(24 nodes) S100/CaBP-9k-type, calcium binding, subdomain network (Sus scrofa)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SNTN	Sentan, cilia apical structure protein. (147 aa)
	S100A5	Protein S100; Belongs to the S-100 family. (93 aa)
	S100A4	Protein S100; Belongs to the S-100 family. (101 aa)
	S100A3	Protein S100; Belongs to the S-100 family. (101 aa)
	S100A14	Protein S100-A14 isoform X1; Belongs to the S-100 family. (104 aa)
	S100A7	EF-hand domain-containing protein. (101 aa)
	TCHHL1	Trichohyalin like 1. (887 aa)
	S100G	Protein S100-G, minor isoform; Belongs to the S-100 family. (108 aa)
	S100A6	Protein S100-A6; May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes such as the reorganization of the actin cytoskeleton and in cell motility. Binds 2 calcium ions. Calcium binding is cooperative (By similarity). (90 aa)
	HRNR	Uncharacterized protein. (266 aa)
	RPTN	EF-hand domain-containing protein. (602 aa)
	S100A9	EF-hand domain-containing protein; Belongs to the S-100 family. (222 aa)
	S100Z	Protein S100; Belongs to the S-100 family. (99 aa)
	LOC110260465	EF-hand domain-containing protein. (100 aa)
	S100A1	S100 calcium binding protein A1; Belongs to the S-100 family. (181 aa)
	S100A2	S100 calcium binding protein A2. (170 aa)
	S100A8	Protein S100; Belongs to the S-100 family. (89 aa)
	S100A10	Protein S100-A10; Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine-specific kinase. (97 aa)
	S100A12	Protein S100-A12; S100A12 is a calcium-, zinc- and copper-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. Its proinflammatory activity involves recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to receptor for advanced glycation endproducts (AGER). Binding to AGER activates the MAP-kinase and NF- kappa-B signaling pathways leadi [...] (95 aa)
	LOC110258323	Protein S100; Belongs to the S-100 family. (133 aa)
	CRNN	Cornulin. (659 aa)
	S100A13	S_100 domain-containing protein; Belongs to the S-100 family. (209 aa)
	S100A11	Protein S100-A11; Facilitates the differentiation and the cornification of keratinocytes. (130 aa)
	S100A16	Protein S100; Belongs to the S-100 family. (103 aa)

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CRNN	RPTN	ENSSSCP00000044932	ENSSSCP00000028403	Cornulin.	EF-hand domain-containing protein.	0.485
CRNN	S100A3	ENSSSCP00000044932	ENSSSCP00000007013	Cornulin.	Protein S100; Belongs to the S-100 family.	0.635
CRNN	TCHHL1	ENSSSCP00000044932	ENSSSCP00000007047	Cornulin.	Trichohyalin like 1.	0.661
HRNR	RPTN	ENSSSCP00000023084	ENSSSCP00000028403	Uncharacterized protein.	EF-hand domain-containing protein.	0.413
LOC110258323	S100A1	ENSSSCP00000033357	ENSSSCP00000030017	Protein S100; Belongs to the S-100 family.	S100 calcium binding protein A1; Belongs to the S-100 family.	0.780
LOC110258323	S100A12	ENSSSCP00000033357	ENSSSCP00000032082	Protein S100; Belongs to the S-100 family.	Protein S100-A12; S100A12 is a calcium-, zinc- and copper-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. Its proinflammatory activity involves recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to receptor for advanced glycation endproducts (AGER). Binding to AGER activates the MAP-kinase and NF- kappa-B signaling pathways leadi [...]	0.579
LOC110258323	S100A2	ENSSSCP00000033357	ENSSSCP00000030063	Protein S100; Belongs to the S-100 family.	S100 calcium binding protein A2.	0.443
LOC110258323	S100A4	ENSSSCP00000033357	ENSSSCP00000007012	Protein S100; Belongs to the S-100 family.	Protein S100; Belongs to the S-100 family.	0.445
LOC110258323	S100A6	ENSSSCP00000033357	ENSSSCP00000020154	Protein S100; Belongs to the S-100 family.	Protein S100-A6; May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes such as the reorganization of the actin cytoskeleton and in cell motility. Binds 2 calcium ions. Calcium binding is cooperative (By similarity).	0.696
LOC110260465	S100A11	ENSSSCP00000029553	ENSSSCP00000067377	EF-hand domain-containing protein.	Protein S100-A11; Facilitates the differentiation and the cornification of keratinocytes.	0.478
LOC110260465	S100A12	ENSSSCP00000029553	ENSSSCP00000032082	EF-hand domain-containing protein.	Protein S100-A12; S100A12 is a calcium-, zinc- and copper-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. Its proinflammatory activity involves recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to receptor for advanced glycation endproducts (AGER). Binding to AGER activates the MAP-kinase and NF- kappa-B signaling pathways leadi [...]	0.628
LOC110260465	S100A13	ENSSSCP00000029553	ENSSSCP00000054548	EF-hand domain-containing protein.	S_100 domain-containing protein; Belongs to the S-100 family.	0.484
LOC110260465	S100A2	ENSSSCP00000029553	ENSSSCP00000030063	EF-hand domain-containing protein.	S100 calcium binding protein A2.	0.504
LOC110260465	S100A5	ENSSSCP00000029553	ENSSSCP00000007011	EF-hand domain-containing protein.	Protein S100; Belongs to the S-100 family.	0.485
LOC110260465	S100A6	ENSSSCP00000029553	ENSSSCP00000020154	EF-hand domain-containing protein.	Protein S100-A6; May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes such as the reorganization of the actin cytoskeleton and in cell motility. Binds 2 calcium ions. Calcium binding is cooperative (By similarity).	0.456
LOC110260465	S100A7	ENSSSCP00000029553	ENSSSCP00000007027	EF-hand domain-containing protein.	EF-hand domain-containing protein.	0.801
RPTN	CRNN	ENSSSCP00000028403	ENSSSCP00000044932	EF-hand domain-containing protein.	Cornulin.	0.485
RPTN	HRNR	ENSSSCP00000028403	ENSSSCP00000023084	EF-hand domain-containing protein.	Uncharacterized protein.	0.413
RPTN	TCHHL1	ENSSSCP00000028403	ENSSSCP00000007047	EF-hand domain-containing protein.	Trichohyalin like 1.	0.445
S100A1	LOC110258323	ENSSSCP00000030017	ENSSSCP00000033357	S100 calcium binding protein A1; Belongs to the S-100 family.	Protein S100; Belongs to the S-100 family.	0.780