STRINGSTRING
ASCL4 ASCL4 ARNTL2 ARNTL2 TCF3 TCF3 MSGN1 MSGN1 MXD4 MXD4 AHRR AHRR TFAP4 TFAP4 MNT MNT NCOA2 NCOA2 HAND1 HAND1 ID1 ID1 NEUROD4 NEUROD4 HES2 HES2 NEUROD2 NEUROD2 TAL1 TAL1 A0A286ZVX9_PIG A0A286ZVX9_PIG NEUROD6 NEUROD6 TCF15 TCF15 HEYL HEYL NEUROG2 NEUROG2 SREBF1 SREBF1 PTF1A PTF1A TCF23 TCF23 ATOH7 ATOH7 LYL1 LYL1 AHR AHR I3LBW9_PIG I3LBW9_PIG SREBF2 SREBF2 ID4 ID4 SIM2 SIM2 BHLHA9 BHLHA9 NEUROD1 NEUROD1 FERD3L FERD3L NEUROG1 NEUROG1 MXD3 MXD3 MYOD1 MYOD1 NPAS4 NPAS4 TFE3 TFE3 OLIG1 OLIG1 USF3 USF3 ATOH1 ATOH1 ID2 ID2 MYCN MYCN EPAS1 EPAS1 MXD1 MXD1 FIGLA FIGLA ATOH8 ATOH8 NPAS2 NPAS2 NCOA3 NCOA3 NHLH2 NHLH2 NHLH1 NHLH1 MSC MSC HEY1 HEY1 MGA MGA HEY2 HEY2 HES7 HES7 OLIG2 OLIG2 OLIG3 OLIG3 HES3 HES3 MYC MYC MYF6 MYF6 TCF24 TCF24 MYF5 MYF5 ASCL5 ASCL5 NPAS3 NPAS3 BHMG1 BHMG1 HAND2 HAND2 ASCL2 ASCL2 MYCL MYCL HES5 HES5 ID3 ID3 TFEC TFEC TCF21 TCF21 BHLHA15 BHLHA15 MXI1 MXI1 ARNTL ARNTL MITF MITF HELT HELT SCX SCX HIF1A HIF1A TCF12 TCF12 NEUROG3 NEUROG3 MAX MAX BHLHE41 BHLHE41 NCOA1 NCOA1 USF2 USF2 MYOG MYOG HES1 HES1 HES4 HES4 NPAS1 NPAS1 HIF3A HIF3A MESP2 MESP2 MESP1 MESP1 TFEB TFEB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ASCL4Achaete-scute family bHLH transcription factor 4. (173 aa)
ARNTL2Aryl hydrocarbon receptor nuclear translocator like 2. (652 aa)
TCF3Transcription factor E2-alpha isoform X12. (642 aa)
MSGN1Mesogenin 1. (194 aa)
MXD4MAX dimerization protein 4. (209 aa)
AHRRUncharacterized protein. (695 aa)
TFAP4Transcription factor AP-4. (338 aa)
MNTMAX network transcriptional repressor. (585 aa)
NCOA2Nuclear receptor coactivator. (1463 aa)
HAND1Heart and neural crest derivatives expressed 1. (218 aa)
ID1Inhibitor of DNA binding 1, dominant negative helix-loop-helix protein. (154 aa)
NEUROD4Neurogenic differentiation factor. (331 aa)
HES2Hes family bHLH transcription factor 2. (165 aa)
NEUROD2Neurogenic differentiation factor. (382 aa)
TAL1TAL bHLH transcription factor 1, erythroid differentiation factor. (331 aa)
A0A286ZVX9_PIGBHLH domain-containing protein. (203 aa)
NEUROD6Neurogenic differentiation factor. (337 aa)
TCF15Transcription factor 15. (197 aa)
HEYLHairy/enhancer-of-split related with YRPW motif-like protein isoform X1. (328 aa)
NEUROG2Neurogenin-2. (272 aa)
SREBF1Processed sterol regulatory element-binding protein 1; Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the fatty acid and to a lesser degree the cholesterol synthesis pathway. Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3') (By similarity). (1151 aa)
PTF1APancreas associated transcription factor 1a. (328 aa)
TCF23Transcription factor 23. (214 aa)
ATOH7Atonal bHLH transcription factor 7. (155 aa)
LYL1LYL1 basic helix-loop-helix family member. (278 aa)
AHRAryl hydrocarbon receptor. (849 aa)
I3LBW9_PIGBHLH domain-containing protein. (426 aa)
SREBF2Sterol regulatory element binding transcription factor 2. (1135 aa)
ID4DNA-binding protein inhibitor ID-4; Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation (By similarity). (161 aa)
SIM2Single-minded homolog 2 long isoform. (673 aa)
BHLHA9Basic helix-loop-helix family member a9. (224 aa)
NEUROD1Neurogenic differentiation factor. (356 aa)
FERD3LFer3 like bHLH transcription factor. (164 aa)
NEUROG1Neurogenin 1. (246 aa)
MXD3MAX dimerization protein 3. (206 aa)
MYOD1Myoblast determination protein 1; Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Together with MYF5 and MYOG, co-occupies muscle-specific gene promoter core region during myogenesis. Induces fibroblasts to differentiate into myoblasts. Interacts with and is inhibited by the twist protein. This interaction probably involves the basic domains of both proteins (By similarity). (319 aa)
NPAS4Neuronal PAS domain protein 4. (803 aa)
TFE3Transcription factor binding to IGHM enhancer 3. (575 aa)
OLIG1Oligodendrocyte transcription factor 1. (269 aa)
USF3Basic helix-loop-helix domain-containing protein USF3 isoform X1. (2255 aa)
ATOH1Atonal bHLH transcription factor 1. (353 aa)
ID2DNA-binding protein inhibitor ID-2; Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the C [...] (134 aa)
MYCNMYCN proto-oncogene, bHLH transcription factor. (465 aa)
EPAS1Uncharacterized protein. (870 aa)
MXD1MAX dimerization protein 1. (221 aa)
FIGLAFolliculogenesis specific basic helix-loop-helix protein. (222 aa)
ATOH8Atonal bHLH transcription factor 8. (315 aa)
NPAS2Neuronal PAS domain protein 2. (796 aa)
NCOA3Uncharacterized protein. (1296 aa)
NHLH2Nescient helix-loop-helix 2. (135 aa)
NHLH1Nescient helix-loop-helix 1. (133 aa)
MSCMusculin. (201 aa)
HEY1Hes related family bHLH transcription factor with YRPW motif 1. (304 aa)
MGAMAX dimerization protein MGA. (3053 aa)
HEY2Hes related family bHLH transcription factor with YRPW motif 2. (337 aa)
HES7Hes family bHLH transcription factor 7. (225 aa)
OLIG2Oligodendrocyte transcription factor 2. (323 aa)
OLIG3Oligodendrocyte transcription factor 3. (272 aa)
HES3Hes family bHLH transcription factor 3. (184 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). (452 aa)
MYF6Myogenic factor 6; Involved in muscle differentiation (myogenic factor). Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein (By similarity). (249 aa)
TCF24Transcription factor 24. (168 aa)
MYF5Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (253 aa)
ASCL5Achaete-scute family bHLH transcription factor 5. (178 aa)
NPAS3Neuronal PAS domain protein 3. (944 aa)
BHMG1Basic helix-loop-helix and HMG-box containing 1. (550 aa)
HAND2Heart-and neural crest derivatives-expressed protein 2. (217 aa)
ASCL2BHLH domain-containing protein. (193 aa)
MYCLMYCL proto-oncogene, bHLH transcription factor. (364 aa)
HES5Hes family bHLH transcription factor 5. (226 aa)
ID3BHLH domain-containing protein. (118 aa)
TFECTranscription factor EC. (317 aa)
TCF21Transcription factor 21. (179 aa)
BHLHA15Basic helix-loop-helix family member a15. (234 aa)
MXI1MAX interactor 1, dimerization protein. (281 aa)
ARNTLAryl hydrocarbon receptor nuclear translocator like. (633 aa)
MITFMicrophthalmia-associated transcription factor isoform 1. (520 aa)
HELTHelt bHLH transcription factor. (242 aa)
SCXBasic helix-loop-helix transcription factor scleraxis. (310 aa)
HIF1AHypoxia-inducible factor 1-alpha isoform 1. (824 aa)
TCF12Transcription factor 12 isoform a. (706 aa)
NEUROG3Neurogenin 3. (214 aa)
MAXMYC associated factor X. (253 aa)
BHLHE41Class E basic helix-loop-helix protein 41. (482 aa)
NCOA1Nuclear receptor coactivator 1; Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone- dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase activity toward H3 and H4; the relevance of such activity remains however unclear. Plays a central role in creating m [...] (1441 aa)
USF2Upstream transcription factor 2, c-fos interacting. (391 aa)
MYOGMyogenin; Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation, cell cycle exit and muscle atrophy. Essential for the development of functional embryonic skeletal fiber muscle differentiation. However is dispensable for postnatal skeletal muscle growth; phosphorylation by CAMK2G inhibits its transcriptional activity in respons to muscle activity. Required for the recruitment of the FACT complex to muscle-specific promoter regions, thus promoting gene expression initiation. During terminal myoblast dif [...] (215 aa)
HES1Uncharacterized protein. (280 aa)
HES4Hes family bHLH transcription factor 4. (228 aa)
NPAS1Neuronal PAS domain protein 1. (594 aa)
HIF3AHypoxia inducible factor 3 subunit alpha. (671 aa)
MESP2Mesoderm posterior bHLH transcription factor 2. (371 aa)
MESP1Mesoderm posterior bHLH transcription factor 1. (256 aa)
TFEBTranscription factor EB. (451 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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