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HTRA1 HTRA1 PRSS8 PRSS8 CELA1 CELA1 TMPRSS7 TMPRSS7 TMPRSS5 TMPRSS5 MASP1 MASP1 KLK12 KLK12 TMPRSS13 TMPRSS13 F12 F12 C1RL C1RL C2 C2 LOC100739080 LOC100739080 F1SGR9_PIG F1SGR9_PIG CTRC CTRC PRSS35 PRSS35 PLAT PLAT PRSS36 PRSS36 LOC396700 LOC396700 PRSS27 PRSS27 PRSS33 PRSS33 HTRA3 HTRA3 TMPRSS11D TMPRSS11D LOC100738056 LOC100738056 TMPRSS11F TMPRSS11F TMPRSS11B TMPRSS11B PRSS48 PRSS48 PRSS12 PRSS12 F10 F10 F1RJP7_PIG F1RJP7_PIG TYSND1 TYSND1 PLAU PLAU COX15 COX15 F1SNW5_PIG F1SNW5_PIG PRSS50 PRSS50 MST1 MST1 F9 F9 FAM111B FAM111B F2 F2 AZU1 AZU1 PRTN3 PRTN3 CFD CFD HGF HGF KLKB1 KLKB1 PRSS56 PRSS56 LOC110259104 LOC110259104 LOC100515176 LOC100515176 PRSS2 PRSS2 F1SRS1_PIG F1SRS1_PIG PRSS58 PRSS58 GZMK GZMK GZMA GZMA GZMA-2 GZMA-2 KLK4 KLK4 I3L7K4_PIG I3L7K4_PIG PRSS46 PRSS46 CTRL CTRL I3LDA9_PIG I3LDA9_PIG OVCH2 OVCH2 PRSS37 PRSS37 LOC100512727 LOC100512727 LOC100621820 LOC100621820 CTRB2 CTRB2 KLK15 KLK15 ELANE ELANE PRSS21 PRSS21 PRSS57 PRSS57 I3LP35_PIG I3LP35_PIG PROC PROC MASP2 MASP2 KLK8 KLK8 HGFAC HGFAC PRSS41 PRSS41 KLK13 KLK13 KLK5 KLK5 F11 F11 MCT7 MCT7 TMPRSS12 TMPRSS12 LOC110256121 LOC110256121 KLK6 KLK6 HTRA2 HTRA2 PAMR1 PAMR1 A0A287AEX0_PIG A0A287AEX0_PIG TMPRSS11E TMPRSS11E ACR ACR PRSS23 PRSS23 KLK1 KLK1 KLK14 KLK14 LOC110261434 LOC110261434 TMPRSS11A TMPRSS11A LOC100154047 LOC100154047 TMPRSS4 TMPRSS4 KLK10 KLK10 FAM111A FAM111A LOC100739735 LOC100739735 PRSS45P PRSS45P PRSS22 PRSS22 CFI CFI LOC100302368 LOC100302368 ST14 ST14 KLK7 KLK7 TMPRSS9 TMPRSS9 PRSS51 PRSS51 LOC100513671 LOC100513671 HP HP CORIN CORIN F7 F7 HPN HPN HABP2 HABP2 PRSS48-2 PRSS48-2 PLG PLG GZMB GZMB A0A5G2QY36_PIG A0A5G2QY36_PIG TMPRSS15 TMPRSS15 CELA2A CELA2A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HTRA1HtrA serine peptidase 1. (479 aa)
PRSS8Serine protease 8; Belongs to the peptidase S1 family. (344 aa)
CELA1Chymotrypsin-like elastase family member 1; Acts upon elastin; Belongs to the peptidase S1 family. Elastase subfamily. (257 aa)
TMPRSS7Transmembrane serine protease 7; Belongs to the peptidase S1 family. (829 aa)
TMPRSS5Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (198 aa)
MASP1Mannan-binding lectin serine protease 1 isoform 2; Belongs to the peptidase S1 family. (728 aa)
KLK12Kallikrein related peptidase 12; Belongs to the peptidase S1 family. (248 aa)
TMPRSS13Transmembrane serine protease 13; Belongs to the peptidase S1 family. (526 aa)
F12Coagulation factor XIIa heavy chain; Factor XII is a serum glycoprotein that participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then trypsin cleaves it to beta-factor XIIa. Alpha-factor XIIa activates factor XI to factor XIa (By similarity). (646 aa)
C1RLComplement C1r subcomponent like; Belongs to the peptidase S1 family. (588 aa)
C2Uncharacterized protein; Belongs to the peptidase S1 family. (853 aa)
LOC100739080Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (237 aa)
F1SGR9_PIGPeptidase S1 domain-containing protein. (236 aa)
CTRCChymotrypsin-C; Belongs to the peptidase S1 family. (268 aa)
PRSS35Inactive serine protease 35. (414 aa)
PLATTissue-type plasminogen activator chain A; Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events (By similarity); Belongs to the peptidase S1 family. (561 aa)
PRSS36Polyserase-2; Serine protease. Has a preference for substrates with an Arg instead of a Lys residue in position P1. Belongs to the peptidase S1 family. (855 aa)
LOC396700Tryptase beta-2 preproprotein; Belongs to the peptidase S1 family. (317 aa)
PRSS27Serine protease 27; Belongs to the peptidase S1 family. (326 aa)
PRSS33Serine protease 33; Belongs to the peptidase S1 family. (278 aa)
HTRA3Uncharacterized protein. (577 aa)
TMPRSS11DTransmembrane protease serine; Belongs to the peptidase S1 family. (418 aa)
LOC100738056Uncharacterized protein; Belongs to the peptidase S1 family. (368 aa)
TMPRSS11FTransmembrane protease serine; Belongs to the peptidase S1 family. (438 aa)
TMPRSS11BTransmembrane protease serine; Belongs to the peptidase S1 family. (417 aa)
PRSS48Serine protease 48; Belongs to the peptidase S1 family. (322 aa)
PRSS12Serine protease 12; Belongs to the peptidase S1 family. (875 aa)
F10Uncharacterized protein. (536 aa)
F1RJP7_PIGPeptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (293 aa)
TYSND1Trypsin domain containing 1. (624 aa)
PLAUUrokinase-type plasminogen activator short chain A; Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin. (442 aa)
COX15Cytochrome c oxidase assembly homolog COX15. (408 aa)
F1SNW5_PIGPeptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (391 aa)
PRSS50Peptidase S1 domain-containing protein. (192 aa)
MST1Hepatocyte growth factor-like protein; Belongs to the peptidase S1 family. Plasminogen subfamily. (725 aa)
F9Coagulation factor IXa heavy chain; Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca(2+) ions, phospholipids, and factor VIIIa. (462 aa)
FAM111BFamily with sequence similarity 111 member B. (732 aa)
F2Activation peptide fragment 1; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity). (623 aa)
AZU1Azurocidin; This is a neutrophil granule-derived antibacterial and monocyte- and fibroblast-specific chemotactic glycoprotein. Binds heparin; Belongs to the peptidase S1 family. Elastase subfamily. (246 aa)
PRTN3Proteinase 3; Belongs to the peptidase S1 family. (268 aa)
CFDComplement factor D; Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway (By similarity). (259 aa)
HGFHepatocyte growth factor; Belongs to the peptidase S1 family. (814 aa)
KLKB1Uncharacterized protein; Belongs to the peptidase S1 family. (643 aa)
PRSS56Serine protease 56; Belongs to the peptidase S1 family. (605 aa)
LOC110259104Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (429 aa)
LOC100515176Peptidase S1 domain-containing protein. (162 aa)
PRSS2Putative trypsinogen; Belongs to the peptidase S1 family. (247 aa)
F1SRS1_PIGPeptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (244 aa)
PRSS58Serine protease 58; Belongs to the peptidase S1 family. (241 aa)
GZMKGranzyme K; Belongs to the peptidase S1 family. (264 aa)
GZMAGranzyme A; Belongs to the peptidase S1 family. (258 aa)
GZMA-2Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (259 aa)
KLK4Enamel matrix serine proteinase 1; Belongs to the peptidase S1 family. (254 aa)
I3L7K4_PIGPDZ domain-containing protein. (155 aa)
PRSS46Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (312 aa)
CTRLChymotrypsin like; Belongs to the peptidase S1 family. (264 aa)
I3LDA9_PIGPeptidase S1 domain-containing protein. (236 aa)
OVCH2Ovochymase 2 (gene/pseudogene); Belongs to the peptidase S1 family. (566 aa)
PRSS37Putative inactive serine protease 37. (235 aa)
LOC100512727Transmembrane protease serine; Belongs to the peptidase S1 family. (407 aa)
LOC100621820Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (263 aa)
CTRB2Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (264 aa)
KLK15Kallikrein related peptidase 15; Belongs to the peptidase S1 family. (260 aa)
ELANEElastase, neutrophil expressed; Belongs to the peptidase S1 family. (271 aa)
PRSS21Serine protease 21; Belongs to the peptidase S1 family. (317 aa)
PRSS57Serine protease 57; Belongs to the peptidase S1 family. (279 aa)
I3LP35_PIGPeptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (253 aa)
PROCVitamin K-dependent protein C heavy chain; Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids. Exerts a protective effect on the endothelial cell barrier function. Belongs to the peptidase S1 family. (523 aa)
MASP2Uncharacterized protein; Belongs to the peptidase S1 family. (823 aa)
KLK8Kallikrein related peptidase 8; Belongs to the peptidase S1 family. (259 aa)
HGFACHGF activator. (661 aa)
PRSS41Serine protease 41; Belongs to the peptidase S1 family. (314 aa)
KLK13Kallikrein related peptidase 13; Belongs to the peptidase S1 family. (278 aa)
KLK5Kallikrein related peptidase 5; Belongs to the peptidase S1 family. (295 aa)
F11Coagulation factor XI; Belongs to the peptidase S1 family. (623 aa)
MCT7Tryptase; Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type; Belongs to the peptidase S1 family. Tryptase subfamily. (275 aa)
TMPRSS12Transmembrane serine protease 12; Belongs to the peptidase S1 family. (366 aa)
LOC110256121Peptidase S1 domain-containing protein. (274 aa)
KLK6Kallikrein related peptidase 6; Belongs to the peptidase S1 family. (246 aa)
HTRA2HtrA serine peptidase 2. (444 aa)
PAMR1Peptidase domain containing associated with muscle regeneration 1; Belongs to the peptidase S1 family. (719 aa)
A0A287AEX0_PIGPeptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (228 aa)
TMPRSS11ETransmembrane protease serine; Belongs to the peptidase S1 family. (422 aa)
ACRAcrosin heavy chain; Acrosin is the major protease of mammalian spermatozoa. It is a serine protease of trypsin-like cleavage specificity, it is synthesized in a zymogen form, proacrosin and stored in the acrosome; Belongs to the peptidase S1 family. (414 aa)
PRSS23Serine protease 23. (381 aa)
KLK1Glandular kallikrein; Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin. (263 aa)
KLK14Kallikrein related peptidase 14; Belongs to the peptidase S1 family. (252 aa)
LOC110261434Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (270 aa)
TMPRSS11ATransmembrane protease serine; Belongs to the peptidase S1 family. (420 aa)
LOC100154047Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (353 aa)
TMPRSS4Transmembrane serine protease 4; Belongs to the peptidase S1 family. (435 aa)
KLK10Kallikrein related peptidase 10; Belongs to the peptidase S1 family. (278 aa)
FAM111AFamily with sequence similarity 111 member A. (605 aa)
LOC100739735Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (290 aa)
PRSS45PSerine protease 45, pseudogene; Belongs to the peptidase S1 family. (318 aa)
PRSS22Serine protease 22; Belongs to the peptidase S1 family. (338 aa)
CFIComplement factor I isoform 1 preproprotein; Belongs to the peptidase S1 family. (587 aa)
LOC100302368Trypsin. (246 aa)
ST14Suppressor of tumorigenicity 14 protein. (856 aa)
KLK7Kallikrein related peptidase 7; Belongs to the peptidase S1 family. (257 aa)
TMPRSS9Transmembrane serine protease 9; Belongs to the peptidase S1 family. (1074 aa)
PRSS51Serine protease 51; Belongs to the peptidase S1 family. (266 aa)
LOC100513671Transmembrane protease serine; Belongs to the peptidase S1 family. (416 aa)
HPHaptoglobin alpha chain; As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidly cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pat [...] (354 aa)
CORINCorin, serine peptidase. (1113 aa)
F7Uncharacterized protein. (455 aa)
HPNHepsin; Belongs to the peptidase S1 family. (449 aa)
HABP2Hyaluronan binding protein 2. (591 aa)
PRSS48-2Serine protease 48 isoform 1. (311 aa)
PLGPlasmin heavy chain A, short form; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invas [...] (816 aa)
GZMBPeptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (250 aa)
A0A5G2QY36_PIGPeptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (331 aa)
TMPRSS15Enteropeptidase non-catalytic heavy chain; Responsible for initiating activation of pancreatic proteolytic proenzymes (trypsin, chymotrypsin and carboxypeptidase A). It catalyzes the conversion of trypsinogen to trypsin which in turn activates other proenzymes including chymotrypsinogen, procarboxypeptidases, and proelastases. (1049 aa)
CELA2AChymotrypsin-like elastase family member 2A; Acts upon elastin; Belongs to the peptidase S1 family. Elastase subfamily. (287 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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