(8 nodes) Peptidase C14 family network (Sus scrofa)

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Your Input:
	CASP6	Caspase 6; Belongs to the peptidase C14A family. (292 aa)
	CASP1	Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracell [...] (406 aa)
	CASP3	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). (266 aa)
	CASP7	Caspase 7; Belongs to the peptidase C14A family. (382 aa)
	LOC100522887	Uncharacterized protein; Belongs to the peptidase C14A family. (376 aa)
	CASP14	Caspase 14, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (242 aa)
	F1SV37_PIG	Uncharacterized protein; Belongs to the peptidase C14A family. (332 aa)
	CASP9	Caspase 9; Belongs to the peptidase C14A family. (438 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CASP1	CASP6	ENSSSCP00000064928	ENSSSCP00000068855	Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracell [...]	Caspase 6; Belongs to the peptidase C14A family.	0.527
CASP1	F1SV37_PIG	ENSSSCP00000064928	ENSSSCP00000015921	Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracell [...]	Uncharacterized protein; Belongs to the peptidase C14A family.	0.571
CASP1	LOC100522887	ENSSSCP00000064928	ENSSSCP00000015922	Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracell [...]	Uncharacterized protein; Belongs to the peptidase C14A family.	0.813
CASP14	CASP9	ENSSSCP00000014708	ENSSSCP00000003758	Caspase 14, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family.	Caspase 9; Belongs to the peptidase C14A family.	0.403
CASP3	CASP6	ENSSSCP00000049424	ENSSSCP00000068855	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity).	Caspase 6; Belongs to the peptidase C14A family.	0.631
CASP3	CASP7	ENSSSCP00000049424	ENSSSCP00000043126	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity).	Caspase 7; Belongs to the peptidase C14A family.	0.916
CASP3	CASP9	ENSSSCP00000049424	ENSSSCP00000003758	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity).	Caspase 9; Belongs to the peptidase C14A family.	0.979
CASP6	CASP1	ENSSSCP00000068855	ENSSSCP00000064928	Caspase 6; Belongs to the peptidase C14A family.	Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracell [...]	0.527
CASP6	CASP3	ENSSSCP00000068855	ENSSSCP00000049424	Caspase 6; Belongs to the peptidase C14A family.	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity).	0.631
CASP6	CASP7	ENSSSCP00000068855	ENSSSCP00000043126	Caspase 6; Belongs to the peptidase C14A family.	Caspase 7; Belongs to the peptidase C14A family.	0.421
CASP6	CASP9	ENSSSCP00000068855	ENSSSCP00000003758	Caspase 6; Belongs to the peptidase C14A family.	Caspase 9; Belongs to the peptidase C14A family.	0.953
CASP7	CASP3	ENSSSCP00000043126	ENSSSCP00000049424	Caspase 7; Belongs to the peptidase C14A family.	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity).	0.916
CASP7	CASP6	ENSSSCP00000043126	ENSSSCP00000068855	Caspase 7; Belongs to the peptidase C14A family.	Caspase 6; Belongs to the peptidase C14A family.	0.421
CASP7	CASP9	ENSSSCP00000043126	ENSSSCP00000003758	Caspase 7; Belongs to the peptidase C14A family.	Caspase 9; Belongs to the peptidase C14A family.	0.951
CASP9	CASP14	ENSSSCP00000003758	ENSSSCP00000014708	Caspase 9; Belongs to the peptidase C14A family.	Caspase 14, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family.	0.403
CASP9	CASP3	ENSSSCP00000003758	ENSSSCP00000049424	Caspase 9; Belongs to the peptidase C14A family.	Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity).	0.979
CASP9	CASP6	ENSSSCP00000003758	ENSSSCP00000068855	Caspase 9; Belongs to the peptidase C14A family.	Caspase 6; Belongs to the peptidase C14A family.	0.953
CASP9	CASP7	ENSSSCP00000003758	ENSSSCP00000043126	Caspase 9; Belongs to the peptidase C14A family.	Caspase 7; Belongs to the peptidase C14A family.	0.951
F1SV37_PIG	CASP1	ENSSSCP00000015921	ENSSSCP00000064928	Uncharacterized protein; Belongs to the peptidase C14A family.	Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracell [...]	0.571
F1SV37_PIG	LOC100522887	ENSSSCP00000015921	ENSSSCP00000015922	Uncharacterized protein; Belongs to the peptidase C14A family.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.571