 member 7. (567 aa)
WDR86WD_REPEATS_REGION domain-containing protein. (557 aa)
RPH3ARabphilin-3A isoform 1. (701 aa)
SYN2Synapsin II. (581 aa)
SYNRGSynergin gamma. (1339 aa)
RASSF9Ras association domain family member 9. (456 aa)
KLHL12BTB domain-containing protein. (916 aa)
DOC2ADouble C2 domain alpha. (487 aa)
SEMA4CSemaphorin 4C; Belongs to the semaphorin family. (896 aa)
SEC24ASEC24 homolog A, COPII coat complex component. (1133 aa)
SEC23BProtein transport protein SEC23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules; Belongs to the SEC23/SEC24 family. SEC23 subfamily. (767 aa)
SV2BSynaptic vesicle glycoprotein 2B. (683 aa)
PDCD6Programmed cell death 6. (292 aa)
SAR1BGTP-binding protein SAR1b; Involved in transport from the endoplasmic reticulum to the Golgi apparatus. Activated by the guanine nucleotide exchange factor PREB. Involved in the selection of the protein cargo and the assembly of the COPII coat complex (By similarity). (198 aa)
STX6Syntaxin 6; Belongs to the syntaxin family. (306 aa)
CDKN2AIPNLXRN2-binding (XTBD) domain-containing protein. (116 aa)
LOC100525027Uncharacterized protein. (376 aa)
CLBA1Clathrin binding box of aftiphilin containing 1. (339 aa)
SAR1AGTP-binding protein SAR1a; Involved in transport from the endoplasmic reticulum to the Golgi apparatus. Required to maintain SEC16A localization at discrete locations on the ER membrane perhaps by preventing its dissociation. SAR1A-GTP-dependent assembly of SEC16A on the ER membrane forms an organized scaffold defining endoplasmic reticulum exit sites (ERES) (By similarity). (198 aa)
ATP2B1Plasma membrane calcium-transporting ATPase 1; Catalyzes the hydrolysis of ATP coupled with the transport of calcium from the cytoplasm to the extracellular space thereby maintaining intracellular calcium homeostasis. Plays a role in blood pressure regulation through regulation of intracellular calcium concentration and nitric oxide production leading to regulation of vascular smooth muscle cells vasoconstriction. Positively regulates bone mineralization through absorption of calcium from the intestine. Plays dual roles in osteoclast differentiation and survival by regulating RANKL-ind [...] (1249 aa)
VMA21Vacuolar ATPase assembly integral membrane protein VMA21; Required for the assembly of the V0 complex of the vacuolar ATPase (V-ATPase) in the endoplasmic reticulum. (267 aa)
RAB5ARas-related protein Rab-5A; Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Active GTP-bound form is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes. Contributes to the regulati [...] (215 aa)
SYN3Synapsin III. (580 aa)
SYNPRSynaptoporin. (288 aa)
CACFD1Calcium channel flower domain containing 1. (172 aa)
SLC17A8Solute carrier family 17 member 8. (544 aa)
SLC18A3Solute carrier family 18 member A3. (528 aa)
SYN1Synapsin-1 isoform Ia. (712 aa)
PRRT1Uncharacterized protein. (305 aa)
AFTPHAftiphilin. (935 aa)
STX12t-SNARE coiled-coil homology domain-containing protein; Belongs to the syntaxin family. (369 aa)
PHLPP2PH domain and leucine rich repeat protein phosphatase 2. (1353 aa)
AMPHUncharacterized protein. (678 aa)
SYNJ2Synaptojanin 2. (1402 aa)
TMEM163Transmembrane protein 163. (287 aa)
RAB3ARas-related protein Rab-3A; Small GTP-binding protein that plays a central role in regulated exocytosis and secretion. Controls the recruitment, tethering and docking of secretory vesicles to the plasma membrane (By similarity). Upon stimulation, switches to its active GTP-bound form, cycles to vesicles and recruits effectors such as RIMS1, RIMS2, Rabphilin-3A/RPH3A, RPH3AL or SYTL4 to help the docking of vesicules onto the plasma membrane (By similarity). Upon GTP hydrolysis by GTPase-activating protein, dissociates from the vesicle membrane allowing the exocytosis to proceed (By simi [...] (254 aa)
STX10Syntaxin 10; Belongs to the syntaxin family. (353 aa)
SLC17A6Solute carrier family 17 member 6. (582 aa)
SYPSynaptophysin. (319 aa)
SEC24CSEC24 homolog C, COPII coat complex component. (1118 aa)
SEC24BSEC24 homolog B, COPII coat complex component. (1258 aa)
SEC24DSEC24 homolog D, COPII coat complex component. (1033 aa)
SLC32A1Vesicular inhibitory amino acid transporter. (526 aa)
AP1G2AP-1 complex subunit gamma. (781 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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