STRINGSTRING
FYN FYN TYRO3 TYRO3 IGF1R IGF1R TEK TEK LYN LYN NTRK1 NTRK1 INSRR INSRR EPHB4 EPHB4 TXK TXK TEC TEC PTK2B PTK2B RET RET EPHB3 EPHB3 INSR INSR FLT4 FLT4 PDGFRB PDGFRB ERBB4 ERBB4 EPHA4 EPHA4 EPHA1 EPHA1 MET MET ERBB2 ERBB2 EPHB1 EPHB1 MST1R MST1R EPHA3 EPHA3 MUSK MUSK NTRK3 NTRK3 EGFR EGFR A0A5G2RBJ3_PIG A0A5G2RBJ3_PIG KIT KIT CSF1R CSF1R FLT1 FLT1 YES1 YES1 HCK HCK PTK2 PTK2 ABL1 ABL1 EPHA7 EPHA7 MATK MATK PDGFRA PDGFRA ABL2 ABL2 ROS1 ROS1 SRMS SRMS FGFR3 FGFR3 AXL AXL NTRK2 NTRK2 MERTK MERTK PTK6 PTK6 SYK SYK ITK ITK EPHA6 EPHA6 JAK1 JAK1 BLK BLK JAK3 JAK3 FGFR2 FGFR2 FGFR1 FGFR1 SRC SRC KDR KDR JAK2 JAK2 BMX BMX FLT3 FLT3 BTK BTK FER FER FES FES CSK CSK EPHA2 EPHA2 EPHA8 EPHA8 EPHB2 EPHB2 TIE1 TIE1 FRK FRK
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FYNTyrosine-protein kinase Fyn; Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motility through [...] (537 aa)
TYRO3TYRO3 protein tyrosine kinase. (913 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
TEKTEK receptor tyrosine kinase. (1147 aa)
LYNTyrosine-protein kinase. (512 aa)
NTRK1Tyrosine-protein kinase receptor. (795 aa)
INSRRTyrosine-protein kinase receptor. (1315 aa)
EPHB4EPH receptor B4. (935 aa)
TXKTyrosine-protein kinase. (551 aa)
TECTyrosine-protein kinase. (632 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
RETProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1111 aa)
EPHB3Ephrin type-B receptor 3. (999 aa)
INSRTyrosine-protein kinase receptor. (1382 aa)
FLT4Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1362 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1181 aa)
ERBB4Receptor protein-tyrosine kinase. (1201 aa)
EPHA4EPH receptor A4. (986 aa)
EPHA1Ephrin type-A receptor 1. (982 aa)
METHepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] (1381 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
EPHB1Ephrin type-B receptor 1. (984 aa)
MST1RMacrophage stimulating 1 receptor. (1398 aa)
EPHA3Ephrin type-A receptor 3 isoform X1. (984 aa)
MUSKMuscle associated receptor tyrosine kinase. (869 aa)
NTRK3NT-3 growth factor receptor; Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation. Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. (864 aa)
EGFRReceptor protein-tyrosine kinase. (1205 aa)
A0A5G2RBJ3_PIGTyrosine-protein kinase receptor. (542 aa)
KITMast/stem cell growth factor receptor Kit; Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activat [...] (975 aa)
CSF1RColony stimulating factor 1 receptor. (1053 aa)
FLT1Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1302 aa)
YES1Tyrosine-protein kinase. (553 aa)
HCKTyrosine-protein kinase. (527 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1119 aa)
ABL1Tyrosine-protein kinase. (1146 aa)
EPHA7Ephrin type-A receptor 7 isoform 1. (998 aa)
MATKTyrosine-protein kinase. (485 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1088 aa)
ABL2Tyrosine-protein kinase. (1096 aa)
ROS1Tyrosine-protein kinase receptor. (2343 aa)
SRMSTyrosine-protein kinase. (494 aa)
FGFR3Fibroblast growth factor receptor. (855 aa)
AXLUncharacterized protein. (871 aa)
NTRK2Tyrosine-protein kinase receptor. (838 aa)
MERTKMER proto-oncogene, tyrosine kinase. (998 aa)
PTK6Tyrosine-protein kinase. (449 aa)
SYK40 kDa tyrosine-protein kinase SYK; Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and vascular development. Assembles into signaling complexes with activated receptors at the plasma membrane via interaction between its SH2 domains and the receptor tyrosine-phosphorylated ITAM domains. The association with the recepto [...] (628 aa)
ITKTyrosine-protein kinase. (598 aa)
EPHA6EPH receptor A6. (1153 aa)
JAK1Tyrosine-protein kinase. (1154 aa)
BLKTyrosine-protein kinase. (501 aa)
JAK3Tyrosine-protein kinase. (1103 aa)
FGFR2Fibroblast growth factor receptor. (820 aa)
FGFR1Fibroblast growth factor receptor. (820 aa)
SRCTyrosine-protein kinase. (559 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1360 aa)
JAK2Tyrosine-protein kinase JAK2; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN- beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors [...] (1131 aa)
BMXTyrosine-protein kinase. (706 aa)
FLT3Receptor-type tyrosine-protein kinase FLT3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (990 aa)
BTKTyrosine-protein kinase. (659 aa)
FERTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (822 aa)
FESTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (822 aa)
CSKTyrosine-protein kinase. (474 aa)
EPHA2Ephrin type-A receptor 2 isoform 1. (975 aa)
EPHA8EPH receptor A8. (930 aa)
EPHB2EPH receptor B2. (987 aa)
TIE1Tyrosine kinase with immunoglobulin like and EGF like domains 1. (1138 aa)
FRKTyrosine-protein kinase. (511 aa)
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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