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TXNIP | Thioredoxin-interacting protein; May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1) (By similarity). Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and co [...] (391 aa) | ||||
ARRDC4 | Arrestin domain containing 4. (413 aa) | ||||
ARR3 | Arrestin-C; May play a role in an as yet undefined retina-specific signal transduction. Could bind to photoactivated-phosphorylated red/green opsins (By similarity). (394 aa) | ||||
ARRB1 | Arrestin beta 1. (607 aa) | ||||
SAG | S-arrestin; Binds to photoactivated, phosphorylated RHO and terminates RHO signaling via G-proteins by competing with G-proteins for the same binding site on RHO. May play a role in preventing light-dependent degeneration of retinal photoreceptor cells. (407 aa) | ||||
ARRDC3 | Arrestin domain-containing protein 3 isoform a. (414 aa) | ||||
ARRB2 | Arrestin beta 2. (493 aa) |