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LONP1 LONP1 IQCA1 IQCA1 PSMC2 PSMC2 RFC4 RFC4 ATAD1 ATAD1 KATNAL1 KATNAL1 SPATA5 SPATA5 FIGN FIGN RFC1 RFC1 WRNIP1 WRNIP1 PSMC1 PSMC1 RFC2 RFC2 LONP2 LONP2 PSMC3 PSMC3 PSMC5 PSMC5 NVL NVL ATAD3A ATAD3A SPATA5L1 SPATA5L1 KATNA1 KATNA1 IQCA1L IQCA1L SPAST SPAST KATNAL2 KATNAL2 ATAD2B ATAD2B PSMC6 PSMC6 ATAD5 ATAD5 VPS4B VPS4B PSMC4 PSMC4 BCS1L BCS1L TRIP13 TRIP13 NSF NSF ATAD2 ATAD2 CLPX CLPX PEX1 PEX1 RFC5 RFC5 VCP VCP CLPB CLPB ORC1 ORC1 FIGNL1 FIGNL1 NAV3 NAV3 VPS4A VPS4A CHTF18 CHTF18
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
LONP1Lon protease homolog, mitochondrial; ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial promoters and RNA in a single-stranded, site-specific, and strand- specific manner. May regulate mi [...] (960 aa)
IQCA1IQ motif containing with AAA domain 1. (830 aa)
PSMC2AAA domain-containing protein; Belongs to the AAA ATPase family. (433 aa)
RFC4Replication factor C subunit 4. (364 aa)
ATAD1ATPase family AAA domain containing 1; Belongs to the AAA ATPase family. (361 aa)
KATNAL1Katanin p60 ATPase-containing subunit A-like 1; Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neur [...] (490 aa)
SPATA5Uncharacterized protein. (886 aa)
FIGNFidgetin, microtubule severing factor; Belongs to the AAA ATPase family. (759 aa)
RFC1Replication factor C subunit 1. (1141 aa)
WRNIP1WRN helicase interacting protein 1. (638 aa)
PSMC126S proteasome regulatory subunit 4 isoform a; Belongs to the AAA ATPase family. (440 aa)
RFC2Replication factor C subunit 2 isoform 1. (352 aa)
LONP2Lon protease homolog 2, peroxisomal; ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import. May indirectly regulate peroxisomal fatty acid beta- oxidation through degradation of the self-processed forms of TYSND1. (852 aa)
PSMC3Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family. (629 aa)
PSMC526S proteasome regulatory subunit 8; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC5 belongs to the heterohexameric ring of AAA (ATPases associated with [...] (435 aa)
NVLNuclear VCP like. (868 aa)
ATAD3AATPase family AAA domain containing 3A. (507 aa)
SPATA5L1Spermatogenesis-associated protein 5-like protein 1 isoform 1. (837 aa)
KATNA1Katanin p60 ATPase-containing subunit A1; Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal p [...] (493 aa)
IQCA1LIQ motif containing with AAA domain 1 like. (818 aa)
SPASTSpastin; ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Severing activity is not dependent on tubulin acetylation or detyrosination. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation [...] (615 aa)
KATNAL2Katanin p60 ATPase-containing subunit A-like 2; Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays. (538 aa)
ATAD2BATPase family AAA domain containing 2B. (1458 aa)
PSMC6Proteasome 26S subunit, ATPase 6; Belongs to the AAA ATPase family. (481 aa)
ATAD5ATPase family AAA domain containing 5. (1891 aa)
VPS4BVacuolar protein sorting-associated protein 4B; Belongs to the AAA ATPase family. (444 aa)
PSMC4Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (418 aa)
BCS1LBCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone; Belongs to the AAA ATPase family. (419 aa)
TRIP13Pachytene checkpoint protein 2 homolog; Plays a key role in chromosome recombination and chromosome structure development during meiosis. Required at early steps in meiotic recombination that leads to non-crossovers pathways. Also needed for efficient completion of homologous synapsis by influencing crossover distribution along the chromosomes affecting both crossovers and non-crossovers pathways. Also required for development of higher- order chromosome structures and is needed for synaptonemal-complex formation. In males, required for efficient synapsis of the sex chromosomes and for [...] (431 aa)
NSFN-ethylmaleimide sensitive factor, vesicle fusing ATPase. (766 aa)
ATAD2ATPase family AAA domain containing 2. (1384 aa)
CLPXATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial. (633 aa)
PEX1Peroxisomal biogenesis factor 1. (1277 aa)
RFC5Replication factor C subunit 5. (343 aa)
VCPTransitional endoplasmic reticulum ATPase; Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is neces [...] (878 aa)
CLPBClpB homolog, mitochondrial AAA ATPase chaperonin. (721 aa)
ORC1Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (865 aa)
FIGNL1Fidgetin-like protein 1 isoform 1; Belongs to the AAA ATPase family. (675 aa)
NAV3Neuron navigator 3. (2383 aa)
VPS4AUncharacterized protein; Belongs to the AAA ATPase family. (518 aa)
CHTF18Chromosome transmission fidelity factor 18. (942 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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