STRINGSTRING
CCNE2 CCNE2 ACVR1B ACVR1B CDK7 CDK7 CCNT1 CCNT1 A0A5G2RI12_PIG A0A5G2RI12_PIG CDK15 CDK15 GTF2H5 GTF2H5 CKM CKM XRCC6 XRCC6 CDK3 CDK3 CCNJ CCNJ ACVR2B ACVR2B PARD6A PARD6A SESN2 SESN2 PARD3 PARD3 AMHR2 AMHR2 IRS1 IRS1 CCND3 CCND3 ATF6 ATF6 CCND1 CCND1 C18orf54 C18orf54 IAH1 IAH1 MAP3K7 MAP3K7 EIF2AK2 EIF2AK2 ACVR1 ACVR1 HSPA5 HSPA5 CCNL2 CCNL2 CDK12 CDK12 CCND2 CCND2 IRS2 IRS2 ULK1 ULK1 PHKA2 PHKA2 TRIM40 TRIM40 XBP1 XBP1 TRPV5 TRPV5 RRNAD1 RRNAD1 IKBKG IKBKG LOC110259300 LOC110259300 ERCC3 ERCC3 INS INS ATG101 ATG101 GTF2H3 GTF2H3 PHKB PHKB CLEC3B CLEC3B CDK14 CDK14 GTF2H2 GTF2H2 ZBTB7A ZBTB7A CCNH CCNH CHFR CHFR ACVR2A ACVR2A ANKRD40 ANKRD40 RELB RELB CDKN2D CDKN2D CCNY CCNY TGFBR1 TGFBR1 PIR PIR MAP3K6 MAP3K6 DAPK1 DAPK1 CCNO CCNO PRKAA1 PRKAA1 BYSL BYSL CCNB1 CCNB1 RB1CC1 RB1CC1 CDK4 CDK4 SH3BP5L SH3BP5L CDK5R2 CDK5R2 CCNYL1 CCNYL1 ANKRD40CL ANKRD40CL BECN1 BECN1 NIM1K NIM1K CDK13 CDK13 WEE2 WEE2 PRKAG2 PRKAG2 PRKAG3 PRKAG3 ACVR1C ACVR1C CCNT2 CCNT2 INSR INSR STK11 STK11 GTF2H1 GTF2H1 ATG13 ATG13 CCNQ CCNQ PHKA1 PHKA1 LAS1L LAS1L PRKCI PRKCI NEK10 NEK10 CRB1 CRB1 CHUK CHUK RASSF4 RASSF4 PRKAB1 PRKAB1 LIG4 LIG4 CCNA1 CCNA1 PHKG2 PHKG2 PHKG1 PHKG1 LOC100515824 LOC100515824 IKBKB IKBKB PRKAB2 PRKAB2 INSRR INSRR PRKDC PRKDC CDK9 CDK9 PGM5 PGM5 MNAT1 MNAT1 IGF1R IGF1R CCNB2 CCNB2 KCNN4 KCNN4 CNTD2 CNTD2 CCNE1 CCNE1 CCNK CCNK NFKBIA NFKBIA CDKN1A CDKN1A CDK2 CDK2 PRKAG1 PRKAG1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CCNE2G1/S-specific cyclin-E2 isoform X1; Belongs to the cyclin family. (405 aa)
ACVR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (547 aa)
CDK7Cyclin dependent kinase 7; Belongs to the protein kinase superfamily. (361 aa)
CCNT1Cyclin T1; Belongs to the cyclin family. (727 aa)
A0A5G2RI12_PIGUncharacterized protein. (55 aa)
CDK15Cyclin dependent kinase 15; Belongs to the protein kinase superfamily. (435 aa)
GTF2H5Uncharacterized protein. (88 aa)
CKMCreatine kinase M-type; Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa (By similarity). (380 aa)
XRCC6X-ray repair cross complementing 6. (606 aa)
CDK3Cyclin dependent kinase 3; Belongs to the protein kinase superfamily. (467 aa)
CCNJCyclin J; Belongs to the cyclin family. (452 aa)
ACVR2BActivin receptor type-2B; Transmembrane serine/threonine kinase activin type-2 receptor forming an activin receptor complex with activin type-1 serine/threonine kinase receptors (ACVR1, ACVR1B or ACVR1c). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to [...] (565 aa)
PARD6APar-6 family cell polarity regulator alpha. (354 aa)
SESN2Sestrin 2. (471 aa)
PARD3Par-3 family cell polarity regulator. (1355 aa)
AMHR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (583 aa)
IRS1Insulin receptor substrate 1. (1241 aa)
CCND3Cyclin D3; Belongs to the cyclin family. (331 aa)
ATF6Activating transcription factor 6. (680 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
C18orf54Lung adenoma susceptibility protein 2 isoform X1. (531 aa)
IAH1Isoamyl acetate hydrolyzing esterase 1 (putative). (249 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
EIF2AK2Eukaryotic translation initiation factor 2 alpha kinase 2. (546 aa)
ACVR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (729 aa)
HSPA5Endoplasmic reticulum chaperone BiP; Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (By similarity). Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate (By similarity). Acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to dis [...] (657 aa)
CCNL2Cyclin-L2 isoform A; Belongs to the cyclin family. (530 aa)
CDK12Cyclin dependent kinase 12. (1483 aa)
CCND2G1/S-specific cyclin-D2; Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. A [...] (288 aa)
IRS2Insulin receptor substrate 2. (1092 aa)
ULK1Unc-51 like autophagy activating kinase 1. (1176 aa)
PHKA2Phosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. (1237 aa)
TRIM40Tripartite motif containing 40. (300 aa)
XBP1BZIP domain-containing protein. (378 aa)
TRPV5Transient receptor potential cation channel subfamily V member 5; Belongs to the transient receptor (TC 1.A.4) family. (792 aa)
RRNAD1Ribosomal RNA adenine dimethylase domain containing 1. (475 aa)
IKBKGNF-kappa-B essential modulator; Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Its binding to scaffolding polyubiquitin seems to play a role in IKK activation by multiple signaling receptor pathways. However, the specific type of polyubiquitin recognized upon cell stimulation (either 'Lys-63'-linked or linear polyubiquitin) and its functional importance is reported conflictingly. Also considered to be a mediator for TAX activati [...] (451 aa)
LOC110259300Uncharacterized protein; Belongs to the cyclin family. (347 aa)
ERCC3ERCC excision repair 3, TFIIH core complex helicase subunit. (801 aa)
INSInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (108 aa)
ATG101Autophagy-related protein 101 isoform X1. (218 aa)
GTF2H3General transcription factor IIH subunit 3 isoform a. (321 aa)
PHKBPhosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. Belongs to the phosphorylase b kinase regulatory chain family. (1090 aa)
CLEC3BC-type lectin domain family 3 member B. (202 aa)
CDK14Cyclin dependent kinase 14. (526 aa)
GTF2H2VWFA domain-containing protein. (613 aa)
ZBTB7AZinc finger and BTB domain containing 7A. (596 aa)
CCNHCyclin-H isoform 1; Belongs to the cyclin family. (328 aa)
CHFRCheckpoint with forkhead and ring finger domains. (679 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (521 aa)
ANKRD40Ankyrin repeat domain 40. (365 aa)
RELBRELB proto-oncogene, NF-kB subunit. (574 aa)
CDKN2DCyclin dependent kinase inhibitor 2D. (166 aa)
CCNYCyclin Y; Belongs to the cyclin family. (416 aa)
TGFBR1TGF-beta receptor type-1; Transmembrane serine/threonine kinase forming with the TGF- beta type II serine/threonine kinase receptor, TGFBR2, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinog [...] (560 aa)
PIRPirin; Belongs to the pirin family. (291 aa)
MAP3K6Mitogen-activated protein kinase kinase kinase 6. (1295 aa)
DAPK1Death associated protein kinase 1. (1442 aa)
CCNOCyclin-O; Belongs to the cyclin family. (351 aa)
PRKAA1Non-specific serine/threonine protein kinase. (559 aa)
BYSLUncharacterized protein. (435 aa)
CCNB1Cyclin B1 transcript variant 1; Belongs to the cyclin family. (435 aa)
RB1CC1RB1 inducible coiled-coil 1. (1608 aa)
CDK4Cyclin-dependent kinase 4; Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. [...] (303 aa)
SH3BP5LSH3 binding domain protein 5 like. (425 aa)
CDK5R2Cyclin-dependent kinase 5 activator. (365 aa)
CCNYL1Cyclin-Y-like protein 1 isoform 3; Belongs to the cyclin family. (363 aa)
ANKRD40CLANKRD40 C-terminal like. (149 aa)
BECN1Beclin-1-C 35 kDa; Plays a central role in autophagy. Acts as core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3- phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2. Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex f [...] (461 aa)
NIM1KNIM1 serine/threonine protein kinase; Belongs to the protein kinase superfamily. (437 aa)
CDK13Cyclin dependent kinase 13. (1513 aa)
WEE2Wee1-like protein kinase 2; Oocyte-specific protein tyrosine kinase that phosphorylates and inhibits CDK1 and acts as a key regulator of meiosis during both prophase I and metaphase II. Required to maintain meiotic arrest in oocytes during the germinal vesicle (GV) stage, a long period of quiescence at dictyate prophase I, by phosphorylating CDK1 at 'Tyr-15', leading to inhibit CDK1 activity and prevent meiotic reentry. Also required for metaphase II exit during egg activation by phosphorylating CDK1 at 'Tyr-15', to ensure exit from meiosis in oocytes and promote pronuclear formation. (565 aa)
PRKAG2Protein kinase AMP-activated non-catalytic subunit gamma 2. (619 aa)
PRKAG35'-AMP-activated protein kinase subunit gamma-3; AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a [...] (499 aa)
ACVR1CReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (500 aa)
CCNT2Cyclin T2; Belongs to the cyclin family. (618 aa)
INSRTyrosine-protein kinase receptor. (1382 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (438 aa)
GTF2H1General transcription factor IIH subunit 1. (674 aa)
ATG13Autophagy-related protein 13; Belongs to the ATG13 family. Metazoan subfamily. (550 aa)
CCNQCyclin Q; Belongs to the cyclin family. (250 aa)
PHKA1Phosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. (1227 aa)
LAS1LLAS1 like, ribosome biogenesis factor. (721 aa)
PRKCIProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (636 aa)
NEK10NIMA related kinase 10. (1116 aa)
CRB1Crumbs cell polarity complex component 1. (1464 aa)
CHUKProtein kinase domain-containing protein. (580 aa)
RASSF4Ras association domain family member 4. (359 aa)
PRKAB15'-AMP-activated protein kinase subunit beta-1; Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a reg [...] (271 aa)
LIG4DNA ligase. (910 aa)
CCNA1Cyclin-A1 isoform X1; Belongs to the cyclin family. (421 aa)
PHKG2Phosphorylase kinase catalytic subunit gamma 2; Belongs to the protein kinase superfamily. (406 aa)
PHKG1Phosphorylase kinase gamma 1; Belongs to the protein kinase superfamily. (388 aa)
LOC100515824Insulin receptor substrate 1-like isoform X2. (512 aa)
IKBKBInhibitor of kappa light chain gene enhancer in B cells, kinase beta. (755 aa)
PRKAB2Protein kinase AMP-activated non-catalytic subunit beta 2. (272 aa)
INSRRTyrosine-protein kinase receptor. (1315 aa)
PRKDCProtein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4136 aa)
CDK9Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (488 aa)
PGM5Phosphoglucomutase-like protein 5; Belongs to the phosphohexose mutase family. (567 aa)
MNAT1CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. (309 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
CCNB2G2/mitotic-specific cyclin-B2; Belongs to the cyclin family. (396 aa)
KCNN4Intermediate conductance calcium-activated potassium channel protein 4. (426 aa)
CNTD2Cyclin N-terminal domain containing 2; Belongs to the cyclin family. (201 aa)
CCNE1Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (410 aa)
CCNKCyclin K; Belongs to the cyclin family. (605 aa)
NFKBIANF-kappa-B inhibitor alpha; Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription. (314 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (163 aa)
CDK2Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (381 aa)
PRKAG15'-AMP-activated protein kinase subunit gamma-1; AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a [...] (298 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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