(55 nodes) DEAD/DEAH box helicase domain network (Sus scrofa)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

Your Input:
	DDX51	DEAD-box helicase 51; Belongs to the DEAD box helicase family. (648 aa)
	YTHDC2	YTH domain containing 2. (1430 aa)
	DDX6	Putative ATP-dependent RNA helicase DDX6 isoform X1; Belongs to the DEAD box helicase family. (483 aa)
	DDX55	RNA helicase. (600 aa)
	DDX58	Antiviral innate immune response receptor RIG-I; Innate immune receptor that senses cytoplasmic viral nucleic acids and activates a downstream signaling cascade leading to the production of type I interferons and proinflammatory cytokines. Forms a ribonucleoprotein complex with viral RNAs on which it homooligomerizes to form filaments. The homooligomerization allows the recruitment of RNF135 an E3 ubiquitin-protein ligase that activates and amplifies the RIG-I-mediated antiviral signaling in an RNA length-dependent manner through ubiquitination-dependent and -independent mechanisms. Up [...] (943 aa)
	ASCC3	Activating signal cointegrator 1 complex subunit 3. (2203 aa)
	DHX57	DExH-box helicase 57. (1396 aa)
	DDX47	Putative ATP-dependent RNA helicase DDX47; Belongs to the DEAD box helicase family. (493 aa)
	DHX34	DExH-box helicase 34. (1098 aa)
	RECQL5	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (984 aa)
	DDX39B	Spliceosome RNA helicase DDX39B; Involved in nuclear export of spliced and unspliced mRNA. Assembling component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pat [...] (467 aa)
	DDX50	DExD-box helicase 50. (737 aa)
	HELQ	Helicase, POLQ like. (1076 aa)
	DHX15	Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15. (795 aa)
	DDX1	DEAD-box helicase 1. (741 aa)
	SNRNP200	U5 small nuclear ribonucleoprotein 200 kDa helicase isoform X1. (2136 aa)
	DHX9	ATP-dependent RNA helicase A. (1384 aa)
	DHX36	DEAH (Asp-Glu-Ala-His) box polypeptide 36 tv1. (1012 aa)
	DHX29	ATP-dependent RNA helicase DHX29; ATP-binding RNA helicase involved in translation initiation. Part of the 43S pre-initiation complex that is required for efficient initiation on mRNAs of higher eukaryotes with structured 5'-UTRs by promoting efficient NTPase-dependent 48S complex formation. Specifically binds to the 40S ribosome near the mRNA entrance. Does not possess a processive helicase activity; Belongs to the DEAD box helicase family. DEAH subfamily. (1366 aa)
	DDX49	DEAD-box helicase 49; Belongs to the DEAD box helicase family. (476 aa)
	DDX20	Putative ATP-dependent RNA helicase DDX20 isoform X1. (832 aa)
	DDX43	Uncharacterized protein; Belongs to the DEAD box helicase family. (641 aa)
	TDRD12	Uncharacterized protein. (1304 aa)
	TDRD9	Tudor domain containing 9. (1389 aa)
	DDX24	DEAD-box helicase 24. (819 aa)
	EIF4A1	Eukaryotic translation initiation factor 4A isoform 1; Belongs to the DEAD box helicase family. (406 aa)
	DDX52	Putative ATP-dependent RNA helicase DDX52 isoform 1. (599 aa)
	DDX27	DEAD-box helicase 27; Belongs to the DEAD box helicase family. (763 aa)
	LOC100624590	ATP-dependent RNA helicase DDX3X isoform 2; Belongs to the DEAD box helicase family. (670 aa)
	DDX28	DEAD-box helicase 28. (540 aa)
	DDX18	RNA helicase. (786 aa)
	DHX40	Putative ATP-dependent RNA helicase DHX40 isoform X1. (779 aa)
	DDX42	DEAD-box helicase 42. (963 aa)
	EIF4A3	Eukaryotic initiation factor 4A-III, N-terminally processed; ATP-dependent RNA helicase. Involved in pre-mRNA splicing as component of the spliceosome. Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expr [...] (488 aa)
	MTREX	Exosome RNA helicase MTR4. (1042 aa)
	WRN	WRN RecQ like helicase. (1466 aa)
	DDX25	ATP-dependent RNA helicase DDX25 isoform 1. (483 aa)
	DDX10	RNA helicase. (877 aa)
	DDX3X	ATP-dependent RNA helicase DDX3X isoform 1; Belongs to the DEAD box helicase family. (662 aa)
	DDX53	Uncharacterized protein; Belongs to the DEAD box helicase family. (630 aa)
	EIF4A2	Eukaryotic translation initiation factor 4A2; Belongs to the DEAD box helicase family. (410 aa)
	DDX21	DEAD (Asp-Glu-Ala-Asp) box helicase 21. (784 aa)
	BLM	BLM RecQ like helicase. (1432 aa)
	SKIV2L	Ski2 like RNA helicase. (1246 aa)
	DHX16	Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16; Required for pre-mRNA splicing as component of the spliceosome. Contributes to pre-mRNA splicing after spliceosome formation and prior to the first transesterification reaction. Belongs to the DEAD box helicase family. DEAH subfamily. DDX16/PRP8 sub-subfamily. (1062 aa)
	DDX23	DEAD (Asp-Glu-Ala-Asp) box polypeptide 23. (820 aa)
	DDX4	Probable ATP-dependent RNA helicase DDX4; ATP-dependent RNA helicase required during spermatogenesis to repress transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Involved in the secondary piRNAs metabolic process, the production of piRNAs in fetal male germ cells through a ping-pong amplification cycl [...] (744 aa)
	DDX46	DEAD-box helicase 46. (1033 aa)
	DDX60	Putative ATP-dependent RNA helicase DDX60 isoform X1. (1704 aa)
	DHX37	DEAH-box helicase 37. (1186 aa)
	DDX39A	DExD-box helicase 39A. (452 aa)
	DDX5	DEAD-box helicase 5; Belongs to the DEAD box helicase family. (617 aa)
	DDX19A	DEAD-box helicase 19B. (484 aa)
	DDX54	ATP-dependent RNA helicase DDX54; Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily. (879 aa)
	DHX33	DEAH-box helicase 33. (702 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ASCC3	DHX15	ENSSSCP00000042651	ENSSSCP00000009333	Activating signal cointegrator 1 complex subunit 3.	Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15.	0.405
ASCC3	DHX16	ENSSSCP00000042651	ENSSSCP00000001456	Activating signal cointegrator 1 complex subunit 3.	Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16; Required for pre-mRNA splicing as component of the spliceosome. Contributes to pre-mRNA splicing after spliceosome formation and prior to the first transesterification reaction. Belongs to the DEAD box helicase family. DEAH subfamily. DDX16/PRP8 sub-subfamily.	0.425
ASCC3	DHX29	ENSSSCP00000042651	ENSSSCP00000026225	Activating signal cointegrator 1 complex subunit 3.	ATP-dependent RNA helicase DHX29; ATP-binding RNA helicase involved in translation initiation. Part of the 43S pre-initiation complex that is required for efficient initiation on mRNAs of higher eukaryotes with structured 5'-UTRs by promoting efficient NTPase-dependent 48S complex formation. Specifically binds to the 40S ribosome near the mRNA entrance. Does not possess a processive helicase activity; Belongs to the DEAD box helicase family. DEAH subfamily.	0.462
ASCC3	YTHDC2	ENSSSCP00000042651	ENSSSCP00000048904	Activating signal cointegrator 1 complex subunit 3.	YTH domain containing 2.	0.606
BLM	DDX58	ENSSSCP00000001986	ENSSSCP00000045260	BLM RecQ like helicase.	Antiviral innate immune response receptor RIG-I; Innate immune receptor that senses cytoplasmic viral nucleic acids and activates a downstream signaling cascade leading to the production of type I interferons and proinflammatory cytokines. Forms a ribonucleoprotein complex with viral RNAs on which it homooligomerizes to form filaments. The homooligomerization allows the recruitment of RNF135 an E3 ubiquitin-protein ligase that activates and amplifies the RIG-I-mediated antiviral signaling in an RNA length-dependent manner through ubiquitination-dependent and -independent mechanisms. Up [...]	0.629
BLM	RECQL5	ENSSSCP00000001986	ENSSSCP00000034802	BLM RecQ like helicase.	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.	0.400
BLM	WRN	ENSSSCP00000001986	ENSSSCP00000016786	BLM RecQ like helicase.	WRN RecQ like helicase.	0.711
DDX1	DDX21	ENSSSCP00000009188	ENSSSCP00000010925	DEAD-box helicase 1.	DEAD (Asp-Glu-Ala-Asp) box helicase 21.	0.952
DDX1	DDX5	ENSSSCP00000009188	ENSSSCP00000056924	DEAD-box helicase 1.	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	0.523
DDX1	DDX50	ENSSSCP00000009188	ENSSSCP00000010924	DEAD-box helicase 1.	DExD-box helicase 50.	0.469
DDX1	DDX58	ENSSSCP00000009188	ENSSSCP00000045260	DEAD-box helicase 1.	Antiviral innate immune response receptor RIG-I; Innate immune receptor that senses cytoplasmic viral nucleic acids and activates a downstream signaling cascade leading to the production of type I interferons and proinflammatory cytokines. Forms a ribonucleoprotein complex with viral RNAs on which it homooligomerizes to form filaments. The homooligomerization allows the recruitment of RNF135 an E3 ubiquitin-protein ligase that activates and amplifies the RIG-I-mediated antiviral signaling in an RNA length-dependent manner through ubiquitination-dependent and -independent mechanisms. Up [...]	0.430
DDX1	DDX60	ENSSSCP00000009188	ENSSSCP00000066827	DEAD-box helicase 1.	Putative ATP-dependent RNA helicase DDX60 isoform X1.	0.474
DDX1	DHX15	ENSSSCP00000009188	ENSSSCP00000009333	DEAD-box helicase 1.	Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15.	0.726
DDX1	DHX16	ENSSSCP00000009188	ENSSSCP00000001456	DEAD-box helicase 1.	Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16; Required for pre-mRNA splicing as component of the spliceosome. Contributes to pre-mRNA splicing after spliceosome formation and prior to the first transesterification reaction. Belongs to the DEAD box helicase family. DEAH subfamily. DDX16/PRP8 sub-subfamily.	0.489
DDX1	DHX29	ENSSSCP00000009188	ENSSSCP00000026225	DEAD-box helicase 1.	ATP-dependent RNA helicase DHX29; ATP-binding RNA helicase involved in translation initiation. Part of the 43S pre-initiation complex that is required for efficient initiation on mRNAs of higher eukaryotes with structured 5'-UTRs by promoting efficient NTPase-dependent 48S complex formation. Specifically binds to the 40S ribosome near the mRNA entrance. Does not possess a processive helicase activity; Belongs to the DEAD box helicase family. DEAH subfamily.	0.614
DDX1	DHX33	ENSSSCP00000009188	ENSSSCP00000052770	DEAD-box helicase 1.	DEAH-box helicase 33.	0.686
DDX1	DHX34	ENSSSCP00000009188	ENSSSCP00000037302	DEAD-box helicase 1.	DExH-box helicase 34.	0.471
DDX1	DHX36	ENSSSCP00000009188	ENSSSCP00000026838	DEAD-box helicase 1.	DEAH (Asp-Glu-Ala-His) box polypeptide 36 tv1.	0.985
DDX1	DHX37	ENSSSCP00000009188	ENSSSCP00000070027	DEAD-box helicase 1.	DEAH-box helicase 37.	0.490
DDX1	DHX40	ENSSSCP00000009188	ENSSSCP00000018719	DEAD-box helicase 1.	Putative ATP-dependent RNA helicase DHX40 isoform X1.	0.487