(29 nodes) Synaptic vesicle membrane network (Sus scrofa)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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protein homology

Your Input:
	RAB3C	RAB3C, member RAS oncogene family. (235 aa)
	SYN1	Synapsin-1 isoform Ia. (712 aa)
	PRRT1	Uncharacterized protein. (305 aa)
	STX12	t-SNARE coiled-coil homology domain-containing protein; Belongs to the syntaxin family. (369 aa)
	AMPH	Uncharacterized protein. (678 aa)
	SYNJ2	Synaptojanin 2. (1402 aa)
	TMEM163	Transmembrane protein 163. (287 aa)
	RAB3A	Ras-related protein Rab-3A; Small GTP-binding protein that plays a central role in regulated exocytosis and secretion. Controls the recruitment, tethering and docking of secretory vesicles to the plasma membrane (By similarity). Upon stimulation, switches to its active GTP-bound form, cycles to vesicles and recruits effectors such as RIMS1, RIMS2, Rabphilin-3A/RPH3A, RPH3AL or SYTL4 to help the docking of vesicules onto the plasma membrane (By similarity). Upon GTP hydrolysis by GTPase-activating protein, dissociates from the vesicle membrane allowing the exocytosis to proceed (By simi [...] (254 aa)
	STX10	Syntaxin 10; Belongs to the syntaxin family. (353 aa)
	SLC17A6	Solute carrier family 17 member 6. (582 aa)
	SYP	Synaptophysin. (319 aa)
	SLC32A1	Vesicular inhibitory amino acid transporter. (526 aa)
	SYT1	Synaptotagmin 1. (379 aa)
	CACFD1	Calcium channel flower domain containing 1. (172 aa)
	SYNPR	Synaptoporin. (288 aa)
	SYN3	Synapsin III. (580 aa)
	RAB5A	Ras-related protein Rab-5A; Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Active GTP-bound form is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes. Contributes to the regulati [...] (215 aa)
	ATP2B1	Plasma membrane calcium-transporting ATPase 1; Catalyzes the hydrolysis of ATP coupled with the transport of calcium from the cytoplasm to the extracellular space thereby maintaining intracellular calcium homeostasis. Plays a role in blood pressure regulation through regulation of intracellular calcium concentration and nitric oxide production leading to regulation of vascular smooth muscle cells vasoconstriction. Positively regulates bone mineralization through absorption of calcium from the intestine. Plays dual roles in osteoclast differentiation and survival by regulating RANKL-ind [...] (1249 aa)
	LOC100525027	Uncharacterized protein. (376 aa)
	CDKN2AIPNL	XRN2-binding (XTBD) domain-containing protein. (116 aa)
	SLC17A8	Solute carrier family 17 member 8. (544 aa)
	STX6	Syntaxin 6; Belongs to the syntaxin family. (306 aa)
	SV2B	Synaptic vesicle glycoprotein 2B. (683 aa)
	SEMA4C	Semaphorin 4C; Belongs to the semaphorin family. (896 aa)
	DOC2A	Double C2 domain alpha. (487 aa)
	SYN2	Synapsin II. (581 aa)
	RPH3A	Rabphilin-3A isoform 1. (701 aa)
	SLC17A7	Solute carrier family 17 member 7. (567 aa)
	MCTP1	Multiple C2 and transmembrane domain containing 1. (995 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AMPH	SYN1	ENSSSCP00000020487	ENSSSCP00000028857	Uncharacterized protein.	Synapsin-1 isoform Ia.	0.425
AMPH	SYNJ2	ENSSSCP00000020487	ENSSSCP00000020455	Uncharacterized protein.	Synaptojanin 2.	0.793
DOC2A	RAB3A	ENSSSCP00000050123	ENSSSCP00000014777	Double C2 domain alpha.	Ras-related protein Rab-3A; Small GTP-binding protein that plays a central role in regulated exocytosis and secretion. Controls the recruitment, tethering and docking of secretory vesicles to the plasma membrane (By similarity). Upon stimulation, switches to its active GTP-bound form, cycles to vesicles and recruits effectors such as RIMS1, RIMS2, Rabphilin-3A/RPH3A, RPH3AL or SYTL4 to help the docking of vesicules onto the plasma membrane (By similarity). Upon GTP hydrolysis by GTPase-activating protein, dissociates from the vesicle membrane allowing the exocytosis to proceed (By simi [...]	0.430
DOC2A	RAB3C	ENSSSCP00000050123	ENSSSCP00000068991	Double C2 domain alpha.	RAB3C, member RAS oncogene family.	0.451
RAB3A	DOC2A	ENSSSCP00000014777	ENSSSCP00000050123	Ras-related protein Rab-3A; Small GTP-binding protein that plays a central role in regulated exocytosis and secretion. Controls the recruitment, tethering and docking of secretory vesicles to the plasma membrane (By similarity). Upon stimulation, switches to its active GTP-bound form, cycles to vesicles and recruits effectors such as RIMS1, RIMS2, Rabphilin-3A/RPH3A, RPH3AL or SYTL4 to help the docking of vesicules onto the plasma membrane (By similarity). Upon GTP hydrolysis by GTPase-activating protein, dissociates from the vesicle membrane allowing the exocytosis to proceed (By simi [...]	Double C2 domain alpha.	0.430
RAB3A	RPH3A	ENSSSCP00000014777	ENSSSCP00000061427	Ras-related protein Rab-3A; Small GTP-binding protein that plays a central role in regulated exocytosis and secretion. Controls the recruitment, tethering and docking of secretory vesicles to the plasma membrane (By similarity). Upon stimulation, switches to its active GTP-bound form, cycles to vesicles and recruits effectors such as RIMS1, RIMS2, Rabphilin-3A/RPH3A, RPH3AL or SYTL4 to help the docking of vesicules onto the plasma membrane (By similarity). Upon GTP hydrolysis by GTPase-activating protein, dissociates from the vesicle membrane allowing the exocytosis to proceed (By simi [...]	Rabphilin-3A isoform 1.	0.878
RAB3A	SLC17A7	ENSSSCP00000014777	ENSSSCP00000066230	Ras-related protein Rab-3A; Small GTP-binding protein that plays a central role in regulated exocytosis and secretion. Controls the recruitment, tethering and docking of secretory vesicles to the plasma membrane (By similarity). Upon stimulation, switches to its active GTP-bound form, cycles to vesicles and recruits effectors such as RIMS1, RIMS2, Rabphilin-3A/RPH3A, RPH3AL or SYTL4 to help the docking of vesicules onto the plasma membrane (By similarity). Upon GTP hydrolysis by GTPase-activating protein, dissociates from the vesicle membrane allowing the exocytosis to proceed (By simi [...]	Solute carrier family 17 member 7.	0.581
RAB3A	SLC32A1	ENSSSCP00000014777	ENSSSCP00000007826	Ras-related protein Rab-3A; Small GTP-binding protein that plays a central role in regulated exocytosis and secretion. Controls the recruitment, tethering and docking of secretory vesicles to the plasma membrane (By similarity). Upon stimulation, switches to its active GTP-bound form, cycles to vesicles and recruits effectors such as RIMS1, RIMS2, Rabphilin-3A/RPH3A, RPH3AL or SYTL4 to help the docking of vesicules onto the plasma membrane (By similarity). Upon GTP hydrolysis by GTPase-activating protein, dissociates from the vesicle membrane allowing the exocytosis to proceed (By simi [...]	Vesicular inhibitory amino acid transporter.	0.633
RAB3A	STX6	ENSSSCP00000014777	ENSSSCP00000041920	Ras-related protein Rab-3A; Small GTP-binding protein that plays a central role in regulated exocytosis and secretion. Controls the recruitment, tethering and docking of secretory vesicles to the plasma membrane (By similarity). Upon stimulation, switches to its active GTP-bound form, cycles to vesicles and recruits effectors such as RIMS1, RIMS2, Rabphilin-3A/RPH3A, RPH3AL or SYTL4 to help the docking of vesicules onto the plasma membrane (By similarity). Upon GTP hydrolysis by GTPase-activating protein, dissociates from the vesicle membrane allowing the exocytosis to proceed (By simi [...]	Syntaxin 6; Belongs to the syntaxin family.	0.444
RAB3A	SYN1	ENSSSCP00000014777	ENSSSCP00000028857	Ras-related protein Rab-3A; Small GTP-binding protein that plays a central role in regulated exocytosis and secretion. Controls the recruitment, tethering and docking of secretory vesicles to the plasma membrane (By similarity). Upon stimulation, switches to its active GTP-bound form, cycles to vesicles and recruits effectors such as RIMS1, RIMS2, Rabphilin-3A/RPH3A, RPH3AL or SYTL4 to help the docking of vesicules onto the plasma membrane (By similarity). Upon GTP hydrolysis by GTPase-activating protein, dissociates from the vesicle membrane allowing the exocytosis to proceed (By simi [...]	Synapsin-1 isoform Ia.	0.718
RAB3A	SYN2	ENSSSCP00000014777	ENSSSCP00000061192	Ras-related protein Rab-3A; Small GTP-binding protein that plays a central role in regulated exocytosis and secretion. Controls the recruitment, tethering and docking of secretory vesicles to the plasma membrane (By similarity). Upon stimulation, switches to its active GTP-bound form, cycles to vesicles and recruits effectors such as RIMS1, RIMS2, Rabphilin-3A/RPH3A, RPH3AL or SYTL4 to help the docking of vesicules onto the plasma membrane (By similarity). Upon GTP hydrolysis by GTPase-activating protein, dissociates from the vesicle membrane allowing the exocytosis to proceed (By simi [...]	Synapsin II.	0.697
RAB3A	SYN3	ENSSSCP00000014777	ENSSSCP00000034146	Ras-related protein Rab-3A; Small GTP-binding protein that plays a central role in regulated exocytosis and secretion. Controls the recruitment, tethering and docking of secretory vesicles to the plasma membrane (By similarity). Upon stimulation, switches to its active GTP-bound form, cycles to vesicles and recruits effectors such as RIMS1, RIMS2, Rabphilin-3A/RPH3A, RPH3AL or SYTL4 to help the docking of vesicules onto the plasma membrane (By similarity). Upon GTP hydrolysis by GTPase-activating protein, dissociates from the vesicle membrane allowing the exocytosis to proceed (By simi [...]	Synapsin III.	0.747
RAB3A	SYP	ENSSSCP00000014777	ENSSSCP00000013081	Ras-related protein Rab-3A; Small GTP-binding protein that plays a central role in regulated exocytosis and secretion. Controls the recruitment, tethering and docking of secretory vesicles to the plasma membrane (By similarity). Upon stimulation, switches to its active GTP-bound form, cycles to vesicles and recruits effectors such as RIMS1, RIMS2, Rabphilin-3A/RPH3A, RPH3AL or SYTL4 to help the docking of vesicules onto the plasma membrane (By similarity). Upon GTP hydrolysis by GTPase-activating protein, dissociates from the vesicle membrane allowing the exocytosis to proceed (By simi [...]	Synaptophysin.	0.777
RAB3A	SYT1	ENSSSCP00000014777	ENSSSCP00000001015	Ras-related protein Rab-3A; Small GTP-binding protein that plays a central role in regulated exocytosis and secretion. Controls the recruitment, tethering and docking of secretory vesicles to the plasma membrane (By similarity). Upon stimulation, switches to its active GTP-bound form, cycles to vesicles and recruits effectors such as RIMS1, RIMS2, Rabphilin-3A/RPH3A, RPH3AL or SYTL4 to help the docking of vesicules onto the plasma membrane (By similarity). Upon GTP hydrolysis by GTPase-activating protein, dissociates from the vesicle membrane allowing the exocytosis to proceed (By simi [...]	Synaptotagmin 1.	0.800
RAB3C	DOC2A	ENSSSCP00000068991	ENSSSCP00000050123	RAB3C, member RAS oncogene family.	Double C2 domain alpha.	0.451
RAB3C	RPH3A	ENSSSCP00000068991	ENSSSCP00000061427	RAB3C, member RAS oncogene family.	Rabphilin-3A isoform 1.	0.486
RAB3C	SV2B	ENSSSCP00000068991	ENSSSCP00000044819	RAB3C, member RAS oncogene family.	Synaptic vesicle glycoprotein 2B.	0.449
RAB3C	SYT1	ENSSSCP00000068991	ENSSSCP00000001015	RAB3C, member RAS oncogene family.	Synaptotagmin 1.	0.409
RAB5A	STX6	ENSSSCP00000034240	ENSSSCP00000041920	Ras-related protein Rab-5A; Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Active GTP-bound form is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes. Contributes to the regulati [...]	Syntaxin 6; Belongs to the syntaxin family.	0.445
RPH3A	RAB3A	ENSSSCP00000061427	ENSSSCP00000014777	Rabphilin-3A isoform 1.	Ras-related protein Rab-3A; Small GTP-binding protein that plays a central role in regulated exocytosis and secretion. Controls the recruitment, tethering and docking of secretory vesicles to the plasma membrane (By similarity). Upon stimulation, switches to its active GTP-bound form, cycles to vesicles and recruits effectors such as RIMS1, RIMS2, Rabphilin-3A/RPH3A, RPH3AL or SYTL4 to help the docking of vesicules onto the plasma membrane (By similarity). Upon GTP hydrolysis by GTPase-activating protein, dissociates from the vesicle membrane allowing the exocytosis to proceed (By simi [...]	0.878