(5 nodes) Nuclear receptor coactivator, interlocking network (Sus scrofa)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	EP300	E1A binding protein p300. (2420 aa)
	NCOA2	Nuclear receptor coactivator. (1463 aa)
	NCOA1	Nuclear receptor coactivator 1; Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone- dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase activity toward H3 and H4; the relevance of such activity remains however unclear. Plays a central role in creating m [...] (1441 aa)
	CREBBP	CREB-binding protein isoform a. (2440 aa)
	NCOA3	Uncharacterized protein. (1296 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CREBBP	EP300	ENSSSCP00000008490	ENSSSCP00000020812	CREB-binding protein isoform a.	E1A binding protein p300.	0.997
CREBBP	NCOA1	ENSSSCP00000008490	ENSSSCP00000048096	CREB-binding protein isoform a.	Nuclear receptor coactivator 1; Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone- dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase activity toward H3 and H4; the relevance of such activity remains however unclear. Plays a central role in creating m [...]	0.986
CREBBP	NCOA2	ENSSSCP00000008490	ENSSSCP00000042311	CREB-binding protein isoform a.	Nuclear receptor coactivator.	0.953
CREBBP	NCOA3	ENSSSCP00000008490	ENSSSCP00000007946	CREB-binding protein isoform a.	Uncharacterized protein.	0.956
EP300	CREBBP	ENSSSCP00000020812	ENSSSCP00000008490	E1A binding protein p300.	CREB-binding protein isoform a.	0.997
EP300	NCOA1	ENSSSCP00000020812	ENSSSCP00000048096	E1A binding protein p300.	Nuclear receptor coactivator 1; Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone- dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase activity toward H3 and H4; the relevance of such activity remains however unclear. Plays a central role in creating m [...]	0.954
EP300	NCOA2	ENSSSCP00000020812	ENSSSCP00000042311	E1A binding protein p300.	Nuclear receptor coactivator.	0.952
EP300	NCOA3	ENSSSCP00000020812	ENSSSCP00000007946	E1A binding protein p300.	Uncharacterized protein.	0.889
NCOA1	CREBBP	ENSSSCP00000048096	ENSSSCP00000008490	Nuclear receptor coactivator 1; Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone- dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase activity toward H3 and H4; the relevance of such activity remains however unclear. Plays a central role in creating m [...]	CREB-binding protein isoform a.	0.986
NCOA1	EP300	ENSSSCP00000048096	ENSSSCP00000020812	Nuclear receptor coactivator 1; Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone- dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase activity toward H3 and H4; the relevance of such activity remains however unclear. Plays a central role in creating m [...]	E1A binding protein p300.	0.954
NCOA1	NCOA2	ENSSSCP00000048096	ENSSSCP00000042311	Nuclear receptor coactivator 1; Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone- dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase activity toward H3 and H4; the relevance of such activity remains however unclear. Plays a central role in creating m [...]	Nuclear receptor coactivator.	0.980
NCOA1	NCOA3	ENSSSCP00000048096	ENSSSCP00000007946	Nuclear receptor coactivator 1; Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone- dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase activity toward H3 and H4; the relevance of such activity remains however unclear. Plays a central role in creating m [...]	Uncharacterized protein.	0.626
NCOA2	CREBBP	ENSSSCP00000042311	ENSSSCP00000008490	Nuclear receptor coactivator.	CREB-binding protein isoform a.	0.953
NCOA2	EP300	ENSSSCP00000042311	ENSSSCP00000020812	Nuclear receptor coactivator.	E1A binding protein p300.	0.952
NCOA2	NCOA1	ENSSSCP00000042311	ENSSSCP00000048096	Nuclear receptor coactivator.	Nuclear receptor coactivator 1; Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone- dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase activity toward H3 and H4; the relevance of such activity remains however unclear. Plays a central role in creating m [...]	0.980
NCOA2	NCOA3	ENSSSCP00000042311	ENSSSCP00000007946	Nuclear receptor coactivator.	Uncharacterized protein.	0.570
NCOA3	CREBBP	ENSSSCP00000007946	ENSSSCP00000008490	Uncharacterized protein.	CREB-binding protein isoform a.	0.956
NCOA3	EP300	ENSSSCP00000007946	ENSSSCP00000020812	Uncharacterized protein.	E1A binding protein p300.	0.889
NCOA3	NCOA1	ENSSSCP00000007946	ENSSSCP00000048096	Uncharacterized protein.	Nuclear receptor coactivator 1; Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone- dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase activity toward H3 and H4; the relevance of such activity remains however unclear. Plays a central role in creating m [...]	0.626
NCOA3	NCOA2	ENSSSCP00000007946	ENSSSCP00000042311	Uncharacterized protein.	Nuclear receptor coactivator.	0.570