STRINGSTRING
STAT4 STAT4 LOC100518097 LOC100518097 STAT6 STAT6 SOCS7 SOCS7 SUPT6H SUPT6H GRB7 GRB7 TNS4 TNS4 STAT5B STAT5B STAT5A STAT5A STAT3 STAT3 GRB2 GRB2 LCP2 LCP2 TNS3 TNS3 INPPL1 INPPL1 HSH2D HSH2D SH2D3A SH2D3A SHD SHD SH2D1A SH2D1A CISH CISH SH2D4B SH2D4B CRKL CRKL SH2B3 SH2B3 STAP1 STAP1 TEC TEC TXK TXK SH2B1 SH2B1 BLNK BLNK PTPN11 PTPN11 TNS1 TNS1 STAT2 STAT2 SOCS4 SOCS4 SOCS5 SOCS5 YES1 YES1 RASA1 RASA1 HCK HCK SHC2 SHC2 CHN2 CHN2 BCAR3 BCAR3 SHC3 SHC3 GRB14 GRB14 ABL1 ABL1 MATK MATK SOCS3 SOCS3 ABL2 ABL2 STAP2 STAP2 CHN1 CHN1 GRAP GRAP SRMS SRMS SOCS6 SOCS6 NCK2 NCK2 INPP5D INPP5D SH3BP2 SH3BP2 SH2D3C SH2D3C PTK6 PTK6 CRK CRK VAV1 VAV1 SH2D2A SH2D2A SYK SYK ITK ITK STAT1 STAT1 JAK1 JAK1 SH2D1B SH2D1B GRB10 GRB10 BLK BLK JAK3 JAK3 SRC SRC SH2B2 SH2B2 JAK2 JAK2 TNS2 TNS2 SH2D7 SH2D7 FES FES CSK CSK RIN3 RIN3 PLCG2 PLCG2 SH2D5 SH2D5 FYN FYN FRK FRK SHB SHB LYN LYN SHE SHE PLCG1 PLCG1 SHC1 SHC1 BMX BMX NCK1 NCK1 BTK BTK SOCS1 SOCS1 FER FER
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
STAT4Signal transducer and activator of transcription. (748 aa)
LOC100518097SH2 domain-containing protein. (448 aa)
STAT6Signal transducer and activator of transcription. (847 aa)
SOCS7Suppressor of cytokine signaling 7. (645 aa)
SUPT6HTranscription elongation factor spt6; Transcription elongation factor that enhances transcription elongation by RNA polymerase II (RNAPII). Belongs to the SPT6 family. (1603 aa)
GRB7Growth factor receptor bound protein 7. (569 aa)
TNS4Tensin-4. (716 aa)
STAT5BSignal transducer and activator of transcription 5B; Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Binds to the GAS element and activates PRL-induced transcription. Positively regulates hematopoietic/erythroid differentiation. (787 aa)
STAT5ASignal transducer and activator of transcription 5A; Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the GAS element and activates PRL-induced transcription. Regulates the expression of milk proteins during lactation (By similarity). (799 aa)
STAT3Signal transducer and activator of transcription 3; Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors. Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA (By similarity). Acts as a regulator of inflammatory response by regul [...] (772 aa)
GRB2Growth factor receptor-bound protein 2 isoform 1. (217 aa)
LCP2Lymphocyte cytosolic protein 2. (532 aa)
TNS3Tensin 3. (1563 aa)
INPPL1Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2; Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. Plays a central role in regulation of PI3K-dependent insulin signaling, although the precise molecular mechanisms and signaling pathways remain unclear. While overexpression reduces both insulin-stimulated MAP kinase and Akt activation, its absence does not affect insulin signaling [...] (1265 aa)
HSH2DHematopoietic SH2 domain-containing protein isoform 1. (359 aa)
SH2D3ASH2 domain containing 3A. (577 aa)
SHDSrc homology 2 domain containing transforming protein D. (340 aa)
SH2D1ASH2 domain-containing protein 1A; Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2. Initially it has been proposed that association with SLAMF1 prevents SLAMF1 binding to inhibitory effectors including INPP5D/SHIP1 and PTPN11/SHP-2. However, by simultaneous interactions, recruits FYN which subsequently phosphorylates and activates SLAMF1. Positively regulates CD244/2B4- and CD84-mediated natural killer (NK) cell functions. Ca [...] (128 aa)
CISHCytokine-inducible SH2-containing protein isoform 2. (254 aa)
SH2D4BSH2 domain-containing protein 4B isoform X1. (431 aa)
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
SH2B3SH2B adaptor protein 3. (600 aa)
STAP1Signal transducing adaptor family member 1. (295 aa)
TECTyrosine-protein kinase. (632 aa)
TXKTyrosine-protein kinase. (551 aa)
SH2B1SH2B adaptor protein 1. (757 aa)
BLNKB-cell linker protein isoform 1. (463 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
TNS1Tensin 1. (1861 aa)
STAT2Signal transducer and activator of transcription 2; Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive [...] (900 aa)
SOCS4Suppressor of cytokine signaling 4 isoform X1. (441 aa)
SOCS5Suppressor of cytokine signaling 5. (536 aa)
YES1Tyrosine-protein kinase. (553 aa)
RASA1RAS p21 protein activator 1. (1040 aa)
HCKTyrosine-protein kinase. (527 aa)
SHC2Uncharacterized protein. (623 aa)
CHN2Chimaerin; GTPase-activating protein for p21-rac. (468 aa)
BCAR3BCAR3 adaptor protein, NSP family member. (860 aa)
SHC3SHC adaptor protein 3. (656 aa)
GRB14Growth factor receptor-bound protein 14 isoform 1. (540 aa)
ABL1Tyrosine-protein kinase. (1146 aa)
MATKTyrosine-protein kinase. (485 aa)
SOCS3Suppressor of cytokine signaling 3. (229 aa)
ABL2Tyrosine-protein kinase. (1096 aa)
STAP2Signal transducing adaptor family member 2. (462 aa)
CHN1Chimaerin; GTPase-activating protein for p21-rac. (459 aa)
GRAPUncharacterized protein. (313 aa)
SRMSTyrosine-protein kinase. (494 aa)
SOCS6Suppressor of cytokine signaling 6 isoform X1. (535 aa)
NCK2Cytoplasmic protein. (376 aa)
INPP5DPhosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 isoform X1. (1199 aa)
SH3BP2SH3 domain binding protein 2. (622 aa)
SH2D3CSH2 domain containing 3C. (702 aa)
PTK6Tyrosine-protein kinase. (449 aa)
CRKCRK proto-oncogene, adaptor protein. (385 aa)
VAV1Vav guanine nucleotide exchange factor 1. (845 aa)
SH2D2ASH2 domain containing 2A. (520 aa)
SYK40 kDa tyrosine-protein kinase SYK; Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and vascular development. Assembles into signaling complexes with activated receptors at the plasma membrane via interaction between its SH2 domains and the receptor tyrosine-phosphorylated ITAM domains. The association with the recepto [...] (628 aa)
ITKTyrosine-protein kinase. (598 aa)
STAT1Signal transducer and activator of transcription 1; Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other cytokines and other growth factors. Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to [...] (856 aa)
JAK1Tyrosine-protein kinase. (1154 aa)
SH2D1BSH2 domain-containing protein. (133 aa)
GRB10Growth factor receptor-bound protein 10; Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin [...] (589 aa)
BLKTyrosine-protein kinase. (501 aa)
JAK3Tyrosine-protein kinase. (1103 aa)
SRCTyrosine-protein kinase. (559 aa)
SH2B2SH2B adaptor protein 2. (695 aa)
JAK2Tyrosine-protein kinase JAK2; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN- beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors [...] (1131 aa)
TNS2Tensin 2. (1350 aa)
SH2D7SH2 domain containing 7. (452 aa)
FESTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (822 aa)
CSKTyrosine-protein kinase. (474 aa)
RIN3Ras and Rab interactor 3. (918 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1265 aa)
SH2D5SH2 domain containing 5. (397 aa)
FYNTyrosine-protein kinase Fyn; Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motility through [...] (537 aa)
FRKTyrosine-protein kinase. (511 aa)
SHBSH2 domain-containing protein. (507 aa)
LYNTyrosine-protein kinase. (512 aa)
SHESH2 domain-containing adapter protein E isoform X1. (506 aa)
PLCG1Phosphoinositide phospholipase C. (1379 aa)
SHC1SHC adaptor protein 1. (583 aa)
BMXTyrosine-protein kinase. (706 aa)
NCK1Cytoplasmic protein. (377 aa)
BTKTyrosine-protein kinase. (659 aa)
SOCS1Suppressor of cytokine signaling 1. (220 aa)
FERTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (822 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.