Your Input: | |
| | NTNG2 | Netrin G2. (529 aa) |
| | VWF | Von Willebrand factor; Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet- surface receptor complex, glycoprotein Ibalpha/IX/V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma (By similarity). (2940 aa) |
| | NTN4 | Netrin 4. (628 aa) |
| | DCN | Decorin; May affect the rate of fibrils formation. (359 aa) |
| | LUM | Lumican. (341 aa) |
| | MESP1 | Mesoderm posterior bHLH transcription factor 1. (256 aa) |
| | PAPLN | Papilin, proteoglycan like sulfated glycoprotein. (961 aa) |
| | FBLN5 | Fibulin-5 isoform X2. (461 aa) |
| | CYTH2 | Uncharacterized protein. (422 aa) |
| | VWA1 | Von Willebrand factor A domain containing 1. (480 aa) |
| | EMILIN2 | Elastin microfibril interfacer 2. (1078 aa) |
| | LAMA3 | Laminin subunit alpha 3. (3345 aa) |
| | LAMA4 | Laminin subunit alpha 4. (1815 aa) |
| | COL10A1 | Type X collagen. (675 aa) |
| | THBS1 | Uncharacterized protein. (1170 aa) |
| | COL15A1 | Collagen type XV alpha 1 chain. (1359 aa) |
| | MEGF9 | Multiple EGF like domains 9. (599 aa) |
| | LAMC3 | Laminin subunit gamma 3. (1575 aa) |
| | COL5A1 | Fibrillar collagen NC1 domain-containing protein. (1918 aa) |
| | PCSK6 | Proprotein convertase subtilisin/kexin type 6 isoform PACE4-AI preproprotein; Belongs to the peptidase S8 family. (965 aa) |
| | NUF2 | NUF2 component of NDC80 kinetochore complex. (464 aa) |
| | BCAN | Brevican core protein isoform X1. (906 aa) |
| | ZP3 | Processed zona pellucida sperm-binding protein 3; Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for zona matrix formation. May not have a sperm- binding activity by itself but may increase sperm-binding activity of ZPB. (421 aa) |
| | ZP2 | Processed zona pellucida sperm-binding protein 2; Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP2 may act as a secondary sperm receptor. Belongs to the ZP domain family. ZPA subfamily. (716 aa) |
| | IL1B2 | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (267 aa) |
| | MATN3 | Matrilin 3. (487 aa) |
| | AMTN | Amelotin. (209 aa) |
| | SFRP2 | Uncharacterized protein. (294 aa) |
| | MMRN1 | Multimerin 1. (1220 aa) |
| | SPARCL1 | SPARC like 1. (675 aa) |
| | LOC100522569 | Complement C1q and tumor necrosis factor-related protein 9A. (333 aa) |
| | POSTN | Periostin. (836 aa) |
| | COL4A2 | Collagen type IV alpha 2 chain. (1712 aa) |
| | NID1 | Nidogen 1. (1309 aa) |
| | RGR | Retinal G protein coupled receptor; Belongs to the G-protein coupled receptor 1 family. Opsin subfamily. (310 aa) |
| | RBP3 | Retinol-binding protein 3; IRBP shuttles 11-cis and all trans retinoids between the retinol isomerase in the pigment epithelium and the visual pigments in the photoreceptor cells of the retina. (1284 aa) |
| | FBLN2 | Fibulin-2 isoform a. (1221 aa) |
| | P3H2 | Prolyl 3-hydroxylase 2 isoform a. (706 aa) |
| | ZPLD1 | Zona pellucida like domain containing 1. (452 aa) |
| | COL4A6 | Collagen type IV alpha 6 chain. (1547 aa) |
| | COL5A3 | Collagen type V alpha 3 chain. (1747 aa) |
| | VCAN | Versican. (3456 aa) |
| | LOX | Protein-lysine 6-oxidase, short form; Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Regulator of Ras expression. May play a role in tumor suppression. Plays a role in the aortic wall architecture (By similarity); Belongs to the lysyl oxidase family. (419 aa) |
| | IL4 | Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (133 aa) |
| | RELL2 | RELT like 2. (305 aa) |
| | COL1A2 | Fibrillar collagen NC1 domain-containing protein. (1135 aa) |
| | LAMB1 | Laminin subunit beta 1. (1785 aa) |
| | LAMC2 | Laminin subunit gamma-2 isoform a. (1191 aa) |
| | LAMB3 | Laminin subunit beta 3. (1172 aa) |
| | IL10 | Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (219 aa) |
| | FN1 | Fibronectin 1. (2462 aa) |
| | COL4A3 | Collagen type IV alpha 3 chain. (1669 aa) |
| | SNORC | Uncharacterized protein. (121 aa) |
| | FGF10 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa) |
| | ADAMTS6 | A disintegrin and metalloproteinase with thrombospondin motifs 6 isoform X1. (1117 aa) |
| | MATN1 | Matrilin 1. (496 aa) |
| | THBS4 | Thrombospondin 4. (976 aa) |
| | VTN | Vitronectin; Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway (By similarity). (523 aa) |
| | COCH | Cochlin isoform X2. (551 aa) |
| | AIPL1 | Aryl hydrocarbon receptor interacting protein like 1. (328 aa) |
| | TINAG | Tubulointerstitial nephritis antigen; Belongs to the peptidase C1 family. (476 aa) |
| | FBN3 | Fibrillin 3. (2858 aa) |
| | IL6 | Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (241 aa) |
| | VIT | Vitrin. (656 aa) |
| | C11orf53 | Chromosome 11 open reading frame 53. (285 aa) |
| | ECM2 | Extracellular matrix protein 2. (696 aa) |
| | ITGA3 | Integrin subunit alpha 3; Belongs to the integrin alpha chain family. (1085 aa) |
| | TGFB1 | Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa) |
| | TGFB3 | Transforming growth factor beta-3 proprotein; Transforming growth factor beta-3 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-3 (TGF-beta-3) chains, which constitute the regulatory and active subunit of TGF-beta-3, respectively. Transforming growth factor beta-3: Multifunctional protein that regulates embryogenesis and cell differentiation and is required in various processes such as secondary palate development (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi appa [...] (456 aa) |
| | COL18A1 | Collagen type XVIII alpha 1 chain. (1755 aa) |
| | IMPG2 | Interphotoreceptor matrix proteoglycan 2. (1244 aa) |
| | LOC110258310 | C1q domain-containing protein. (248 aa) |
| | COL3A1 | Collagen alpha-1(III) chain preproprotein. (1471 aa) |
| | COL16A1 | Collagen alpha-1(XVI) chain isoform X2. (1624 aa) |
| | AGRN | Agrin. (2108 aa) |
| | PTPRZ1 | Protein tyrosine phosphatase receptor type Z1. (2323 aa) |
| | MS4A12 | Membrane spanning 4-domains A12. (258 aa) |
| | SERPINB12 | Serpin family B member 12; Belongs to the serpin family. (425 aa) |
| | COL2A1 | Collagen type II alpha 1 chain. (1486 aa) |
| | C1QTNF2 | C1q and TNF related 2. (396 aa) |
| | IFNG | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (166 aa) |
| | ADAMTS10 | Uncharacterized protein. (1102 aa) |
| | LAMA2 | Uncharacterized protein. (2070 aa) |
| | LAMC1 | Uncharacterized protein. (1607 aa) |
| | LAMA2-2 | Uncharacterized protein. (921 aa) |
| | CCDC80 | Coiled-coil domain containing 80. (1016 aa) |
| | KAZALD1 | Kazal-type serine protease inhibitor domain-containing protein 1 isoform X1. (315 aa) |
| | OTOL1 | Otolin 1. (513 aa) |
| | HSPG2 | Heparan sulfate proteoglycan 2. (4346 aa) |
| | LOC110258312 | Complement C1q and tumor necrosis factor-related protein 9A. (212 aa) |
| | TGFBR3L | Transforming growth factor beta receptor 3 like. (285 aa) |
| | USHBP1 | USH1 protein network component harmonin binding protein 1. (733 aa) |
| | COL8A2 | Collagen type VIII alpha 2 chain. (707 aa) |
| | ASIC4 | Acid sensing ion channel subunit family member 4; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (604 aa) |
| | NID2 | Nidogen 2. (1348 aa) |
| | IL1B | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells. (267 aa) |
| | LOXL2 | Lysyl oxidase like 2. (758 aa) |
| | SSC4D | Scavenger receptor cysteine rich family member with 4 domains. (621 aa) |
| | DSPP | Uncharacterized protein. (1023 aa) |
| | COL4A5 | Collagen type IV alpha 5 chain. (1689 aa) |
| | LOC100622849 | Centrin-2. (168 aa) |
| | TNC | Tenascin; Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha- V/beta-6. In tumors, stimulates angiogenesis by elongation, migration and sprouting of endothelial cells (By similarity). Belongs to the tenascin family. (2420 aa) |
| | LAMB2 | Laminin subunit beta-2. (1881 aa) |
| | NCAN | Neurocan. (1313 aa) |
| | MATN2 | Matrilin 2. (956 aa) |
| | COL4A4 | Collagen type IV alpha 4 chain. (1691 aa) |
| | MFAP4 | Microfibril associated protein 4. (304 aa) |
| | FOXP3 | Forkhead box protein P3 isoform a. (475 aa) |
| | LAMB4 | Uncharacterized protein. (719 aa) |
| | USH2A | Uncharacterized protein. (1544 aa) |
| | RARRES2 | Retinoic acid receptor responder 2. (177 aa) |
| | ACAN | Aggrecan core protein 2; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. (2434 aa) |
| | CHADL | Chondroadherin like. (760 aa) |
| | MMRN2 | Multimerin 2. (931 aa) |
| | DAG1 | Alpha-dystroglycan; The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sacrolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization. Beta-dystroglycan is a transmembrane protein that plays important roles in connecting the extracellular matrix to the cytoskeleton. Acts as a cell adhesion receptor in both muscle and non- muscle tissues. Receptor for both DMD and UTRN and, through these interactions, scaffolds axin to the cytoskeleton. Also functions in cell ad [...] (912 aa) |
| | SMAD2 | Mothers against decapentaplegic homolog 3; Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP- 1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and m [...] (472 aa) |
| | COL5A2 | Collagen alpha-2(V) chain preproprotein. (1499 aa) |
| | TNN | Tenascin N. (1472 aa) |
| | COL28A1 | Collagen type XXVIII alpha 1 chain. (1236 aa) |
| | FREM1 | FRAS1 related extracellular matrix 1. (2182 aa) |
| | COL6A5 | Collagen type VI alpha 5 chain. (2337 aa) |
| | CDC42EP1 | Cdc42 effector protein 1 isoform X1. (376 aa) |
| | LTBP3 | Latent transforming growth factor beta binding protein 3. (1332 aa) |
| | NTNG1 | Netrin G1. (588 aa) |
| | LOC100517188 | Uncharacterized protein. (1592 aa) |
| | LOC110258309 | C1q domain-containing protein. (189 aa) |
| | CILP | Cartilage intermediate layer protein 1 C2; Probably plays a role in cartilage scaffolding. May act by antagonizing TGF-beta1 (TGFB1) and IGF1 functions. Has the ability to suppress IGF1-induced proliferation and sulfated proteoglycan synthesis, and inhibits ligand-induced IGF1R autophosphorylation. May inhibit TGFB1-mediated induction of cartilage matrix genes via its interaction with TGFB1. Overexpression may lead to impair chondrocyte growth and matrix repair and indirectly promote inorganic pyrophosphate (PPi) supersaturation in aging and osteoarthritis cartilage (By similarity). (1193 aa) |
| | COL11A2 | Collagen type XI alpha 2 chain. (1796 aa) |
| | TNR | Tenascin R. (1270 aa) |
| | SMOC1 | SPARC related modular calcium binding 1. (469 aa) |
| | THBS2 | Thrombospondin 2. (1223 aa) |
| | EMILIN1 | Elastin microfibril interfacer 1. (1292 aa) |
| | PERCC1 | Uncharacterized protein. (280 aa) |
| | A0A5G2QUL4_PIG | Uncharacterized protein. (536 aa) |
| | AMELX | Uncharacterized protein. (203 aa) |
| | ABI3BP | ABI family member 3 binding protein. (1668 aa) |
| | COL4A1 | Collagen IV NC1 domain-containing protein. (461 aa) |
| | ANGPT1 | Angiopoietin-1; Binds and activates TIE2 receptor by inducing its tyrosine phosphorylation. Implicated in endothelial developmental processes later and distinct from that of VEGF. Appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme. Mediates blood vessel maturation/stability. It may play an important role in the heart early development (By similarity). (510 aa) |
| | COL14A1 | Collagen alpha-1(XIV) chain isoform X1. (1796 aa) |
| | FBN2 | Fibrillin 2. (2910 aa) |
| | NTN1 | Netrin-1; Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. Binding to UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion (By similarity). Involved in dorsal root ganglion axon projection towards the spinal cord (By similarity). It also serves as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involve [...] (651 aa) |
| | COL6A1 | Collagen type VI alpha 1 chain. (1028 aa) |
| | COL1A1 | Collagen type I alpha 1 chain. (1477 aa) |
| | LOC110258314 | C1q domain-containing protein. (174 aa) |
| | FRAS1 | Fraser extracellular matrix complex subunit 1. (4013 aa) |
| | ANGPT2 | Angiopoietin-2; Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating angiogenic signals mediated by ANGPT1. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell- matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal (By similarity). (495 aa) |
| | IMPG1 | Interphotoreceptor matrix proteoglycan 1. (787 aa) |
| | SEPTIN7 | Septin 7; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (437 aa) |
| | C1QTNF7 | C1q and TNF related 7. (311 aa) |
| | PLSCR1 | Phospholipid scramblase; May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. Belongs to the phospholipid scramblase family. (321 aa) |
| | TGFBR3 | Transforming growth factor beta receptor type 3; Binds to TGF-beta. Could be involved in capturing and retaining TGF-beta for presentation to the signaling receptors. (952 aa) |
| | COL8A1 | Collagen type VIII alpha 1 chain. (759 aa) |
| | COL6A6 | Collagen type VI alpha 6 chain. (2266 aa) |
| | MATN4 | Matrilin 4. (774 aa) |
| | AMELY | Amelogenin; Plays a role in the biomineralization of teeth. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel; Belongs to the amelogenin family. (189 aa) |
| | COL11A1 | Collagen type XI alpha 1 chain. (1816 aa) |
| | SPARC | SPARC; Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity (By similarity); Belongs to the SPARC family. (331 aa) |
