Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of proteins in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| EOMES | RUNX3 | ENSSSCP00000036035 | ENSSSCP00000065933 | Eomesodermin. | Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. | 0.572 |
| NFAT5 | STAT3 | ENSSSCP00000029262 | ENSSSCP00000018439 | Nuclear factor of activated T cells 5. | Signal transducer and activator of transcription 3; Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors. Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA (By similarity). Acts as a regulator of inflammatory response by regul [...] | 0.474 |
| NFATC1 | NFATC2 | ENSSSCP00000040717 | ENSSSCP00000029783 | Nuclear factor of activated T-cells, cytoplasmic 1; Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 or IL-4 gene transcription. Also controls gene expression in embryonic cardiac cells. Could regulate not only the activation and proliferation but also the differentiation and programmed death of T-lymphocytes as well as lymphoid and non-lymphoid cells. Required for osteoclastogenesis and regulates many genes important for osteoclast differentiation and function. | Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2. | 0.937 |
| NFATC1 | RUNX2 | ENSSSCP00000040717 | ENSSSCP00000070509 | Nuclear factor of activated T-cells, cytoplasmic 1; Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 or IL-4 gene transcription. Also controls gene expression in embryonic cardiac cells. Could regulate not only the activation and proliferation but also the differentiation and programmed death of T-lymphocytes as well as lymphoid and non-lymphoid cells. Required for osteoclastogenesis and regulates many genes important for osteoclast differentiation and function. | Runt-related transcription factor 2 isoform a. | 0.604 |
| NFATC1 | TP53 | ENSSSCP00000040717 | ENSSSCP00000050664 | Nuclear factor of activated T-cells, cytoplasmic 1; Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 or IL-4 gene transcription. Also controls gene expression in embryonic cardiac cells. Could regulate not only the activation and proliferation but also the differentiation and programmed death of T-lymphocytes as well as lymphoid and non-lymphoid cells. Required for osteoclastogenesis and regulates many genes important for osteoclast differentiation and function. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] | 0.492 |
| NFATC2 | NFATC1 | ENSSSCP00000029783 | ENSSSCP00000040717 | Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2. | Nuclear factor of activated T-cells, cytoplasmic 1; Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 or IL-4 gene transcription. Also controls gene expression in embryonic cardiac cells. Could regulate not only the activation and proliferation but also the differentiation and programmed death of T-lymphocytes as well as lymphoid and non-lymphoid cells. Required for osteoclastogenesis and regulates many genes important for osteoclast differentiation and function. | 0.937 |
| NFATC2 | RELA | ENSSSCP00000029783 | ENSSSCP00000013805 | Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2. | Transcription factor p65 isoform 1. | 0.414 |
| NFKB1 | NFKB2 | ENSSSCP00000048015 | ENSSSCP00000011271 | Uncharacterized protein. | Nuclear factor NF-kappa-B p100 subunit isoform X1. | 0.981 |
| NFKB1 | RELA | ENSSSCP00000048015 | ENSSSCP00000013805 | Uncharacterized protein. | Transcription factor p65 isoform 1. | 0.998 |
| NFKB1 | RELB | ENSSSCP00000048015 | ENSSSCP00000034265 | Uncharacterized protein. | RELB proto-oncogene, NF-kB subunit. | 0.965 |
| NFKB1 | STAT1 | ENSSSCP00000048015 | ENSSSCP00000033087 | Uncharacterized protein. | Signal transducer and activator of transcription 1; Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other cytokines and other growth factors. Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to [...] | 0.576 |
| NFKB1 | STAT3 | ENSSSCP00000048015 | ENSSSCP00000018439 | Uncharacterized protein. | Signal transducer and activator of transcription 3; Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors. Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA (By similarity). Acts as a regulator of inflammatory response by regul [...] | 0.630 |
| NFKB1 | TP53 | ENSSSCP00000048015 | ENSSSCP00000050664 | Uncharacterized protein. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] | 0.774 |
| NFKB2 | NFKB1 | ENSSSCP00000011271 | ENSSSCP00000048015 | Nuclear factor NF-kappa-B p100 subunit isoform X1. | Uncharacterized protein. | 0.981 |
| NFKB2 | RELA | ENSSSCP00000011271 | ENSSSCP00000013805 | Nuclear factor NF-kappa-B p100 subunit isoform X1. | Transcription factor p65 isoform 1. | 0.989 |
| NFKB2 | RELB | ENSSSCP00000011271 | ENSSSCP00000034265 | Nuclear factor NF-kappa-B p100 subunit isoform X1. | RELB proto-oncogene, NF-kB subunit. | 0.999 |
| NFKB2 | STAT1 | ENSSSCP00000011271 | ENSSSCP00000033087 | Nuclear factor NF-kappa-B p100 subunit isoform X1. | Signal transducer and activator of transcription 1; Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other cytokines and other growth factors. Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to [...] | 0.408 |
| NFKB2 | STAT3 | ENSSSCP00000011271 | ENSSSCP00000018439 | Nuclear factor NF-kappa-B p100 subunit isoform X1. | Signal transducer and activator of transcription 3; Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors. Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA (By similarity). Acts as a regulator of inflammatory response by regul [...] | 0.466 |
| RBPJ | RBPJL | ENSSSCP00000038442 | ENSSSCP00000057959 | Recombination signal binding protein for immunoglobulin kappa J region. | Recombination signal binding protein for immunoglobulin kappa J region like. | 0.907 |
| RBPJ | RUNX3 | ENSSSCP00000038442 | ENSSSCP00000065933 | Recombination signal binding protein for immunoglobulin kappa J region. | Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. | 0.543 |
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